用于癌症诊断的肿瘤来源的外泌体的免疫应答谱分析

文档序号:1343388 发布日期:2020-07-17 浏览:1次 >En<

阅读说明:本技术 用于癌症诊断的肿瘤来源的外泌体的免疫应答谱分析 (Immune response profiling of tumor-derived exosomes for cancer diagnosis ) 是由 应仪如 郑毅然 李怡霏 于 2018-12-06 设计创作,主要内容包括:本发明总体涉及产生肿瘤来源的外泌体诱导的免疫应答或癌症特异性应答谱,其通过从患有特定癌症类型的患者的血液样品分离肿瘤来源的外泌体,并体外测定肿瘤来源的外泌体对免疫细胞尤其是T细胞的免疫学影响来进行。所述肿瘤来源的外泌体诱导的免疫应答或产生的癌症特异性应答谱可用于检测或诊断受试者中的癌症或癌症类型以及鉴定受试者患有的癌症类型是否响应于该癌症类型的治疗的方法中。(The present invention relates generally to generating tumor-derived exosome-induced immune responses or cancer-specific response profiles by isolating tumor-derived exosomes from blood samples of patients with specific cancer types and determining in vitro the immunological impact of the tumor-derived exosomes on immune cells, particularly T cells. The tumor-derived exosomes induce immune responses or generate cancer-specific response profiles that are useful in methods of detecting or diagnosing cancer or a type of cancer in a subject and identifying whether a subject has a type of cancer responsive to treatment for that type of cancer.)

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