阅读说明：本技术 一种治疗小儿夜啼的中药组合及制备工艺 (Traditional Chinese medicine composition for treating nocturnal fretfulness infants and preparation process ) 是由 陈文文 李�根 江永贤 陶婉君 杨佳 杨卓 于 2020-06-30 设计创作，主要内容包括：本发明公开了一种治疗小儿夜啼的中药组合及制备工艺,包括如下步骤：1)称取党参、炒白术、伏神、钩藤、酸枣仁、蝉花、炙甘草七味中药加8倍量水煎煮2小时,过滤得第一提取液；2)取步骤1)的滤渣加6倍量水煎煮1小时,过滤得第二提取液；3)合并第一提取液和第二提取液,过滤,滤液浓缩至50℃温度下相对密度为1.2的清膏,喷雾干燥；4)可溶性淀粉150份,甜菊素0.3份,制成颗粒,干燥,得到无蔗糖中药颗粒。本发明的小儿夜啼的中药组合,组方精简,治养结合,能够对脾虚气滞和惊恐伤神引起的小儿夜啼进行多方位的调理,健脾利湿,宁心镇惊,增强婴幼儿睡眠质量。(The invention discloses a traditional Chinese medicine composition for treating nocturnal fretfulness infants and a preparation process thereof, and the traditional Chinese medicine composition comprises the following steps: 1) weighing seven traditional Chinese medicines of codonopsis pilosula, fried bighead atractylodes rhizome, fushen, uncaria, spina date seed, cicada fungus and honey-fried licorice root, adding 8 times of water, decocting for 2 hours, and filtering to obtain a first extracting solution; 2) adding 6 times of water into the filter residue obtained in the step 1), decocting for 1 hour, and filtering to obtain a second extracting solution; 3) mixing the first and second extractive solutions, filtering, concentrating the filtrate to fluid extract with relative density of 1.2 at 50 deg.C, and spray drying; 4) 150 parts of soluble starch and 0.3 part of steviosin, and preparing into granules and drying to obtain the sucrose-free traditional Chinese medicine granules. The traditional Chinese medicine composition for treating the nocturnal fretfulness of the infants is simple in formula and combines treatment and nourishment, can be used for comprehensively conditioning the nocturnal fretfulness of the infants caused by spleen deficiency, qi stagnation and panic and spirit impairment, tonifying spleen and removing dampness, calming heart and relieving convulsion, and improving the sleep quality of the infants.)

1. The traditional Chinese medicine composition for treating nocturnal fretfulness infants is characterized by comprising the following components in parts by mass: 180 portions of codonopsis pilosula, 220 portions of fried atractylodes macrocephala, 180 portions of fushen, 220 portions of uncaria, 90-110 portions of spina date seed, 90-110 portions of cicada flower and 90-110 portions of honey-fried licorice root.

2. The traditional Chinese medicine composition for treating nocturnal fretfulness infants according to claim 1, which comprises the following components in parts by mass: 200 parts of codonopsis pilosula, 200 parts of fried bighead atractylodes rhizome, 200 parts of fushen, 100 parts of uncaria, 100 parts of spina date seed, 100 parts of cicada fungus and 100 parts of honey-fried licorice root.

3. A preparation process of a traditional Chinese medicine composition for treating nocturnal fretfulness infants is characterized by comprising the following steps: 1) weighing seven traditional Chinese medicines of codonopsis pilosula, fried bighead atractylodes rhizome, fushen, uncaria, spina date seed, cicada fungus and honey-fried licorice root according to a proportion, adding 8 times of water, decocting for 2 hours, and filtering to obtain a first extracting solution; 2) adding 6 times of water into the filter residue obtained in the step 1), decocting for 1 hour, and filtering to obtain a second extracting solution; 3) mixing the first and second extractive solutions, filtering, concentrating the filtrate to fluid extract with relative density of 1.2 at 50 deg.C, and spray drying; 4) adding soluble starch and steviosin, granulating, and drying to obtain sucrose-free Chinese medicinal granule.

4. The preparation process of the traditional Chinese medicine composition for treating nocturnal fretfulness infants according to claim 3, characterized in that 150 parts of soluble starch and 0.3 part of stevioside are added.

Technical Field

The invention relates to the field of traditional Chinese medicines, and in particular relates to a traditional Chinese medicine composition for treating nocturnal fretfulness infants and a preparation process thereof.

Background

The syndrome of integrated infant and night cry: the morbid night crying of infants is characterized by several syndromes: there are chills in the zang-fu organs, heart-heat, restlessness, and frisby crying, and the difference of the chills and the fever should be clearly distinguished. ' night cry of infants is classified into spleen cold and qi stagnation type, heart channel heat accumulation type and panic and nerve injury type. At present, dosage forms and medicines suitable for children are relatively lacked, Chinese patent medicines on the market are few in variety, only one infant nocturnal fretfulness granule is provided, and the components of the granule comprise 150g of sophora flower, 70g of microcos paniculata, 30g of hawthorn leaf, 70g of fructus forsythiae, 30g of honeysuckle, 30g of chrysanthemum, 30g of lophatherum gracile, 30g of rush, 8g of cicada slough, 150g of uncaria, 8g of liquorice and 793g of cane sugar; the variety only aims at the syndrome of nocturnal fretfulness in infants caused by disharmony between the spleen and the stomach and food accumulation and heat transformation, and cannot meet the actual clinical needs.

