阅读说明：本技术 一种杀菌消毒驱蚊液及其制备方法 (Sterilizing and disinfecting mosquito repellent liquid and preparation method thereof ) 是由 刘群鸿 刘主良 苏洁茹 刘志辉 于 2020-06-19 设计创作，主要内容包括：本发明涉及一种杀菌消毒驱蚊液,包括溶剂、护肤剂、驱蚊剂、有机抗菌剂、无机抗菌剂、柔软稳定剂和芳香剂,其中溶剂由溶剂A和溶剂B混合制成具有去离子水及与去离子水互溶的醇类溶剂。本发明一方面可以利用表面积大的双乳包芯纳米抗菌粒子吸附部分驱蚊剂和芳香剂,提高吸附载体,延缓驱蚊剂和芳香剂的挥发,延长驱蚊和芳香的有效时长,另一方面可避免无机抗菌剂因团聚而活力失效的问题,又可以延缓释放,延长抑菌的有效时长,同时利用纳米抗菌粒子的双乳包裹层起到抑制或者减少了无机抗菌剂进入人体或植物表皮细胞的量,提高产品安全性,兼具驱蚊、抑菌、芳香、护肤特点,婴幼儿适用,可有效满足客户的日常需求。(The invention relates to a sterilization, disinfection and mosquito repellent liquid, which comprises a solvent, a skin care agent, a mosquito repellent agent, an organic antibacterial agent, an inorganic antibacterial agent, a softening stabilizer and an aromatic, wherein the solvent is prepared by mixing a solvent A and a solvent B and is provided with deionized water and an alcohol solvent mutually soluble with the deionized water. According to the invention, on one hand, the double-emulsion core-spun nano antibacterial particles with large surface area can be used for adsorbing part of the mosquito repellent and the aromatic, so that the adsorption carrier is improved, the volatilization of the mosquito repellent and the aromatic is delayed, the effective duration of mosquito repellent and aromatic is prolonged, on the other hand, the problem that the activity of the inorganic antibacterial agent is ineffective due to agglomeration can be avoided, the release can be delayed, the effective duration of antibacterial is prolonged, meanwhile, the double-emulsion coating layer of the nano antibacterial particles is used for inhibiting or reducing the amount of the inorganic antibacterial agent entering human bodies or plant epidermal cells, so that the safety of products is improved, the characteristics of mosquito repellent, antibacterial, aromatic and skin protection are provided, the nano antibacterial agent is suitable for infants, and the daily.)

1. The sterilizing and disinfecting mosquito repellent liquid is characterized in that: the composition comprises the following components in parts by weight: 50-80 parts of solvent, 5-20 parts of skin care agent, 5-20 parts of mosquito repellent agent, 0.1-1 part of organic antibacterial agent, 0.25-2 parts of inorganic antibacterial agent, 1-5 parts of soft stabilizer and 0.05-1 part of aromatic, wherein the solvent is prepared by mixing solvent A and solvent B into deionized water and alcohol solvent mutually soluble with the deionized water.

2. The sterilizing, disinfecting and mosquito-repellent liquid according to claim 1, characterized in that: the alcohol solvent is one or more of absolute ethyl alcohol, propylene glycol, 1, 3-butanediol, hexanediol, polyethylene glycol, polyether polyol and sorbitol.

3. The sterilizing, disinfecting and mosquito-repellent liquid according to claim 1, characterized in that: the mosquito repellent is one or more of culicifumide, Yimeining, Ecameratin, eucalyptus oil, peppermint oil and camphor oil.

4. The sterilizing, disinfecting and mosquito-repellent liquid according to claim 1, characterized in that: the organic antibacterial agent is one or more of nipagin ester, Gemama BP, methylisothiazolinone, PHMB, PHMG, benzalkonium chloride, benzalkonium bromide, cetyl trimethyl ammonium bromide and bisdecyl dimethyl ammonium chloride.

