阅读说明：本技术 一种抑制幽门螺杆菌的中药组合物及其制备方法 (Traditional Chinese medicine composition for inhibiting helicobacter pylori and preparation method thereof ) 是由 姚美村 彭昶 申雪 袁月梅 严家慧 张唯佳 陈鹏婷 于 2020-07-07 设计创作，主要内容包括：本发明涉及中药领域,具体涉及一种抑制幽门螺杆菌的中药组合物及其制备方法,按重量份计,包括青果5～15份,槐米0～6份,甘草0～5份。本发明公开的一种抑制幽门螺杆菌的中药组合物,具有多成分、多途径、多靶点的作用特点,并且中药疗法耐药发生率低,不良反应少,患者服药依从性好。本发明组合物配伍合理,对幽门螺杆菌抗生素敏感株和耐药株都有很强抑制作用,并避免了苦寒伤胃,适用于幽门螺杆菌感染者,并且中药的应用能减少抗生素的使用从而降低幽门螺杆菌耐药率。(The invention relates to the field of traditional Chinese medicines, and in particular relates to a traditional Chinese medicine composition for inhibiting helicobacter pylori and a preparation method thereof. The traditional Chinese medicine composition for inhibiting helicobacter pylori disclosed by the invention has the characteristics of multi-component, multi-path and multi-target action, and the traditional Chinese medicine therapy has low drug resistance incidence rate, less adverse reaction and good patient compliance. The composition has reasonable compatibility, has strong inhibiting effect on helicobacter pylori antibiotic sensitive strains and drug-resistant strains, avoids stomach injury caused by bitter cold, is suitable for helicobacter pylori infected persons, and can reduce the use of antibiotics by the application of traditional Chinese medicines so as to reduce the drug-resistant rate of the helicobacter pylori.)

1. The traditional Chinese medicine composition for inhibiting helicobacter pylori is characterized by comprising, by weight, 5-15 parts of Chinese olive, 0-6 parts of sophora flower bud and 0-5 parts of liquorice.

2. The traditional Chinese medicine composition for inhibiting helicobacter pylori according to claim 1, which comprises, by weight, 8-12 parts of Chinese olive, 1-5 parts of sophora flower bud and 0.5-1.5 parts of liquorice.

3. The traditional Chinese medicine composition for inhibiting helicobacter pylori according to claim 1, which is characterized by comprising, by weight, 10 parts of Chinese olive, 3 parts of sophora flower bud and 1 part of liquorice.

4. The method for preparing a helicobacter pylori inhibiting Chinese medicinal composition according to any one of claims 1 to 3, which comprises the following steps:

s1, mixing Chinese olive, sophora flower bud and liquorice in proportion, and adding 10-15 mL of water into each gram of medicinal material;

s2, boiling the mixture obtained in the step S1 in an electric heating jacket at a voltage of 220V, and then decocting for 1-3 h at a voltage of 100V to obtain a leaching solution;

and S3, purifying the leaching liquor obtained in the step S2 to obtain the plant extract.

5. Use of the helicobacter pylori inhibiting traditional Chinese medicine composition of any one of claims 1 to 3 in the preparation of helicobacter pylori resistant food.

Technical Field

The invention relates to the field of traditional Chinese medicines, and in particular relates to a traditional Chinese medicine composition for inhibiting helicobacter pylori and a preparation method thereof.

Technical Field

Helicobacter pylori (Hp) is a spiroidal, microaerophilic gram-negative bacterium that colonizes the stomach in approximately 50% of the population of the world. Studies have shown that the rate of H.pylori infection has continued to increase over the past three decades. The fifth consensus report on H.pylori infection management throughout the country indicates that Hp infection is an infectious disease, whether clinically symptomatic or not, and that eradication therapy should be applied once the infection has occurred. Hp infection is closely related to various gastrointestinal diseases such as gastritis, peptic gastric ulcer, mucosa-associated lymphoid tissue lymphoma, and gastric cancer, and also related to various parenteral diseases. In a small number of susceptible people, it may lead to a progressive progression to cancer through gastric atrophy, intestinal metaplasia and dysplasia. Thus, as early as 1994, Hp has been classified as a human carcinogen by the international agency for research on cancer (IARC).

The first-line treatment scheme for clinical eradication therapy of Hp infection mainly comprises standard triple therapy and bismuth agent quadruple therapy. The standard triple therapy is a treatment scheme which is established in 1996 and takes clarithromycin as a core, the standard triple therapy is composed of 1 Proton Pump Inhibitor (PPI) +2 antibacterial drugs, and the bismuth agent quadruple therapy is characterized in that a bismuth agent is added on the basis of the triple therapy, compared with the triple therapy, the bismuth agent quadruple therapy has better curative effect, but the administration compliance of patients is poor due to more side effects, complex administration sequence and other factors. With the abuse of antibiotics at home and abroad and the use of a plurality of antibiotics in large dose and for a long time in the antibiotic therapy, the drug resistance rate of Hp to the plurality of antibiotics is increased day by day. Antibiotic resistance is the leading cause of failure of Hp eradication therapy. In the face of the continuous rising of the ratio of antibiotic-resistant Hp strains in the world, under the condition that new antibiotics which are difficult to resist drugs are more and more difficult to discover, at present, the method has no effective method for clinically changing antibiotic combinations, increasing antibiotic dosage and prolonging treatment time, so that the Hp infection treatment is subjected to bottleneck.

