阅读说明：本技术 一种治疗骨质疏松症的纯中药透皮擦剂及其制备方法 (Pure traditional Chinese medicine transdermal liniment for treating osteoporosis and preparation method thereof ) 是由 金黎华 李少龙 于 2021-08-20 设计创作，主要内容包括：本发明公开了一种治疗骨质疏松症的纯中药透皮擦剂及其制备方法,包括以下重量份的原料：鹿角9-12份、龟版9-12份、人参15-20份、枸杞子10-15份、山药20-25份、丹参10-15份、白术12-15份、杜仲15-18份。该透皮擦剂的制备方法包括以下步骤：(1)将鹿角、龟版、人参、枸杞子、山药、丹参、白术、杜仲按所述的重量份放入石臼中,捣烂成粉；(2)将捣烂的混合粉放入50-100重量份的酒精内泡制20-25天即可使用。本发明原料安全,配比合理,治疗效果显著,其制备方法简单,使原料的药效发挥更好。(The invention discloses a pure traditional Chinese medicine transdermal liniment for treating osteoporosis and a preparation method thereof, wherein the pure traditional Chinese medicine transdermal liniment comprises the following raw materials in parts by weight: 9-12 parts of antler, 9-12 parts of tortoise plastron, 15-20 parts of ginseng, 10-15 parts of wolfberry fruit, 20-25 parts of Chinese yam, 10-15 parts of salvia miltiorrhiza, 12-15 parts of bighead atractylodes rhizome and 15-18 parts of eucommia bark. The preparation method of the transdermal liniment comprises the following steps: (1) putting antler, tortoise plastron, ginseng, medlar, yam, salvia miltiorrhiza, bighead atractylodes rhizome and eucommia bark into a stone mortar according to the weight parts, and pounding the mixture into powder; (2) the mashed mixed powder is put into 50 to 100 weight parts of alcohol to be soaked for 20 to 25 days for use. The invention has the advantages of safe raw materials, reasonable proportion, obvious treatment effect, simple preparation method and better drug effect of the raw materials.)

1. A pure traditional Chinese medicine transdermal liniment for treating osteoporosis is characterized by comprising the following raw materials in parts by weight: 9-12 parts of antler, 9-12 parts of tortoise plastron, 15-20 parts of ginseng, 10-15 parts of wolfberry fruit, 20-25 parts of Chinese yam, 10-15 parts of salvia miltiorrhiza, 12-15 parts of bighead atractylodes rhizome and 15-18 parts of eucommia bark.

2. The pure traditional Chinese medicine transdermal liniment for treating osteoporosis according to claim 1, which is characterized by comprising the following raw materials in parts by weight: 9 parts of antler, 9 parts of tortoise plastron, 15 parts of ginseng, 10 parts of medlar, 20 parts of yam, 10 parts of salvia miltiorrhiza, 12 parts of bighead atractylodes rhizome and 15 parts of eucommia bark.

3. The pure traditional Chinese medicine transdermal liniment for treating osteoporosis according to claim 1, which is characterized by comprising the following raw materials in parts by weight: 10 parts of antler, 11 parts of tortoise plastron, 17 parts of ginseng, 13 parts of medlar, 22 parts of Chinese yam, 13 parts of salvia miltiorrhiza, 14 parts of bighead atractylodes rhizome and 16 parts of eucommia bark.

4. The pure traditional Chinese medicine transdermal liniment for treating osteoporosis according to claim 1, which is characterized by comprising the following raw materials in parts by weight: 12 parts of antler, 12 parts of tortoise plastron, 20 parts of ginseng, 15 parts of medlar, 25 parts of yam, 15 parts of salvia miltiorrhiza, 15 parts of bighead atractylodes rhizome and 18 parts of eucommia bark.

5. A process for preparing a pure Chinese medicinal transdermal liniment for the treatment of osteoporosis as claimed in any of claims 1 to 4, comprising the steps of:

(1) putting antler, tortoise plastron, ginseng, medlar, yam, salvia miltiorrhiza, bighead atractylodes rhizome and eucommia bark into a stone mortar according to the weight parts, and pounding the mixture into powder;

(2) the mashed mixed powder is put into 50 to 100 weight parts of alcohol to be soaked for 20 to 25 days for use.

