阅读说明：本技术 一种液体妇科抗菌剂的配方及制作方法 (Formula and preparation method of liquid gynecological antibacterial agent ) 是由 马少辉 于 2021-07-13 设计创作，主要内容包括：本发明涉及一种液体妇科抗菌剂的配方及制作方法,包括以下重量份的原料：苦参7-9份、黄柏4-6份、蛇床子10-15份、薄荷3-5份、红花10-15份、蒲公英4-6份、地肤子10-15份、冰片0.1-0.3份、透明质酸钠7-9份、聚六亚甲基双胍0.02-0.03份。一种液体妇科抗菌剂的制作方法,包括以下步骤：1)制作浓缩液；2)制作中间体溶液：向浓缩液内加入透明质酸钠和聚六亚甲基双胍,混合而成中间体溶液；3)混合配料：将中间体溶液过200目筛网；4)半成品检测、灌装、外包装、成品检验、入库。本发明优点在于：与现有技术相比较,具有止痒迅速,杀菌彻底,清洁护理、改善阴道环境,并且给药方便,易于制造,成本低廉,安全,毒副作用小,使用方便等优点。(The invention relates to a formula and a preparation method of a liquid gynecological antibacterial agent, which comprises the following raw materials in parts by weight: 7-9 parts of radix sophorae flavescentis, 4-6 parts of cortex phellodendri, 10-15 parts of fructus cnidii, 3-5 parts of mint, 10-15 parts of safflower, 4-6 parts of dandelion, 10-15 parts of fructus kochiae, 0.1-0.3 part of borneol, 7-9 parts of sodium hyaluronate and 0.02-0.03 part of polyhexamethylene biguanide. A method for preparing a liquid gynecological antibacterial agent comprises the following steps: 1) preparing a concentrated solution; 2) preparing an intermediate solution: adding sodium hyaluronate and polyhexamethylene biguanide into the concentrated solution, and mixing to obtain an intermediate solution; 3) mixing ingredients: passing the intermediate solution through a 200-mesh screen; 4) and (4) detecting a semi-finished product, filling, externally packaging, inspecting a finished product and warehousing. The invention has the advantages that: compared with the prior art, has the advantages of rapid itching relieving, thorough sterilization, clean nursing, vaginal environment improvement, convenient administration, easy manufacture, low cost, safety, small toxic and side effect, convenient use and the like.)

1. The formula of the liquid gynecological antibacterial agent is characterized by comprising the following raw materials in parts by weight: 7-9 parts of radix sophorae flavescentis, 4-6 parts of cortex phellodendri, 10-15 parts of fructus cnidii, 3-5 parts of mint, 10-15 parts of safflower, 4-6 parts of dandelion, 10-15 parts of fructus kochiae, 0.1-0.3 part of borneol, 7-9 parts of sodium hyaluronate and 0.02-0.03 part of polyhexamethylene biguanide.

2. The formula of the liquid gynecological antibacterial agent according to claim 1, characterized by comprising the following raw materials in parts by weight: 8 parts of radix sophorae flavescentis, 5 parts of golden cypress, 13 parts of fructus cnidii, 4 parts of mint, 12 parts of safflower, 5 parts of dandelion, 13 parts of fructus kochiae, 0.2 part of borneol, 8 parts of sodium hyaluronate and 0.02 part of polyhexamethylene biguanide.

3. The formula of the liquid gynecological antibacterial agent according to claim 1, characterized by comprising the following raw materials in parts by weight: 7 parts of radix sophorae flavescentis, 6 parts of golden cypress, 10 parts of fructus cnidii, 5 parts of mint, 10 parts of safflower, 6 parts of dandelion, 10 parts of fructus kochiae, 0.3 part of borneol, 7 parts of sodium hyaluronate and 0.03 part of polyhexamethylene biguanide.

4. The formula of the liquid gynecological antibacterial agent according to claim 1, characterized by comprising the following raw materials in parts by weight: 9 parts of radix sophorae flavescentis, 4 parts of golden cypress, 15 parts of fructus cnidii, 3 parts of mint, 15 parts of safflower, 4 parts of dandelion, 15 parts of fructus kochiae, 0.1 part of borneol, 9 parts of sodium hyaluronate and 0.02 part of polyhexamethylene biguanide.

