阅读说明：本技术 一种缬沙坦氨氯地平片制备的系统和方法 (System and method for preparing valsartan amlodipine tablets ) 是由 付长华 吴迎庆 陈兴加 方焱琳 汪柳明 于 2020-06-15 设计创作，主要内容包括：本发明涉及医药制剂的制备,更具体的说是一种缬沙坦氨氯地平片制备的系统和方法,包括步骤一：将缬沙坦和氨氯地平按重量比例80：5放置在搅拌筒内,将缬沙坦和氨氯地平的原料分别放置在两个供料箱内,调整供料底板在供料槽内的滑动高度,使得供料支架转动一圈向搅拌箱内提供原料的比例为缬沙坦和氨氯地平按重量比例80：5；步骤二：启动搅拌机构对搅拌箱的内的原料进行搅拌,搅拌完成装夹机构摆动将搅拌箱内的原料倒入漏斗上,漏斗内的原料掉落在更换机构上；步骤三：更换机构转动时带动供料支架转动一圈进行供料,装夹机构复位推动闭合机构运动,供料支架内的原料掉落在搅拌箱内；步骤四：压片、包衣和检测。(The invention relates to preparation of a medicinal preparation, in particular to a system and a method for preparing valsartan amlodipine tablets, which comprises the following steps: valsartan and amlodipine are mixed according to the weight ratio of 80: 5 in placing the churn, place valsartan and amlodipine's raw materials respectively in two feed tanks, the slip height of adjustment feed bottom plate in the feed tank for the proportion that the feed support rotates the round and provides raw materials in to the agitator tank is valsartan and amlodipine according to weight ratio 80: 5; step two: starting a stirring mechanism to stir the raw materials in the stirring box, swinging a clamping mechanism after stirring to pour the raw materials in the stirring box into a funnel, and dropping the raw materials in the funnel onto a replacing mechanism; step three: when the replacing mechanism rotates, the feeding support is driven to rotate for a circle to feed, the clamping mechanism resets to push the closing mechanism to move, and raw materials in the feeding support fall into the stirring box; step four: tabletting, coating and detecting.)

1. The utility model provides a system of preparation of valsartan amlodipine tablet, includes device support (1), clamping machine structure (2), agitator tank (3), rabbling mechanism (4), funnel (5), changes mechanism (6), feed support (7), feed mechanism (8) and closing mechanism (9), its characterized in that: the device comprises a device support (1), wherein a clamping mechanism (2) is fixedly connected to the middle of the device support (1), a stirring box (3) is clamped on the clamping mechanism (2), a stirring mechanism (4) is fixedly connected to the upper end of the middle of the device support (1), the stirring mechanism (4) is positioned on the upper side of the stirring box (3), a funnel (5) is fixedly connected to the device support (1), a replacing mechanism (6) is rotatably connected to the front end of the device support (1), the funnel (5) is positioned on the upper side of the replacing mechanism (6), a feeding support (7) is fixedly connected to the rear end of the device support (1), the feeding support (7) is positioned on the upper side of the stirring box (3), a feeding mechanism (8) is rotatably connected to the rear end of the device support (1), the feeding mechanism (8) is positioned in the feeding support (7), a closing mechanism (9) is slidably connected to the rear end of the device support (1), and a compression spring I is fixedly, the upper end of the closing mechanism (9) is connected to the feeding support (7) in a sliding mode, the lower end of the closing mechanism (9) is in contact with the clamping mechanism (2), and the replacing mechanism (6) is in transmission connection with the feeding mechanism (8).

2. The system for preparing the valsartan amlodipine tablets according to claim 1, wherein the valsartan amlodipine tablets comprise: device support (1) is including collateral branch frame (101), support frame (102), backup pad I (103), backup pad II (104) and mounting panel (105), collateral branch frame (101) are provided with two, fixedly connected with support frame (102) between the middle part of two collateral branch frames (101), the equal fixedly connected with backup pad I (103) in front end of two collateral branch frames (101), the equal fixedly connected with backup pad II (104) in rear end of two collateral branch frames (101), fixedly connected with mounting panel (105) between the upper end of two backup pad II (104).

