阅读说明：本技术 提供消毒泡沫的制剂 (Formulation for providing a disinfecting foam ) 是由 马可·赫斯 于 2018-11-21 设计创作，主要内容包括：本发明提供了一种基于电化学活化的盐溶液的制剂,该制剂用于提供消毒泡沫,该试剂能够以泡沫的形式实施,同时保持电化学活化的盐溶液的杀菌效果。为此,所述制剂包含至少一种表面活性剂泡沫载体组分和至少一种基于电化学活化的盐溶液的抗菌有效组分,所述制剂具有至少10ppm含量的选自以下物质的游离氯：氢氯酸、次氯酸根离子、次氯酸钠或溶解的氯气的物质,并且在红外光谱中表现出与C-F振动相关的振动带。(The present invention provides a formulation based on an electrochemically activated salt solution for providing a disinfecting foam, which can be implemented in the form of a foam while maintaining the bactericidal effect of the electrochemically activated salt solution. To this end, the preparation comprises at least one surfactant foam carrier component and at least one antibacterial active component based on an electrochemically activated salt solution, the preparation having a content of at least 10ppm of free chlorine selected from the group consisting of: hydrochloric acid, hypochlorite ions, sodium hypochlorite or dissolved chlorine gas, and exhibits a vibrational band associated with C-F vibrations in the infrared spectrum.)

1. A formulation for providing a disinfecting foam, wherein the formulation comprises at least one surfactant foam carrier component and at least one electrochemically activated salt solution based antimicrobially effective component, wherein the formulation has a content of at least 10ppm free chlorine selected from the group consisting of hydrochloric acid, hypochlorite ion, sodium hypochlorite, and dissolved chlorine, and exhibits a vibrational band associated with C-F vibration in the infrared spectrum.

2. The formulation according to claim 1, wherein the formulation has a free chlorine content of more than 20 mg/L, preferably more than 300 mg/L.

3. The formulation according to claim 1 or 2, wherein the pH of the formulation is between 4 and 9, preferably between 5 and 7.5.

4. The formulation according to any one of claims 1 to 3, wherein the free chlorine content of the initial salt solution is greater than 500 mg/L, preferably greater than 600 mg/L.

5. The formulation according to any one of claims 1 to 4, wherein the redox potential of the formulation is at least 200mV, preferably 600-1000 mV, preferably 700-900 mV, most preferably about 800 mV.

6. The formulation of any one of claims 1 to 5, wherein the initial conductivity of the salt solution is 12-16 mS/cm.

7. The formulation of any one of claims 1 to 6, wherein the agent comprises perfluoroalkyl or perfluoroetheralkyl as a surfactant foam carrier component.

8. A sterilising foam obtained by foaming the formulation of any one of claims 1 to 7.

9. The sterilizing foam of claim 8 wherein the sterilizing foam exhibits a vibrational band associated with C-F vibrations in the infrared spectrum.

10. Use of a foam according to claim 8 or 9 as a disinfectant, in particular for surface or hand disinfection.

Technical Field

The present invention relates to formulations for providing disinfecting foams. Also relates to a sterilising foam obtained by the formulation.

Background

Electrochemically activated salt solutions (also called anolyte solutions) produced according to the so-called "ECA" ("electrochemical activation") process are highly effective disinfectants with excellent bactericidal properties. In particular, such a solution can be obtained by electrolysis of a sodium chloride solution. Depending on the dilution chosen, such anolyte solutions can be used for surface disinfection, for example: for disinfection of countertops, tables and floors; can also be used for cold disinfection to remove von microorganisms in agriculture; for washing laundry; used in indoor swimming pools and even for preventing foot fungi. The anolyte may also be used as an active agent against any kind of microorganisms, in particular bacteria, viruses and fungi, when desired and in the form of suitable preparations.

From EP1728768a1, for example, a system is known for producing electrochemically activated salt solutions by electrolysis, wherein a water stream charged with salt solution or brine is supplied to an electrolysis device, by electrolytic decomposition of such a water stream containing brine, electrochemically activated salt solutions can be obtained which have a "free chlorine" content of up to 500 mg/L, with a redox potential of +150mlV to +1.350mlV (which can be determined, for example, by amperometric measurement), which, due to the high free chlorine content, are particularly convenient for use as disinfectants, for example for disinfecting water and/or aqueous solutions, furthermore, according to the information given in WO2009/013019, the chemically activated salt solutions obtainable according to the concept known from EP1728768a1 are also particularly convenient for use as disinfectants in general terms, for example for work tables, floors, laundry for sterilization purposes, or also as carrier materials for pharmaceuticals.

It is desirable, inter alia, to utilize such an anolyte or an electrochemically activated salt solution, in particular having a free chlorine content of more than 300 mg/L, as an agent for disinfecting wounds to promote the healing process, or as a medicament for preventive measures, such as hand disinfection.

Disclosure of Invention

It is therefore an object of the present invention to provide a formulation suitable for providing a sterilising foam based on an electrochemically activated salt solution, which can be implemented in the form of a foam, while maintaining the sterilising effect of the electrochemically activated salt solution. In addition, a foam having a particularly high bactericidal effect is provided.

The object of the invention is achieved by a formulation according to the invention having a content of free chlorine of at least 10ppm, selected from hydrochloric acid, hypochlorite ions, sodium hypochlorite or dissolved chlorine, and showing a vibration band in the infrared spectrum associated with C-F vibrations, by at least one surfactant foam carrier component and at least one electrochemically activated salt solution based antibacterially effective component.

Advantageous embodiments of the invention are the subject matter of the dependent claims.

