阅读说明：本技术 元胡止痛滴丸治疗膝骨关节炎的用途 (Application of rhizoma corydalis pain-relieving dropping pill in treatment of knee osteoarthritis ) 是由 康海军 邓月婷 张政 贾继禧 于 2020-05-30 设计创作，主要内容包括：本发明属于医药技术领域,具体涉及一种元胡止痛滴丸的新用途。发明人意外发现单独使用元胡止痛滴丸能够抑制炎症因子,具有抑制软骨降解、促进软骨细胞增殖、促进蛋白聚糖合成等功效,其效果优于单用双氯芬酸钠缓释胶囊及联合使用双氯芬酸钠缓释胶囊和元胡止痛滴丸的效果；并且发明人发现在临床水平单独使用元胡止痛滴丸能够显著缓解关节疼痛、关节僵硬,促进关节活动能力的恢复,对于KOA具有良好的临床治疗效果,其效果显著优于双氯芬酸钠的治疗效果,并且与双氯芬酸钠相比,单独使用元胡止痛滴丸能够显著降低胃肠道刺激等不良反应,长期服用安全性较高。(The invention belongs to the technical field of medicines, and particularly relates to a new application of a rhizoma corydalis pain relieving dropping pill. The inventor surprisingly finds that the corydalis tuber pain relieving dropping pill can inhibit inflammatory factors, has the effects of inhibiting cartilage degradation, promoting chondrocyte proliferation, promoting proteoglycan synthesis and the like, and has the effect superior to that of a diclofenac sodium sustained-release capsule singly and a diclofenac sodium sustained-release capsule and a corydalis tuber pain relieving dropping pill jointly used; the inventor finds that the corydalis tuber pain relieving dropping pill used alone in clinical level can remarkably relieve joint pain and joint stiffness and promote the recovery of joint mobility, has good clinical treatment effect on KOA, has the effect remarkably superior to that of diclofenac sodium, can remarkably reduce adverse reactions such as gastrointestinal tract irritation and the like compared with the diclofenac sodium, and has higher safety after being taken for a long time.)

1. The application of the corydalis tuber analgesic dropping pill in preparing the medicine for inhibiting the generation of the inflammatory factor IL-1 alpha is that the corydalis tuber analgesic dropping pill consists of corydalis tuber processed by vinegar and angelica dahurica with the weight ratio of 1:1-3: 1.

2. The application of the corydalis tuber pain relieving dropping pill in preparing a medicine for inhibiting cartilage degradation comprises corydalis tuber processed with vinegar and angelica dahurica in a weight ratio of 1:1-3: 1.

3. The rhizoma corydalis pain-relieving dropping pill is applied to preparing a medicine for promoting generation of inflammatory factor TGF-beta, and consists of vinegar-processed rhizoma corydalis and radix angelicae in a weight ratio of 1:1-3: 1.

4. The application of the corydalis tuber analgesic dropping pill in preparing the medicine for promoting the synthesis of proteoglycan comprises corydalis tuber and angelica dahurica which are processed by vinegar and have the weight ratio of 1:1-3: 1.

5. The application of the corydalis tuber analgesic dropping pill in preparing the medicine for promoting the proliferation of the chondrocytes is that the corydalis tuber analgesic dropping pill consists of corydalis tuber processed by vinegar and angelica dahurica with the weight ratio of 1:1-3: 1.

6. The application of the rhizoma corydalis pain-relieving dropping pill in preparing a medicine for inhibiting inflammation comprises vinegar-processed rhizoma corydalis and radix angelicae in a weight ratio of 1:1-3: 1.

7. The rhizoma corydalis pain-relieving dropping pill is applied to the preparation of the medicine for assisting in inhibiting knee osteoarthritis inflammation symptoms, and consists of vinegar-processed rhizoma corydalis and radix angelicae in a weight ratio of 1:1-3: 1.

8. The application of the rhizoma corydalis pain-relieving dropping pill in preparing the medicine for treating knee osteoarthritis is that the rhizoma corydalis pain-relieving dropping pill consists of corydalis tuber and angelica dahurica which are processed by vinegar and have the weight ratio of 1:1-3: 1.

9. The application of the rhizoma corydalis pain-relieving dropping pill in preparing the medicine for promoting the joint function recovery comprises rhizoma corydalis and radix angelicae dahuricae which are processed by vinegar and have the weight ratio of 1:1-3: 1.

10. The application of the corydalis tuber pain relieving dropping pill in preparing the medicine for relieving the joint stiffness comprises corydalis tuber processed with vinegar and angelica dahurica in a weight ratio of 1:1-3: 1.

Technical Field

The invention belongs to the technical field of medicines, and particularly relates to an application of a corydalis tuber pain relieving dropping pill in treating knee osteoarthritis.