3. The system for preparing the valsartan amlodipine tablets according to claim 2, wherein the valsartan amlodipine tablets comprise: the clamping mechanism (2) comprises clamping discs (201), clamping sliding columns (202), spring baffle plates (203), clamping sliding cylinders (204), rotating wheel frames (205), rotating wheels (206), telescopic mechanisms I (207), connecting plates (208) and swing motors (209), the clamping sliding columns (202) are fixedly connected to two ends of each clamping disc (201), an included angle between the two clamping sliding columns (202) is 90 degrees, the spring baffle plates (203) are fixedly connected to the two clamping sliding columns (202), the number of the clamping discs (201) is eight, each four of the eight clamping discs (201) form a group, the clamping sliding cylinders (204) are slidably connected between the corresponding two clamping sliding columns (202), compression springs II are fixedly connected between the clamping sliding cylinders (204) and the corresponding spring baffle plates (203), the rotating wheel frame (205) is fixedly connected to the inner side of each clamping disc (201), and the rotating wheels (206) are rotatably connected to each rotating wheel frame (205), telescopic machanism I (207) are provided with four, two liang connect through connecting plate (208) between four telescopic machanism I (207), the flexible end difference fixed connection of four telescopic machanism I (207) is on four dress chucks (201) that correspond, telescopic machanism I (207) that are located the upside left end rotate to be connected on support frame (102), be located on the output shaft of telescopic machanism I (207) fixed connection swing motor (209) of upside right-hand member, swing motor (209) fixed connection is on support frame (102).

4. The system for preparing the valsartan amlodipine tablets according to claim 3, wherein the valsartan amlodipine tablets comprise: agitator tank (3) are including churn (301), agitator disk (302) and play charging tray (303), and churn (301) clamping is between eight rotating wheel (206), and the inside sliding connection of churn (301) has agitator disk (302), fixedly connected with compression spring III between the bottom of agitator disk (302) and churn (301), and the upper end toper setting of churn (301) inside, the upper end fixedly connected with of churn (301) goes out charging tray (303).

5. The system for preparing the valsartan amlodipine tablets according to claim 4, wherein the valsartan amlodipine tablets comprise: rabbling mechanism (4) are including telescopic machanism II (401), agitator motor (402) and stirring cone pulley (403), telescopic machanism II (401) fixed connection is on support frame (102), telescopic machanism II's (401) flexible end fixedly connected with agitator motor (402), fixedly connected with stirring cone pulley (403) on the output shaft of agitator motor (402), be provided with the toper screw thread on stirring cone pulley (403), stirring cone pulley (403) are located the upside of churn (301), fixedly connected with funnel (5) on support frame (102).

6. The system for preparing the valsartan amlodipine tablets according to claim 5, wherein the valsartan amlodipine tablets comprise: change mechanism (6) including more changing axle (601), change dish (602), change support (603), articulated ring (604), counterweight frame (605) and storage barrel (606), more change axle (601) rotate to be connected between two backup pads I (103), the middle part fixedly connected with who changes axle (601) changes dish (602), change four change supports (603) of fixedly connected with on dish (602), four change all rotate on support (603) and be connected with articulated ring (604), equal fixedly connected with counterweight frame (605) on four articulated ring (604), storage barrel (606) have all been placed on four articulated ring (604).

7. The system for preparing the valsartan amlodipine tablets according to claim 6, wherein the valsartan amlodipine tablets comprise: the feeding support (7) comprises two feeding boxes (701), arc baffles (702), feeding pipelines (703) and a closed cavity (704), wherein the two feeding boxes (701) are provided with two arc baffles (702) which are fixedly connected in the two feeding boxes (701), the feeding pipelines (703) are fixedly connected between the two arc baffles (702), the closed cavity (704) is arranged on the feeding pipelines (703), the two feeding boxes (701) are fixedly connected on a mounting plate (105), and the feeding pipelines (703) are located on the upper side of the discharging disc (303).

