阅读说明：本技术 一种无糖型舒肝益脾颗粒药剂及其制备方法 (Sugar-free liver-soothing spleen-benefiting granule medicament and preparation method thereof ) 是由 张云 金春东 王有智 于灜波 姜晶 杨健 于 2020-06-15 设计创作，主要内容包括：本发明公开了一种无糖型舒肝益脾颗粒药剂及其制备方法,涉及舒肝益脾颗粒药剂制备方法技术领域,包括：茵陈1335g～1340g、蒲公英1335g～1340g、五味子165g～170g、茯苓665g～670g、山楂835g～840g、黄芪665g～670g,采用茵陈、蒲公英、五味子、茯苓、山楂以及黄芪进行制备舒肝益脾颗粒药剂,具有清化湿热、舒肝利胆、解毒退黄、健脾和胃作用,用于湿热阻滞而致的各类病症,可以养护和调理肝胆脾胃功能,恢复和提高肝脏代谢解毒功能,脾脏血液过滤作用,清除体内毒素垃圾,改善各类不适症状,提高机体免疫力,远离疾病困扰,并且不添加辅料使得舒肝益脾颗粒药剂为无糖颗粒,从而提高了舒肝益脾颗粒药剂的药效质量,保证疗效,并且无糖的舒肝益脾颗粒药剂适合的人群更为广泛。(The invention discloses a sugar-free liver-soothing spleen-benefiting granule medicament and a preparation method thereof, relating to the technical field of preparation methods of liver-soothing spleen-benefiting granule medicaments, and comprising the following steps: 1335-1340 g of oriental wormwood, 1335-1340 g of dandelion, 165-170 g of schisandra fruit, 665-670 g of poria cocos, 835-840 g of hawthorn and 665-670 g of astragalus root, wherein the medicinal granules prepared from oriental wormwood, dandelion, schisandra fruit, poria cocos, hawthorn and astragalus root have the functions of clearing damp-heat, soothing liver and promoting bile flow, detoxifying and removing jaundice, strengthening spleen and stomach, can be used for curing and regulating the functions of the liver, the gallbladder, the spleen and the stomach caused by damp-heat retardation, recovering and improving the functions of liver metabolism and detoxification, filtering the blood of the spleen, removing vivotoxin garbage, improving various uncomfortable symptoms, improving the immunity of the organism, keeping away from the trouble of diseases, and the liver-soothing and spleen-benefiting granule medicament is sugar-free granules without adding auxiliary materials, thereby improving the drug effect quality of the liver-soothing spleen-tonifying granule medicament, ensuring the curative effect, and the sugar-free liver-soothing spleen-tonifying granule medicament is more suitable for the crowds.)

1. A sugar-free liver-soothing spleen-benefiting granule medicament and a preparation method thereof are characterized in that the medicament comprises the following raw materials by weight: 1335-1340 g of oriental wormwood, 1335-1340 g of dandelion, 165-170 g of schisandra chinensis, 665-670 g of poria cocos, 835-840 g of hawthorn and 665-670 g of astragalus membranaceus, wherein the preparation method of the sugar-free liver-soothing spleen-tonifying granule medicament is realized by the following steps:

step 1: selecting 1335-1340 g of oriental wormwood, 1335-1340 g of dandelion, 165-170 g of schisandra chinensis, 665-670 g of poria cocos, 835-840 g of hawthorn and 665-670 g of astragalus membranaceus for later use;

step 2: percolating 165-170 g of fructus Schisandrae in step 1 according to fluid extract and extract percolation method to obtain percolate and residue;

and step 3: concentrating the percolate obtained in the step (2) at the temperature of 58-62 ℃ to obtain a first thick extract with the relative density of 1.28-1.30;

and 4, step 4: vacuum drying the first thick extract in the step 3 at the temperature of 58-62 ℃, vacuum drying under the pressure of-0.07 Mpa-0.09 Mpa to form first dry extract, and crushing the first dry extract into first fine powder for later use;

and 5: adding 8 times of water into 1335-1340 g of oriental wormwood, 1335-1340 g of dandelion, 665-670 g of poria cocos, 835-840 g of hawthorn, 665-670 g of astragalus membranaceus and the dregs of a decoction in the step 2, and decocting for two times, wherein the first time is 2 hours, and the second time is 1 hour;

step 6: combining and filtering the decoctions decocted twice in the step 5 to obtain filtrate, and concentrating the filtrate at the temperature of 58-62 ℃ to obtain a second thick extract with the relative density of 1.28-1.30;

and 7: vacuum drying the second soft extract in step 6 at 58-62 deg.C under-0.07 Mpa to-0.09 Mpa to obtain second dry extract, and pulverizing the second dry extract into second fine powder;

and 8: and (4) combining the first fine powder and the second fine powder obtained in the step (4) and the step (7), granulating and drying to obtain the sugar-free liver-soothing spleen-benefiting granule.

