阅读说明：本技术 红药贴剂及其制备方法 (Red medicine patch and preparation method thereof ) 是由 赵喆 张春玲 吴世福 于 2020-06-08 设计创作，主要内容包括：本发明涉及一种红药贴剂及其制备方法,属于中药技术领域。一种红药贴剂,它是由下述物料制备而成：三七、白芷、土鳖虫、川芎、当归、红花、冰片、薄荷脑、甘油、聚乙烯吡咯烷酮,氮酮,聚丙烯酸钠、明胶,羧甲基纤维素钠,聚乙烯醇,液体石蜡,纯化水。本发明方法制备的红药贴剂,对皮肤无刺激和过敏反应,安全性高,有很好的保水性,易使皮肤角质层软化,有利于药物的透皮吸收,其透气性、对皮肤粘着性、保温性、均优于传统红药贴膏,本发明红药贴剂具有使用舒适、可以反复揭扯和贴敷、不污染衣物、无残留、使用后揭扯无痛感的优点,其起效快、疗程短、止痛效果好,药物有效作用时间长,优于传统红药贴膏。(The invention relates to a red medicine patch and a preparation method thereof, belonging to the technical field of traditional Chinese medicines. A red medicine patch is prepared from the following materials: pseudo-ginseng, angelica dahurica, ground beeltle, ligusticum wallichii, angelica sinensis, safflower, borneol, menthol, glycerol, polyvinylpyrrolidone, azone, sodium polyacrylate, gelatin, sodium carboxymethylcellulose, polyvinyl alcohol, liquid paraffin and purified water. The red medicine patch prepared by the method has no stimulation and anaphylactic reaction to skin, high safety, good water-retaining property, easy softening of skin cuticle and favorable transdermal absorption of medicines, and has the advantages of air permeability, skin adhesiveness and heat preservation which are superior to those of the traditional red medicine plaster.)

1. The red medicine patch is characterized by being prepared from the following materials in parts by weight: 750 parts of pseudo-ginseng, 175 parts of angelica dahurica, 175 parts of ground beeltle, 175 parts of ligusticum wallichii, 175 parts of angelica sinensis, 175 parts of safflower, 25-30 parts of borneol, 55-65 parts of menthol, 160 parts of glycerol 140-.

2. The red-drug patch according to claim 1, characterized in that it is prepared from the following materials in parts by weight: 750 parts of pseudo-ginseng, 175 parts of angelica dahurica, 175 parts of ground beeltle, 175 parts of ligusticum wallichii, 175 parts of angelica sinensis, 175 parts of safflower, 27 parts of borneol, 58 parts of menthol, 150 parts of glycerol, 35 parts of polyvinylpyrrolidone, 60 parts of azone, 200 parts of sodium polyacrylate, 180 parts of gelatin, 25 parts of sodium carboxymethylcellulose, 42 parts of polyvinyl alcohol, 30 parts of liquid paraffin and 900 parts of purified water.

3. A method for preparing the red drug patch of claim 1, comprising the steps of: mixing six materials of pseudo-ginseng, angelica dahurica, ground beeltle, ligusticum wallichii, angelica sinensis and safflower in parts by weight, performing reflux extraction for three times by using 90% ethanol, adding ethanol with the weight being four times of the total weight of the six materials for the first time, extracting for 2.5 hours, adding ethanol with the weight being three times of the total weight of the six materials for the second time and the third time respectively, extracting for 1.5 hours respectively, standing, filtering, combining filtrate obtained in the three times, concentrating to obtain a concentrated solution with the relative density of 1.10 ℃ at 40 ℃, slowly adding purified water with the same weight into the concentrated solution, continuously stirring, fully mixing and dissolving, standing for 48-60 hours at normal temperature, taking supernatant, filtering until the filtrate is clear and transparent, and concentrating under reduced pressure to obtain an extract with the relative density of 1.20 ℃ at 40 ℃ for later use; uniformly mixing glycerol, gelatin, sodium carboxymethylcellulose, polyvinyl alcohol, sodium polyacrylate and the rest of purified water according to the weight parts to prepare a matrix, adding the extract and borneol, menthol, polyvinylpyrrolidone, azone and liquid paraffin according to the weight parts to the matrix, uniformly stirring to prepare a patch coating, standing for 1.5-2 hours, uniformly coating the prepared patch coating on water-repellent cloth, drying in the sun, and slicing to prepare the red medicine patch.

Technical Field

The invention relates to a red medicine patch for treating traumatic injury, arthralgia and myalgia and local blood stasis and swelling and having the effects of relieving pain, activating blood and promoting tissue regeneration and a preparation method thereof, belonging to the technical field of traditional Chinese medicines.

Background

Traumatic injury is caused by improper posture, overexertion and trauma in labor or exercise, and can directly damage muscles, bones and muscles without lacerations, and because of the rupture of muscles, small blood vessels and ligaments at the injured part, accumulation of blood stasis and large amount of extravasation of tissue fluid, skin bluish purple, swelling and tenderness, severe pain and dysfunction are caused. The common clinical symptoms of blood stasis and pain in bones and muscles and soft tissue injury caused by traumatic injury are mainly caused by injury of qi and blood in local channels and collaterals and circulatory dysfunction, and after treatment, the symptoms of severe swelling, stabbing pain and difficulty in moving still appear. The traditional Chinese medicine treatment has rich experience and unique curative effect, has the functions of diminishing inflammation, easing pain, promoting blood circulation and removing blood stasis, improves the blood circulation of an affected part, can accelerate the clearing of blood stasis and inflammatory secretion and the repair of wound tissues, and can quickly reduce swelling and relieve pain.

