阅读说明：本技术 一种治疗急性上呼吸道感染的广藿香油软胶囊及其疗法 (Patchouli oil soft capsule for treating acute upper respiratory tract infection and therapy thereof ) 是由 王钲霖 刘胜贵 薛红芬 付彬彬 李智高 孔令羽 蒋永昌 马海悦 于 2020-06-11 设计创作，主要内容包括：本发明公开了一种治疗急性上呼吸道感染的广藿香油软胶囊及其疗法。广藿香是重要的岭南道地药材,广藿香油是其挥发性成分,作为药用提取物被广泛应用。广藿香油具有抗菌、抗病毒、抗炎、止咳化痰、镇痛、抗疟原虫、调节肠胃运动功能、免疫调节等广泛药理作用。本发明以广藿香油为药效成分,将广藿香油制备成软胶囊剂型,以电子加热器为给药工具,利用加热器的机械结构破坏软胶囊,缓慢释放内含的挥发油,通过电加热的方式,使挥发油汽化,经口鼻吸入呼吸道,药效分子可直达鼻腔、咽部、喉部等病变部位,快速发挥其作用。所述疗法作为一种呼吸系统疾病定向给药途径,具有明显的速效作用和定位作用,局部用药,药效快,药量小,对治疗急性上呼吸道感染有明显疗效。(The invention discloses patchouli oil soft capsules for treating acute upper respiratory tract infection and a therapy thereof. Patchouli is an important medicinal material from Ling-south China, and patchouli oil is a volatile component of the patchouli oil and is widely used as a medicinal extract. Patchouli oil has wide pharmacological effects of resisting bacteria, viruses and viruses, resisting inflammation, relieving cough, reducing sputum, relieving pain, resisting plasmodium, regulating gastrointestinal motion function, regulating immunity and the like. The invention takes patchouli oil as the drug effect component, prepares the patchouli oil into the soft capsule dosage form, takes an electronic heater as the drug administration tool, destroys the soft capsule by utilizing the mechanical structure of the heater, slowly releases the contained volatile oil, vaporizes the volatile oil by an electric heating mode, inhales the respiratory tract by mouth and nose, and the drug effect molecule can directly reach the pathological change parts of the nasal cavity, the pharyngeal portion, the throat portion and the like, and rapidly plays the role. The therapy is taken as a directional administration way for respiratory diseases, has obvious quick-acting effect and positioning effect, is applied topically, has quick effect and small dosage, and has obvious curative effect on acute upper respiratory infection.)

1. A patchouli oil soft capsule for treating acute upper respiratory tract infection and a therapy thereof are characterized in that the therapy comprises the following steps: patchouli oil is used as a medicinal effective component, the patchouli oil is prepared into a soft capsule dosage form, an electronic heater is used as a medicine feeding tool, the patchouli oil soft capsule is placed in a heating cavity of the electronic heater, the soft capsule is damaged by using a mechanical structure of the heater to release volatile oil contained in the soft capsule, a switch of the electronic heater is turned on, the heating temperature is accurately set, when the temperature exceeds the boiling point of a compound in the patchouli oil, medicine molecules are vaporized and are inhaled into a breathing system through the mouth and the nose to reach pathological changes of the nasal cavity, the pharyngeal portion, the throat portion and the like, and therefore the.

2. The patchouli oil soft capsules for the treatment of acute upper respiratory infection and the therapies thereof according to claim 1, wherein the patchouli oil is in a soft capsule formulation; the patchouli oil is prepared by extracting by a steam distillation method.

3. The patchouli oil soft capsules for the treatment of acute upper respiratory infection and the therapy thereof according to claim 1, wherein the heating chamber is set at a temperature ranging from 300 ℃ to 1000 ℃.

4. The patchouli oil soft capsules for the treatment of acute upper respiratory tract infections and the therapies thereof according to claim 1, wherein the mechanical structure of the destructive soft capsules is pinholes.

