阅读说明：本技术 乳液聚合磷酸氯喹微胶囊浸渍涂覆纤维表面工艺 (Process for dipping and coating fiber surface by emulsion polymerization chloroquine phosphate microcapsule ) 是由 陈俊兵 刘娜 郭鸣明 刘也卓 程小文 于 2020-04-15 设计创作，主要内容包括：本发明属于纺丝技术领域,尤其涉及一种乳液聚合磷酸氯喹微胶囊浸渍涂覆纤维表面工艺。本发明,包括将纤维主材和羟丙基甲基纤维素加入至溶剂中,加热溶解制得原液,再将原液加入至纺丝箱中；将纺丝箱中的原液通过喷丝头喷出,并在DMAC的水溶液中凝固得到复合纤维；以包括磷酸氯喹的抗病毒剂为囊心,以纤维主材为囊壁的微胶囊涂覆至复合纤维表面,得到纤维成品。本发明发明将包括磷酸氯喹的抗病毒剂作为微胶囊的囊心,再将微胶囊涂覆至复合纤维表面制得纤维成品,使得在使用过程中,纤维成品表面的抗病毒剂具有缓释性,延长抗病毒的有效时间。(The invention belongs to the technical field of spinning, and particularly relates to a process for dipping and coating fiber surfaces by emulsion polymerization chloroquine phosphate microcapsules. Adding a main fiber material and hydroxypropyl methyl cellulose into a solvent, heating and dissolving to obtain a stock solution, and adding the stock solution into a spinning box; spraying the stock solution in the spinning box through a spinning nozzle, and solidifying in an aqueous solution of DMAC (dimethylacetamide) to obtain composite fibers; an antiviral agent containing chloroquine phosphate is used as a capsule core, and microcapsules with fiber main materials as capsule walls are coated on the surface of the composite fiber to obtain a fiber finished product. The invention takes the antiviral agent containing chloroquine phosphate as the core of the microcapsule, and then coats the microcapsule on the surface of the composite fiber to prepare the finished fiber product, so that the antiviral agent on the surface of the finished fiber product has slow release property and prolongs the antiviral effective time in the using process.)

1. The process for dipping and coating the surface of the fiber by the emulsion polymerization chloroquine phosphate microcapsule is characterized by comprising the following steps of:

the method comprises the following steps: adding a main fiber material and hydroxypropyl methyl cellulose into a solvent, heating and dissolving to obtain a stock solution, and adding the stock solution into a spinning box;

step two: spraying the stock solution in the spinning box through a spinning nozzle, and solidifying in an aqueous solution of DMAC (dimethylacetamide) to obtain composite fibers;

step three: an antiviral agent containing chloroquine phosphate is used as a capsule core, and microcapsules with fiber main materials as capsule walls are coated on the surface of the composite fiber to obtain a fiber finished product.

2. The process of claim 1, wherein the emulsion polymerization chloroquine phosphate microcapsule is impregnated on the surface of the fiber, and the process comprises the following steps: the microcapsule coating in the third step comprises the following specific steps: winding the composite fiber on a winding machine, drawing the composite fiber by a tractor, enabling the composite fiber to sequentially pass through a coating groove and a drying box, wherein a polylactic acid solution is arranged in the coating groove, microcapsules are distributed in the polylactic acid solution, and the dried fiber dried by the drying box is wound on the winding machine again to obtain a fiber finished product.

3. The process for impregnating and coating the surface of the fiber with the emulsion polymerization chloroquine phosphate microcapsule according to claim 2, wherein: the solvent of the polylactic acid solution in the coating groove is ethanol or dichloromethane, and the drying temperature of the drying oven is 50-80 ℃.

4. The process of claim 1, wherein the emulsion polymerization chloroquine phosphate microcapsule is impregnated on the surface of the fiber, and the process comprises the following steps: the microcapsule in the third step is prepared by an interfacial polymerization method.

5. The process of claim 1, wherein the emulsion polymerization chloroquine phosphate microcapsule is impregnated on the surface of the fiber, and the process comprises the following steps: the microcapsule in the third step is prepared by a physical extrusion method.

6. The process of claim 1, wherein the emulsion polymerization chloroquine phosphate microcapsule is impregnated on the surface of the fiber, and the process comprises the following steps: the antiviral agent in step three further comprises one or more of human fibroblast interferon, interferon-alpha, lopinavir, ribavirin and arbidol.

7. The process of claim 6, wherein the emulsion polymerization chloroquine phosphate microcapsule is impregnated on the surface of the fiber, and the process comprises the following steps: the antiviral agent is chloroquine phosphate.

8. The process of claim 1, wherein the emulsion polymerization chloroquine phosphate microcapsule is impregnated on the surface of the fiber, and the process comprises the following steps: the main fiber material in the first step is acrylic fiber, viscose fiber, polyester fiber, nylon fiber or polypropylene fiber.

9. The process of claim 1, wherein the emulsion polymerization chloroquine phosphate microcapsule is impregnated on the surface of the fiber, and the process comprises the following steps: the stock solution in the first step is prepared by the following steps: feeding main fiber materials and hydroxypropyl methyl cellulose into a horizontal mixer, simultaneously feeding solvent DMAC (dimethyl acetamide) through an elliptical flowmeter, arranging a spiral propeller type stirring blade in the horizontal mixer, enabling the distance between the blade and the wall of the mixer to be 5-10mm, enabling the rotation speed to be 60-90r/min, mixing through the rotation of the spiral propeller, feeding the mixed material into a mixing tank, arranging a stirrer in the mixing tank, stirring by the stirrer to obtain slurry, pumping the slurry into a dissolving tank, and heating the slurry in the dissolving tank until the slurry is dissolved into uniform liquid, thereby obtaining stock solution.

