阅读说明：本技术 N,n-二甲基甲酰胺在抗凝血杀鼠剂渗透剂中的应用 (Application of N, N-dimethylformamide in anticoagulant rodenticide penetrant ) 是由 姜洪雪 姚丹丹 冯志勇 于 2020-06-29 设计创作，主要内容包括：本发明公开了N,N-二甲基甲酰胺在抗凝血杀鼠剂渗透剂中的应用。该N,N-二甲基甲酰胺作为渗透剂可以提高抗凝血杀鼠剂的水溶性,增加药物进入谷壳内米粒的含量,提升了药物的利用率,即对抗凝血杀鼠剂有增效作用,可以在降低抗凝血杀鼠剂使用浓度的情况下保证不降低灭鼠效果,且该渗透剂的使用可以提高抗凝血杀鼠剂的适口性。因此,本发明中的渗透剂的使用可以降低灭鼠成本,减轻环境污染的风险,减少人畜中毒事件发生的概率,保证人畜安全,同时,可以延长抗凝血杀鼠剂的使用寿命,延缓杀鼠剂的抗性发展。(The invention discloses application of N, N-dimethylformamide in an anticoagulant rodenticide penetrant. The N, N-dimethylformamide can be used as a penetrant to improve the water solubility of the anticoagulant rodenticide, increase the content of rice grains entering the rice husks of the medicine, improve the utilization rate of the medicine, namely, the anticoagulant rodenticide has a synergistic effect, the rodenticide effect can be ensured not to be reduced under the condition of reducing the use concentration of the anticoagulant rodenticide, and the palatability of the anticoagulant rodenticide can be improved by using the penetrant. Therefore, the use of the penetrant in the invention can reduce the deratization cost, reduce the risk of environmental pollution, reduce the probability of poisoning events of people and livestock, ensure the safety of people and livestock, prolong the service life of the anticoagulant rodenticide and delay the resistance development of the rodenticide.)

The application of N, N-dimethyl formamide in preparing anticoagulant rodenticide penetrant.

2. The use of N, N-dimethylformamide as claimed in claim 1 for the preparation of an anticoagulant rodenticide penetrant, characterized in that:

the anticoagulant rodenticide penetrant can also contain a solvent;

the solvent is water;

the volume ratio of the N, N-dimethylformamide to the water is 1-3: 1-3.

The application of N, N-dimethyl formamide as anticoagulant rodenticide penetrant.

Application of N, N-dimethylformamide as an anticoagulant rodenticide penetrant in preparation of synergistic anticoagulant rodenticide poison bait.

5. Use according to claim 4, characterized in that:

the synergistic anticoagulant rodenticide poison bait also contains grains and bromadiolone;

the dosage of the N, N-dimethylformamide is calculated according to the proportion of adding 20-60 mL of N, N-dimethylformamide per 1000g of grains;

the content of the effective components in the bromadiolone accounts for 0.0025-0.01 percent of the weight of the grains.

6. Use according to claim 5, characterized in that:

the grain is at least one of rice, wheat and corn;

the bromadiolone is a bromadiolone mother solution with the effective component content of 0.5 percent.

7. A synergistic anticoagulant rodenticide poison bait is characterized in that: including N, N-dimethylformamide, cereals and bromadiolone.

8. The synergistic anticoagulant rodenticide bait according to claim 7, wherein:

the dosage of the N, N-dimethylformamide is calculated according to the proportion of adding 20-60 mL of N, N-dimethylformamide per 1000g of grains;

the content of the effective components in the bromadiolone accounts for 0.0025 to 0.01 percent of the weight of the grains;

the grain is at least one of rice, wheat and corn;

the bromadiolone is a bromadiolone mother solution with the effective component content of 0.5 percent.

9. The synergistic anticoagulant rodenticide bait according to claim 8, wherein:

the dosage of the N, N-dimethylformamide is calculated according to the proportion that 40mL of N, N-dimethylformamide is added into every 1000g of grains;

the content of the effective components in the bromadiolone accounts for 0.0025 percent of the weight of the grains.