5. A method for preparing a liquid gynecological antibacterial agent, which adopts the formula of the liquid gynecological antibacterial agent as claimed in any one of claims 1 to 4, characterized by comprising the following steps:

1) preparing a concentrated solution: mixing radix sophorae flavescentis, golden cypress, fructus cnidii, mint, safflower, dandelion, fructus kochiae and borneol, adding water, decocting for 2 times, adding 8 times of water for the first time, decocting for 1.5 hours, filtering, adding 6 times of water for the second time, decocting for 1 hour, filtering, combining filtrates of the two times, concentrating to a relative density of 1.10-1.20 at 60 ℃, adding ethanol until the alcohol content is 75%, standing for 24 hours, and recovering ethanol until no alcohol smell exists, thus obtaining a concentrated solution;

2) preparing an intermediate solution: adding sodium hyaluronate and polyhexamethylene biguanide into the concentrated solution, and mixing to obtain an intermediate solution;

3) mixing ingredients: passing the intermediate solution through a 200-mesh screen;

4) and (4) detecting a semi-finished product, filling, externally packaging, inspecting a finished product and warehousing.

6. The method for preparing a gynecological liquid antibacterial agent according to claim 5, characterized in that said semi-finished product detection comprises: sensory detection, net content deviation detection, pH value detection and content detection.

7. A method for preparing a liquid gynecological antibacterial agent according to claim 5 characterized in that said final product inspection comprises: sensory detection, net content deviation detection, pH value detection, content detection, microorganism limit detection and pathogen detection.

Technical Field

The invention relates to the field of disinfection antibacterial products, in particular to a formula of a liquid gynecological antibacterial agent and a preparation method thereof.

Background

Gynecological inflammation is a common disease of women, mainly refers to inflammation of female reproductive organs, and various female organs can be subjected to acute and chronic inflammation, and specifically comprise female vulvitis and vaginitis. In recent years, the incidence rate of gynecological inflammation is on a remarkable rising trend along with the influence of sexual infection and environmental factors. Due to the special reasons of female physiological structure, female reproductive organs are very easy to be infected by pathogens such as staphylococcus aureus, candida albicans, novel candida, pseudomonas aeruginosa, streptococcus B, pseudomonas aeruginosa, escherichia coli, saccharomycetes, trichomonas and the like.

At present, gynecological inflammation treatment is mainly carried out by external medicines, such as lotion, suppository, effervescent agent, foaming agent, gel and the like, most medicines contain metronidazole, clotrimazole antibiotics or chemical disinfectants, and long-term excessive use of the medicines can not only damage organs such as liver, kidney and the like, but also easily cause pathogenic bacteria to generate drug resistance, destroy the mutual restriction relationship among normal vaginal flora to cause flora imbalance, further cause the destruction of vaginal self-cleaning and defense capacity, cause pathogenic bacteria such as fungi to grow vigorously, treat incompletely and repeat disease conditions. Therefore, the research on the formula and the preparation method of the liquid gynecological antibacterial agent which is convenient to prepare and has ideal antibacterial and bacteriostatic effects and meets the nursing requirements of users becomes the research direction.

Disclosure of Invention

The invention aims to provide a formula and a preparation method of a liquid gynecological antibacterial agent, and aims to solve the problems in the background technology.

In order to solve the technical problems, the technical scheme provided by the invention is as follows: the formula of the liquid gynecological antibacterial agent comprises the following raw materials in parts by weight: 7-9 parts of radix sophorae flavescentis, 4-6 parts of cortex phellodendri, 10-15 parts of fructus cnidii, 3-5 parts of mint, 10-15 parts of safflower, 4-6 parts of dandelion, 10-15 parts of fructus kochiae, 0.1-0.3 part of borneol, 7-9 parts of sodium hyaluronate and 0.02-0.03 part of polyhexamethylene biguanide.

As a preferred scheme, the formula of the liquid gynecological antibacterial agent comprises the following raw materials in parts by weight: 8 parts of radix sophorae flavescentis, 5 parts of golden cypress, 13 parts of fructus cnidii, 4 parts of mint, 12 parts of safflower, 5 parts of dandelion, 13 parts of fructus kochiae, 0.2 part of borneol, 8 parts of sodium hyaluronate and 0.02 part of polyhexamethylene biguanide.