5. The patchouli oil soft capsules for the treatment of acute upper respiratory infection and the therapy thereof according to claim 1, wherein the heating cavity further comprises a filler, and the filler is 20-40 mesh mugwort leaf powder.

6. The patchouli oil soft capsules for treating acute upper respiratory tract infection and the therapies thereof according to claims 1 and 2, wherein the patchouli oil is prepared by extracting with steam distillation method, and the steps are as follows: weighing a certain amount of dry overground part of cablin potchouli herb, crushing, placing in a round-bottom flask, and mixing according to a material-liquid ratio of 1: 10-20, adding distilled water, soaking at room temperature for 12 h, performing ultrasonic treatment for 30min, and heating and distilling for 5 h; when no oil drop appears on the condensation pipe, the distillation is thorough, the obtained product is put into a separating funnel, and a proper amount of petroleum ether is added for shaking up and extraction; standing, collecting the upper layer, absorbing excessive water with anhydrous sodium sulfate, transferring into a distillation flask, vacuum rotary evaporating at 45 deg.C, evaporating petroleum ether completely to obtain patchouli oil, weighing, and storing at 4 deg.C.

7. The patchouli oil soft capsules for the treatment of acute upper respiratory infection and the therapies thereof according to claims 1 and 2, wherein the preparation method of the patchouli oil soft capsules comprises the following steps:

s1, preparing internal feed liquid: the inner feed liquid comprises: 0.5 to 5 percent of patchouli oil, 10 to 20 percent of hemp wax, 0.1 to 1 percent of borneol, 0.1 to 1 percent of menthol and the balance of solvent by weight; heating solvent to 50-60 deg.C, adding cannabis wax, dissolving, cooling to room temperature, adding Borneolum Syntheticum and Mentholum, adding oleum Pogostemonis, and stirring to obtain inner liquid;

s2, preparing capsule shells: medical gelatin, glycerol and purified water are taken as capsule shell materials, and the weight ratio of the gelatin: glycerol: water = 2-4: 1-2: 2-4; soaking gelatin in 80% purified water for swelling, mixing the rest purified water and glycerol, injecting into a gelatin dissolving tank, heating and stirring to about 75 deg.C, adding gelatin solution, stirring for 30min, cooling, standing, and vacuum defoaming to obtain capsule shell material gelatin solution;

s3, tabletting: putting the capsule shell material glue solution into a glue storage barrel which is pre-insulated at 60 ℃, preserving heat, defoaming and standing the glue solution at 60 ℃ for 4 hours, and pressing the glue solution at 60 ℃; pressing the qualified film and the content prepared in S1 into soft capsule by an automatic rotary capsule making machine; in the production process of the automatic rotary capsule making machine, the temperature of the pressed pills is controlled to be 25-35 ℃, and the rotating speed of a rolling die is about 3 r/min; controlling the indoor temperature at 20-25 ℃ and the relative air humidity at 40%; controlling the charging amount of each pill to be 0.4-0.5 g;

s4, pelleting and forming: blowing the pressed soft capsule in a net machine at 20 ℃ for shaping for 4 hours;

s5, washing and drying pills: washing off an oil layer on the surface of the capsule by using 70-95% ethanol, and drying for 12-24 h under the conditions of 25-40 ℃ and 25-40% of relative humidity to obtain the patchouli oil soft capsule.

8. The soft capsule of patchouli oil and its therapy according to claim 7, wherein the hemp wax of step S1 is industrial hemp flower and leaf processed by supercritical CO₂Extracting the extract, winterizing and dewaxing to obtain extractWax; the solvent is as follows: medical glycerin.

Technical Field

The invention belongs to the field of natural medicines, and particularly relates to patchouli oil soft capsules for treating acute upper respiratory infection and a therapy thereof.

Background

Acute Upper Respiratory Tract Infection (AURTI), which refers to a general term for acute inflammation from the nostril to the lower margin of the cricoid including the nasal cavity, pharynx or larynx, is the most common infectious disease of the respiratory tract. The main clinical manifestations of infection are rhinitis, pharyngolaryngitis and tonsillitis. The disease is not classified into gender, age, occupation and region, and people with low immune function are susceptible.