10. The method of preparing a synergistic anticoagulant rodenticide bait according to any one of claims 7 to 9, which comprises the steps of:

adding N, N-dimethylformamide into water, adding bromadiolone, uniformly mixing with grains, and airing after the liquid medicine is sucked dry to obtain the synergistic anticoagulant rodenticide poison bait.

Technical Field

The invention belongs to the technical field of deratization, and particularly relates to application of N, N-dimethylformamide in an anticoagulant rodenticide penetrant.

Background

Rodents are the most diverse, widespread, and numerous groups of mammals, some of which pose significant hazards to agricultural production, human life safety, and public safety. In order to control the harm of the pest rats, comprehensive treatment technology based on ecological regulation is generally adopted, wherein chemical control is an extremely important control measure.

The use of chemical rodenticides is still the main prevention and control method at present worldwide, and the method has low cost, quick response, good effect and easy popularization. The anticoagulant raticide is a raticide which is relatively safe, good in palatability and high in deratization efficiency, is the most important chronic chemical agent for preventing and controlling rat damage at present, and is widely used in rural and pastoral areas and cities in China since the last 80 years. However, the occurrence of the drug resistance of the rats, the occurrence of cross resistance and resistant species groups are reported in succession in areas continuously used for more than 6 years, so that the rat killing effect is greatly reduced, and the rat killing difficulty and cost are improved. The new medicine is difficult to create, and the characteristics of good palatability, high efficiency, safety and economy must be simultaneously met. Therefore, exploring and researching the synergistic effect of some chemical components on the anticoagulant rodenticide, and prolonging the service life of the rodenticide become research hotspots in recent years, and substances such as aspirin, diclofenac sodium, salicylic acid and the like have a synergistic anticoagulant effect with the anticoagulant rodenticide, but the synergistic effect is limited.

In the south of China, the climate is humid and rainy, the paddy is the most suitable bait for killing rats in agricultural areas, and the bait has the advantages of better palatability, long fresh-keeping period and wide sources. But the anticoagulant rodenticide is insoluble in water, the rice hulls have a blocking effect on the drugs, about 90% of the rodenticide is adhered to the surfaces of the rice hulls, the rice contains very little content, the rats are husked to eat the rice, the utilization rate of the drugs is low, and the risk of environmental pollution and non-target animal poisoning caused by the low utilization rate of the drugs is also higher. The penetrant belongs to one of pesticide adjuvants, has the effects of improving the permeability of effective components of the pesticide, improving the pesticide effect and reducing the usage amount of the pesticide. The condition that the penetrant is used in rodenticide is very few, Chinese patent 201310316842.3, entitled anticoagulant rodenticide penetrant and preparation method and application thereof, discloses an anticoagulant penetrant compounded by sodium hydroxide, sodium chloride, ethanol and dimethyl sulfoxide, but the research has more compounded components, the preparation method is relatively complex, and the practical application is limited.

At present, N, N-dimethylformamide which is an organic solvent is not applied in rat killing practice, and has important research value and application prospect.

Disclosure of Invention

In order to overcome the defects of the prior art, the invention mainly aims to provide the application of the N, N-dimethylformamide in the preparation of the anticoagulant rodenticide penetrant so as to improve the utilization rate and the prevention and control effect of the rodenticide, reduce the using amount of the rodenticide and reduce the ecological risk of the rodenticide.

The invention also aims to provide application of the N, N-dimethylformamide as the anticoagulant rodenticide penetrant in preparation of the synergistic anticoagulant rodenticide poison bait.

The invention further aims to provide the synergistic anticoagulant rodenticide poison bait.

The purpose of the invention is realized by the following technical scheme:

application of N, N-dimethylformamide in preparation of anticoagulant rodenticide penetrant.

The anticoagulant rodenticide penetrant can also contain other solvents.

The solvent is preferably water.

The volume ratio of the N, N-dimethylformamide to the water is 1-3: 1-3.

The application of N, N-dimethyl formamide as anticoagulant rodenticide penetrant.

The application of N, N-dimethylformamide as an anticoagulant rodenticide penetrant in preparation of synergistic anticoagulant rodenticide poison bait.

