阅读说明：本技术 一种治疗脑性瘫痪的中药制剂及其制备方法 (Traditional Chinese medicine preparation for treating cerebral palsy and preparation method thereof ) 是由 宋虎杰 于 2020-06-23 设计创作，主要内容包括：本发明公开一种治疗脑性瘫痪的中药制剂,其特征在于,包括如下重量份的中药组分：僵蚕110-130g,白芍62-82g,地龙62-82g,当归38-58g,葛根26-46g,木瓜26-46g,白胡椒26-46g,厚朴38-58g,甘草2-22g,本发明可以平肝熄风、养血柔脉,用于脑性瘫痪、中风、颅脑损伤之肝强脾弱证。(The invention discloses a traditional Chinese medicine preparation for treating cerebral palsy, which is characterized by comprising the following traditional Chinese medicine components in parts by weight: 110 g of stiff silkworm, 62-82g of white paeony root, 62-82g of earthworm, 38-58g of Chinese angelica, 26-46g of kudzu-vine root, 26-46g of pawpaw, 26-46g of white pepper, 38-58g of officinal magnolia bark and 2-22g of liquorice.)

1. The traditional Chinese medicine preparation for treating cerebral palsy is characterized by comprising the following traditional Chinese medicine components in parts by weight: 110-130g of stiff silkworm, 62-82g of white paeony root, 62-82g of earthworm, 38-58g of Chinese angelica, 26-46g of kudzu root, 26-46g of pawpaw, 26-46g of white pepper, 38-58g of mangnolia officinalis and 2-22g of liquorice.

2. The traditional Chinese medicine preparation for treating cerebral palsy as claimed in claim 1, which is characterized by comprising the following traditional Chinese medicine components in parts by weight: 125g of stiff silkworm 115-containing material, 67-77g of white paeony root, 67-77g of earthworm, 43-53g of Chinese angelica, 31-41g of kudzu root, 31-41g of pawpaw, 31-41g of white pepper, 43-53g of officinal magnolia bark and 7-17g of liquorice.

3. The traditional Chinese medicine preparation for treating cerebral palsy as claimed in claim 2, which is characterized by comprising the following traditional Chinese medicine components in parts by weight: : 120g of stiff silkworm, 72g of white paeony root, 72g of earthworm, 48g of Chinese angelica, 36g of kudzu root, 36g of pawpaw, 36g of white pepper, 48g of officinal magnolia bark and 12g of liquorice.

4. A preparation method of a traditional Chinese medicine preparation for treating cerebral palsy is characterized by adopting the preparation raw materials according to any one of claims 1, 2 and 3 and the following steps: (1) selecting and removing impurities from the preparation raw materials, weighing the preparation raw materials in parts by weight, drying the white paeony root, the earthworm, the Chinese angelica and the white pepper by blowing air at 60 ℃, crushing into fine powder, and sieving by a sieve of 100 meshes for later use;

(2) weighing the batryticated silkworm, the kudzu vine root, the pawpaw, the magnolia officinalis and the liquorice according to the weight parts of the raw materials, mixing, adding 8 times of water, decocting for 30 minutes, pouring out the decoction after 2.5 hours of first decoction, decocting for 1.5 hours again, combining the two decoctions, filtering, and concentrating the filtrate under reduced pressure to obtain thick paste with the relative density of 1.30-1.35 for later use;

(3) adding the above fine powder, mixing, air drying at 60 deg.C, pulverizing, sieving with 100 mesh sieve, mixing, granulating with ethanol, drying, grading, making into capsule, and bottling.

5. The preparation method of the traditional Chinese medicine preparation for treating cerebral palsy according to claim 4, which is characterized by comprising the following steps: the pressure condition of concentrating the filtrate under reduced pressure in the step (2) to a thick paste with the relative density of 1.30-1.35 is as follows: -0.08 to-0.09 MPa, 60 to 70 ℃.

Technical Field

The invention relates to the field of medicines, in particular to a traditional Chinese medicine preparation for treating cerebral palsy and a preparation method thereof.

Background

Cerebral palsy is a complex disease, a non-progressive, central motor dysfunction caused by brain injury due to a variety of causes. Most scholars in the past believe that the recovery of damaged brain cells is irreversible and no effective drug treatment is available, and new theories are generated as global brain research heat rises, and recent researches show that the brain nerve cells have certain plasticity-regeneration capacity, and the damage of central nerves caused by various factors does not necessarily lead to the death of all nerve cells, wherein most nerve cells are damaged to different degrees or are in a semi-death or dormant state due to insufficient nutrition supply, and the neurons can be reactivated once being sufficiently supplied. The key to the treatment of cerebral palsy and mental retardation is to enhance neuronal activity. Biological medicines, especially Chinese traditional medicines, can effectively improve brain circulation, improve the metabolism function of brain cells and promote the regeneration of neurons. A large number of animal experiments, clinical observations and resuscitation of plants and people prove the theory, the generation of the theory and the negative of the theory that the original brain cells can not be regenerated lead people to have qualitative leap on the research idea of treating cerebral palsy by medicaments and the development of medicaments. The physician of all ages is comprehensively concerned about the pathogenesis of the cerebral spastic cerebral palsy, which is based on the heart-liver-kidney deficiency syndrome, the heart-spleen deficiency syndrome, the fetal essence deficiency, the malnutrition failure, the stagnation of the blood stasis in the brain collateral or the phlegm-dampness. Covering the liver and storing blood, governing tendons; the spleen governs transportation and transformation to generate and transform essence; kidneys store essence, dominate bones and produce marrow, and warm and nourish spleen earth, so only if liver, spleen and kidney function are normal, they can transform blood and produce essence to nourish tendons, bones and vessels.

