阅读说明：本技术 一种壳聚糖季铵盐杀菌纱布及其制备方法 (Chitosan quaternary ammonium salt sterilization gauze and preparation method thereof ) 是由 程国钢 马洁 赵刚 于 2020-03-18 设计创作，主要内容包括：本发明涉及一种壳聚糖季铵盐杀菌纱布,包括碘伏层、壳聚糖季铵盐杀菌层、吸水层及冷敷层,碘伏层由若干填充碘伏液的单元凝胶球组成。该壳聚糖季铵盐杀菌纱布制备方法,包括：⑴将壳聚糖季铵盐配制成浓度为4mg/mL的水溶液,在37℃的温度下将纱布浸入混合2小时,脱液,烘干；⑵将上述纱布浸泡在6mg/mL壳聚糖季铵盐水溶液中5小时,脱液,定型,二次烘干,形成壳聚糖季铵盐杀菌层；⑶将碘伏层、壳聚糖季铵盐杀菌层、吸水层及冷敷层经过压合工艺压合。本发明设计科学合理、创新杀菌纱布结构和制备工艺,使用舒适柔软,具有良好的透气吸湿、消肿、止血功能,且无毒、无味、无刺激、无腐蚀、无污染,属于环境友好型的医疗产品。(The invention relates to chitosan quaternary ammonium salt sterilization gauze which comprises an iodophor layer, a chitosan quaternary ammonium salt sterilization layer, a water absorbing layer and a cold coating layer, wherein the iodophor layer consists of a plurality of unit gel balls filled with iodophor liquid, the preparation method of the chitosan quaternary ammonium salt sterilization gauze comprises ⑴ preparing chitosan quaternary ammonium salt into aqueous solution with the concentration of 4mg/m L, soaking and mixing the gauze for 2 hours at the temperature of 37 ℃, removing liquid and drying, ⑵ soaking the gauze in 6mg/m L aqueous solution for 5 hours, removing liquid, sizing and drying for the second time to form the chitosan quaternary ammonium salt sterilization layer, and ⑶ pressing and pressing the iodophor layer, the chitosan quaternary ammonium salt sterilization layer, the water absorbing layer and the cold coating layer through a pressing and pressing process.)

1. The chitosan quaternary ammonium salt sterilization gauze is characterized in that: the iodine layer is composed of a plurality of unit gel balls filled with iodine solution, the matrix of the iodine layer is gel, and the upper layer of the iodine layer is covered with a tearing layer.

2. A preparation method of chitosan quaternary ammonium salt sterilization gauze comprises the following steps:

⑴ preparing chitosan quaternary ammonium salt into water solution with concentration of 4mg/m L, soaking gauze at 37 deg.C, mixing for 2 hr, removing liquid, and oven drying;

⑵ soaking the gauze in 6mg/m L chitosan quaternary ammonium salt water solution for 5 hours, removing liquid, shaping, and drying for the second time to form a chitosan quaternary ammonium salt sterilizing layer;

⑶ the iodophor layer, the chitosan quaternary ammonium salt sterilization layer, the water absorption layer and the cold compress layer are pressed together by a pressing process.

3. The chitosan quaternary ammonium salt sterilization gauze and the preparation method thereof according to claim 1 or 2, wherein the chitosan quaternary ammonium salt sterilization gauze comprises the following components in parts by weight:

the chitosan quaternary ammonium salt is 2-hydroxypropyl trimethyl ammonium chloride chitosan.

4. The chitosan quaternary ammonium salt bactericidal gauze of claim 1, which is characterized in that: the water absorption layer is medical gauze.

Technical Field

The invention belongs to the field of medical consumables, and relates to sterilization gauze, in particular to chitosan quaternary ammonium salt sterilization gauze and a preparation method thereof.

Background

The sterilization gauze is prepared from absorbent cotton gauze, is basically used for medical or medical disinfection and sterilization, is white and has strong water absorption capacity, and is used for external application debridement nursing and health care nursing by medical units.

The sterilization gauze has the advantages that the sterilization gauze has good water absorption performance and does not fall off cotton wool, and the sterilization gauze also has the sterilization function, so that secondary infection at a wound is avoided. After infection of the wound, the surrounding skin becomes whitish and becomes soft leading to secondary infection with bacteria, which further worsens the wound. In addition, the wound surface of the patient is accompanied by pain, the patient can be rubbed and pain by contacting the wound surface of the patient, and the gauze is an improvement direction for effectively solving the discomfort.