8. The system for preparing the valsartan amlodipine tablets according to claim 7, wherein the valsartan amlodipine tablets comprise: the feeding mechanism (8) comprises a feeding shaft (801), a feeding rotator (802), a feeding groove (803), a telescopic mechanism III (804) and a feeding bottom plate (805), the feeding shaft (801) is rotatably connected between two support plates II (104), two feeding rotators (802) fixedly connected to the feeding shaft (801), the two feeding rotators (802) are respectively rotatably connected to two feeding boxes (701), the inner sides of the two arc baffles (702) are respectively attached to the two feeding rotators (802), the two feeding rotators (802) are respectively provided with a feeding groove (803), two feeding grooves (803) are respectively and fixedly connected with a telescopic mechanism III (804), the telescopic ends of the two telescopic mechanisms III (804) are respectively and fixedly connected with a feeding bottom plate (805), the two feeding bottom plates (805) are respectively and slidably connected to the two feeding grooves (803), and the transmission ratio between the feeding shaft (801) and the replacing shaft (601) is one fourth.

9. The system for preparing the valsartan amlodipine tablets according to claim 8, wherein the valsartan amlodipine tablets comprise: the closing mechanism (9) comprises a closing connecting rod (901), a closing baffle (902) and a pushing column (903), the upper end and the lower end of the closing connecting rod (901) are fixedly connected with the closing baffle (902) and the pushing column (903) respectively, the closing baffle (902) is connected in a closing cavity (704) in a sliding mode, a compression spring I is fixedly connected between the closing baffle (902) and a mounting plate (105), and the pushing column (903) is in contact with a clamping disc (201) located at the upper end of the rear side.

10. The method for preparing valsartan amlodipine tablets using the system for preparing valsartan amlodipine tablets according to claim 9, wherein: the method comprises the following steps:

the method comprises the following steps: valsartan and amlodipine besylate are mixed according to the weight ratio of 80: 5, placing raw materials of the valsartan and the amlodipine besylate in a stirring cylinder (301), respectively placing the raw materials of the valsartan and the amlodipine besylate in two feeding tanks (701), and adjusting the sliding height of a feeding bottom plate (805) in a feeding groove (803) so that the feeding support (7) rotates for one circle to provide raw materials in the stirring tank (3) in a proportion of 80: 5;

step two: starting a stirring mechanism (4) to stir the raw materials in the stirring box (3), swinging the clamping mechanism (2) after stirring to pour the raw materials in the stirring box (3) onto a funnel (5), and dropping the raw materials in the funnel (5) onto a replacing mechanism (6);

step three: when the replacing mechanism (6) rotates, the feeding support (7) is driven to rotate for a circle for feeding, the clamping mechanism (2) resets to push the closing mechanism (9) to move, and raw materials in the feeding support (7) fall into the stirring box (3);

step four: putting the mixture of valsartan and amlodipine besylate in a storage barrel (606) into a wet mixer, adding 50 parts of microcrystalline cellulose, 20 parts of crospovidone, 10 parts of croscarmellose sodium and 2 parts of silicon dioxide according to parts by weight, and mixing; adding the uniformly mixed materials into a dry-method granulator for granulation; collecting the granules, putting the granules into a three-dimensional mixer, adding 2 parts of magnesium stearate by weight, and uniformly mixing; tabletting and coating; and (6) detecting.

Technical Field

The invention relates to preparation of a medicinal preparation, in particular to a system and a method for preparing valsartan amlodipine tablets.

Background

The valsartan amlodipine tablet belongs to a compound preparation, is mainly used for treating essential hypertension clinically, can help to control the blood pressure value and promote the blood pressure to return to a normal level. The valsartan amlodipine tablet contains two antihypertensive active ingredients, wherein valsartan belongs to angiotensin antagonist drugs, and amlodipine belongs to calcium channel blocker drugs, so that the two ingredients have the antihypertensive effect, but simultaneously play a role in controlling blood pressure and have a complementary action mechanism effect, so that the valsartan amlodipine tablet has a more remarkable curative effect in treating hypertension compared with the common single-drug therapy.

The valsartan raw material is white powder, has hygroscopicity and is not easy to mix, and the proportion of the valsartan raw material to the amlodipine besylate raw material is 80: and 5, a three-dimensional mixer and a wet granulator are adopted for mixing in general industrial production, but the two raw materials are easy to adhere in the mixing process, and the mixing uniformity is poor, so that the content uniformity of the valsartan amlodipine tablets is beyond the range specified in Chinese pharmacopoeia. If the content is too high, the single dose exceeds the safe dose; the content is too low, the blood concentration can not reach the effective concentration, the treatment effect can not be achieved, and great risk is generated in the clinical administration process.