6. The preparation method of the pure traditional Chinese medicine transdermal liniment for treating osteoporosis as claimed in claim 5, is characterized in that: the concentration of the alcohol in the step (2) is 75%.

Technical Field

The invention relates to the technical field of traditional Chinese medicines, in particular to a pure traditional Chinese medicine transdermal liniment for treating osteoporosis and a preparation method thereof.

Background

Osteoporosis is a metabolic bone disease, is frequently generated in middle-aged and elderly people mainly due to reduction of bone formation and increase of bone absorption, and has become an important reason influencing the life quality of middle-aged and elderly people. At present, the method for treating osteoporosis is carried out by adding bone health supplements, carrying out medicine intervention and rehabilitation treatment together, the treatment method is long in time, high in treatment cost, slow in curative effect and not obvious in curative effect, most of medicine intervention is western medicines, the side effect of taking the western medicines is large, and the medicine resistance is easy to generate.

Disclosure of Invention

The pure traditional Chinese medicine transdermal liniment for treating osteoporosis is prepared from traditional Chinese medicines, is safe in raw materials, reasonable in proportion, small in toxic and side effects, obvious in treatment effect and low in treatment cost, and does not produce drug resistance.

In order to achieve the first purpose, the invention adopts the following technical scheme:

a pure traditional Chinese medicine transdermal liniment for treating osteoporosis comprises the following raw materials in parts by weight: 9-12 parts of antler, 9-12 parts of tortoise plastron, 15-20 parts of ginseng, 10-15 parts of wolfberry fruit, 20-25 parts of Chinese yam, 10-15 parts of salvia miltiorrhiza, 12-15 parts of bighead atractylodes rhizome and 15-18 parts of eucommia bark.

Preferably, the feed comprises the following raw materials in parts by weight: 9 parts of antler, 9 parts of tortoise plastron, 15 parts of ginseng, 10 parts of medlar, 20 parts of yam, 10 parts of salvia miltiorrhiza, 12 parts of bighead atractylodes rhizome and 15 parts of eucommia bark.

Preferably, the feed comprises the following raw materials in parts by weight: 10 parts of antler, 11 parts of tortoise plastron, 17 parts of ginseng, 13 parts of medlar, 22 parts of Chinese yam, 13 parts of salvia miltiorrhiza, 14 parts of bighead atractylodes rhizome and 16 parts of eucommia bark.

Preferably, the feed comprises the following raw materials in parts by weight: 12 parts of antler, 12 parts of tortoise plastron, 20 parts of ginseng, 15 parts of medlar, 25 parts of yam, 15 parts of salvia miltiorrhiza, 15 parts of bighead atractylodes rhizome and 18 parts of eucommia bark.

The second purpose of the invention is to provide a preparation method of a pure traditional Chinese medicine transdermal liniment for treating osteoporosis, which has simple steps, and ensures that the raw materials are fully fused and the drug effect is exerted.

In order to achieve the second object, the invention adopts the following technical scheme:

a method for preparing pure traditional Chinese medicine transdermal liniment for treating osteoporosis comprises the following steps:

(1) putting antler, tortoise plastron, ginseng, medlar, yam, salvia miltiorrhiza, bighead atractylodes rhizome and eucommia bark into a stone mortar according to the weight parts, and pounding the mixture into powder;

(2) the mashed mixed powder is put into 50 to 100 weight parts of alcohol to be soaked for 20 to 25 days for use.

Preferably, the alcohol concentration in step (2) is 75%.

The raw materials in the invention have the following effects:

deer horn: has the effects of warming kidney yang, strengthening tendons and bones, promoting blood circulation and relieving swelling.

Tortoise shell: has effects in nourishing yin, suppressing hyperactive yang, invigorating kidney, and strengthening bone.

Ginseng: has effects of invigorating primordial qi, restoring pulse, relieving depletion, invigorating spleen, benefiting lung, tranquilizing mind, and improving intelligence.

Wolfberry fruit: has effects of nourishing liver and kidney, replenishing vital essence, and improving eyesight.

Chinese yam: has effects of invigorating spleen, nourishing stomach, benefiting lung, and relieving cough.

Red sage root: has the effects of promoting blood circulation, removing blood stasis, dredging channels, relieving pain, cooling blood and resolving carbuncle.

