阅读说明：本技术 一种牙痛一粒丸的制备方法 (Preparation method of toothache pill ) 是由 杨毛志 于 2020-07-22 设计创作，主要内容包括：本发明公开了医药制造技术领域的一种牙痛一粒丸的制备方法,该牙痛一粒丸的生产方法包括如下步骤：原料：蟾酥、朱砂、雄黄和甘草；原料前处理：对蟾酥、朱砂、雄黄和甘草进行加工前处理,将药材中的非药用部分及杂质剔除,并对其进行水飞、干燥灭菌和粉碎并将药材的粉末混合在一起；制丸：将混合后的药材粉末制成药丸；干燥：将制好的药丸放入干燥箱中进行干燥；打光：将干燥后选好的药丸置荸荠式包衣机中进行打光至表面光滑,大小一致,色泽均匀的药丸,本发明优化了牙痛一粒丸的生产工艺,细化了工艺参数,使蟾酥、朱砂、雄黄投料过程中的粉碎细度、加入量、加入方法能得到有效控制,提供了药品质量。(The invention discloses a preparation method of a toothache pill in the technical field of medicine manufacturing, and the production method of the toothache pill comprises the following steps: raw materials: venenum Bufonis, Cinnabaris, Realgar, and radix Glycyrrhizae; pretreatment of raw materials: processing Bufonis venenum, Cinnabaris, Realgar and Glycyrrhrizae radix, removing non-medicinal parts and impurities, refining with water, drying, sterilizing, pulverizing, and mixing the powders; pelleting: making the mixed medicinal powder into pill; and (3) drying: putting the prepared pills into a drying box for drying; polishing: the invention optimizes the production process of the toothache one-pill, refines the process parameters, effectively controls the crushing fineness, the adding amount and the adding method in the feeding process of the toad venom, the cinnabar and the realgar, and provides the medicine quality.)

1. A preparation method of a toothache pill is characterized in that: the production method of the toothache pill comprises the following steps:

s1: raw materials: venenum Bufonis, Cinnabaris, Realgar, and radix Glycyrrhizae;

s2: pretreatment of raw materials: processing Bufonis venenum, Cinnabaris, Realgar and Glycyrrhrizae radix, removing non-medicinal parts and impurities, refining with water, drying, sterilizing, pulverizing, and mixing the powders;

s3: pelleting: making the mixed medicinal powder into pill;

s4: and (3) drying: putting the prepared pills into a drying box for drying;

s5: polishing: polishing the dried pills in a water chestnut type coating machine until the surfaces of the pills are smooth, the sizes of the pills are consistent, the colors of the pills are uniform, and operating according to the operation program of the water chestnut type coating machine;

s6: selecting pills: placing the polished pills in a pill screening machine for pill selection;

s7: inner packaging: the post operating personnel gets the inner package materials with quality meeting the requirements from the temporary storage, carefully checks the name, code, batch number and identification of the received materials again to ensure that the inner package materials used for production are correct and meet the requirements, debugs the equipment operation parameters according to the operating regulations of the pellet packaging machine, fills the materials according to 10 pills/unit, performs intermediate control, and checks whether the medicine bottles are tightly covered and the pills are consistent;

s8: and (3) outer packaging: and externally packaging the pills which are internally packaged by using polyvinyl chloride solid medicinal hard sheets or medicinal packaging aluminum foil packages.

2. The method for preparing the toothache pill according to claim 1, wherein the method comprises the following steps: the raw material pretreatment step in step S2 includes:

a1: sorting: respectively moving the cinnabar, realgar and liquorice which are taken to a sorting post and pouring the mixture on a sorting table to remove non-medicinal parts and impurities of the mixture; the selected impurities are not more than 2.0%;

a2: washing and moistening: respectively placing the selected licorice medicinal materials into a turnover basket, placing the turnover basket into a medicine washing pool, washing the turnover basket with flowing drinking water from top to bottom until the medicine is clear, wherein the washing time is not more than 5 minutes, and after the medicine is cleaned, soaking the medicine in water until no dry core exists in the medicine, taking out the medicine, and draining;

a3: cutting: cutting the cleaned and soaked licorice medicinal material into sections of 1-2 cm by using a QYJ1-200C chopper type medicine cutting machine, containing the cut medicinal material in a clean container, weighing, and labeling for later use;