As a preferred scheme, the formula of the liquid gynecological antibacterial agent comprises the following raw materials in parts by weight: 7 parts of radix sophorae flavescentis, 6 parts of golden cypress, 10 parts of fructus cnidii, 5 parts of mint, 10 parts of safflower, 6 parts of dandelion, 10 parts of fructus kochiae, 0.3 part of borneol, 7 parts of sodium hyaluronate and 0.03 part of polyhexamethylene biguanide.

As a preferred scheme, the formula of the liquid gynecological antibacterial agent comprises the following raw materials in parts by weight: 9 parts of radix sophorae flavescentis, 4 parts of golden cypress, 15 parts of fructus cnidii, 3 parts of mint, 15 parts of safflower, 4 parts of dandelion, 15 parts of fructus kochiae, 0.1 part of borneol, 9 parts of sodium hyaluronate and 0.02 part of polyhexamethylene biguanide.

The preparation method of the liquid gynecological antibacterial agent adopts the formula of the liquid gynecological antibacterial agent and comprises the following steps:

1) preparing a concentrated solution: mixing radix sophorae flavescentis, golden cypress, fructus cnidii, mint, safflower, dandelion, fructus kochiae and borneol, adding water, decocting for 2 times, adding 8 times of water for the first time, decocting for 1.5 hours, filtering, adding 6 times of water for the second time, decocting for 1 hour, filtering, combining filtrates of the two times, concentrating to a relative density of 1.10-1.20 at 60 ℃, adding ethanol until the alcohol content is 75%, standing for 24 hours, and recovering ethanol until no alcohol smell exists, thus obtaining a concentrated solution;

2) preparing an intermediate solution: adding sodium hyaluronate and polyhexamethylene biguanide into the concentrated solution, and mixing to obtain an intermediate solution;

3) mixing ingredients: passing the intermediate solution through a 200-mesh screen;

4) and (4) detecting a semi-finished product, filling, externally packaging, inspecting a finished product and warehousing.

Preferably, the semi-finished product detection comprises: sensory detection, net content deviation detection, pH value detection and content detection.

Preferably, the finished product inspection comprises: sensory detection, net content deviation detection, pH value detection, content detection, microorganism limit detection and pathogen detection.

The invention has the advantages that: compared with the prior art, has the advantages of rapid itching relieving, thorough sterilization, clean nursing, vaginal environment improvement, convenient administration, easy manufacture, low cost, safety, small toxic and side effect, convenient use and the like.

Drawings

FIG. 1 is a process flow diagram of the present invention.

Detailed Description

The invention is illustrated below by means of specific examples, without being restricted thereto.

Example 1

The formula of the liquid gynecological antibacterial agent comprises the following raw materials in parts by weight: 8 parts of radix sophorae flavescentis, 5 parts of golden cypress, 13 parts of fructus cnidii, 4 parts of mint, 12 parts of safflower, 5 parts of dandelion, 13 parts of fructus kochiae, 0.2 part of borneol, 8 parts of sodium hyaluronate and 0.02 part of polyhexamethylene biguanide.

The preparation method of the liquid gynecological antibacterial agent adopts the formula of the liquid gynecological antibacterial agent and comprises the following steps:

1) preparing a concentrated solution: mixing radix sophorae flavescentis, golden cypress, fructus cnidii, mint, safflower, dandelion, fructus kochiae and borneol, adding water, decocting for 2 times, adding 8 times of water for the first time, decocting for 1.5 hours, filtering, adding 6 times of water for the second time, decocting for 1 hour, filtering, combining filtrates of the two times, concentrating to a relative density of 1.10-1.20 at 60 ℃, adding ethanol until the alcohol content is 75%, standing for 24 hours, and recovering ethanol until no alcohol smell exists, thus obtaining a concentrated solution;

2) preparing an intermediate solution: adding sodium hyaluronate and polyhexamethylene biguanide into the concentrated solution, and mixing to obtain an intermediate solution;

3) mixing ingredients: passing the intermediate solution through a 200-mesh screen;

4) and (4) detecting a semi-finished product, filling, externally packaging, inspecting a finished product and warehousing.

As a preferred embodiment of this embodiment, the semi-finished product inspection includes: sensory detection, net content deviation detection, pH value detection and content detection.

As a preferred implementation of this embodiment, the finished product inspection includes: sensory detection, net content deviation detection, pH value detection, content detection, microorganism limit detection and pathogen detection.