Background

The Corydalis tuber pain-relieving dropping pill consists of Corydalis tuber prepared by traditional Chinese medicine vinegar and angelica dahurica, wherein the Corydalis tuber of the monarch drug in the prescription is a dried tuber of Corydalis tuber of Papaveraceae, namely Corydalis yanhusuo W.T.Wang, and the pungent-warm-natured drug is good medicine for promoting qi, activating blood and relieving pain and is good for treating various pains on the upper and lower parts of the whole body; the ministerial drug radix Angelicae Dahuricae is dry root of Angelica dahurica (Fisch. ex Hoffm.) Benth. et hook. f. or Angelica dahurica (Fisch. ex Hoffm.) Benth. et hook. f. var. fortmosana (Boiss.) Shann et Yuan of Angelica dahurica of Umbelliferae, and can be used for dispelling pathogenic wind and cold, eliminating dampness arthralgia, and promoting flow of qi and blood to remove headache and body pain. The two medicines are mutually reinforced, have the effects of regulating qi, promoting blood circulation and relieving pain, and are used for treating stomachache, headache, costalgia and dysmenorrhea caused by qi stagnation and blood stasis. The prescription has the advantages of refinement, definite curative effect and wide clinical application. At present, pharmacological research shows that the corydalis tuber analgesic prescription has obvious pharmacological effects of easing pain, relieving smooth muscle spasm and the like.

Knee Osteoarthritis (KOA), abbreviated as knee osteoarthritis, is a chronic, progressive disease occurring in the active joints, characterized mainly by disintegration of the joint matrix and significant decrease of chondrocytes. Knee osteoarthritis is also called knee proliferative arthritis, degenerative arthritis, hypertrophic arthritis, degenerative osteoarthropathy and the like, is a frequently chronic progressive osteoarthropathy and is a common clinical disease in orthopedics. The disease is characterized by degeneration of knee joint cartilage as a main pathological feature. With the increasing aging population in the world in recent years, the incidence rate of knee osteoarthritis is on the trend of rising year by year in the global scope, the daily life and work of middle-aged and elderly people are seriously affected, and the incidence rate and disability rate are very high. The existing research shows that the pathological characteristics of the cartilage repair and regeneration are changed into progressive degeneration and disappearance of articular cartilage tissues, formation of articular marginal osteophytes and reactivity change of subchondral bone, and the degeneration speed exceeds the repair and regeneration speed. Primary or secondary degenerative changes of articular cartilage occur at the early stage of onset, and subchondral bone destruction and hyperosteogeny are accompanied, so that joints are gradually destroyed and malformations are generated. The entire course of its pathology affects not only the knee cartilage, but also the meniscus, subchondral bone, ligaments, joint capsule, synovium and periarticular muscles. The clinical manifestations are mainly progressive and chronic developed joint swelling and pain, stiffness and limited movement, and X-ray shooting suggests formation of knee joint bony spur.

The knee osteoarthritis has a plurality of treatment methods, including physical therapy, western medicine therapy, surgical therapy, traditional Chinese medicine treatment and the like, the physical therapy only can relieve pain for patients and can not cure diseases, and the physical therapy is only suitable for auxiliary treatment; the operation treatment cost is high, the postoperative recovery is slow, the treatment risk is large, and the use is not recommended; at present, western medicine for treating the gonitis mainly comprises symptom control, disease improvement, cartilage protection, local external application and the like, and mainly aims at relieving or eliminating pain. The traditional Chinese medicine composition mainly comprises non-steroidal anti-inflammatory drugs, glucocorticoids, anti-inflammatory drugs, analgesic drugs, anxiolytic drugs and the like in clinic, mainly comprises the non-steroidal anti-inflammatory drugs, is mainly applied to glucosamine hydrochloride in recent years, can relieve inflammation and pain, but cannot change the pathological change of osteoarthritis fundamentally, namely only treats the symptoms, is difficult to treat due to long-term application of antipyretic analgesic and hormone drugs, has large harm to the body and multiple side effects, and has obvious gastrointestinal adverse reactions. Therefore, no particularly effective treatment for the disease is available in western medicine.

The research of the traditional Chinese medicine in the field is gradually increased, and good effects are obtained. The traditional Chinese medicine for treating knee osteoarthritis mainly aims at relieving joint pain, relieving joint swelling and the like. For example, chinese patent CN102327380B discloses a Chinese medicinal composition for treating knee osteoarthritis, which can relieve joint pain; chinese patent CN102846751B discloses a hyperplasia collateral-activating pill for treating knee osteoarthritis, which can relieve pain and shorten the treatment time of patients; chinese patent CN103520654B discloses a traditional Chinese medicine composition for treating knee osteoarthritis, which has an obvious effect on relieving knee pain.