a4: and (3) drying: setting the temperature of a CT-C-III type hot air circulation oven to 70-80 ℃, respectively spreading the cut licorice medicinal material in a clean stainless steel baking pan, wherein the spreading thickness is less than or equal to 5cm, placing the cut licorice medicinal material in the CT-C-III type hot air circulation oven for drying, turning over the cut licorice medicinal material once every 30 minutes, wherein the drying temperature is 70-80 ℃, the drying time is 3-4 hours, and the water content of the dried medicinal material is controlled not to exceed 12.0%. The dried liquorice tablets are contained in a clean container, weighed and marked for later use;

a5: crushing: grinding Bufonis venenum and selected Cinnabaris and Realgar with colloid mill to obtain fine powder; taking the dried liquorice pieces from the intermediate station, and crushing the liquorice pieces by using a universal crusher provided with a stainless steel screen of 80 meshes; filling the pulverized Glycyrrhrizae radix powder into clean low density polyethylene plastic bags, wherein the name, amount, date, etc. are indicated for each bag. Hanging a material state marking card and filling batch production records;

a6: and (3) sterilization: respectively spreading the water-refined venenum bufonis, cinnabar, realgar powder and liquorice powder in a stainless steel tray with the spreading thickness of 3-5 cm, placing the stainless steel tray in a DMH-1 dry heat sterilization cabinet, setting the temperature to be 70-80 ℃, and sterilizing for 3 hours. Respectively filling the sterilized powder into clean low-density polyethylene plastic bags, sealing, marking the name, the quantity, the date and the like on each bag, hanging a material state marking card, and filling batch production records;

a7: total mixing: placing sterilized venenum Bufonis, Cinnabaris, Realgar powder and Glycyrrhrizae radix powder in EYH-6000 motion mixer, setting rotation speed at 10 r/min, mixing for 30 min, placing the powder into clean nontoxic plastic bags, sealing, weighing, marking name, quantity, date, etc. on each bag, hanging material status marking card, inspecting, and transferring to intermediate station or transferring to next procedure and filling production record after passing inspection.

3. The method for preparing the toothache pill according to claim 1, wherein the method comprises the following steps: the step of pelletizing in step S3 includes:

b1: drawing a mold and preparing pills: putting the fine powder in a mold drawing pot, spraying water, starting the mold drawing pot, knocking off edges, rolling to be round, taking fine particles, passing through a No. 2 sieve, screening a uniform spherical mold, adding into a pill making pot, continuously spraying the decoction and adding the fine powder, gradually increasing the screening to a specified degree, taking out, putting into a stainless steel plate, and transferring to the next process;

b2: molding: and (3) repeatedly adding water to the pill mould for wetting, adding powder, rolling, screening, gradually growing up to qualified pills, and transferring to the next drying procedure.

4. The method for preparing the toothache pill according to claim 3, wherein the method comprises the following steps: in the step B1, the amount of the powder for stripping is 8-9%, and the rotating speed of the pill making pot is 28 r/min.

5. The method for preparing the toothache pill according to claim 1, wherein the method comprises the following steps: the drying oven in the step S4 is a CT-C-III hot air circulation oven, the drying temperature is set to be 50-60 ℃, and the drying time is set to be 8 hours.

Technical Field

The invention relates to the technical field of medicine manufacturing, in particular to a preparation method of toothache pills.

Background

The medicine preparation refers to a process of changing raw materials into new medicine products after physical change or chemical change, and comprises the preparation of Chinese and western medicines, and veterinary medicines also comprise raw medicine and sanitary materials.

Toothache pill is mainly used for treating swelling and aching of gum and pain of decayed tooth caused by excessive heat in clinic. Is mainly prepared from venenum Bufonis, Cinnabaris, Realgar, and Glycyrrhrizae radix by respectively refining Cinnabaris and Realgar with water to obtain superfine powders; pulverizing Bufonis venenum and Glycyrrhrizae radix into fine powder, respectively, grinding the above powders, sieving, mixing, making into pellet with water, and drying.

However, the toad venom, the cinnabar and the realgar in the toothache pill are toxic medicinal materials, and the pretreatment crushing method of the toad venom, the cinnabar and the realgar in the production process is improper, so that the mixing is not uniform, and the curative effect of the product can be directly influenced.