The chitosan is natural cationic basic polysaccharide, has the chemical name of β - (1-4) -2-amino-2-deoxy-D-glucan, is a polymer obtained by gradually deacetylating the chitin, is widely existed in organisms such as shells of higher fungi, shrimps, crabs and insects in the nature, has very large storage amount on the earth, and is the second most biological resource in the nature.

However, chitosan has a large amount of intramolecular and intermolecular hydrogen bonds, so that chitosan is not dissolved in water and dilute alkali solution, is not dissolved in common organic solvent, and is only dissolved in low-concentration inorganic acid acidic solution such as dilute acetic acid and dilute hydrochloric acid (pH <6) and individual organic solvent, so that the application of chitosan in the field of hemostatic dressings is greatly limited.

Although the published patent literature describes the bactericidal function of chitosan quaternary ammonium salt through the search of the prior published patent literature, the preparation method and the improvement of the use comfort of gauze cannot influence the novelty and the creativity of the invention.

Disclosure of Invention

The invention aims to overcome the defects of the prior art and provides the chitosan quaternary ammonium salt sterilization gauze capable of effectively improving the sterilization effect and the use comfort and the preparation method thereof.

The technical problem to be solved by the invention is realized by adopting the following technical scheme:

a chitosan quaternary ammonium salt sterilization gauze comprises an iodophor layer, a chitosan quaternary ammonium salt sterilization layer, a water absorption layer and a cold compress layer, wherein the iodophor layer consists of a plurality of unit gel balls filled with iodophor liquid, a matrix of the iodophor layer is gel, and a tearing layer covers the matrix.

A preparation method of chitosan quaternary ammonium salt sterilization gauze comprises the following steps:

⑴ preparing chitosan quaternary ammonium salt into water solution with concentration of 4mg/m L, soaking gauze at 37 deg.C, mixing for 2 hr, removing liquid, and oven drying;

⑵ soaking the gauze in 6mg/m L chitosan quaternary ammonium salt water solution for 5 hours, removing liquid, shaping, and drying for the second time to form a chitosan quaternary ammonium salt sterilizing layer;

⑶ the iodophor layer, the chitosan quaternary ammonium salt sterilization layer, the water absorption layer and the cold compress layer are pressed together by a pressing process.

Moreover, the chitosan quaternary ammonium salt is 2-hydroxypropyl trimethyl ammonium chloride chitosan.

Moreover, the water absorption layer is medical gauze.

The invention has the advantages and positive effects that:

1. the iodophor layer is composed of a plurality of unit gel balls filled with iodophor liquid, the matrix of the iodophor layer is gel, the iodophor liquid in the unit gel layer is released to achieve the effects of disinfecting and sterilizing wounds and improving the use comfort, and the sterilization effect of the chitosan quaternary ammonium salt sterilization layer can be promoted.

2. The chitosan quaternary ammonium salt adopted by the chitosan quaternary ammonium salt sterilizing layer is 2-hydroxypropyl trimethyl ammonium chloride chitosan, the chitosan quaternary ammonium salt is obtained by chemically modifying chitosan, the water solubility is good, the application range of the chitosan is enlarged, the used 2-hydroxypropyl trimethyl ammonium chloride chitosan not only plays the advantages of wide chitosan source and the like, but also mainly inherits the sterilizing characteristic of the chitosan, can be well combined with common gauze, effectively reduces the infection rate of wounds and promotes healing.

3. The water absorption layer mainly absorbs redundant moisture, the adhesive tape keeps dry and comfortable in the long-time use process of the band-aid, the band-aid is prevented from being used for a long time, the adhesive tape on the outer layer of the band-aid is not breathable, so that the wound and the skin around the wound are whitened and become soft to cause secondary infection of bacteria, and the wound is further deteriorated.

4. The cold coating is prepared by taking a high-molecular hydrogel material as a matrix, contains natural cool traditional Chinese medicine components, takes away heat after being vaporized by contacting with air, and can achieve the effect of local cooling, and the medicine can rapidly penetrate a fat layer through the medicine components after the hydrogel is combined, and then permeates to subcutaneous tissues to directly reach focuses, so that the effects and effects of cold compress pain relief, percutaneous absorption and sustained release administration are achieved.

5. The invention has scientific and reasonable design, innovatively sterilizes the gauze structure, utilizes the sterilization efficacy of the chitosan quaternary ammonium salt and optimizes the preparation process, adds the iodophor layer and the cold coating layer, is comfortable and soft to use, has good functions of ventilation, moisture absorption, detumescence and hemostasis, is nontoxic, tasteless, non-irritant, non-corrosive and non-pollution, and belongs to an environment-friendly medical product. The adhesive is clinically applicable to the application of the band-aid, has simple preparation process, low cost, easy realization of large-scale industrialization, low product price and good clinical use effect, and does not need to purchase a large amount of equipment.