Example 2

The formula of the liquid gynecological antibacterial agent comprises the following raw materials in parts by weight: 7 parts of radix sophorae flavescentis, 6 parts of golden cypress, 10 parts of fructus cnidii, 5 parts of mint, 10 parts of safflower, 6 parts of dandelion, 10 parts of fructus kochiae, 0.3 part of borneol, 7 parts of sodium hyaluronate and 0.03 part of polyhexamethylene biguanide.

The preparation method of the liquid gynecological antibacterial agent adopts the formula of the liquid gynecological antibacterial agent and comprises the following steps:

1) preparing a concentrated solution: mixing radix sophorae flavescentis, golden cypress, fructus cnidii, mint, safflower, dandelion, fructus kochiae and borneol, adding water, decocting for 2 times, adding 8 times of water for the first time, decocting for 1.5 hours, filtering, adding 6 times of water for the second time, decocting for 1 hour, filtering, combining filtrates of the two times, concentrating to a relative density of 1.10-1.20 at 60 ℃, adding ethanol until the alcohol content is 75%, standing for 24 hours, and recovering ethanol until no alcohol smell exists, thus obtaining a concentrated solution;

2) preparing an intermediate solution: adding sodium hyaluronate and polyhexamethylene biguanide into the concentrated solution, and mixing to obtain an intermediate solution;

3) mixing ingredients: passing the intermediate solution through a 200-mesh screen;

4) and (4) detecting a semi-finished product, filling, externally packaging, inspecting a finished product and warehousing.

As a preferred embodiment of this embodiment, the semi-finished product inspection includes: sensory detection, net content deviation detection, pH value detection and content detection.

As a preferred implementation of this embodiment, the finished product inspection includes: sensory detection, net content deviation detection, pH value detection, content detection, microorganism limit detection and pathogen detection.

Example 3

The formula of the liquid gynecological antibacterial agent comprises the following raw materials in parts by weight: 9 parts of radix sophorae flavescentis, 4 parts of golden cypress, 15 parts of fructus cnidii, 3 parts of mint, 15 parts of safflower, 4 parts of dandelion, 15 parts of fructus kochiae, 0.1 part of borneol, 9 parts of sodium hyaluronate and 0.02 part of polyhexamethylene biguanide.

The preparation method of the liquid gynecological antibacterial agent adopts the formula of the liquid gynecological antibacterial agent and comprises the following steps:

1) preparing a concentrated solution: mixing radix sophorae flavescentis, golden cypress, fructus cnidii, mint, safflower, dandelion, fructus kochiae and borneol, adding water, decocting for 2 times, adding 8 times of water for the first time, decocting for 1.5 hours, filtering, adding 6 times of water for the second time, decocting for 1 hour, filtering, combining filtrates of the two times, concentrating to a relative density of 1.10-1.20 at 60 ℃, adding ethanol until the alcohol content is 75%, standing for 24 hours, and recovering ethanol until no alcohol smell exists, thus obtaining a concentrated solution;

2) preparing an intermediate solution: adding sodium hyaluronate and polyhexamethylene biguanide into the concentrated solution, and mixing to obtain an intermediate solution;

3) mixing ingredients: passing the intermediate solution through a 200-mesh screen;

4) and (4) detecting a semi-finished product, filling, externally packaging, inspecting a finished product and warehousing.

As a preferred embodiment of this embodiment, the semi-finished product inspection includes: sensory detection, net content deviation detection, pH value detection and content detection.

As a preferred implementation of this embodiment, the finished product inspection includes: sensory detection, net content deviation detection, pH value detection, content detection, microorganism limit detection and pathogen detection.

The invention has the following environmental requirements: the ventilation is good, the facility of airing exhaust is perfect, and the wall, ceiling, door and window of workshop adopt and prevent easy washing, prevent fires, prevent static, and clean level in the workshop is controlled more than 30 ten thousand grades.

The equipment requirements are as follows: the equipment is corrosion resistant and easy to clean and disinfect.

The requirements of raw materials and auxiliary materials are as follows: the Chinese medicinal materials conform to the contents specified in the first part of Chinese pharmacopoeia.

The above description is only for the preferred embodiment of the present invention, but the scope of the present invention is not limited thereto, and any person skilled in the art should be considered to be within the technical scope of the present invention, and the technical solutions and the inventive concepts thereof according to the present invention should be equivalent or changed within the scope of the present invention.