The synergistic anticoagulant rodenticide poison bait also contains grains (namely anticoagulant rodenticide bait), bromadiolone and the like.

The grain is at least one of common grains such as rice, wheat, corn and the like; preferably rice.

The dosage of the N, N-dimethylformamide is calculated according to the proportion of adding 20-60 mL of N, N-dimethylformamide per 1000g of grains; preferably, the amount of N, N-dimethylformamide added is 40mL per 1000g of grain.

The bromadiolone is preferably a bromadiolone mother solution with the effective component content of 0.5 percent.

The content of the effective components in the bromadiolone accounts for 0.0025 to 0.01 percent of the weight of the grains; preferably 0.0025% by weight of the cereal.

A synergistic anticoagulant rodenticide poison bait is prepared from N, N-dimethyl formamide, grains and bromadiolone.

The dosage of the N, N-dimethylformamide is calculated according to the proportion of adding 20-60 mL of N, N-dimethylformamide per 1000g of grains; preferably, the amount of N, N-dimethylformamide added is 40mL per 1000g of grain.

The grain is at least one of common grains such as rice, wheat, corn and the like; preferably rice.

The bromadiolone is preferably a bromadiolone mother solution with the effective component content of 0.5 percent.

The content of the effective components in the bromadiolone accounts for 0.0025 to 0.01 percent of the weight of the grains; preferably 0.0025% by weight of the cereal.

The synergistic anticoagulant rodenticide poison bait can also contain other solvents.

The solvent is preferably water.

The preparation method of the synergistic anticoagulant rodenticide poison bait comprises the following steps: adding N, N-dimethylformamide into water, adding bromadiolone, uniformly mixing with grains, and airing after the liquid medicine is sucked dry to obtain the synergistic anticoagulant rodenticide poison bait.

Compared with the prior art, the invention has the following advantages and effects:

(1) most anticoagulant rodenticides are insoluble in water, the southern regions have humid climate and abundant rainfall, the rice poison bait is commonly used for killing rats, about 90 percent of drugs are adhered to the surfaces of rice hulls, the drugs are easily washed by rainwater or naturally fall off to reduce the prevention and control effect, and the poisonous rice hulls left behind after rats eat the ratchets to pollute the environment. Therefore, the invention provides the penetrant which improves the solubility and permeability of the anticoagulant rodenticide, increases the content of the rice grains entering the rice husks of the medicament, thereby improving the utilization rate of the medicament, reducing the use concentration of the rodenticide, ensuring the deratization effect under the frequent rainfall condition, lightening the environmental pollution and reducing the probability of toxic events of people and livestock; meanwhile, the service life of the anticoagulant rodenticide is prolonged, and the resistance development of the rodenticide is delayed.

(2) The anticoagulant rodenticide provided by the invention can ensure that the deratization effect is not reduced under the condition of reducing the use concentration of the anticoagulant rodenticide, and the effect is that the penetrant can improve the water solubility of the anticoagulant rodenticide, increase the content of rice grains entering the rice husks of drugs and improve the utilization rate of the drugs.

(3) The infiltration agent can improve the water solubility of the anticoagulant rodenticide, increase the content of rice grains entering the hulls of the drugs and improve the utilization rate of the drugs.

(4) The use of the penetrating agent in the invention reduces the deratization cost, lightens the risk of environmental pollution and ensures the safety of people and livestock, and the effect is that the penetrating agent causes more medicine to permeate into rice, thereby reducing the use concentration of the medicine.

(5) The use of the penetrants in the present invention enhances the palatability of the anticoagulant rodenticide, which may be due to the special odor of the penetrants.

Drawings

FIG. 1 is a graph of the amount of rodenticide in the kernels of hazel rice formulated with different adjuvants.

Detailed Description

The present invention will be described in further detail with reference to examples, but the embodiments of the present invention are not limited thereto. Except where expressly indicated, the medicaments, methods and apparatus employed in the present invention are conventional in the art. The following examples are given without reference to specific experimental conditions, and are generally in accordance with conventional experimental conditions. Unless otherwise specified, all agents, reagents and raw materials used in the present invention are commercially available.