White atractylodes rhizome: has the effects of invigorating spleen and stomach, eliminating dampness and promoting diuresis.

Eucommia ulmoides: has effects of invigorating kidney, tonifying yang, nourishing liver and kidney, and strengthening tendons and bones.

The invention has the beneficial effects that: according to the pure traditional Chinese medicine transdermal liniment for treating osteoporosis and the preparation method thereof, antler, tortoise plastron, ginseng, wolfberry fruit, Chinese yam, salvia miltiorrhiza, bighead atractylodes rhizome and eucommia bark are selected as raw materials, the raw materials are safe, the proportion is reasonable, so that the pure traditional Chinese medicine transdermal liniment has the effect of treating osteoporosis, does not generate drug resistance, is small in toxic and side effects and obvious in treatment effect, and is convenient to use and low in treatment cost due to the adoption of a liniment mode; the preparation method has simple steps, and the raw materials are fully fused by using alcohol, so that the drug effect is better exerted.

Detailed Description

The technical solutions in the embodiments of the present invention will be clearly and completely described below, and it is obvious that the described embodiments are only a part of the embodiments of the present invention, and not all embodiments. All other embodiments, which can be derived by a person skilled in the art from the embodiments given herein without making any creative effort, shall fall within the protection scope of the present invention.

Example one

A pure traditional Chinese medicine transdermal liniment for treating osteoporosis comprises the following raw materials in parts by weight: 9 parts of antler, 9 parts of tortoise plastron, 15 parts of ginseng, 10 parts of medlar, 20 parts of yam, 10 parts of salvia miltiorrhiza, 12 parts of bighead atractylodes rhizome and 15 parts of eucommia bark.

The preparation method of the pure traditional Chinese medicine transdermal liniment for treating osteoporosis comprises the following steps:

(1) putting antler, tortoise plastron, ginseng, medlar, yam, salvia miltiorrhiza, bighead atractylodes rhizome and eucommia bark into a stone mortar according to the weight parts, and pounding the mixture into powder;

(2) the mashed mixed powder is put into 50 parts by weight of 75% alcohol to be soaked for 20 days.

Example two

A pure traditional Chinese medicine transdermal liniment for treating osteoporosis comprises the following raw materials in parts by weight: 10 parts of antler, 11 parts of tortoise plastron, 17 parts of ginseng, 13 parts of medlar, 22 parts of Chinese yam, 13 parts of salvia miltiorrhiza, 14 parts of bighead atractylodes rhizome and 16 parts of eucommia bark.

The preparation method of the pure traditional Chinese medicine transdermal liniment for treating osteoporosis comprises the following steps:

(1) putting antler, tortoise plastron, ginseng, medlar, yam, salvia miltiorrhiza, bighead atractylodes rhizome and eucommia bark into a stone mortar according to the weight parts, and pounding the mixture into powder;

(2) the mashed mixed powder is put into 70 parts by weight of 75% alcohol to be soaked for 22 days.

EXAMPLE III

A pure traditional Chinese medicine transdermal liniment for treating osteoporosis comprises the following raw materials in parts by weight: 12 parts of antler, 12 parts of tortoise plastron, 20 parts of ginseng, 15 parts of medlar, 25 parts of yam, 15 parts of salvia miltiorrhiza, 15 parts of bighead atractylodes rhizome and 18 parts of eucommia bark.

The preparation method of the pure traditional Chinese medicine transdermal liniment for treating osteoporosis comprises the following steps:

(1) putting antler, tortoise plastron, ginseng, medlar, yam, salvia miltiorrhiza, bighead atractylodes rhizome and eucommia bark into a stone mortar according to the weight parts, and pounding the mixture into powder;

(2) the mashed mixed powder is put into 100 parts by weight of alcohol with the concentration of 75 percent for soaking for 25 days.

The use method of the above embodiment of the invention is as follows: when in use, the pure traditional Chinese medicine transdermal liniment is rubbed on acupoints and skin of the whole body for 3 times a day, and a treatment course is 40 days.

And (3) clinical trials:

1. basic information

140 patients with osteoporosis are selected, the age distribution is 50-65 years, the longest course of disease is 1 year, the shortest course of disease is 2 months, and the symptoms of the patients are manifested by hypodynamia, lumbago and backache or general bone pain, spinal deformation, falling and easy fracture.

