使用靶基因表达的数学建模评估mapk-ap-1细胞信号传导途径活性

文档序号:1132148 发布日期:2020-10-02 浏览:18次 >En<

阅读说明:本技术 使用靶基因表达的数学建模评估mapk-ap-1细胞信号传导途径活性 (Assessment of MAPK-AP-1 cell signaling pathway activity using mathematical modeling of target gene expression ) 是由 A·范德斯托尔佩 L·H·F·M·霍尔特泽尔 于 2018-09-28 设计创作,主要内容包括:本发明涉及用于基于在对象样品中测量的MAPK-AP-1细胞信号传导途径的三个或更多个靶基因的表达水平来推测对象中MAPK-AP-1细胞信号传导途径活性的计算机执行方法。本发明进一步涉及用于推测对象中MAPK-AP-1细胞信号传导途径活性的装置、非暂时性存储介质和计算机程序。本发明进一步涉及用于测量对象样品中MAPK-AP-1细胞信号传导途径的三个或更多个靶基因的表达水平的试剂盒,用于推测对象中MAPK-AP-1细胞信号传导途径活性的试剂盒,以及这些试剂盒在进行所述方法中的应用。(The present invention relates to a computer-implemented method for inferring MAPK-AP-1 cellular signaling pathway activity in a subject based on measured expression levels of three or more target genes of the MAPK-AP-1 cellular signaling pathway in a sample from the subject. The invention further relates to an apparatus, a non-transitory storage medium and a computer program for inferring MAPK-AP-1 cellular signaling pathway activity in a subject. The invention further relates to kits for measuring the expression levels of three or more target genes of the MAPK-AP-1 cellular signaling pathway in a sample from a subject, kits for inferring the activity of the MAPK-AP-1 cellular signaling pathway in a subject, and the use of these kits for performing the methods.)

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