阅读说明：本技术 一种抑菌中药配方及其制备方法 (Bacteriostatic traditional Chinese medicine formula and preparation method thereof ) 是由 王瑞锋 于 2020-06-04 设计创作，主要内容包括：本发明公开了一种抑菌中药配方,属于中药制备技术领域,由下列物质制成：丹参、枯矾、当归、大黄、15份黄芩、35份黄柏、25份龙胆草、35份金银花、35份苦参、35份藿香、20份薄荷、8份甘草、6份苦楝子、4份板蓝根、2份虎杖、5份牡丹皮、5份五味子。本发明配方原料成分相对简单,整体成本较低,易于生产制造,能够穿透皮肤深层,对女性私处的细菌、真菌、霉菌、病毒等有效触杀,很好的平衡了菌群,有效保护了女性妇科健康。(The invention discloses an antibacterial traditional Chinese medicine formula, which belongs to the technical field of traditional Chinese medicine preparation and is prepared from the following substances: red sage root, dried alum, angelica, rhubarb, 15 parts of scutellaria, 35 parts of phellodendron, 25 parts of gentian, 35 parts of honeysuckle, 35 parts of sophora flavescens, 35 parts of wrinkled gianthyssop, 20 parts of mint, 8 parts of liquorice, 6 parts of chinaberry fruit, 4 parts of isatis root, 2 parts of giant knotweed, 5 parts of tree peony bark and 5 parts of schisandra. The formula disclosed by the invention is relatively simple in raw material components, low in overall cost and easy to produce and manufacture, can penetrate deep layers of skin, effectively kills bacteria, fungi, mildew, viruses and the like in female private parts by contact, well balances flora, and effectively protects female gynecological health.)

1. The bacteriostatic traditional Chinese medicine formula is characterized by being prepared from the following substances in parts by weight:

10-15 parts of salvia miltiorrhiza, 15-20 parts of dried alum, 10-15 parts of angelica, 10-15 parts of rhubarb, 10-15 parts of scutellaria baicalensis, 30-35 parts of golden cypress, 20-25 parts of gentian, 30-35 parts of honeysuckle, 30-35 parts of sophora flavescens, 30-35 parts of wrinkled gianthyssop, 15-20 parts of mint, 6-8 parts of liquorice, 3-6 parts of chinaberry fruit, 2-4 parts of isatis root, 1-2 parts of polygonum cuspidatum, 3-5 parts of moutan bark and 2-5 parts of schisandra chinensis.

2. The bacteriostatic traditional Chinese medicine formula according to claim 1, which is prepared from the following substances in parts by weight:

13 parts of salvia miltiorrhiza, 18 parts of dried alum, 12 parts of angelica, 12 parts of rhubarb, 12 parts of scutellaria, 32 parts of phellodendron, 24 parts of gentian, 33 parts of honeysuckle, 32 parts of sophora flavescens, 33 parts of wrinkled gianthyssop herb, 18 parts of mint, 7 parts of liquorice, 5 parts of chinaberry fruit, 3 parts of isatis root, 1.5 parts of giant knotweed rhizome, 4 parts of moutan bark and 4 parts of schisandra chinensis.

3. The preparation method of the bacteriostatic traditional Chinese medicine formula according to claim 1 or 2, characterized by comprising the following steps:

(1) selecting red sage root, angelica, rhubarb and scutellaria baicalensis, removing impurities, crushing, sieving with a 80-mesh sieve, performing chromatography by using anhydrous ethanol with the volume of 3-6 times of that of the red sage root, angelica, rhubarb and scutellaria baicalensis, performing reflux extraction for 2-4 times, controlling the time length for each time to be 30-35 min, and finally collecting eluent to obtain an extracting solution A for later use;

(2) selecting golden cypress, felwort, honeysuckle, radix sophorae flavescentis and agastache rugosus to remove impurities, then spraying clear water to clean, fishing out, shredding, drying in the sun, crushing, sieving with a 100-mesh sieve, then carrying out chromatography by using absolute ethyl alcohol with the volume of 5-7 times of that of the crushed materials, carrying out reflux extraction for 3-5 times, controlling the time length for each time to be 60-70 min, and finally collecting eluent to obtain an extracting solution B for later use;

(3) selecting mint, liquorice, chinaberry fruit, isatis root, giant knotweed, tree peony bark and Chinese magnoliavine fruit to remove impurities, then spraying clear water to clean, fishing out, mixing with dried alum, drying, crushing, sieving with a 120-mesh sieve, then carrying out ultrasonic extraction for 2-2.5 h by using 90% ethanol with the volume being 10-12 times of that of the mixture, and finally carrying out suction filtration to obtain filtrate C for later use;

(4) mixing the extract A obtained in the step (1), the extract B obtained in the step (2) and the filtrate C obtained in the step (3), and finally sterilizing.

4. The preparation method of a bacteriostatic traditional Chinese medicine formula according to claim 3, characterized in that the drying temperature in step (3) is 80-85 ℃.

5. The preparation method of a bacteriostatic traditional Chinese medicine formula according to claim 3, characterized in that, the frequency of the ultrasonic wave is controlled to be 300-360 kHz during the ultrasonic wave extraction in the step (3).

Technical Field

The invention belongs to the technical field of traditional Chinese medicine preparation, and particularly relates to an antibacterial traditional Chinese medicine formula and a preparation method thereof.

