阅读说明：本技术 一种鳄鱼血在制备抗肿瘤抗病毒药物中的应用 (Application of crocodile blood in preparing anti-tumor and anti-virus medicines ) 是由 晏雪初 李季民 于 2020-07-09 设计创作，主要内容包括：本发明公开了一种鳄鱼血在制备抗肿瘤抗病毒药物中的应用。属于鳄鱼血加工技术领域,本发明对鳄鱼血进行加工处理,将其用于制备抗病毒抗肿瘤的药物,提供了一种新的技术手段,此药物具有很强的抗肿瘤抗病毒的能力,服用后能够明显提高人体的免疫能力。(The invention discloses an application of crocodile blood in preparing anti-tumor and anti-virus medicines. The invention belongs to the technical field of crocodile blood processing, provides a new technical means for processing crocodile blood and using the crocodile blood for preparing antiviral and antitumor medicaments, and the medicaments have strong antitumor and antiviral abilities and can obviously improve the immunological competence of a human body after being taken.)

1. An application of crocodile blood in preparing antitumor and antivirus medicine is provided.

2. The application of crocodile blood in preparing an anti-tumor and anti-virus medicine according to claim 1, wherein the crocodile blood is prepared into freeze-dried powder, and the freeze-dried powder is matched with a common conventional medicament filling agent to prepare the required medicine by a conventional method.

3. The use of crocodile blood in the preparation of an anti-tumor and anti-virus medicament according to claim 2, wherein the medicament filler is a pharmaceutically acceptable acid, base, salt, hydrate or ester and other excipients.

4. The use of crocodile blood for the preparation of an anti-tumor and anti-viral medicament according to claim 2, wherein the medicament is in the form of at least one of a tablet, a capsule, an oral liquid, an emulsion and an injection.

5. The use of crocodile blood in the preparation of an anti-tumor and anti-virus medicament according to claim 2, wherein the preparation method of the freeze-dried powder comprises the following steps:

1) performing heart intubation on crocodile to obtain blood aseptically, then adding an anticoagulant and a preservative into the blood, mixing and shaking uniformly, then placing the mixture into a high-speed centrifuge, centrifuging, and collecting supernatant to obtain blood plasma for later use;

2) blending treatment:

mixing the plasma obtained in the step 1) with the composite treatment solution, and uniformly stirring to obtain a blending solution for later use;

3) and (3) freeze drying:

freeze-drying the mixed solution prepared in the step 2) to prepare powder, and taking out to obtain the freeze-dried powder.

6. The application of crocodile blood in preparing an anti-tumor and anti-virus medicine according to claim 5, wherein the addition amount of the anticoagulant and the preservative in the step 1) is 1.5-2.5% and 3.5-4.5% of the total mass of the taken blood respectively.

7. The use of crocodile blood in the preparation of an anti-tumor and anti-virus medicament according to claim 6, wherein the anticoagulant is any one of sodium citrate, sodium citrate and sodium oxalate; the preservative is vitamin E.

8. The application of crocodile blood in preparing an anti-tumor and anti-virus medicine according to claim 5, wherein the adding amount of the compound treatment liquid in the step 2) is 10-15% of the total mass of blood plasma.

9. The application of crocodile blood in preparing an anti-tumor and anti-virus medicament according to claim 8, wherein the composite treatment fluid consists of the following substances in parts by weight: 20-25 parts of polyvinylpyrrolidone, 4-7 parts of chitosan, 0.1-0.3 part of organic selenium and 5-8 parts of vitamin C.

Technical Field

The invention belongs to the technical field of crocodile blood processing, and particularly relates to an application of crocodile blood in preparation of anti-tumor and anti-virus medicines.

Background

According to the latest report, about 392.9 ten thousand people suffer from malignant tumor in China, and about 233.8 ten thousand people die. On average, over 1 million people per day were diagnosed with cancer, and 7.5 people per minute were diagnosed with cancer. The cancer burden is in a continuously rising state compared to historical data. Over the last 10 years, the incidence of malignancy has remained on the order of 3.9% and mortality has remained 2.5% per year. The problem seriously threatens the health and development of people in China and the world, and needs to be improved and solved urgently.

Disclosure of Invention

The invention aims to provide application of crocodile blood in preparing anti-tumor and anti-virus medicines.

The technical purpose of the invention is realized by the following technical scheme:

an application of crocodile blood in preparing antitumor and antivirus medicine is provided.

Furthermore, after crocodile blood is prepared into freeze-dried powder, the freeze-dried powder is matched with a common conventional medicament filling agent to prepare the required medicament by a conventional method.

Furthermore, the medicament filler is medically acceptable acid, alkali, salt, hydrate or ester and other auxiliary materials.

Further, the drug may be formulated into at least one of tablets, capsules, oral liquid preparations, emulsions, and injections.

Further, the preparation method of the freeze-dried powder comprises the following steps:

1) performing heart intubation on crocodile to obtain blood aseptically, then adding an anticoagulant and a preservative into the blood, mixing and shaking uniformly, then placing the mixture into a high-speed centrifuge, centrifuging, and collecting supernatant to obtain blood plasma for later use;

2) blending treatment:

mixing the plasma obtained in the step 1) with the composite treatment solution, and uniformly stirring to obtain a blending solution for later use;

3) and (3) freeze drying:

freeze-drying the mixed solution prepared in the step 2) to prepare powder, and taking out to obtain the freeze-dried powder.

Further, the addition amount of the anticoagulant and the preservative in the step 1) is 1.5-2.5% and 3.5-4.5% of the total mass of the blood.

Further, the anticoagulant is any one of sodium citrate, sodium citrate and sodium oxalate; the preservative is vitamin E.

Further, the adding amount of the composite treatment liquid in the step 2) is 10-15% of the total mass of the blood plasma.

Further, the composite treatment liquid is composed of the following substances in parts by weight: 20-25 parts of polyvinylpyrrolidone, 4-7 parts of chitosan, 0.1-0.3 part of organic selenium and 5-8 parts of vitamin C.

Compared with the prior art, the invention has the following advantages:

the crocodile blood freeze-dried powder is prepared by firstly adding protective agents such as centrifugation and anticoagulation, mixing treatment by composite treatment liquid and freeze-drying process, has low protein denaturation amount, high trace element retention amount, rich content, no special blood fishy smell and good edibility, and is finally matched with common and conventional medicament fillers to prepare proper dosage forms such as tablets, capsules, oral liquid preparations, emulsions, injection, nasal drops and the like according to requirements by a conventional method. The medicine has strong anti-tumor and anti-virus capability, can obviously improve the immunity of human bodies after being taken, and has great market competitiveness and popularization and application values.

Detailed Description

The present invention is further illustrated by the following specific examples, which are not intended to limit the invention in any way. Reagents, methods and apparatus used in the present invention are conventional in the art unless otherwise indicated.