2. The sugar-free liver-soothing spleen-benefiting granule medicament as claimed in claim 1, wherein the percolation method under the condition of fluid extract and extract of 165g to 170g of schisandra chinensis in the step 2 is realized by the following steps:

s1: selecting 165-170 g of coarse powder of schisandra chinensis, introducing the coarse powder into a stainless steel barrel, adding ethanol solution which is 1.5 times of the coarse powder of schisandra chinensis, uniformly stirring, and covering to fully expand the coarse powder;

s2: introducing the fully expanded coarse powder of the schisandra chinensis in the step S1 into a percolation barrel for several times until the fully expanded coarse powder of the schisandra chinensis is completely introduced into the percolation barrel, laying a layer of gauze on the surface of the medicine, and firmly pressing the gauze by using a stainless steel plate with a mesh hole provided with a vertical rod;

s3: opening a liquid outlet valve at the bottom of the percolation barrel in the S2, placing a container below the percolation barrel for liquid receiving, slowly adding residual ethanol in a stainless steel barrel into the percolation barrel, closing the liquid outlet valve when no bubbles are generated at the liquid outlet, adding ethanol solution 1.5 times of the coarse powder of the schisandra again until the amount of the ethanol solution is 20cm higher than the medicine surface, and covering, sealing and soaking for 12 hours;

s4: the outlet valve of the percolation barrel after 12 hours of immersion was opened and the percolate was collected with a stainless steel barrel with a respirator.

3. The sugar-free liver-soothing spleen-tonifying granule preparation and the preparation method thereof as claimed in claim 2, wherein the ethanol is 55% ethanol solution.

4. The sugar-free granule for soothing liver and invigorating spleen of claim 2, wherein the coarsest powder of substantially swollen schisandra chinensis fractionated in S2 is 10cm thick each time.

5. The sugar-free liver-soothing spleen-benefiting granule preparation as claimed in claim 2, wherein the outlet valve is adjusted in S3 to make the flow rate of the percolate at 44-48 ml/min.

6. The sugar-free liver-soothing spleen-tonifying granule preparation as claimed in claim 1, wherein the step 4 and the step 7 are pulverized by a pulverizer and passed through a 100-mesh sieve.

7. The sugar-free liver-soothing spleen-tonifying granule medicament as claimed in claim 1, wherein the first and second thick extracts are dried in a pulsating vacuum drying oven in steps 4 and 7.

8. The sugar-free liver-soothing spleen-tonifying granule preparation as claimed in claim 1, wherein the drying time in steps 4 and 7 is 6-8 hours.

9. The sugar-free liver-soothing spleen-tonifying granule preparation according to claim 1, wherein the concentration time in steps 3 and 6 is 3-4 hours.

10. The sugar-free liver-soothing spleen-tonifying granule preparation and the preparation method thereof according to claim 1, wherein the step 8 is a one-step granulation by using a spray drying granulator.

Technical Field

The invention relates to the technical field of preparation methods of liver-soothing spleen-benefiting granular medicaments, in particular to a sugar-free liver-soothing spleen-benefiting granular medicament and a preparation method thereof.

Background

Medical statistics show that: at present, about 1180 chemical poisons are exposed to people every day, 175 chemical substances are averagely coated on the face of a female every day, and the pesticide and fertilizer are up to 200 micrograms and the meat hormone is 150 micrograms.

Everyone is a toxin carrier, and the more toxins are in the age, the more toxins erode viscera and destroy cells, and the channels for the cells to absorb nutrition and metabolic waste are blocked, so that various sub-health symptoms such as dizziness, headache, fatigue, insomnia, dreaminess, inappetence, resistance reduction and the like are caused.

The liver and spleen are important organs for detoxification, filtration and immunity of human body. The liver has a plurality of functions of synthesis, metabolism, detoxification and excretion, is known as a chemical processing plant, a metabolism center and a detoxification master of the human body, the spleen is the largest immune organ of the human body, has the functions of blood storage and blood filtration, is called as a blood filter, and once the blood filtration function of the spleen and the detoxification function of the liver are reduced, the consequence is unreasonable.

The liver-soothing spleen-benefiting granule conforms to the theory of liver-spleen concordance and disease treatment, and has the effects of clearing away damp-heat, soothing liver and benefiting gallbladder, detoxifying and removing jaundice, and strengthening spleen and stomach, but most of the existing liver-soothing spleen-benefiting granule products contain sugar granules, sucrose is used as a common auxiliary material of the traditional Chinese medicine granule, and the traditional Chinese medicine granule takes the sucrose as the auxiliary material, so that a series of problems of product process and stability are solved to a certain degree, but the problems of dilution of effective components, discount of curative effect, limitation of suitable crowds and the like are objectively caused, and due to the high-definition sucrose, the granule has personal safety hidden danger when being taken by most of.

Disclosure of Invention

The invention aims to solve the problems and designs a sugar-free liver-soothing spleen-tonifying granule medicament and a preparation method thereof.