The invention is based on the idea that a preparation capable of providing the desired foam should comprise a component based on an electrochemically activated salt solution, which component should be present in the preparation in the form of a measurable amount of free chlorine or free chlorine species, as a disinfecting or sterilizing component. In order to be able to carry out the process in the desired foam form, including the associated extended possible exposure times, the formulation should additionally comprise a surfactant foam carrier component. Compatibility or bondability with the electrochemically activated salt solution should be specifically considered in selecting the foam carrier component. In particular with regard to the following factors: after the formulation, i.e., after combining and mixing the components, the formulation must be stored for a relatively long storage period in order to be used when needed, and should be selected so that the surfactant component does not unduly affect the effectiveness of the germicidal component, nor excessively degrade or degrade the surfactant component.

Surprisingly, this compatibility is not present with many common surfactants or foaming agents, since free chlorine is used as an essential component of the antimicrobially effective component. I.e., common surfactants, are generally considered to be hydrocarbon surfactants and accordingly include a hydrocarbon chain. In the present case, their C — H bonds are considered to be a weak point of compatibility with free chlorine species in the antibacterially effective component, as they may disrupt the chlorine reaction, leading to decomposition of the surfactant chains and/or free chlorine species.

Thus, in accordance with the present invention, it is contemplated to provide a fluorosurfactant-based surfactant blowing agent composition. That is, in contrast to conventional hydrocarbon surfactants, which are also commonly used in the detergent and personal care industries, fluorosurfactants include perfluorinated carbon chains in addition to the polar hydrophilic components to make them superior in performance. Polar groups generally impart water solubility to the molecule at this point, while perfluorinated chains generally have both hydrophobic and lipophobic properties.

The perfluorinated chains of the fluorosurfactants used in accordance with the invention contain multiple C-F bonds. Thus, the surfactant foam carrier component may be provided by a fluorosurfactant, which application is embodied in the infrared spectrum of the formulation and/or of the foam obtainable therefrom by the vibration bands associated with the C-F vibrations; thus, the use of fluorosurfactants according to the invention is specifically identified by the presence of vibration bands associated with C-F vibrations in the infrared spectrum.

Infrared spectroscopy is a standard method of instrumental analysis to analyze and characterize atomic and molecular spectra and their structures and compositions. Here, the vibration band associated with C-F oscillations may be expected to be, for example, about 1050cm^-1Or about 1250cm^-1At a frequency or wavelength of (c).

To achieve particularly high antimicrobial effect, in a preferred embodiment, the free chlorine content of the formulation is preferably greater than 20ppm, more preferably greater than 300ppm, and similarly, the content of the aqueous solution is preferably greater than 20 mg/L, more preferably greater than 300 mg/L. it is more preferred herein that the antimicrobially active component is preferably prepared by the ECA process, which is the type of electrochemically activated salt solution described in the background section.

Preferably, the pH value of the preparation is preferably 4-9, and more preferably 5-7.5. The formulations, and the sterilising foam formulations obtained therefrom, are particularly suitable for the skin and are environmentally friendly.

The redox potential of the formulation is at least 200mV, preferably 600-1000 mV, more preferably 700-900 mV, and most preferably about 800mV, and a formulation with an effective redox potential can achieve a high antimicrobial effect. In an alternative or further preferred embodiment, the conductivity of the initial salt solution is 12-16 mS/cm.

By including perfluoroalkyl groups or perfluoroether alkyl groups as the surfactant foam carrier component in particularly preferred embodiments, particularly good mutual resistance or compatibility of the antimicrobial agent and the surfactant component is achieved. Here, the use of perfluoroether alkyl groups is particularly preferred, since the perfluorocarbon chains present therein contain oxygen intermediate points. It can act as a point of attack for bacterial breakdown, thereby rendering the foam formed from the formulation biodegradable and therefore particularly safe to the environment.

With regard to the sterilising foam, the formulation according to the above description solves the above problems by foaming. In this case, it is particularly preferred that the disinfecting foam has a vibration band which is associated with C-F vibrations in the infrared spectrum.

According to one embodiment of the invention, the foam obtained in this way is used as a disinfectant, preferably for surface or hand disinfection and/or for veterinary applications.

The advantages achieved by the invention are, in particular, that an antimicrobial effect is achieved on the basis of an electrochemically activated initial salt solution having a sufficient content of free chlorine species and that, in combination with a surfactant foaming agent based on fluorosurfactants, it is possible to provide a formulation in which the antimicrobially effective component and the foam-forming component can be stored together without the substances decomposing or destroying one another. Thus, the foam obtained by foaming the formulation has a high antibacterial effect, even after storage of the formulation for a certain period of time, in combination with a reliable foam formation. Due to the foaming effect, e.g. due to the fact that the formulation according to the invention can greatly enhance the effect of the antibacterial agent compared to the effect achievable with the original liquid, it can be stated that the formulation according to the invention achieves a very high retention time and antibacterial time.

Detailed Description

One embodiment of the present invention specifically directed to the preparation of the formulation will be described in detail below.

This anolyte has a free chlorine content of about 700 mg/L, a redox potential of about 800mV, a pH of about 7 and a conductivity of about 14 mS/cm. can be prepared electrically and by electrochemical activation of the salt solution according to the method described in EP1728768A1, the process parameters being appropriately selected according to the desired product properties.

The electrochemically activated initial salt solution is provided with a fluorosurfactant by mixing. In this embodiment, surfactants may be used at appropriate concentrations, for example: available from Fluorochem under the system name (Perfluro (2-ethoxy) sulfonic acid).