阅读说明：本技术 一种祛痘凝胶及其制备方法 (Acne removing gel and preparation method thereof ) 是由 张小燕 邱瑞林 于 2020-04-20 设计创作，主要内容包括：本发明提供一种祛痘凝胶及其制备方法,属于化妆品领域。所述祛痘凝胶是通过水杨酸溶于丙二醇,再加入泊洛沙姆407制得；所述丙二醇和泊洛沙姆407的质量比为1:1-2。本发明还公开了祛痘凝胶的制备方法。本发明通过丙二醇来溶解水杨酸,从而降低产品对皮肤及痘痘的刺激性,同时提高功效物的利用率。(The invention provides an acne-removing gel and a preparation method thereof, belonging to the field of cosmetics. The acne-removing gel is prepared by dissolving salicylic acid in propylene glycol and adding poloxamer 407; the mass ratio of the propylene glycol to the poloxamer 407 is 1: 1-2. The invention also discloses a preparation method of the acne-removing gel. The salicylic acid is dissolved by the propylene glycol, so that the irritation of the product to skin and pox is reduced, and the utilization rate of an effect substance is improved.)

1. An acne removing gel is characterized in that the acne removing gel is prepared by dissolving salicylic acid in propylene glycol and then adding poloxamer 407; the mass ratio of the propylene glycol to the poloxamer 407 is 1: 1-2.

2. The preparation method of the acne removing gel is characterized by comprising the following specific steps:

s1, dissolving poloxamer 407 in deionized water at room temperature, standing and refrigerating;

s2, adding salicylic acid into propylene glycol, and heating to 45-55 ℃ to dissolve;

and S3, taking out the completely dissolved poloxamer 407 aqueous solution, slowly pouring the dissolved propylene glycol salicylate solution into the solution, and stirring the solution at room temperature until the solution is uniform to obtain the poloxamer.

3. The preparation method of the acne removing gel according to claim 2, wherein the mass ratio of the poloxamer 407 to the deionized water in step S1 is 1: 5-10.

4. The method for preparing the acne removing gel according to claim 2, wherein the refrigeration temperature in step S1 is 5 ℃.

5. The preparation method of the acne removing gel according to claim 2, wherein the refrigerating time in step S1 is 8-12 h.

6. The preparation method of the acne removing gel according to claim 2, wherein the mass ratio of the salicylic acid to the propylene glycol in step S2 is 1: 5-10.

Technical Field

The invention relates to the field of cosmetics, and particularly relates to an acne-removing gel and a preparation method thereof.

Background

Salicylic acid is a fat-soluble organic acid, and can dissolve the constituent substances between horny layers to cause the horny layer to fall off, so that the horny layer accumulated too thickly can be removed to promote metabolism. The salicylic acid acts on hair follicle wall cells, can help to remove blocked hair follicles, correct abnormal cell shedding, and has an auxiliary effect on pox caused by pore obstruction. Salicylic acid is therefore commonly used in anti-acne products. Salicylic acid is only slightly soluble in water and easily soluble in ethanol, diethyl ether, chloroform, etc., so many products are often added with alcohol as a solvent for salicylic acid. However, a large part of the acne skin belongs to sensitive skin, and the addition of acne causes the destruction of the cuticle, so that adverse reactions such as pain, wound healing inhibition and the like are easily caused after the acne skin contacts alcohol. In addition, the alcohol acne removing product causes the dissolved salicylic acid to precipitate and become a solid crystal state again along with the volatilization of alcohol, thereby influencing the skin absorption and reducing the utilization rate of the efficacy materials. Ethanol toxicology data-rabbit eye: 500mg, heavy stimulation; rabbit percutaneous open stimulation test: 15mg/24 h, moderate stimulation.

Disclosure of Invention

The first purpose of the invention is to provide an acne removing gel.

The second purpose of the invention is to provide a preparation method of the acne removing gel.

In order to achieve the purpose, the acne removing gel provided by the invention is prepared by dissolving salicylic acid in propylene glycol and then adding poloxamer 407; wherein the mass ratio of the propylene glycol to the poloxamer 407 is 1: 1-2.

The invention also provides a preparation method of the acne removing gel, which comprises the following specific steps:

s1, dissolving 10g of poloxamer 407 in 50-100g of deionized water at room temperature, standing and refrigerating;

s2, adding 1g of salicylic acid into 5-10g of propylene glycol, and heating to 45-55 ℃ for dissolution;

and S3, taking out the completely dissolved poloxamer 407 aqueous solution, slowly pouring the dissolved propylene glycol salicylate solution into the solution, and stirring the solution at room temperature until the solution is uniform to obtain the poloxamer.

Wherein the mass ratio of the poloxamer 407 to the deionized water in the step S1 is 1: 5-10.

Wherein the refrigeration temperature in step S1 is 5 ℃.

Wherein the refrigerating time in the step S1 is 8-12 h.

Wherein the mass ratio of the salicylic acid to the propylene glycol in the step S2 is 1: 5-10.

Propylene glycol belongs to a low-irritation and low-toxicity solvent, and rats are injected intravenously and intraperitoneally with LD₅₀7000-8000mg/kg, oral LD₅₀It was 2800 mg/kg. Poise (a Chinese character)Loxam 407 was used as a stabilizer for salicylic acid, which forms micelles in water, increasing the surface solubility of salicylic acid; poloxamer 407 has good compatibility with skin, can be used as an absorption enhancer, and can increase the absorption and utilization of salicylic acid by skin; poloxamer 407 as a high molecular material for preparing the temperature-sensitive in-situ gel has the advantages of good spreadability, large mucous membrane coverage, long detention time, simple preparation, convenient use and the like.

The invention has the beneficial effects that:

according to the invention, the propylene glycol is used as a solvent, so that the stimulation of the use of alcohol to the skin in the traditional process is reduced, and the propylene glycol and the poloxamer 407 in a specific proportion can effectively improve the acne removing effect of the acne removing gel. The invention has simple process, good product effect and better use value.

Detailed Description

In order to more clearly and completely describe the technical scheme of the invention, the invention is further described in detail by the specific embodiments, and it should be understood that the specific embodiments described herein are only used for explaining the invention, and are not used for limiting the invention, and various changes can be made within the scope defined by the claims of the invention.