Drawings

FIG. 1 is a schematic view of a gauze structure according to the present invention;

fig. 2 is a schematic structural diagram of an embodiment of the adhesive bandage.

Detailed Description

The present invention is further illustrated by the following specific examples, which are intended to be illustrative, not limiting and are not intended to limit the scope of the invention.

A chitosan quaternary ammonium salt sterilization gauze is shown in figure 1 and comprises an iodophor layer 2, a chitosan quaternary ammonium salt sterilization layer 6, a water absorbing layer 5 and a cold compress layer 4, wherein the iodophor layer is composed of a plurality of unit gel balls 3 filled with iodophor liquid, a matrix of the iodophor layer is gel, a tearing layer 1 covers the upper layer of the iodophor layer, the tearing layer is removed during use, the iodophor liquid in the unit gel balls is leached, the use comfort is improved while the wound is sterilized, and the sterilization effect of the chitosan quaternary ammonium salt sterilization layer can be promoted.

The preparation method of the chitosan quaternary ammonium salt sterilizing layer comprises the following steps:

⑴ preparing chitosan quaternary ammonium salt into water solution with concentration of 4mg/m L, soaking gauze at 37 deg.C, mixing for 2 hr, removing liquid, and oven drying;

⑵ soaking the gauze in 6mg/m L chitosan quaternary ammonium salt water solution for 5 hours, removing liquid, shaping, and drying for the second time to form a chitosan quaternary ammonium salt sterilizing layer;

⑶ the iodophor layer, the chitosan quaternary ammonium salt sterilization layer, the water absorption layer and the cold compress layer are pressed together by a pressing process.

The chitosan quaternary ammonium salt is 2-hydroxypropyl trimethyl ammonium chloride chitosan.

The cold coating is prepared by taking a high-molecular hydrogel material as a matrix, contains natural cool traditional Chinese medicine components, takes away heat after being vaporized by contacting with air, and can achieve the effect of local cooling, and the medicine can rapidly penetrate a fat layer through the medicine components after the hydrogel is combined, and then permeates to subcutaneous tissues to directly reach focuses, so that the effects and effects of cold compress pain relief, percutaneous absorption and sustained release administration are achieved.

The water absorbing layer is common medical gauze.

The band-aid made of the chitosan quaternary ammonium salt sterilization gauze is shown in figure 2 and comprises a supporting layer 10 and a covering film 8, wherein the chitosan quaternary ammonium salt sterilization gauze 11 is arranged between the supporting layer and the covering film, two sides of the chitosan quaternary ammonium salt sterilization gauze on the supporting layer are provided with adhesive layers 9, the adhesive layers and the covering film are matched to form an adhesive part of the band-aid, a plurality of air holes (not shown in the figure) are formed in the adhesive part, and the use air permeability is improved.

The supporting layer, the covering film and the chitosan quaternary ammonium salt sterilization gauze are manufactured through a physical pressing process, and the supporting layer and the chitosan quaternary ammonium salt sterilization gauze are completely covered by the covering film.

The tearing layer of the embodiment comprises an A glue layer 1 adhered on the iodophor layer and a B glue layer 7 adhered on the covering layer, wherein the B glue layer is adhered with the A glue layer, the covering layer is torn when the tearing layer is used, the A glue layer is torn along the B glue layer,

when the chitosan quaternary ammonium salt sterilization layer is used, the covering layer is torn, the adhesive layer A is torn along the adhesive layer B, and the iodophor solution in the unit gel balls is leached, so that the use comfort is improved while the wound is sterilized, and the sterilization effect of the chitosan quaternary ammonium salt sterilization layer can be promoted. The paste part is pasted on an affected part, the cold compress layer contacts with air to be vaporized and takes away heat, so that the effect of local cooling can be achieved, and the medicine can rapidly penetrate through the fat layer through the medicine components after the hydrogel is combined, and then permeates into subcutaneous tissues to reach the focus, so that the effects and effects of cold compress pain relief, percutaneous absorption and sustained release administration are achieved.

Although the embodiments of the present invention have been disclosed for illustrative purposes, those skilled in the art will appreciate that: various substitutions, changes and modifications are possible without departing from the spirit and scope of the invention and the appended claims, and therefore the scope of the invention is not limited to the embodiments disclosed.