Meanwhile, the preparation process comprises the steps of adding water into the eleven medicinal materials, decocting for three times, each time lasting for 2 hours, mixing decoctions, filtering, concentrating the filtrate into thick paste with the relative density of 1.35-1.40 (80 ℃), adding cane sugar, mixing uniformly, granulating by using 75% ethanol, and drying to obtain the traditional Chinese medicine. The process has the defects of large viscosity, strong hygroscopicity, difficult molding, difficult granulation, easy moisture absorption and adhesion of the prepared granules, unstable quality and the like of the traditional Chinese medicine extract added with the cane sugar. The granule is sugar-containing granule, and is not suitable for patients with damp turbidity, such as patients with thick tongue coating, gastric acid regurgitation and distention, gastric ulcer, etc., and can also cause infantile dental caries if sucrose is taken for a long time.

Disclosure of Invention

In order to solve the problems, the invention provides a traditional Chinese medicine composition for treating nocturnal fretfulness infants and a preparation process thereof, the composition is simple, the treatment and nourishing are combined, the multidirectional conditioning can be performed on the nocturnal fretfulness infants caused by spleen deficiency, qi stagnation and panic and nerve hurting, the spleen is strengthened, the dampness is excreted, the heart is calmed, the convulsion is relieved, and the sleep quality of the infants is enhanced; the prepared granules do not contain sucrose, have good formability and solubility, are not easy to absorb moisture and adhere, and have stable quality.

The invention is realized by the following technical scheme:

a traditional Chinese medicine composition for treating nocturnal fretfulness infants comprises the following components in parts by mass: 180 portions of codonopsis pilosula, 220 portions of fried atractylodes macrocephala, 180 portions of fushen, 220 portions of uncaria, 90-110 portions of spina date seed, 90-110 portions of cicada flower and 90-110 portions of honey-fried licorice root.

A traditional Chinese medicine composition for treating nocturnal fretfulness infants comprises the following components in parts by mass: 200 parts of codonopsis pilosula, 200 parts of fried bighead atractylodes rhizome, 200 parts of fushen, 100 parts of uncaria, 100 parts of spina date seed, 100 parts of cicada fungus and 100 parts of honey-fried licorice root.

A preparation process of a traditional Chinese medicine composition for treating nocturnal fretfulness infants comprises the following steps: 1) weighing seven traditional Chinese medicines of 180 portions of codonopsis pilosula, 220 portions of fried rhizoma atractylodis macrocephalae, 220 portions of fushen, 90-110 portions of uncaria, 90-110 portions of spina date seeds, 90-110 portions of cicada fungus and 90-110 portions of honey-fried licorice root, adding 8 times of water, decocting for 2 hours, and filtering to obtain a first extracting solution; 2) adding 6 times of water into the filter residue obtained in the step 1), decocting for 1 hour, and filtering to obtain a second extracting solution; 3) mixing the first and second extractive solutions, filtering, concentrating the filtrate to fluid extract with relative density of 1.2 at 50 deg.C, and spray drying; 4) 150 parts of soluble starch and 0.3 part of steviosin, and preparing into granules and drying to obtain the sucrose-free traditional Chinese medicine granules.

The traditional Chinese medicine composition for treating the nocturnal fretfulness of the infants is simple in formula and combines treatment and nourishment, can be used for comprehensively conditioning the nocturnal fretfulness of the infants caused by spleen deficiency, qi stagnation and panic and spirit impairment, tonifying spleen, promoting qi circulation, removing dampness, calming heart, relieving convulsion and enhancing the sleep quality of the infants. In the formula, because spleen deficiency is easy to generate dampness, the main medicine codonopsis pilosula is sweet and warm, strengthens the spleen and nourishes the stomach, tonifies middle-jiao energy, strengthens the spleen and stomach, enhances the transportation and transformation capability and generates qi and blood; the bighead atractylodes rhizome is sweet, bitter and slightly warm in taste, can tonify middle-jiao and qi, strengthen spleen and stomach, eliminate dampness and promote diuresis, is used in combination with the codonopsis pilosula, can enhance the spleen and qi tonifying function of the codonopsis pilosula, eliminate dampness and assist transportation and transformation as a ministerial drug; the poria cocos is sweet and light in flavor, can excrete dampness, invigorate spleen, calm heart, and help the bighead atractylodes rhizome to invigorate spleen and remove dampness as an adjuvant drug; the uncaria is sweet in nature and taste and cool, is most suitable for the constitution of infants with insufficient yin and exuberant yang, has the effects of clearing heat and calming the liver, calming endogenous wind and arresting convulsion, is used for treating infantile cry and dysphoria with smothery sensation caused by liver wind fire, and is an adjuvant drug; the spina date seed is sweet and sour in taste and neutral in nature, has the effects of tonifying liver, calming heart, arresting sweating and promoting the secretion of saliva or body fluid, is used for treating dysphoria and insomnia, palpitation and dreaminess, is supplemented with uncaria for enhancing the effects of calming heart and arresting convulsion, and is used as an adjuvant drug; prepared licorice root, radix Glycyrrhizae Praeparata, sweet and warm in taste, acts as a guiding drug for tonifying the middle-jiao and regulating the stomach.

Compared with the prior art, the invention has the following advantages and beneficial effects:

1. the traditional Chinese medicine composition for treating nocturnal fretfulness infants is simple in formula and combined with treatment and nourishment, can be used for conditioning nocturnal fretfulness infants caused by spleen deficiency, qi stagnation and panic and spirit impairment in a multidirectional manner, and is capable of tonifying spleen to promote diuresis, calming heart and relieving convulsion and enhancing the sleep quality of infants;

2. according to the traditional Chinese medicine composition for treating nocturnal fretfulness in infants and the preparation process, sucrose is not added, and the prepared granules are good in formability and solubility, not prone to moisture absorption and adhesion and stable in quality.

Detailed Description

In order to make the objects, technical solutions and advantages of the present invention more apparent, the present invention is further described in detail below with reference to examples, and the exemplary embodiments and descriptions thereof are only used for explaining the present invention and are not used as limitations of the present invention.