5. The sterilizing, disinfecting and mosquito-repellent liquid according to claim 1, characterized in that: the inorganic antibacterial agent is one or more of nano silver, nano titanium oxide, nano magnesium oxide and nano zinc oxide.

6. The sterilizing, disinfecting and mosquito-repellent liquid according to claim 1, characterized in that: the skin care agent is one or more of glycerol, methyl silicone oil, cholesterol, vegetable oil, animal oil and naphtha.

7. The sterilizing, disinfecting and mosquito-repellent liquid according to claim 1, characterized in that: the aromatic is one or more of Artemisia alba essential oil, menthol, Borneolum Syntheticum, radix aucklandiae essential oil, lemon oil, rosemary oil, geranium oil, cysteine, peach gum powder, tea tree essential oil, milk essence, rose essential oil, and lavender essential oil.

8. The sterilizing, disinfecting and mosquito-repellent liquid according to claim 1, characterized in that: the softening stabilizer is one or more of span, tween, dextran, dodecyl trimethyl ammonium chloride, dodecyl trimethyl ammonium bromide, hexadecyl trimethyl ammonium chloride, hexadecyl trimethyl ammonium bromide, dodecyl sodium sulfate and dodecyl sodium benzenesulfonate.

9. The preparation method of the sterilizing, disinfecting and mosquito-repellent liquid as claimed in claim 1, is characterized in that: the method specifically comprises the following steps:

s1, preparing solution A: adding a solvent A into a reaction kettle, sequentially adding a skin care agent and a mosquito repellent, and stirring to dissolve the skin care agent and the mosquito repellent into the solvent A;

s2, preparing liquid B: adding a solvent B into a reaction kettle, adding an inorganic antibacterial agent and an organic antibacterial agent, stirring to dissolve the organic antibacterial agent in the solvent B and disperse the inorganic antibacterial agent in the solvent B, wherein the solvent A and the solvent B are mutually soluble;

s3, preparing the sterilizing and disinfecting mosquito repellent liquid: and continuously stirring the solution B, slowly adding a soft stabilizer, continuously stirring for 10-40 min, increasing the rotating speed, slowly dropwise adding the solution A, controlling the temperature to be below 60 ℃, adding an aromatic after the dropwise adding is finished, and continuously stirring to completely react.

10. The preparation method of the sterilizing, disinfecting and mosquito-repellent liquid according to claim 9, characterized in that: the inorganic antibacterial agent is pretreated before the step S2, and the specific treatment process comprises the following steps: dissolving PLGA in a low-boiling-point organic solvent, performing ultrasonic oscillation to obtain a PLGA solution with the concentration of 10-50 mg/ml, adding an inorganic antibacterial agent ground to be nano-scale into the PLGA solution, and stirring to enable the PLGA solution to fully wrap the inorganic antibacterial agent to form a primary emulsion; adding 10 mg/ml-50 mg/ml of sorbitan fatty acid ester solution into the primary emulsion, and performing ultrasonic oscillation and then performing soft stirring by using a magnetic stirrer at a temperature above the boiling point of the solvent to obtain inorganic antibacterial emulsion; and finally, carrying out spray drying on the inorganic antibacterial emulsion to prepare the nano particles.

Technical Field

The invention belongs to the technical field of mosquito repellent liquid, and particularly relates to a sterilizing and disinfecting mosquito repellent liquid and a preparation method thereof.

Background

Summer and autumn are the most rampant seasons of mosquito activity, prevent mosquito and sting, eliminate the mosquito and can prevent the emergence of disease effectively, and at present, common mosquito repellent mode is: 1. physical mosquito repelling, garbage and vegetation removing, door and window closing, 2 chemical mosquito repelling, and products such as DEET, p-menthane-3, 8-diol (PMD) and the like are commonly used, but the mosquito repelling time is short and the temperature is strong when the components are used alone, so that the mosquito repelling product needs to be further improved. Meanwhile, the daily life also faces the requirements of bacteriostasis and sterilization.