Disclosure of Invention

In order to solve the technical problems, the invention provides the following technical scheme:

a traditional Chinese medicine preparation for treating cerebral palsy comprises the following traditional Chinese medicine components in parts by weight: 110-130g of stiff silkworm, 62-82g of white paeony root, 62-82g of earthworm, 38-58g of Chinese angelica, 26-46g of kudzu root, 26-46g of pawpaw, 26-46g of white pepper, 38-58g of mangnolia officinalis and 2-22g of liquorice.

In the further scheme, the method comprises the following steps of,

comprises the following traditional Chinese medicine components in parts by weight: 125g of stiff silkworm 115-containing material, 67-77g of white paeony root, 67-77g of earthworm, 43-53g of Chinese angelica, 31-41g of kudzu root, 31-41g of pawpaw, 31-41g of white pepper, 43-53g of officinal magnolia bark and 7-17g of liquorice.

In the further scheme, the method comprises the following steps of,

comprises the following traditional Chinese medicine components in parts by weight: : 120g of stiff silkworm, 72g of white paeony root, 72g of earthworm, 48g of Chinese angelica, 36g of kudzu root, 36g of pawpaw, 36g of white pepper, 48g of officinal magnolia bark and 12g of liquorice.

In the further scheme, the method comprises the following steps of,

a preparation method of a traditional Chinese medicine preparation for treating cerebral palsy comprises the following steps: (1) selecting and removing impurities from the preparation raw materials, weighing the preparation raw materials in parts by weight, drying the white paeony root, the earthworm, the Chinese angelica and the white pepper by blowing air at 60 ℃, crushing into fine powder, and sieving by a sieve of 100 meshes for later use;

(2) weighing the batryticated silkworm, the kudzu vine root, the pawpaw, the magnolia officinalis and the liquorice according to the weight parts of the raw materials, mixing, adding 8 times of water, decocting for 30 minutes, pouring out the decoction after 2.5 hours of first decoction, decocting for 1.5 hours again, combining the two decoctions, filtering, and concentrating the filtrate under reduced pressure to obtain thick paste with the relative density of 1.30-1.35 for later use;

(3) adding the above fine powder, mixing, air drying at 60 deg.C, pulverizing, sieving with 100 mesh sieve, mixing, granulating with ethanol, drying, grading, making into capsule, and bottling.

In the further scheme, the method comprises the following steps of,

the pressure condition of concentrating the filtrate under reduced pressure in the step (2) to a thick paste with the relative density of 1.30-1.35 is as follows: -0.08 to-0.09 MPa, 60 to 70 ℃.

By adopting the technical scheme, the beneficial effects are that:

1. the invention can calm the liver, stop the wind, nourish the blood and soften the pulse, and is used for treating the liver-spleen-weak syndrome of cerebral palsy, stroke and craniocerebral injury.

2. The medicament of the invention mainly uses the stiff silkworm for calming the liver and calming the wind to stop convulsion; the angelica has the functions of nourishing blood and promoting blood circulation, and is used as monarch drug together with the functions of stimulating the menstrual flow and softening the vessels; the radix paeoniae alba is matched with the liquorice, is sour and sweet to transform yin, and helps the angelica to benefit yin and nourish blood so as to relieve spasm and urgency of muscle and vein; the earthworm assists the stiff silkworm to calm the liver and calm the wind, calms the nerves and calms the mind, is good at clearing and activating the channels and collaterals, strengthens the functions of calming the liver and calming the wind, nourishing the blood and softening the pulse of monarch drugs, and is a ministerial drug; radix puerariae is used for assisting in expelling muscles and stimulating the circulation of the blood and stimulating the circulation of the yang; pawpaw has the effects of calming the liver, relaxing the muscles and tendons, harmonizing stomach and eliminating dampness; white pepper and magnolia officinalis warm the middle-jiao to dispel cold and remove dampness to invigorate the spleen, help the medicines to dredge the tendons and activate collaterals, remove dampness and invigorate the spleen, and are used as adjuvant medicines together. Wherein the liquorice is also used as a guiding drug for harmonizing the other drugs in the recipe; all the medicines are combined to play the effects of calming liver wind, nourishing blood and softening vessels, relieving muscles and spasm, calming nerves and tranquilizing mind.

Detailed Description

The present invention will be further described with reference to the following examples, which should not be construed as limiting the scope of the present invention.