Therefore, a preparation system capable of rapidly and uniformly mixing two materials according to different proportions is needed to be invented for industrial production of valsartan amlodipine tablets, so that the product quality is uniform, and the occurrence of drug overdose or drug underdose in the using process of the drug is prevented.

Disclosure of Invention

The invention aims to provide a system and a method for preparing valsartan amlodipine tablets, which can realize the rapid and uniform mixing of raw materials with different proportions.

The purpose of the invention is realized by the following technical scheme:

a system for preparing valsartan amlodipine tablets comprises a device support, a clamping mechanism, a stirring box, a stirring mechanism, a funnel, a replacing mechanism, a feeding support, a feeding mechanism and a closing mechanism, wherein the middle part of the device support is fixedly connected with the clamping mechanism, the clamping mechanism is provided with the stirring box, the upper end of the middle part of the device support is fixedly connected with the stirring mechanism, the stirring mechanism is positioned at the upper side of the stirring box, the device support is fixedly connected with the funnel, the front end of the device support is rotatably connected with the replacing mechanism, the funnel is positioned at the upper side of the replacing mechanism, the rear end of the device support is fixedly connected with the feeding support, the feeding support is positioned at the upper side of the stirring box, the rear end of the device support is rotatably connected with the feeding mechanism, the feeding mechanism is positioned in the feeding support, the rear end of the device support is slidably connected with the closing, the upper end of the closing mechanism is connected to the feeding support in a sliding mode, the lower end of the closing mechanism is in contact with the clamping mechanism, and the replacing mechanism is in transmission connection with the feeding mechanism.

According to the further optimization of the technical scheme, the valsartan amlodipine tablet preparation system comprises a device support, two side supports, two support plates I, two support plates II and an installation plate, wherein the support frames are fixedly connected between the middle parts of the two side supports, the front ends of the two side supports are fixedly connected with the support plates I, the rear ends of the two side supports are fixedly connected with the support plates II, and the installation plate is fixedly connected between the upper ends of the two support plates II.

As a further optimization of the technical scheme, the valsartan amlodipine tablet preparation system comprises clamping discs, clamping sliding columns, spring baffles, clamping sliding cylinders, rotating wheel carriers, rotating wheels, telescopic mechanisms I, connecting plates and a swing motor, wherein the clamping sliding columns are fixedly connected to two ends of each clamping disc, the included angle between the two clamping sliding columns is 90 degrees, the spring baffles are fixedly connected to the two clamping sliding columns, the eight clamping discs are arranged, each four clamping discs form a group, the clamping sliding cylinders are respectively and slidably connected between the two corresponding clamping sliding columns, the compression springs II are respectively and fixedly connected between the clamping sliding cylinders and the corresponding spring baffles, the rotating wheel carriers are respectively and fixedly connected to the inner sides of the clamping discs, the rotating wheels are respectively and rotatably connected to the rotating wheel carriers, the four telescopic mechanisms I are arranged, and the four telescopic mechanisms I are connected with each other through the connecting plates in pairs, the telescopic ends of the four telescopic mechanisms I are respectively fixedly connected to the corresponding four clamping plates, the telescopic mechanism I located at the left end of the upper side is rotatably connected to the support frame, the telescopic mechanism I located at the right end of the upper side is fixedly connected to an output shaft of a swing motor, and the swing motor is fixedly connected to the support frame.

As a further optimization of the technical scheme, the system for preparing the valsartan amlodipine tablets comprises a stirring tank, a stirring disc and a discharging disc, wherein the stirring tank is clamped between eight rotating wheels, the stirring disc is connected to the inside of the stirring tank in a sliding manner, a compression spring III is fixedly connected between the stirring disc and the bottom of the stirring tank, the upper end of the inside of the stirring tank is arranged in a conical manner, and the discharging disc is fixedly connected to the upper end of the stirring tank.

As a further optimization of the technical scheme, the system for preparing the valsartan amlodipine tablets comprises a telescopic mechanism II, a stirring motor and a stirring cone wheel, wherein the telescopic mechanism II is fixedly connected to a support frame, the telescopic end of the telescopic mechanism II is fixedly connected with the stirring motor, the output shaft of the stirring motor is fixedly connected with the stirring cone wheel, the stirring cone wheel is provided with a conical thread, the stirring cone wheel is positioned on the upper side of a stirring cylinder, and the support frame is fixedly connected with a funnel.