Modern medicine believes that the common cause of acute upper respiratory tract infections is viral, and a few are caused by bacteria. The pathogens are classified into two major types, namely acute viral and bacterial upper respiratory tract infections. Acute viral upper respiratory tract infection accounts for 70-80% of the incidence rate of acute upper respiratory tract infection, and more than 10 viruses which can cause respiratory tract infection are known to be about more than 200 types, wherein the most main viruses are rhinoviruses, adenoviruses, coronaviruses, influenza viruses, parainfluenza viruses, respiratory syncytial viruses, certain enteroviruses (echoviruses, coxsackieviruses) and the like. In addition, 20-30% of acute upper respiratory tract infections are caused by bacterial infections, and can occur singly or secondarily after viral infections, and common pathogenic bacteria are madder, streptococcus pneumoniae, staphylococcus aureus, haemophilus influenzae and the like; the Western medicine can treat acute upper respiratory tract infection by administering corresponding medicines according to different causes. Viral infection is treated by antiviral drugs, but the current western medicines have no specific antiviral drugs; if bacterial infection exists, sensitive antibacterial drugs are selected for treatment according to pathogenic bacteria, however, in recent years, the phenomenon of unreasonable use of the antibacterial drugs is more obvious, the bacteria generate drug resistance, the drug resistance degree is gradually increased, and even multiple drug-resistant bacteria resistant to various antibiotics, such as staphylococcus aureus resistant bacteria methicillin-resistant staphylococcus aureus (MRSA), appear, and the health of human beings is seriously threatened. In recent years, a large number of research results and clinical data show that the traditional Chinese medicine has the advantages of good curative effect, low price and the like in treating acute upper respiratory infection, and plays an important role in treating the acute upper respiratory infection.

At present, most of the clinical treatment medicines and methods are from experience of treating SARS, MERS and the like, and no specific treatment medicines and treatment schemes are found. The national Wei Jian Wei Jie issued a diagnosis and treatment scheme for pneumonia infected by novel coronavirus (trial sixth edition), and various Chinese medicinal treatment compounds are recommended in the treatment scheme. Researchers count the frequency of the medicines, and find that one of 3 medicines with the total frequency more than 7 is the patchouli.

Patchouli is a dry aerial part of patchouli Pogostemon cablin (Blanco) Benth, a family of Labiatae, and is one of the famous ten southern medicines in China. The patchouli is an aromatic dampness-resolving medicine commonly used in the traditional Chinese medicine, and is one of the important components of more than 30 Chinese patent medicines such as patchouli qi-strengthening water (liquid, powder and pills), antiviral oral liquid, hopanax bile pills and the like. It is pungent in flavor and slightly warm in nature; it enters spleen, stomach and lung meridians.

Patchouli oil is a volatile component of patchouli and is also a main medicinal component of patchouli. The chemical components of patchouli oil include ketones, alcohols, monoterpenes, sesquiterpenes, aldehydes, alkanoic acids, etc., wherein patchouli ketone and patchouli alcohol are the main components (the total amount is more than 40%). The content of patchouli alcohol and patchouli ketone is used as an index component for analyzing the quality of patchouli in the Chinese pharmacopoeia of 2010 edition. Patchouli oil has wide pharmacological effects of resisting bacteria, viruses and viruses, resisting inflammation, relieving cough, reducing sputum, relieving pain, resisting plasmodium, regulating gastrointestinal motion function, regulating immunity and the like. Studies find that patchouli oil and patchouli alcohol serving as an active ingredient thereof have different degrees of inhibition effects on cytopathic effect caused by 3 viruses which can induce respiratory tract infection, such as coxsackie virus, adenovirus and influenza virus. In addition, the patchouli oil has good bacteriostatic activity on staphylococcus aureus which can cause respiratory tract infection. Research reports show that the stimulation test of the patchouli oil on the rabbit muscles and eyeballs shows that the patchouli oil has no obvious stimulation, shows that the stimulation of the patchouli oil is not large, infers that the mucous membrane of the patchouli oil has no toxic effect, and can be used for drug delivery through the mucous membrane.