Chinese published literature (CN105997675A) discloses mosquito repellent containing green prickly ash and a preparation method thereof, wherein the main active ingredients are extracts of the green prickly ash, lavender, rose, wrinkled gianthyssop and mint, the invention combines and uses various plant extracts, not only has good mosquito repellent effect, but also has the effects of refreshing brain, cooling, relieving itching, inhibiting bacteria and killing bacteria, including the effect that the skin is free from being bitten by insects, however, the plant extracts used in the invention can be completely volatilized in a short time, and the mosquito repellent and bacteria inhibiting time is short.

In addition, currently widely used antibacterial agents are mainly classified into four types, i.e., inorganic antibacterial agents, organic antibacterial agents, natural antibacterial agents, and polymeric antibacterial agents. The organic antibacterial agent has poor heat resistance and is easy to decompose, the natural and high-molecular antibacterial agents have poor heat resistance and are difficult to process, the inorganic antibacterial agent which has good heat resistance, wide antibacterial spectrum and long validity period is most widely applied at present, and the nano silver particles prepared in the form of the nanotechnology have the advantages of broad-spectrum antibacterial property, strong sterilization, high safety, no drug resistance and the like which cannot be compared with the traditional antibacterial agent. However, the use of nano silver particles alone often results in particle agglomeration due to oxidation, resulting in loss of antibacterial activity. In addition, the inorganic antibacterial agent has side effects on skin or plant surface cells, and is rarely applied to the mosquito repellent liquid directly applied to the skin.

Disclosure of Invention

In view of the defects of the prior art, the invention aims to provide the sterilizing and disinfecting mosquito repellent liquid which has the characteristics of mosquito repelling, bacteriostasis, fragrance and skin care, has high product safety, is suitable for infants and can effectively meet the daily requirements of clients.

In order to solve the technical problems, the invention adopts the technical scheme that:

the sterilizing, disinfecting and mosquito-repellent liquid comprises the following components in parts by weight: 50-80 parts of solvent, 5-20 parts of skin care agent, 5-20 parts of mosquito repellent agent, 0.1-1 part of organic antibacterial agent, 0.25-2 parts of inorganic antibacterial agent, 1-5 parts of soft stabilizer and 0.05-1 part of aromatic, wherein the solvent is prepared by mixing solvent A and solvent B into deionized water and alcohol solvent mutually soluble with the deionized water.

Preferably, the alcoholic solvent is one or more of absolute ethyl alcohol, propylene glycol, 1, 3-butylene glycol, hexylene glycol, polyethylene glycol, polyether polyol and sorbitol.

Preferably, the mosquito repellent is one or more of culicin, emennin, escin, eucalyptus oil, peppermint oil and camphor oil.

Preferably, the organic antibacterial agent is one or more of nipagin ester, germabp, methylisothiazolinone, PHMB, PHMG, benzalkonium chloride, benzalkonium bromide, cetyltrimethylammonium bromide, and bisdecyl dimethyl ammonium chloride.

Preferably, the inorganic antibacterial agent is one or more of nano silver, nano titanium oxide, nano magnesium oxide and nano zinc oxide.

Preferably, the skin care agent is one or more of glycerin, methyl silicone oil, cholesterol, vegetable oil, animal oil, and naphtha. Wherein the vegetable oil comprises one or more of jojoba ester wheat germ oil, cacao oil, oleum Olivarum, oleum Helianthi, and peanut oil, and the animal oil comprises one or more of squalane, cod liver oil, and sheep oil.

Preferably, the aromatic is one or more of artemisia alba essential oil, menthol, borneol, elecampane essential oil, lemon oil, rosemary oil, geranium oil, cysteine, peach gum powder, tea tree essential oil, milk essence, rose essential oil and lavender essential oil.