The technical scheme of the invention is that the sugar-free liver-soothing spleen-tonifying granule medicament and the preparation method thereof comprise the following raw materials by weight: 1335-1340 g of oriental wormwood, 1335-1340 g of dandelion, 165-170 g of schisandra chinensis, 665-670 g of poria cocos, 835-840 g of hawthorn and 665-670 g of astragalus membranaceus, wherein the preparation method of the sugar-free liver-soothing spleen-tonifying granule medicament is realized by the following steps:

step 1: selecting 1335-1340 g of oriental wormwood, 1335-1340 g of dandelion, 165-170 g of schisandra chinensis, 665-670 g of poria cocos, 835-840 g of hawthorn and 665-670 g of astragalus membranaceus for later use;

step 2: percolating 165-170 g of fructus Schisandrae in step 1 according to fluid extract and extract percolation method to obtain percolate and residue;

and step 3: concentrating the percolate obtained in the step (2) at the temperature of 58-62 ℃ to obtain a first thick extract with the relative density of 1.28-1.30;

and 4, step 4: vacuum drying the first thick extract in the step 3 at the temperature of 58-62 ℃, vacuum drying under the pressure of-0.07 Mpa-0.09 Mpa to form first dry extract, and crushing the first dry extract into first fine powder for later use;

and 5: adding 8 times of water into 1335-1340 g of oriental wormwood, 1335-1340 g of dandelion, 665-670 g of poria cocos, 835-840 g of hawthorn, 665-670 g of astragalus membranaceus and the dregs of a decoction in the step 2, and decocting for two times, wherein the first time is 2 hours, and the second time is 1 hour;

step 6: combining and filtering the decoctions decocted twice in the step 5 to obtain filtrate, and concentrating the filtrate at the temperature of 58-62 ℃ to obtain a second thick extract with the relative density of 1.28-1.30;

and 7: vacuum drying the second soft extract in step 6 at 58-62 deg.C under-0.07 Mpa to-0.09 Mpa to obtain second dry extract, and pulverizing the second dry extract into second fine powder;

and 8: and (4) combining the first fine powder and the second fine powder obtained in the step (4) and the step (7), granulating and drying to obtain the sugar-free liver-soothing spleen-benefiting granule.

Preferably, 165g to 170g of schisandra chinensis in the step 2 is realized by the following steps according to a percolation method under the conditions of fluid extract and extract:

s1: selecting 165-170 g of coarse powder of schisandra chinensis, introducing the coarse powder into a stainless steel barrel, adding ethanol solution which is 1.5 times of the coarse powder of schisandra chinensis, uniformly stirring, and covering to fully expand the coarse powder;

s2: introducing the fully expanded coarse powder of the schisandra chinensis in the step S1 into a percolation barrel for several times until the fully expanded coarse powder of the schisandra chinensis is completely introduced into the percolation barrel, laying a layer of gauze on the surface of the medicine, and firmly pressing the gauze by using a stainless steel plate with a mesh hole provided with a vertical rod;

s3: opening a liquid outlet valve at the bottom of the percolation barrel in the S2, placing a container below the percolation barrel for liquid receiving, slowly adding residual ethanol in a stainless steel barrel into the percolation barrel, closing the liquid outlet valve when no bubbles are generated at the liquid outlet, adding ethanol solution 1.5 times of the coarse powder of the schisandra again until the amount of the ethanol solution is 20cm higher than the medicine surface, and covering, sealing and soaking for 12 hours;

s4: the outlet valve of the percolation barrel after 12 hours of immersion was opened and the percolate was collected with a stainless steel barrel with a respirator.

Preferably, the ethanol is 55% ethanol solution.

Preferably, the fully expanded fructus Schisandrae chinensis coarsest powder introduced in step S2 is 10cm thick each time.

Preferably, the liquid outlet valve in S3 is adjusted to make the flow rate of the percolate between 44ml/min and 48 ml/min.

Preferably, the step 4 and the step 7 are crushed by a crusher and pass through a 100-mesh sieve.

Preferably, in the step 4 and the step 7, a pulsating vacuum drying oven is adopted to dry the first thick extract and the second thick extract.

Preferably, the drying time of the step 4 and the step 7 is 6 to 8 hours.

Preferably, the concentration time in the step 3 and the step 6 is 3-4 hours.

Preferably, the step 8 is carried out by adopting a spray drying granulator for one-step granulation.

Advantageous effects

The sugar-free liver-soothing spleen-tonifying granule medicament prepared by the technical scheme of the invention has the functions of clearing damp-heat, soothing liver, benefiting gallbladder, detoxifying, removing jaundice, strengthening spleen and stomach, is used for treating various diseases caused by damp-heat retardation, can maintain and condition the functions of liver, gallbladder and spleen and stomach, recover and improve the liver metabolism detoxification function, has the spleen blood filtration function, removes vivotoxin garbage, improves various uncomfortable symptoms, improves the immunity of organisms, is far away from disease troubles, is free of auxiliary materials, is sugar-free, improves the drug effect quality of the liver-soothing spleen-tonifying granule medicament, ensures the curative effect, and is suitable for more extensive crowds.

Detailed Description

The present invention will be further described with reference to the following examples.