Since 1928 Alexander Fleming discovered penicillin occasionally and was applied clinically, human struggle with infectious diseases was a stage of success. However, the phenomenon that drug-resistant bacteria are increased rapidly due to the abuse of antibiotics causes people to worry about the post-antibiotic era of 'no drug and rescue'. The traditional Chinese medicine as a novel antibacterial medicine is concerned with the small toxic and side effect, and the traditional Chinese medicine is not easy to cause the drug resistance of bacteria to the traditional Chinese medicine.

The method for treating the upper respiratory tract infection has the following defects: firstly, the problem of heavy use of antibiotics and drug resistance; secondly, no specific antiviral drug is found for viral infection; thirdly, the medicine is orally taken or injected to stimulate the gastrointestinal tract and damage the liver; fourth, the Chinese patent medicine loses many therapeutically effective volatile components during the process of preparing the medicine or decocting the medicine, and the medicine fails to work. Therefore, patchouli oil is used as a medicinal effective component to develop a directional administration mode for treating upper respiratory tract infection, and the patchouli oil can be used as a high-efficiency and low-toxicity treatment means.

Disclosure of Invention

In view of the above problems, the present invention aims to provide patchouli oil soft capsules for treating acute upper respiratory tract infection and a therapy thereof. The method comprises using an electronic heater as administration tool, making oleum herba Pogostemonis into soft capsule, placing into heating cavity of the electronic heater, puncturing the soft capsule with needle hole in the heater to release volatile oil, electrically heating to vaporize medicinal molecules in the volatile oil, and inhaling via oral cavity and nasal cavity to directly reach infected diseased parts such as nasal cavity, pharynx, and larynx, thereby achieving the purpose of directional administration.

In order to achieve the purpose, the invention adopts the following technical scheme:

a patchouli oil soft capsule for treating acute upper respiratory tract infection and a therapy thereof, the patchouli oil is extracted by a steam distillation method and comprises the following steps: weighing a certain amount of dry overground part of cablin potchouli herb, crushing, placing in a round-bottom flask, and mixing according to a material-liquid ratio of 1: adding distilled water 10-20, soaking at room temperature for 12 hr, performing ultrasonic treatment for 30min, and heating and distilling for 5 hr. When no oil drop appears on the condensing tube, the distillation is thorough, the obtained product is put into a separating funnel, and a proper amount of petroleum ether is added to shake up and extract. Standing, collecting the upper layer, absorbing excessive water with anhydrous sodium sulfate, transferring into a distillation flask, vacuum rotary evaporating at 45 deg.C, evaporating petroleum ether completely to obtain patchouli oil, weighing, and storing at 4 deg.C.

In order to improve the stability of the patchouli oil, reduce the irritation of the patchouli oil and control the accuracy of the dosage of the medicine, the patchouli oil is prepared into a soft capsule preparation, and the preparation method comprises the following steps:

s1, preparing internal feed liquid: the inner feed liquid comprises: 0.5 to 5 percent of patchouli oil, 10 to 20 percent of hemp wax, 0.1 to 1 percent of borneol, 0.1 to 1 percent of menthol and the balance of solvent by weight. Heating solvent to 50-60 deg.C, adding cannabis wax, dissolving, cooling to room temperature, adding Borneolum Syntheticum and Mentholum, adding oleum herba Pogostemonis, and stirring to obtain the inner liquid.

S2, preparing capsule shells: medical gelatin, glycerol and purified water are taken as capsule shell materials, and the weight ratio of the gelatin: glycerol: water = 2-4: 1-2: 2-4. Soaking gelatin in 80% purified water for swelling, mixing the rest purified water and glycerol, injecting into a gelatin dissolving tank, heating and stirring to about 75 deg.C, adding gelatin solution, stirring for 30min, cooling, standing, and vacuum defoaming to obtain capsule shell material gelatin solution.