According to the further optimization of the technical scheme, the system for preparing the valsartan amlodipine tablets comprises a replacing mechanism, a replacing disc, a replacing support, hinge rings, a counterweight frame and storage barrels, wherein the replacing mechanism comprises a replacing shaft, the replacing disc, the replacing support, the hinge rings, the counterweight frame and the storage barrels, the replacing shaft is rotatably connected between two support plates I, the replacing disc is fixedly connected to the middle of the replacing shaft, the four replacing supports are fixedly connected to the replacing disc, the hinge rings are rotatably connected to the four replacing supports, the counterweight frame is fixedly connected to the four hinge rings, and the storage barrels are placed on the four hinge rings.

As a further optimization of the technical scheme, the system for preparing the valsartan amlodipine tablets comprises two feeding boxes, two arc baffles, two feeding pipelines and a closed cavity, wherein the two feeding boxes are fixedly connected with the arc baffles, the feeding pipeline is fixedly connected between the two arc baffles, the closed cavity is arranged on the feeding pipeline, the two feeding boxes are fixedly connected on the mounting plate, and the feeding pipelines are positioned on the upper side of the discharging tray.

As a further optimization of the technical scheme, the system for preparing the valsartan amlodipine tablets comprises a feeding mechanism, feeding rotators, feeding grooves, telescopic mechanisms III and feeding bottom plates, wherein the feeding mechanism comprises a feeding shaft, the feeding rotators, the feeding groove, the telescopic mechanisms III and the feeding bottom plates, the feeding shaft is rotatably connected between two supporting plates II, the feeding shaft is fixedly connected with two feeding rotators, the two feeding rotators are respectively rotatably connected in two feeding boxes, the inner sides of two arc baffles are respectively attached to the two feeding rotators, the two feeding rotators are respectively provided with the feeding grooves, the telescopic mechanisms III are respectively and fixedly connected in the two feeding grooves, the telescopic ends of the two telescopic mechanisms III are respectively and fixedly connected with the feeding bottom plates, the two feeding bottom plates are respectively and slidably connected in the two feeding grooves, and the transmission ratio between the feeding shaft and the.

As a further optimization of the technical scheme, the system for preparing the valsartan amlodipine tablets comprises a closing mechanism, a closing baffle and a pushing column, wherein the upper end and the lower end of the closing mechanism are respectively and fixedly connected with the closing baffle and the pushing column, the closing baffle is slidably connected in a closing cavity, a compression spring I is fixedly connected between the closing baffle and a mounting plate, and the pushing column is in contact with a clamping disc positioned at the upper end of the rear side.

A method of preparing a tablet of valsartan amlodipine comprising the steps of:

the method comprises the following steps: valsartan and amlodipine besylate are mixed according to the weight ratio of 80: 5 in the churn, place valsartan and amlodipine besylate's raw materials respectively in two feed tanks, the slip height of adjustment feed bottom plate in the feed tank for the proportion that the feed support rotated the round and provided the raw materials to the agitator tank is valsartan and amlodipine besylate according to weight ratio 80: 5;

step two: starting a stirring mechanism to stir the raw materials in the stirring box, swinging a clamping mechanism after stirring to pour the raw materials in the stirring box into a funnel, and dropping the raw materials in the funnel onto a replacing mechanism;

step three: when the replacing mechanism rotates, the feeding support is driven to rotate for a circle to feed, the clamping mechanism resets to push the closing mechanism to move, and raw materials in the feeding support fall into the stirring box;

step four: putting the mixture of valsartan and amlodipine besylate in the storage barrel into a wet mixer, adding 50 parts of microcrystalline cellulose, 20 parts of crospovidone, 10 parts of croscarmellose sodium and 2 parts of silicon dioxide according to parts by weight, and mixing; adding the uniformly mixed materials into a dry-method granulator for granulation; collecting the granules, putting the granules into a three-dimensional mixer, adding 2 parts of magnesium stearate by weight, and uniformly mixing; tabletting and coating; and (4) detecting according to Chinese pharmacopoeia and the quality standard of the valsartan amlodipine tablets.