Technical Field

The invention belongs to the technical field of spinning, and particularly relates to a process for dipping and coating fiber surfaces by emulsion polymerization chloroquine phosphate microcapsules.

Background

Coronaviruses belong to the phylogenetic group of the order of the nested viruses (Nidovirales) the family of coronaviruses (Coronaviridae) the genus Coronavirus (Coronavirus). Viruses of the genus coronaviruses are enveloped (envelope) RNA viruses with a linear single-stranded positive strand genome, and are a large group of viruses widely found in nature. The coronavirus has the diameter of about 80-120 nm, the 5 'end of the genome has a methylated cap structure, the 3' end has a poly (A) tail, and the total length of the genome is about 27-32kb, so that the coronavirus is the largest virus in the genome of the currently known RNA viruses.

Coronavirus only infects vertebrates such as human, mouse, pig, cat, dog, wolf, chicken, cattle and poultry, and has stronger infectivity, so that an auxiliary product capable of improving the capability of resisting the coronavirus is urgently needed to be provided.

The applicant has also filed a patent application on a method for manufacturing an anti-coronavirus acrylic fiber of an acrylic fiber added with an anti-viral agent such as chloroquine phosphate, but the applicant has found in the subsequent experimental process that the technical scheme in the former application still has a problem to be improved, namely, the problem that the release rate of the anti-viral agent is too high, so that the manufactured fabric faces the problem of rapid reduction of the anti-viral effect at the initial stage of use, and further research is carried out on the basis of the application.

Disclosure of Invention

The invention aims to solve the problems and provides a process for preparing the emulsion polymerization chloroquine phosphate microcapsule immersion coating fiber surface, which can be used for preparing the slow-release anti-coronavirus fiber with long anti-coronavirus time effect.

In order to achieve the purpose, the invention adopts the following technical scheme:

a process for dipping and coating the surface of fiber by emulsion polymerization chloroquine phosphate microcapsule is characterized in that,

the method comprises the following steps: adding a main fiber material and hydroxypropyl methyl cellulose into a solvent, heating and dissolving to obtain a stock solution, and adding the stock solution into a spinning box;

step two: spraying the stock solution in the spinning box through a spinning nozzle, and solidifying in an aqueous solution of DMAC (dimethylacetamide) to obtain composite fibers;

step three: an antiviral agent containing chloroquine phosphate is used as a capsule core, and microcapsules with fiber main materials as capsule walls are coated on the surface of the composite fiber to obtain a fiber finished product.

In the above process for dipping and coating the surface of the fiber by the emulsion polymerization chloroquine phosphate microcapsule, the microcapsule coating in the third step comprises the following specific steps: winding the composite fiber on a winding machine, drawing the composite fiber by a tractor, enabling the composite fiber to sequentially pass through a coating groove and a drying box, wherein a polylactic acid solution is arranged in the coating groove, microcapsules are distributed in the polylactic acid solution, and the dried fiber dried by the drying box is wound on the winding machine again to obtain a fiber finished product.

In the process for dipping and coating the surface of the fiber by the emulsion polymerization chloroquine phosphate microcapsule, the solvent of the polylactic acid solution in the coating tank is ethanol or dichloromethane, and the drying temperature of the drying oven is 50-80 ℃.

In the process for dipping and coating the surface of the fiber by the emulsion polymerization chloroquine phosphate microcapsule, the microcapsule in the third step is prepared by an interfacial polymerization method.

In the process for dipping and coating the surface of the fiber by the emulsion polymerization chloroquine phosphate microcapsule, the microcapsule in the third step is prepared by a physical extrusion method.

In the above process of dipping and coating the fiber surface by the emulsion polymerization chloroquine phosphate microcapsule, the antiviral agent in the third step further comprises one or more of human fibroblast interferon, alpha-interferon, lopinavir, ribavirin and arbidol.

In the above process for dipping and coating the surface of the fiber by the emulsion polymerization chloroquine phosphate microcapsule, the antiviral agent is chloroquine phosphate.

In the process for dipping and coating the surface of the fiber by the emulsion polymerization chloroquine phosphate microcapsule, the main fiber material in the first step is acrylic fiber, viscose fiber, polyester fiber, nylon fiber or polypropylene fiber.

In the process for dipping and coating the surface of the fiber by the emulsion polymerization chloroquine phosphate microcapsule, the stock solution in the step one is prepared by the following steps: feeding main fiber materials and hydroxypropyl methyl cellulose into a horizontal mixer, simultaneously feeding solvent DMAC (dimethyl acetamide) through an elliptical flowmeter, arranging a spiral propeller type stirring blade in the horizontal mixer, enabling the distance between the blade and the wall of the mixer to be 5-10mm, enabling the rotation speed to be 60-90r/min, realizing mixing through the rotation of the spiral propeller, feeding the mixed slurry into a mixing tank, arranging a stirrer in the mixing tank, stirring by the stirrer to obtain slurry, pumping the slurry into a dissolving tank, and heating the slurry in the dissolving tank until the slurry is dissolved into uniform liquid, thereby obtaining stock solution.

Compared with the prior art, the invention has the advantages that:

1. the invention takes the antiviral agent containing chloroquine phosphate as the core of the microcapsule, and then coats the microcapsule on the surface of the composite fiber to prepare the finished fiber product, so that the antiviral agent on the surface of the finished fiber product has slow release property and prolongs the antiviral effective time in the using process.

2. According to the invention, the microcapsule carrying the antiviral agent is coated on the surface of the composite fiber through the polylactic acid solution, and then a part of polylactic acid molecules are grafted on the surface of the composite fiber through the drying and heating processes, so that the adhesiveness and cohesiveness of the microcapsule are enhanced.

Detailed Description

The present invention will be described in further detail with reference to specific embodiments.