S3, tabletting: putting the capsule shell material glue solution into a glue storage barrel which is pre-insulated at 60 ℃, preserving heat, defoaming and standing the glue solution at 60 ℃ for 4 hours, and pressing the glue solution at 60 ℃; and (4) pressing the prepared qualified film and the content prepared in the step (S1) into soft capsules by an automatic rotary capsule making machine. In the production process of the automatic rotary capsule making machine, the temperature of the pressed pills is controlled to be 25-35 ℃, and the rotating speed of a rolling die is about 3 r/min; controlling the indoor temperature at 20-25 ℃ and the relative air humidity at 40%; the charging amount of each pill is controlled to be 0.4-0.5 g.

S4, pelleting and forming: the soft capsule is shaped by blowing in a net machine at 20 ℃ for 4 hours.

S5, washing and drying pills: washing off an oil layer on the surface of the capsule by using 70-95% ethanol, and drying for 12-24 h under the conditions of 25-40 ℃ and 25-40% of relative humidity to obtain the patchouli oil soft capsule.

Further, the hemp wax of step S1 is prepared by subjecting industrial hemp flowers and leaves to supercritical CO₂Extracting the obtained extract, and performing winterization and dewaxing to obtain dewaxed wax; the solvent is as follows: medical glycerin.

A patchouli oil soft capsule for treating acute upper respiratory tract infection and a therapy thereof are disclosed, wherein the therapy comprises the following steps: patchouli oil is used as a medicinal effective component, the patchouli oil is prepared into a soft capsule dosage form, an electronic heater is used as a medicine feeding tool, the patchouli oil soft capsule is placed in a heating cavity of the electronic heater, the soft capsule is damaged by using a mechanical structure of the heater to release volatile oil contained in the soft capsule, a switch of the electronic heater is turned on, the heating temperature is accurately set, when the temperature exceeds the boiling point of a compound in the patchouli oil, medicine molecules are vaporized and are inhaled into a breathing system through the mouth and the nose to reach pathological changes of the nasal cavity, the pharyngeal portion, the throat portion and the like, and therefore the.

Further, the heating cavity is set at a temperature of 300-1000 ℃.

Further, the heating cavity also comprises a filler, and the filler is folium artemisiae argyi powder with 30-50 meshes;

further, the mechanical structure of the soft capsule is a pinhole.

Compared with the prior art, the invention has the advantages and beneficial effects that:

(1) the patchouli oil is used as a drug effect component for treating acute upper respiratory tract infection, can effectively replace antibiotics or hormone drugs, reduces the damage of the antibiotics or hormone drugs to the body, and avoids the generation of drug resistance and dependence.

(2) As a respiratory tract infection directional administration mode, the medicine molecules in the patchouli oil are vaporized by electronic heating and inhaled through the mouth and the nose, so that the patchouli oil can quickly reach infected diseased parts such as nasal cavities, pharyngeal parts, throats and the like, has the advantages of obvious curative effect, small medicine dosage, quick response, small side effect, convenient use and the like, and is an efficient and low-toxicity resistance-reducing and resistance-replacing treatment means.

(3) The medicinal components of the invention directly enter a respiratory system by gas molecules to exert curative effect, do not pass through gastrointestinal tracts, can reduce the irritation of medicaments to the gastrointestinal tracts, and can avoid the first pass effect of livers.

(4) The patchouli oil is prepared into a soft capsule dosage form, can prevent volatile oil from volatilizing, improve the stability of the volatile oil, reduce the irritation of the volatile oil and control the accuracy of the dosage of the medicine.

Detailed Description

While the following is a description of the preferred embodiments of the present invention, it will be understood by those skilled in the art that various changes and modifications may be made without departing from the spirit and scope of the invention.