阅读说明：本技术 小动物垂体抽除器 (Small animal pituitary extractor ) 是由 冯展鹏 武广森 欧毅超 周明锋 李凯 彭君洁 龚浩东 王兴勤 刘亚伟 漆松涛 于 2020-03-27 设计创作，主要内容包括：本发明公开了一种小动物垂体抽除器,其抽吸内芯具备穿刺针和连接部,穿刺针的上段为进深段,连接部用于与外部吸引装置接通,为垂体的抽除提供吸引动力支持；在穿刺针外套设有缓冲套管,缓冲套管包括调节部及固定部,固定部与穿刺针相固定并与调节部的下端螺旋式连接,通过调整固定部与调节部之间的配合圈数即可对缓冲套管的长度进行调节,从而对进深段从调节部中伸出的长度进行调整,使之达到所需穿刺深度,又由于进深段上设有沿长度方向分布的第一刻度,使实验人员能够对进深段的伸出长度得到直观的了解,更好地确保进深段伸出长度与穿刺深度保持一致,防止因进针过深致抽吸时对脑组织造成过多的损伤,此发明用于生物实验器械领域。(The invention discloses a hypophysis extractor for small animals, wherein a suction inner core of the hypophysis extractor is provided with a puncture needle and a connecting part, the upper section of the puncture needle is a depth section, and the connecting part is used for being communicated with an external suction device and providing suction power support for extracting the hypophysis; the puncture needle is sleeved with the buffer sleeve, the buffer sleeve comprises an adjusting part and a fixing part, the fixing part is fixed with the puncture needle and is spirally connected with the lower end of the adjusting part, the length of the buffer sleeve can be adjusted by adjusting the number of matching turns between the fixing part and the adjusting part, so that the length of the depth section extending out of the adjusting part is adjusted to reach the required puncture depth, and the depth section is provided with first scales distributed along the length direction, so that an experimenter can visually know the extending length of the depth section, the extending length of the depth section is better ensured to be consistent with the puncture depth, and excessive damage to brain tissues during suction due to over-deep needle insertion is prevented.)

1. Small animal pituitary extractor is connected with external suction device, its characterized in that includes:

the suction inner core is provided with a puncture needle and a connecting part fixed at the bottom end of the puncture needle, the connecting part is communicated with an external suction device, the upper section of the puncture needle is a depth section, and a plurality of first scales distributed along the length direction are arranged on the depth section;

the buffer sleeve is sleeved on the puncture needle and comprises an adjusting part and a fixing part in spiral connection with the lower end of the adjusting part, the fixing part is fixed with the lower section of the puncture needle, and the top end of the puncture needle extends out of the upper end of the adjusting part.

2. The small animal pituitary extractor of claim 1, wherein: the adjustable adjusting part comprises an outer sleeve, and the outer wall of the lower section of the outer sleeve is provided with an external thread matched with the internal thread.

3. The small animal pituitary extractor of claim 2, wherein: at least one locking screw is installed on the fixing portion, and the tail end of each locking screw extends into the through hole from the outer side face of the fixing portion.

4. The small animal pituitary extractor of claim 3, wherein: the outer sleeve pipe outer wall of external screw thread top is equipped with the identification area, draw in the identification area and establish a plurality of second scales that distribute along length direction, adjacent the interval between the second scale equals.

5. The small animal pituitary extractor of claim 4, wherein: a cover body is arranged around the outer sleeve, the top edge of the cover body is flush with the top end of the outer sleeve, and the bottom edge of the cover body is not lower than the identification area.

6. The small animal pituitary extractor of claim 5, wherein: the upper end of the cover body is trumpet-shaped, and the included angle between two side edges of the longitudinal section at the upper end of the cover body is 18-30 degrees.

7. The small animal pituitary extractor of claim 5, wherein: the cover body is made of hard plastic.

8. The small animal pituitary extractor of claim 1, wherein: the needle tip of the puncture needle forms an inclined plane, the length of the inclined plane is 2mm to 5mm, and the inclination angle is 5 degrees to 58 degrees.

9. The small animal pituitary extractor of claim 8, wherein: the upper end of connecting portion is equipped with directional orientation mark up, the outer wall of fixed part is carved with a pair of directional angle location mark and the diapire of pointing down and is around a plurality of rotation angle degree marks of through-hole equipartition, the rotation angle on inclined plane is jointly confirmed to orientation mark, angle location mark and rotation angle mark.

10. The small animal pituitary extractor of any one of claims 1 to 9, wherein: the connecting part is a connecting sleeve nozzle, at least one layer of filter paper is transversely arranged in the connecting sleeve nozzle, and each filter paper is in a grid shape.

Technical Field

The invention relates to the field of biological experimental instruments, in particular to a hypophysis extractor for small animals.

Background

In neuroscience research, experimental animal research directed to the hypothalamic-pituitary system is a crucial part. The hypothalamus-pituitary system is the central nervous signal integration cooperation and hormone regulation of the body, and the position of the hypothalamus-pituitary system is deep and is the brain central, so that the research on the intrinsic pathophysiological mechanism has great prospect, and the construction technology of related experimental animal models is a basic and important research means.