At present, the treatment of knee osteoarthritis mainly comprises operation puncture combined medicine and Chinese and western medicine combined treatment, wherein a document (Yanyanling, lissening. curative effect observation of treating knee osteoarthritis by the knee puncture combined rhizoma corydalis pain relieving dropping pill [ J ] mathematical and pharmacology medicine journal, 2019,32(04):100 and 101.) discloses that the knee puncture combined rhizoma corydalis pain relieving dropping pill can relieve joint pain; the literature (Wangliang corydalis tuber analgesic dropping pill for treating acute gouty arthritis 55 cases [ J ]. Chinese traditional medicine science and technology 2015,022(006):716.) discloses that the corydalis tuber analgesic dropping pill and diclofenac sodium can obviously improve the treatment efficiency of the acute gouty arthritis, but the diclofenac sodium has serious gastrointestinal adverse reactions. The inventor surprisingly finds that the corydalis tuber pain relieving dropping pill can inhibit inflammatory factors, has the effects of inhibiting cartilage degradation, promoting chondrocyte proliferation, promoting proteoglycan synthesis and the like, and has the effect superior to that of a diclofenac sodium sustained-release capsule singly and a diclofenac sodium sustained-release capsule and a corydalis tuber pain relieving dropping pill jointly used; the inventor finds that the corydalis tuber pain relieving dropping pill used alone in clinical level can remarkably relieve joint pain and joint stiffness and promote the recovery of joint mobility, has good clinical treatment effect on KOA, has the effect remarkably superior to that of diclofenac sodium, can remarkably reduce adverse reactions such as gastrointestinal tract irritation and the like compared with the diclofenac sodium, and has higher safety.

Disclosure of Invention

The invention aims to provide an application of a rhizoma corydalis pain-relieving dropping pill in preparing a medicine for inhibiting generation of an inflammatory factor IL-1 alpha, wherein the rhizoma corydalis pain-relieving dropping pill consists of vinegar-processed rhizoma corydalis and radix angelicae in a weight ratio of 1:1-3: 1.

The invention also aims to provide an application of the corydalis tuber pain relieving dropping pill in preparing a medicine for inhibiting cartilage degradation, wherein the corydalis tuber pain relieving dropping pill consists of corydalis tuber processed with vinegar and dahurian angelica root in a weight ratio of 1:1-3: 1.

The invention also aims to provide application of the corydalis tuber analgesic dropping pill in preparing a medicine for promoting generation of inflammatory factor TGF-beta, wherein the corydalis tuber analgesic dropping pill consists of corydalis tuber processed with vinegar and dahurian angelica root in a weight ratio of 1:1-3: 1.

The invention also aims to provide application of the corydalis tuber analgesic dropping pill in preparing a medicine for promoting proteoglycan synthesis, wherein the corydalis tuber analgesic dropping pill consists of corydalis tuber processed with vinegar and angelica dahurica in a weight ratio of 1:1-3: 1.

The invention also aims to provide application of the corydalis tuber pain relieving dropping pill in preparing a medicine for promoting chondrocyte proliferation, wherein the corydalis tuber pain relieving dropping pill consists of corydalis tuber processed with vinegar and angelica dahurica in a weight ratio of 1:1-3: 1.

The invention also aims to provide application of the corydalis tuber analgesic dropping pill in preparing a medicament for inhibiting inflammation, wherein the corydalis tuber analgesic dropping pill consists of corydalis tuber processed with vinegar and dahurian angelica root in a weight ratio of 1:1-3: 1.

The invention also aims to provide application of the corydalis tuber pain relieving dropping pill in preparation of a medicine for assisting in inhibiting knee osteoarthritis inflammation symptoms, wherein the corydalis tuber pain relieving dropping pill consists of corydalis tuber and angelica dahurica which are processed with vinegar in a weight ratio of 1:1-3: 1.

The invention also aims to provide application of the corydalis tuber pain relieving dropping pill in preparation of a medicine for promoting joint function recovery, wherein the corydalis tuber pain relieving dropping pill consists of corydalis tuber processed with vinegar and angelica dahurica in a weight ratio of 1:1-3: 1.

The invention also aims to provide an application of the corydalis tuber pain relieving dropping pill in preparing a medicine for relieving joint stiffness, wherein the corydalis tuber pain relieving dropping pill consists of corydalis tuber processed with vinegar and dahurian angelica root in a weight ratio of 1:1-3: 1.

The invention has the beneficial effects that: the inventor surprisingly finds that the corydalis tuber pain relieving dropping pill can inhibit inflammatory factors, has the effects of inhibiting cartilage degradation, promoting chondrocyte proliferation, promoting proteoglycan synthesis and the like, and has the effect superior to that of a diclofenac sodium sustained-release capsule singly and a diclofenac sodium sustained-release capsule and a corydalis tuber pain relieving dropping pill jointly used; the inventor finds that the corydalis tuber pain relieving dropping pill can remarkably relieve joint pain and joint stiffness and promote the recovery of joint mobility in clinical level, has good clinical treatment effect on KOA, has the effect remarkably superior to that of diclofenac sodium, can remarkably reduce adverse reactions such as gastrointestinal tract irritation and the like compared with the diclofenac sodium by singly using the corydalis tuber pain relieving dropping pill, and has good safety after long-term taking of the corydalis tuber pain relieving dropping pill (more than or equal to 2 weeks).

Detailed Description

The corydalis tuber analgesic dropping pill described in the following examples is prepared from corydalis tuber (processed with vinegar) and dahurian angelica root with auxiliary materials, and is prepared from Gansu Longshen-Ongfa pharmaceutical industry GmbH.