Disclosure of Invention

The invention aims to provide a preparation method of a toothache treatment pill, and aims to solve the problems that toad venom, cinnabar and realgar in the toothache treatment pill proposed in the background technology are toxic medicinal materials, and the treatment effect of the product is directly influenced due to improper crushing method and nonuniform mixing during pretreatment of the toad venom, the cinnabar and the realgar in the production process.

In order to achieve the purpose, the invention provides the following technical scheme: a preparation method of a toothache pill comprises the following steps:

s1: raw materials: venenum Bufonis, Cinnabaris, Realgar, and radix Glycyrrhizae;

s2: pretreatment of raw materials: processing Bufonis venenum, Cinnabaris, Realgar and Glycyrrhrizae radix, removing non-medicinal parts and impurities, refining with water, drying, sterilizing, pulverizing, and mixing the powders;

s3: pelleting: making the mixed medicinal powder into pill;

s4: and (3) drying: putting the prepared pills into a drying box for drying;

s5: polishing: polishing the dried pills in a water chestnut type coating machine until the surfaces of the pills are smooth, the sizes of the pills are consistent, the colors of the pills are uniform, and operating according to the operation program of the water chestnut type coating machine;

s6: selecting pills: placing the polished pills in a pill screening machine for pill selection;

s7: inner packaging: the post operating personnel gets the inner package materials with quality meeting the requirements from the temporary storage, carefully checks the name, code, batch number and identification of the received materials again to ensure that the inner package materials used for production are correct and meet the requirements, debugs the equipment operation parameters according to the operating regulations of the pellet packaging machine, fills the materials according to 10 pills/unit, performs intermediate control, and checks whether the medicine bottles are tightly covered and the pills are consistent;

s8: and (3) outer packaging: and externally packaging the pills which are internally packaged by using polyvinyl chloride solid medicinal hard sheets or medicinal packaging aluminum foil packages.

Preferably, the raw material pretreatment step in step S2 includes:

a1: sorting: respectively moving the cinnabar, realgar and liquorice which are taken to a sorting post and pouring the mixture on a sorting table to remove non-medicinal parts and impurities of the mixture; the selected impurities are not more than 2.0%;

a2: washing and moistening: respectively placing the selected licorice medicinal materials into a turnover basket, placing the turnover basket into a medicine washing pool, washing the turnover basket with flowing drinking water from top to bottom until the medicine is clear, wherein the washing time is not more than 5 minutes, and after the medicine is cleaned, soaking the medicine in water until no dry core exists in the medicine, taking out the medicine, and draining;

a3: cutting: cutting the cleaned and soaked licorice medicinal material into sections of 1-2 cm by using a QYJ1-200C chopper type medicine cutting machine, containing the cut medicinal material in a clean container, weighing, and labeling for later use;

a4: and (3) drying: setting the temperature of a CT-C-III type hot air circulation oven to 70-80 ℃, respectively spreading the cut licorice medicinal material in a clean stainless steel baking pan, wherein the spreading thickness is less than or equal to 5cm, placing the cut licorice medicinal material in the CT-C-III type hot air circulation oven for drying, turning over the cut licorice medicinal material once every 30 minutes, wherein the drying temperature is 70-80 ℃, the drying time is 3-4 hours, and the water content of the dried medicinal material is controlled not to exceed 12.0%. The dried liquorice tablets are contained in a clean container, weighed and marked for later use;

a5: crushing: grinding Bufonis venenum and selected Cinnabaris and Realgar with colloid mill to obtain fine powder; taking the dried liquorice pieces from the intermediate station, and crushing the liquorice pieces by using a universal crusher provided with a stainless steel screen of 80 meshes; filling the pulverized Glycyrrhrizae radix powder into clean low density polyethylene plastic bags, wherein the name, amount, date, etc. are indicated for each bag. Hanging a material state marking card and filling batch production records;

a6: and (3) sterilization: respectively spreading the water-refined venenum bufonis, cinnabar, realgar powder and liquorice powder in a stainless steel tray with the spreading thickness of 3-5 cm, placing the stainless steel tray in a DMH-1 dry heat sterilization cabinet, setting the temperature to be 70-80 ℃, and sterilizing for 3 hours. Respectively filling the sterilized powder into clean low-density polyethylene plastic bags, sealing, marking the name, the quantity, the date and the like on each bag, hanging a material state marking card, and filling batch production records;

a7: total mixing: placing sterilized venenum Bufonis, Cinnabaris, Realgar powder and Glycyrrhrizae radix powder in EYH-6000 motion mixer, setting rotation speed at 10 r/min, mixing for 30 min, placing the powder into clean nontoxic plastic bags, sealing, weighing, marking name, quantity, date, etc. on each bag, hanging material status marking card, inspecting, and transferring to intermediate station or transferring to next procedure and filling production record after passing inspection.