At present, rat models of the hypothalamic pituitary axis are roughly divided into two types, one is pituitary stalk separation operation, the other is holoptotomy, and the operation modes comprise craniocerebral vertex approach, auditory canal approach, pharyngeal bypass approach and the like. The craniocerebral tissue structure around the approach needs to be damaged when the craniocerebral roof enters the approach, and the operation microscope is needed for the suction of the pituitary body through the pharyngeal approach, so that the time and the labor are wasted, the operation time is long, the operation technical requirement on operators is high, and the animal death rate is high. The common suction of pituitary by the ear requires a specially-made stereotaxic device, has high equipment requirement, easy loss and low repeatability, and simultaneously restricts the development of different research centers on the model. In addition, the existing experimental apparatus does not fit the actual anatomical structure, has no specific parameter which can be referred to, has no fixed standard for the depth and angle of the needle insertion, and does not reasonably protect the brain tissue and the like. The above reasons all lead researchers to lack a highly effective and stable experimental animal hypophysis model for research.

Disclosure of Invention

The invention aims to solve at least one technical problem in the prior art and provide a pituitary extractor for small animals, wherein the puncture depth can be adjusted as required.

The pituitary extractor for the small animals is connected with an external suction device and comprises an inner suction core and a buffer sleeve; the suction inner core is provided with a puncture needle and a connecting part fixed at the bottom end of the puncture needle, the connecting part is communicated with an external suction device, the upper section of the puncture needle is a depth section, and a plurality of first scales distributed along the length direction are arranged on the depth section; the buffer sleeve is sleeved on the puncture needle and comprises an adjusting part and a fixing part in spiral connection with the lower end of the adjusting part, the fixing part is fixed with the lower section of the puncture needle, and the top end of the puncture needle extends out of the upper end of the adjusting part.

The small animal pituitary extractor provided by the embodiment of the invention has at least the following beneficial effects: the small animal pituitary extractor does not need the assistance of high-price stereotactic equipment when in use, is easy to develop and apply an animal model, the suction inner core of the small animal pituitary extractor is provided with a puncture needle and a connecting part, the upper section of the puncture needle is a depth section, and the connecting part is used for being communicated with an external suction device to provide suction power support for the extraction of the pituitary; be equipped with buffer sleeve at pjncture needle overcoat, buffer sleeve includes regulating part and fixed part, the fixed part is fixed mutually with the pjncture needle and is connected with the lower extreme spiral of regulating part, can adjust buffer sleeve's length through the cooperation number of turns between adjustment fixed part and the regulating part, thereby adjust the length that stretches out in the deep section follow regulating part, make it reach required depth of penetration, again because be equipped with the first scale along length direction distribution on the deep section, make the experimenter can obtain audio-visual understanding to the length of stretching out of deep section, ensure deep section length of stretching out and the depth of penetration keep unanimous better, prevent to cause too much damage to brain tissue when sending the needle and sending the suction deeply.

According to some embodiments of the present invention, a through hole is formed in the fixing portion and penetrates from the bottom end to the top end, an inner thread is formed on a hole wall of a lower portion of the through hole, the adjusting portion includes an outer sleeve, and an outer thread adapted to the inner thread is formed on an outer wall of a lower section of the outer sleeve.

According to some embodiments of the present invention, at least one locking screw is mounted on the fixing portion, and a tail end of each locking screw extends into the through hole from an outer side surface of the fixing portion.

According to some embodiments of the present invention, the outer wall of the outer sleeve above the external thread is provided with a mark area, a plurality of second scales distributed along the length direction are scribed in the mark area, and the intervals between the adjacent second scales are equal.

According to some embodiments of the invention, a cover is provided around the outer sleeve, the cover having a top edge flush with the top end of the outer sleeve and a bottom edge not lower than the indicator region.

According to some embodiments of the invention, the upper end of the cover body is trumpet-shaped, and an included angle between two side edges of a longitudinal section of the upper end of the cover body is 18 to 30 degrees.

According to some embodiments of the invention, the cover is made of a hard plastic.

According to some embodiments of the present invention, the tip of the puncture needle forms a bevel having a length of 2mm to 5mm and an inclination angle of 5 ° to 58 °.

According to some embodiments of the invention, the upper end of the connecting part is provided with an orientation mark pointing upwards, the outer wall of the fixing part is engraved with a pair of angle positioning marks pointing downwards, the bottom wall is uniformly distributed with a plurality of rotation angle marks around the through hole, and the orientation mark, the angle positioning marks and the rotation angle marks jointly determine the rotation angle of the inclined plane.

According to some embodiments of the invention, the connecting portion is a connecting nipple, at least one layer of filter paper is transversely arranged in the connecting nipple, and each filter paper is in a grid shape.

Drawings

The invention will be further described with reference to the accompanying drawings in which:

FIG. 1 is a schematic view of the overall construction of a small animal pituitary extractor according to an embodiment of the present invention;

FIG. 2 is an exploded view of a buffer tube according to an embodiment of the present invention;

figure 3 is a schematic diagram of the construction of a suction core according to an embodiment of the present invention.

Detailed Description

Reference will now be made in detail to the present preferred embodiments of the present invention, examples of which are illustrated in the accompanying drawings, wherein like reference numerals refer to like elements throughout.

In the description of the present invention, it should be understood that the orientation or positional relationship referred to in the description of the orientation, such as the upper, lower, front, rear, left, right, etc., is based on the orientation or positional relationship shown in the drawings, and is only for convenience of description and simplification of description, and does not indicate or imply that the device or element referred to must have a specific orientation, be constructed and operated in a specific orientation, and thus, should not be construed as limiting the present invention.

In the description of the present invention, the meaning of a plurality of means is one or more, the meaning of a plurality of means is two or more, and larger, smaller, larger, etc. are understood as excluding the number, and larger, smaller, inner, etc. are understood as including the number. If the first and second are described for the purpose of distinguishing technical features, they are not to be understood as indicating or implying relative importance or implicitly indicating the number of technical features indicated or implicitly indicating the precedence of the technical features indicated.