The existing medicines for treating traumatic injuries have various varieties, but the medicines have poor curative effect on treating the traumatic injuries, have long treatment course, increase the pain of patients, and have the problems of high medical expense, low cure rate, unobvious anti-inflammatory and analgesic effects and the like. In the existing medicines for treating traumatic injuries, the 'Hongyao plaster' has obvious treatment effects on blood stasis, swelling, rheumatism, numbness and other symptoms, has low price and is accepted by the majority of patients, but the existing 'Hongyao plaster' has the following defects: the red-drug plaster has poor air permeability, is easy to sensitize, is inconvenient to use, slow in effect taking, short in effective action time of the drug and long in treatment course, and the pain relieving effect of the red-drug plaster needs to be further improved.

Disclosure of Invention

The invention aims at solving the technical problem of providing a red-drug patch and a preparation method thereof, aiming at the problems, the red-drug patch has no stimulation and anaphylactic reaction to skin, high safety, good water retention property, easy softening of skin cuticle and favorable transdermal absorption of drugs, and has air permeability, skin adhesiveness and heat preservation which are all superior to those of the traditional red-drug plaster.

The weight ratio range of each material is obtained by a large amount of grope and experiment summary of the inventor, and the weight ratio of each material has better curative effect in the following weight range. The invention adopts the following seventeen materials for combination, and the materials are combined to ensure that the efficacies of all the medicines generate synergistic action, thereby effectively treating traumatic injury.

In order to solve the technical problems, the invention is realized by the following technical scheme:

the red medicine patch is prepared from the following materials in parts by weight: 750 parts of pseudo-ginseng, 175 parts of angelica dahurica, 175 parts of ground beeltle, 175 parts of ligusticum wallichii, 175 parts of angelica sinensis, 175 parts of safflower, 25-30 parts of borneol, 55-65 parts of menthol, 160 parts of glycerol 140-.

The red medicine patch is prepared from the following materials in parts by weight: 750 parts of pseudo-ginseng, 175 parts of angelica dahurica, 175 parts of ground beeltle, 175 parts of ligusticum wallichii, 175 parts of angelica sinensis, 175 parts of safflower, 27 parts of borneol, 58 parts of menthol, 150 parts of glycerol, 35 parts of polyvinylpyrrolidone, 60 parts of azone, 200 parts of sodium polyacrylate, 180 parts of gelatin, 25 parts of sodium carboxymethylcellulose, 42 parts of polyvinyl alcohol, 30 parts of liquid paraffin and 900 parts of purified water.

The preparation method of the red medicine patch comprises the following steps: mixing six materials of pseudo-ginseng, angelica dahurica, ground beeltle, ligusticum wallichii, angelica sinensis and safflower in parts by weight, performing reflux extraction for three times by using 90% ethanol, adding ethanol with the weight being four times of the total weight of the six materials for the first time, extracting for 2.5 hours, adding ethanol with the weight being three times of the total weight of the six materials for the second time and the third time respectively, extracting for 1.5 hours respectively, standing, filtering, combining filtrate obtained in the three times, concentrating to obtain a concentrated solution with the relative density of 1.10 ℃ at 40 ℃, slowly adding purified water with the same weight into the concentrated solution, continuously stirring, fully mixing and dissolving, standing for 48-60 hours at normal temperature, taking supernatant, filtering until the filtrate is clear and transparent, and concentrating under reduced pressure to obtain an extract with the relative density of 1.20 ℃ at 40 ℃ for later use; uniformly mixing glycerol, gelatin, sodium carboxymethylcellulose, polyvinyl alcohol, sodium polyacrylate and the rest of purified water according to the weight parts to prepare a matrix, adding the extract and borneol, menthol, polyvinylpyrrolidone, azone and liquid paraffin according to the weight parts into the matrix, uniformly stirring to prepare a patch coating, standing for 1.5-2 hours, uniformly coating the prepared patch coating on water-repellent cloth, drying in the sun, and slicing to prepare the red medicine patch.

Due to the adoption of the technical scheme, the invention has the following advantages and effects:

animal experiments prove that the red medicine patch has exact curative effect on treating acute soft tissue injury, and has particularly remarkable curative effect on local pain, swelling and dysfunction. The patch has obvious analgesic effect, and can generate the analgesic effect in a short time after being taken; due to the adoption of the patch, the side effects of poor air permeability, easy sensitization and the like of the red-paste plaster are overcome; and is convenient to use. Compared with the prior patent red-drug plaster, the red-drug patch does not contain components which can stimulate the skin, does not remain on the skin, has simple use method, can be cool and pleasant for patients, has no discomfort, is safe and effective, has quicker drug effect, longer drug effect duration and better analgesic effect.

Due to the synergistic effect of the materials and the auxiliary materials, the medicine has the advantages of quicker response, longer duration of the medicine effect, long effective action time and good pain relieving effect. The matrix of the invention has large drug-loading rate, generates synergistic action with main drugs, causes no stimulation and anaphylactic reaction to skin, has high safety, good water retention property, is easy to soften skin cuticle and beneficial to transdermal absorption of the drug, has better air permeability, skin adhesiveness and heat preservation than the traditional emplastrum, thus having the advantages of comfortable use, repeated tearing and application, no pollution to clothes, no residue and no pain after tearing off. The methods in the following examples are conventional methods unless otherwise specified.

Detailed Description

The percentages in the following examples are by mass unless otherwise specified.

The methods in the following examples are conventional methods unless otherwise specified.

In order to make the objects, technical solutions and advantages of the present invention more apparent, the present invention is further described in detail below with reference to examples and experimental data. It should be understood that the specific embodiments described herein are merely illustrative of the invention and are not intended to limit the invention.