Preferably, the softening stabilizer is one or more of span, tween, glucose anhydride, dodecyl trimethyl ammonium chloride, dodecyl trimethyl ammonium bromide, hexadecyl trimethyl ammonium chloride, hexadecyl trimethyl ammonium bromide, sodium dodecyl sulfate and sodium dodecyl benzene sulfonate.

The invention further provides a preparation method of the sterilizing and disinfecting mosquito repellent liquid, which comprises the following steps:

s1, preparing solution A: adding a solvent A into a reaction kettle, sequentially adding a skin care agent and a mosquito repellent, and stirring to dissolve the skin care agent and the mosquito repellent into the solvent A;

s2, preparing liquid B: adding a solvent B into a reaction kettle, adding an inorganic antibacterial agent and an organic antibacterial agent, stirring to dissolve the organic antibacterial agent in the solvent B and disperse the inorganic antibacterial agent in the solvent B, wherein the solvent A and the solvent B are mutually soluble;

s3, preparing the sterilizing and disinfecting mosquito repellent liquid: and continuously stirring the solution B, slowly adding a soft stabilizer, continuously stirring for 10-40 min, increasing the rotating speed, slowly dropwise adding the solution A, controlling the temperature to be below 60 ℃, adding an aromatic after the dropwise adding is finished, and continuously stirring to completely react.

Wherein: the inorganic antibacterial agent is double-emulsion core-spun nano antibacterial particles, namely nano particles with double emulsion layers wrapped outside the nano inorganic antibacterial agent, and is pretreated before the step S2, wherein the specific treatment process comprises the following steps: dissolving PLGA in a low-boiling-point organic solvent, performing ultrasonic oscillation to obtain a PLGA solution with the concentration of 10-50 mg/ml, adding an inorganic antibacterial agent ground to be nano-scale into the PLGA solution, and stirring to enable the PLGA solution to fully wrap the inorganic antibacterial agent to form a primary emulsion; adding 10 mg/ml-50 mg/ml of sorbitan fatty acid ester solution into the primary emulsion, and performing ultrasonic oscillation and then performing soft stirring by using a magnetic stirrer at a temperature above the boiling point of the solvent to obtain inorganic antibacterial emulsion; and finally, carrying out spray drying on the inorganic antibacterial emulsion to prepare the nano particles.

Compared with the prior art, the invention has the following beneficial effects:

1. the sterilization, disinfection and mosquito repellent liquid contains a mosquito repellent, an organic antibacterial agent, an inorganic antibacterial agent, a skin care agent, a soft stabilizer and an aromatic component, all the components except the inorganic antibacterial agent are well dissolved in a compound solvent, oil-water stratification is not easy to occur, the antibacterial performance is effectively enhanced by using the organic antibacterial agent and the inorganic antibacterial agent in combination, meanwhile, as the inorganic antibacterial agent adopts double-emulsion core-spun nano antibacterial particles, on one hand, the double-emulsion core-spun nano antibacterial particles with large surface area can be used for adsorbing part of the mosquito repellent and aromatic agent, improving the adsorption carrier, delaying the volatilization of the mosquito repellent and aromatic agent, prolonging the effective time of mosquito repelling and aroma, on the other hand, the problem of activity failure of the inorganic antibacterial agent due to agglomeration can be avoided, the release can be delayed, the effective time of bacteriostasis can be prolonged, and simultaneously, the double-emulsion wrapping layer of the nano antibacterial particles is used for inhibiting or reducing the amount of the, the safety of the product is improved.

2. The sterilizing and disinfecting mosquito repellent liquid has the characteristics of mosquito repelling, bacteriostasis, fragrance and skin care, has high product safety, is suitable for infants, can effectively meet the daily requirements of customers, can be directly smeared on the skin of a human body to repel mosquitoes, can be added into a plug-in electric heating mosquito dispeller to repel the mosquitoes, and can also be used for soaking wood carbon to prepare mosquito repellent incense and the like.

Detailed Description