The system and the method for preparing the valsartan amlodipine tablets have the beneficial effects that:

the system and the method for preparing the valsartan amlodipine tablets can prepare the valsartan and the amlodipine besylate according to the weight proportion of 80: 5 in the churn, place valsartan and amlodipine besylate's raw materials respectively in two feed tanks, the slip height of adjustment feed bottom plate in the feed tank for the proportion that the feed support rotated the round and provided the raw materials to the agitator tank is valsartan and amlodipine besylate according to weight ratio 80: 5; starting a stirring mechanism to stir the raw materials in the stirring box, swinging a clamping mechanism after stirring to pour the raw materials in the stirring box into a funnel, and dropping the raw materials in the funnel onto a replacing mechanism; when the replacing mechanism rotates, the feeding support is driven to rotate for a circle to feed, the clamping mechanism resets to push the closing mechanism to move, and raw materials in the feeding support fall into the stirring box; the device can efficiently and quickly mix the raw materials with different proportions by repeated work; the valsartan amlodipine tablet prepared by the method has content uniformity obviously lower than the indexes specified in Chinese pharmacopoeia.

Drawings

The invention is described in further detail below with reference to the accompanying drawings and specific embodiments.

In the description of the present invention, it should be noted that the terms "center", "longitudinal", "lateral", "up", "down", "front", "back", "left", "right", "top", "bottom", "inner", "outer" and "upright", etc., indicate orientations or positional relationships based on those shown in the drawings, and are only for convenience of description and simplicity of description, but do not indicate or imply that the referred device or element must have a specific orientation, be constructed and operated in a specific orientation, and thus, should not be construed as limiting the present invention.

In the description of the present invention, it should be noted that unless otherwise explicitly stated or limited, the terms "mounted," "connected," and "connected" are to be construed broadly, and may be, for example, fixedly connected, detachably connected, or integrally connected, directly or indirectly connected through an intermediate medium, and may be a communication between two members. The specific meanings of the above terms in the present invention can be understood in specific cases to those skilled in the art.

In addition, in the description of the present invention, the meaning of "a plurality", and "a plurality" is two or more unless otherwise specified.

Fig. 1 is a schematic diagram of the overall structure of a system for preparing valsartan amlodipine tablets according to the invention;

FIG. 2 is a schematic diagram of the overall structure of a system for preparing valsartan amlodipine tablets according to the invention;

FIG. 3 is a schematic view of the device support structure of the present invention;

FIG. 4 is a schematic structural view of a clamping mechanism of the present invention;

FIG. 5 is a schematic view of the construction of the agitator tank of the present invention;

FIG. 6 is a schematic view of the stirring mechanism of the present invention;

FIG. 7 is a schematic view of the funnel configuration of the present invention;

FIG. 8 is a schematic view of the replacement mechanism of the present invention;

FIG. 9 is a schematic view of the feed support structure of the present invention;

FIG. 10 is a first schematic view of the feeding mechanism of the present invention;

FIG. 11 is a second schematic structural view of the feeding mechanism of the present invention;

fig. 12 is a schematic view of the closure mechanism of the present invention.

In the figure: a device holder 1; side brackets 101; a support frame 102; a support plate I103; a support plate II 104; a mounting plate 105; a clamping mechanism 2; a chucking plate 201; clamping the sliding column 202; a spring retainer 203; clamping the sliding cylinder 204; a truck frame 205; a rotating wheel 206; a telescoping mechanism I207; a connecting plate 208; a swing motor 209; a stirring tank 3; a mixing drum 301; a stir plate 302; a discharge tray 303; a stirring mechanism 4; a telescoping mechanism II 401; a stirring motor 402; a stirring cone 403; a funnel 5; a replacement mechanism 6; a replacement shaft 601; a replacement disc 602; replacing the holder 603; a hinge ring 604; a weight rack 605; a receiving cylinder 606; a feed support 7; a supply tank 701; a circular arc baffle 702; a feed line 703; a closed cavity 704; a feeding mechanism 8; a supply shaft 801; a feed swivel 802; a supply tank 803; a telescoping mechanism III 804; a feed shoe 805; a closing mechanism 9; a closing link 901; a closure flap 902; pushing the column 903.

Detailed Description

The present invention will be described in further detail with reference to the accompanying drawings.