Disclosure of Invention

The invention aims to overcome the technical problems of increase of antibiotic-resistant Hp strains, lack of drugs for effectively inhibiting Hp and the like in the prior art, and provides a traditional Chinese medicine composition for inhibiting Hp and a preparation method thereof.

The purpose of the invention is realized by the following technical scheme:

a traditional Chinese medicine composition for inhibiting Hp comprises, by weight, 5-15 parts of Chinese olive, 0-6 parts of sophora flower bud and 0-5 parts of liquorice.

Preferably, the Chinese olive fruit and sophora flower bud beverage comprises 8-12 parts of Chinese olive, 1-5 parts of sophora flower bud and 0.5-1.5 parts of liquorice by weight.

Preferably, the Chinese olive fruit and sophora flower bud tea comprises 10 parts of Chinese olive, 3 parts of sophora flower bud and 1 part of liquorice in parts by weight.

The traditional Chinese medicine has the characteristics of multiple components, multiple ways and multiple targets, and the traditional Chinese medicine therapy has low drug resistance incidence rate, less adverse reaction and good patient compliance. Compared with the traditional antibiotic therapy, the traditional Chinese medicine therapy has unique advantages in the aspect of Hp resistance.

Hp infection is usually caused by exogenous pathogenic factors, and belongs to excess syndrome and heat syndrome, in traditional Chinese medicine, the Hp infection belongs to epigastric pain and stomach fullness, and the clinical syndrome differentiation indicates that the spleen and stomach damp-heat type is abundant. The traditional Chinese medicines selected in the invention mostly enter spleen and stomach channels, are mostly heat-clearing and detoxifying medicines, are reasonable in compatibility, avoid stomach injury caused by bitter cold, and are suitable for Hp infected patients, and the application of the traditional Chinese medicines can reduce the use of antibiotics, thereby reducing the Hp drug resistance rate.

In addition, the invention combines the traditional Chinese medicine ideas of ' treating diseases without illness ' by combining edutainment of medicine and food ', and the like, and the raw materials of the traditional Chinese medicine composition are all from medicine-food homologous traditional Chinese medicines, so that the traditional Chinese medicine composition has a strong Hp resistance effect, and meanwhile, the safety is greatly guaranteed.

The preparation method of the traditional Chinese medicine composition for inhibiting helicobacter pylori comprises the following steps:

s1, mixing Chinese olive, sophora flower bud and liquorice in proportion, and adding 10-15 mL of water into each gram of medicinal material;

s2, boiling the mixture obtained in the step S1 in an electric heating jacket at a voltage of 220V, and then decocting for 1-3 h at a voltage of 100V to obtain a leaching solution;

and S3, purifying the leaching liquor obtained in the step S2 to obtain the plant extract.

The specific purification method comprises the following steps: filtering the leaching solution with two layers of medium-speed filter paper while the solution is hot, removing filter residue, concentrating the filtrate by rotary evaporation under reduced pressure, refrigerating overnight in a refrigerator at-80 deg.C for prefreezing, and freeze drying to obtain extract powder.

The application of the traditional Chinese medicine composition for inhibiting the helicobacter pylori in preparing the anti-helicobacter pylori food.

The application in preparing the anti-helicobacter pylori food comprises the application in health food.

Compared with the prior art, the invention has the following technical effects:

the traditional Chinese medicine composition for inhibiting helicobacter pylori disclosed by the invention has the characteristics of multi-component, multi-path and multi-target action, and the traditional Chinese medicine therapy has low drug resistance incidence rate, less adverse reaction and good patient compliance. The composition has reasonable compatibility, has strong inhibiting effect on helicobacter pylori antibiotic sensitive strains and drug-resistant strains, avoids stomach injury caused by bitter cold, is suitable for helicobacter pylori infected persons, and can reduce the use of antibiotics by the application of traditional Chinese medicines so as to reduce the drug-resistant rate of the helicobacter pylori.

Detailed Description

In order to make the objects, technical solutions and advantages of the present invention more apparent, the technical solutions of the present invention will be described in detail with reference to specific embodiments. It is to be understood that the described embodiments are merely exemplary of the invention, and not restrictive of the full scope of the invention. All other embodiments, which can be derived by a person skilled in the art from the examples given herein without any inventive step, are within the scope of the present invention.

Unless otherwise specified, the devices used in this example are all conventional experimental devices, the materials and reagents used are commercially available, and the experimental methods without specific descriptions are also conventional experimental methods.