Preferably, the step of pelletizing in step S3 includes:

b1: drawing a mold and preparing pills: putting the fine powder in a mold drawing pot, spraying water, starting the mold drawing pot, knocking off edges, rolling to be round, taking fine particles, passing through a No. 2 sieve, screening a uniform spherical mold, adding into a pill making pot, continuously spraying the decoction and adding the fine powder, gradually increasing the screening to a specified degree, taking out, putting into a stainless steel plate, and transferring to the next process;

b2: molding: and (3) repeatedly adding water to the pill mould for wetting, adding powder, rolling, screening, gradually growing up to qualified pills, and transferring to the next drying procedure.

Preferably, in the step B1, the amount of the die-drawing powder is 8-9%, and the rotation speed of the pill-making pan is 28 rpm.

Preferably, the drying oven in step S4 is a CT-C-iii hot air circulation oven, the drying temperature is set to 50 ℃ to 60 ℃, and the drying time is set to 8 hours.

Compared with the prior art, the invention has the beneficial effects that: the invention optimizes the production process of the toothache one-pill, refines the process parameters, and enables the crushing fineness, the adding amount and the adding method in the feeding process of the toad venom, the cinnabar and the realgar to be effectively controlled, thereby providing the medicine quality, fully ensuring the clinical treatment effect of the toothache one-pill, preparing the toad venom, the cinnabar, the realgar and the liquorice, and respectively refining the cinnabar and the realgar into superfine powder by water; the venenum bufonis and the liquorice are respectively crushed into fine powder, the fine powder is mixed, ground, sieved and mixed evenly, the fine powder is made into pellets by water, and the pellets are dried, so that the preparation method is obtained.

Drawings

FIG. 1 is a flow chart of the preparation method of the present invention.

Detailed Description

The technical solutions in the embodiments of the present invention will be clearly and completely described below with reference to the drawings in the embodiments of the present invention, and it is obvious that the described embodiments are only a part of the embodiments of the present invention, and not all of the embodiments. All other embodiments, which can be derived by a person skilled in the art from the embodiments given herein without making any creative effort, shall fall within the protection scope of the present invention.

The invention provides a preparation method of a toothache single-pill, which optimizes the production process of the toothache single-pill, refines the process parameters, effectively controls the crushing fineness, the adding amount and the adding method in the feeding process of toad venom, cinnabar and realgar, and provides the medicine quality, thereby fully ensuring the clinical treatment effect of the toothache single-pill, and the production method of the toothache single-pill comprises the following steps:

s1: raw materials: venenum Bufonis, Cinnabaris, Realgar, and radix Glycyrrhizae;

s2: pretreatment of raw materials: processing Bufonis venenum, Cinnabaris, Realgar and Glycyrrhrizae radix, removing non-medicinal parts and impurities, refining with water, drying, sterilizing, pulverizing, and mixing the powders;

s3: pelleting: making the mixed medicinal powder into pill;

s4: and (3) drying: putting the prepared pills into a drying box for drying;

s5: polishing: polishing the dried pills in a water chestnut type coating machine until the surfaces of the pills are smooth, the sizes of the pills are consistent, the colors of the pills are uniform, and operating according to the operation program of the water chestnut type coating machine;

s6: selecting pills: placing the polished pills in a pill screening machine for pill selection;

s7: inner packaging: the post operating personnel gets the inner package materials with quality meeting the requirements from the temporary storage, carefully checks the name, code, batch number and identification of the received materials again to ensure that the inner package materials used for production are correct and meet the requirements, debugs the equipment operation parameters according to the operating regulations of the pellet packaging machine, fills the materials according to 10 pills/unit, performs intermediate control, and checks whether the medicine bottles are tightly covered and the pills are consistent;

s8: and (3) outer packaging: and externally packaging the pills which are internally packaged by using polyvinyl chloride solid medicinal hard sheets or medicinal packaging aluminum foil packages.