Background

The physiological structure of female reproductive organs is special, is easy to be polluted by the outside, is not easy to clean and keep dry, provides a hotbed for breeding various bacteria, and the breeding of pathogenic bacteria breaks the balance system of the reproductive organs with flora, influences the self-cleaning and vaginal waste removal functions of the reproductive organs and easily causes gynecological inflammation. At present, a plurality of lotion for treating or nursing reproductive organs are available, but the main components of the lotion are strong bactericides such as antibiotics and the like, the sterilization effect is rapid, but the antibacterial and sterilization types are single, the drug resistance is easy to generate, and the strong bactericides can generate chemical stimulation to reproductive organs, destroy the PH environment of the reproductive organs, and easily cause repeated attack of allergy and inflammation. The gynecological inflammation belongs to the downward flow of damp-heat according to the theoretical explanation of the traditional Chinese medicine, and is prepared by using the traditional Chinese medicines with the functions of clearing heat, drying dampness, purging fire, detoxifying, killing parasites and relieving itching, so that the aims of bacteriostasis and inflammation diminishing can be achieved.

Disclosure of Invention

The invention aims to provide a bacteriostatic traditional Chinese medicine formula and a preparation method thereof.

The technical purpose of the invention is realized by the following technical scheme:

an antibacterial traditional Chinese medicine formula is prepared from the following substances in parts by weight:

10-15 parts of salvia miltiorrhiza, 15-20 parts of dried alum, 10-15 parts of angelica, 10-15 parts of rhubarb, 10-15 parts of scutellaria baicalensis, 30-35 parts of golden cypress, 20-25 parts of gentian, 30-35 parts of honeysuckle, 30-35 parts of sophora flavescens, 30-35 parts of wrinkled gianthyssop, 15-20 parts of mint, 6-8 parts of liquorice, 3-6 parts of chinaberry fruit, 2-4 parts of isatis root, 1-2 parts of polygonum cuspidatum, 3-5 parts of moutan bark and 2-5 parts of schisandra chinensis.

Preferably, the food is prepared from the following substances in parts by weight:

13 parts of salvia miltiorrhiza, 18 parts of dried alum, 12 parts of angelica, 12 parts of rhubarb, 12 parts of scutellaria, 32 parts of phellodendron, 24 parts of gentian, 33 parts of honeysuckle, 32 parts of sophora flavescens, 33 parts of wrinkled gianthyssop herb, 18 parts of mint, 7 parts of liquorice, 5 parts of chinaberry fruit, 3 parts of isatis root, 1.5 parts of giant knotweed rhizome, 4 parts of moutan bark and 4 parts of schisandra chinensis.

A preparation method of a bacteriostatic traditional Chinese medicine formula comprises the following steps:

(1) selecting red sage root, angelica, rhubarb and scutellaria baicalensis, removing impurities, crushing, sieving with a 80-mesh sieve, performing chromatography by using anhydrous ethanol with the volume of 3-6 times of that of the red sage root, angelica, rhubarb and scutellaria baicalensis, performing reflux extraction for 2-4 times, controlling the time length for each time to be 30-35 min, and finally collecting eluent to obtain an extracting solution A for later use;

(2) selecting golden cypress, felwort, honeysuckle, radix sophorae flavescentis and agastache rugosus to remove impurities, then spraying clear water to clean, fishing out, shredding, drying in the sun, crushing, sieving with a 100-mesh sieve, then carrying out chromatography by using absolute ethyl alcohol with the volume of 5-7 times of that of the crushed materials, carrying out reflux extraction for 3-5 times, controlling the time length for each time to be 60-70 min, and finally collecting eluent to obtain an extracting solution B for later use;

(3) selecting mint, liquorice, chinaberry fruit, isatis root, giant knotweed, tree peony bark and Chinese magnoliavine fruit to remove impurities, then spraying clear water to clean, fishing out, mixing with dried alum, drying, crushing, sieving with a 120-mesh sieve, then carrying out ultrasonic extraction for 2-2.5 h by using 90% ethanol with the volume being 10-12 times of that of the mixture, and finally carrying out suction filtration to obtain filtrate C for later use;

(4) mixing the extract A obtained in the step (1), the extract B obtained in the step (2) and the filtrate C obtained in the step (3), and finally sterilizing.

Further, the drying temperature in the step (3) is 80-85 ℃.

Further, the frequency of the ultrasonic wave is controlled to be 300-360 kHz during the ultrasonic wave extraction in the step (3).

Compared with the prior art, the invention has the following advantages:

the invention provides a new traditional Chinese medicine formula component, which has strong antibacterial and sterilization effects under the coordination of various components, can penetrate through the deep layer of skin, effectively kills bacteria, fungi, mildew, viruses and the like in female private parts, well balances flora, has the characteristics of relieving itching, clearing heat, detoxifying, resisting inflammation and resisting allergy, does not generate drug resistance after long-term use, has no side reaction, and is safe and reliable. The formula of the invention has relatively simple raw material components, low overall cost and easy production and manufacture, well protects the female gynecological health and has great market competitiveness.

Detailed Description

The present invention is further illustrated by the following specific examples, which are not intended to limit the invention in any way. Reagents, methods and apparatus used in the present invention are conventional in the art unless otherwise indicated.