2. Test method

Seven groups of test examples are set, namely example one, example two, example three, comparison example one, comparison example two, comparison example three and comparison example four, 20 persons are randomly distributed to each group of test examples, and each group of test examples is treated by the corresponding medicament of the group for 80 days.

The comparative example is that the raw materials in the first example are replaced by: 15 parts of ginseng, 10 parts of medlar, 20 parts of yam, 10 parts of salvia miltiorrhiza, 12 parts of bighead atractylodes rhizome and 15 parts of eucommia bark.

The second comparative example replaces the raw materials in the second example with: 10 parts of antler, 11 parts of tortoise plastron, 13 parts of salvia miltiorrhiza, 14 parts of bighead atractylodes rhizome and 16 parts of eucommia bark.

In a third comparative example, the raw materials in the third example are replaced by: 12 parts of antler, 12 parts of tortoise plastron, 20 parts of ginseng, 15 parts of wolfberry fruit and 25 parts of Chinese yam.

In the fourth comparative example, the raw materials in the first example are replaced by: 2 parts of antler, 3 parts of tortoise plastron, 4 parts of ginseng, 2 parts of medlar, 5 parts of yam, 3 parts of salvia miltiorrhiza, 2 parts of bighead atractylodes rhizome and 1 part of eucommia bark.

3. Judgment of therapeutic effect

The therapeutic effect judgment standard is divided into four grades of cure, obvious effect, effective and ineffective.

And (3) curing: has no clinical symptoms.

The effect is shown: the clinical symptoms are mostly eliminated.

The method has the following advantages: the clinical symptoms are relieved.

And (4) invalidation: there was no change in clinical symptom manifestation.

4. Test results

Test examples	Total number of people	The number of people cured	Number of effective people	Number of effective persons	Number of invalid persons
						Example one	20	15	3	1	1
Example two	20	16	4	0	0
						EXAMPLE III	20	14	2	3	1
Comparison example 1	20	0	3	5	12
						Comparative example two	20	1	2	4	13
Comparative example three	20	0	2	6	12
						Comparative example four	20	2	2	8	8

The pure traditional Chinese medicine transdermal liniment has obvious curative effect on osteoporosis.

Typical case 1

When a male is aged 57 years old, the osteoporosis is diagnosed in a hospital, the disease condition is not improved after the bone health supplement is taken for treatment at first, and then the pure traditional Chinese medicine transdermal liniment prepared by the invention is used for applying for 3 times every day, the symptoms disappear after the pure traditional Chinese medicine transdermal liniment is continuously used for one treatment course, and the osteoporosis of the patient is cured after the diagnosis in the hospital.

Typical case 2

When a woman is in the age of 59 years and is diagnosed as osteoporosis in a hospital, the bone health supplement and the medicine are added for intervention for treatment at first, the side effect is serious, and the condition of the disease is not improved, the pure traditional Chinese medicine transdermal liniment prepared by the invention is used for 3 times per day, a treatment course is continuously used, the symptoms are relieved, the treatment course is continuously used, the symptoms disappear, and the osteoporosis of the patient is cured through the diagnosis in the hospital.

Typical case 3

The pure traditional Chinese medicine transdermal liniment prepared by the invention is used for 3 times per day, one treatment course is continuously used, the symptoms are relieved, two treatment courses are continuously used, the symptoms disappear, and the osteoporosis of a patient is cured through hospital diagnosis.

It is noted that, herein, relational terms such as first and second, and the like may be used solely to distinguish one entity or action from another entity or action without necessarily requiring or implying any actual such relationship or order between such entities or actions. Also, the terms "comprises," "comprising," or any other variation thereof, are intended to cover a non-exclusive inclusion, such that a process, method, article, or apparatus that comprises a list of elements does not include only those elements but may include other elements not expressly listed or inherent to such process, method, article, or apparatus.

Although embodiments of the present invention have been shown and described, it will be appreciated by those skilled in the art that changes, modifications, substitutions and alterations can be made in these embodiments without departing from the principles and spirit of the invention, the scope of which is defined in the appended claims and their equivalents.