阅读说明：本技术 可降解吸收医用缝合线制备方法及该缝合线的配料设备 (Preparation method of degradable and absorbable medical suture and batching equipment of suture ) 是由 吴德成 李春博 申金彪 于 2019-12-18 设计创作，主要内容包括：本发明涉及一种可降解吸收医用缝合线制备方法及该缝合线的配料设备,其特征在于：包括如下步骤：S1：芯纱的制作：S2：编织层的制作：S3：将步骤一所得芯纱和将步骤二所得编织层的单股绳编织在一起：S4：抗菌涂覆层的制作。本发明所述的可降解吸收医用缝合线制备方法及该缝合线的配料设备,工艺简单,操作方便,成本低廉以及能耗低,极具应用前景；本发明所述的可降解吸收医用缝合线制备方法及该缝合线的配料设备,能够有效提高了纤维以及最终制得的医用缝合线的力学性能及载药性能；本发明所述的可降解吸收医用缝合线制备方法及该缝合线的配料设备,可保持缝合线的外观与机械性物理性质的同时可增进生物相容性与人体内各种生理活性效果。(The invention relates to a preparation method of a degradable and absorbable medical suture and batching equipment of the suture, which is characterized in that: the method comprises the following steps: s1: making a core yarn: s2: manufacturing a woven layer: s3: weaving the core yarn obtained in the step one and the single-strand ropes of the woven layer obtained in the step two together: s4: and (5) manufacturing an antibacterial coating layer. The preparation method of the degradable and absorbable medical suture line and the batching equipment of the suture line have the advantages of simple process, convenient operation, low cost and low energy consumption, and have great application prospect; the preparation method of the degradable and absorbable medical suture and the batching equipment of the suture can effectively improve the mechanical property and the drug-loading property of the fiber and the finally prepared medical suture; the preparation method of the degradable and absorbable medical suture and the batching equipment of the suture can maintain the appearance and the mechanical physical properties of the suture and simultaneously improve the biocompatibility and various physiological activity effects in a human body.)

1. A preparation method of a degradable and absorbable medical suture and a batching device of the suture are characterized in that: the method comprises the following steps:

s1: production of the core yarn (1):

s11, weighing the raw materials, chitosan and hyaluronic acid according to the requirement, dissolving the chitosan in an acetic acid solution, and stirring to obtain a first mixture;

s12, adding hyaluronic acid into the first mixture, stirring at the speed of 150-200rpm for 5-8min, and defoaming to obtain a coating solution;

s13, coating the suture I with the coating solution, and then drying to obtain a core yarn (1);

s2: manufacturing a braided layer (2):

s21, weighing the raw materials, chitosan and hyaluronic acid according to the requirement, dissolving the chitosan in an acetic acid solution, and stirring to obtain a first mixture;

s22, adding hyaluronic acid into the first mixture, stirring at the speed of 150-200rpm for 5-8min, and defoaming to obtain a coating solution;

s23, coating the suture II with the coating solution, and then drying to obtain a single strand of the braided layer (2);

s3: weaving the core yarn (1) obtained in the step one and the single-strand rope of the weaving layer (2) obtained in the step two together:

s31, taking single strands of a plurality of weaving layers (2) and core yarns (1), and connecting the head ends and the tail ends of the core yarns (1) to form an annular guide piece; wherein, the single-stranded rope of the braided layer (2) is arranged into a spiral structure;

s32, connecting the head end and the tail end of the core yarn (1) to form an annular guide piece, and winding the single-strand rope of the woven layer (2) on the annular guide piece to arrange the annular guide piece at the central position of the spiral structure of the single-strand rope of the woven layer (2);

s33, arranging single strands of the plurality of braided layers (2) to be wound outside the annular guide piece and tightly attached to the annular guide piece to obtain the braided layers (2);

s4: manufacturing an antibacterial coating layer (3):

and (3) taking the coating solution prepared in the step two, coating the combination of the core yarn (1) and the weaving layer (2) obtained in the step three with the coating solution, and then drying to obtain the medical operation suture with the antibacterial coating layer (3).

2. The method for preparing a degradable and absorbable medical suture line and the dispensing equipment for the suture line according to claim 1, wherein: braided layer (2) is the winding structure that six single strands of ropes constitute, is first strand rope, second strand rope, third strand rope, fourth strand rope, fifth strand rope, sixth strand rope respectively.

3. The preparation method of the degradable medical suture line and the blending equipment of the suture line according to claim 2 are characterized in that: the first strand of rope is spirally wound on the core yarn (1); the second strand is spirally wound on the core yarn (1) and tightly presses the first strand; the third strand is spirally wound on the core yarn (1) and tightly presses the second strand; the fourth strand is spirally wound on the core yarn (1) and tightly presses the third strand; the fifth strand is spirally wound on the core yarn (1) and tightly presses the fourth strand; the sixth strand is spirally wound around the core yarn (1) and compresses the fifth strand.

4. The method for preparing a degradable and absorbable medical suture line and the dispensing equipment thereof as claimed in claim 4, wherein: the suture is an absorbent suture.

5. The method for preparing a degradable and absorbable medical suture line and the dispensing equipment thereof as claimed in claim 4, wherein: the steps S11 and S12 are performed in the batching device, the batching device is a batching tank and comprises a batching tank body (4), the upper part of the batching tank body (4) is provided with a plurality of feeding ports (5) for feeding, different types of materials can be fed into the batching tank body (4) for mixing, a mixing motor (6) is fixed at the top of the batching tank body (4), an output shaft of the mixing motor (6) is fixedly connected with a mixing shaft (7), the mixing shaft (7) extends into the batching tank body (4), a stirring paddle (8) for stirring the materials is fixed at the bottom of the mixing shaft (7), the bottom of the batching tank body (4) is of a hemispherical structure, a discharging device (9) for discharging is fixed at the lowest point position of the bottom of the batching tank body (4), the discharging device (9) is a liquid pump, and a discharging pipe (10) is connected to a discharging port of the discharging device (9), the bottom of the batching tank body (4) is also provided with a supporting column base (11); the hybrid motor (6) is a variable frequency motor, and the hybrid motor (6) is connected to 380V industrial electricity.

6. The method for preparing a degradable and absorbable medical suture line and the dispensing equipment for the suture line according to claim 5 are characterized in that: the coating solution is prepared by adding the following raw materials into a stirring kettle according to the mass percentage and uniformly stirring the raw materials by a batching tank: 10-30 parts of chitosan: 0.6-0.9 of hyaluronic acid; the concentration of the acetic acid solution is 0.6-5.0 mmol/L.

7. The method for preparing degradable and absorbable medical suture line and the dispensing equipment thereof as claimed in claim 6, wherein: the coating solution is prepared by adding the following raw materials into a stirring kettle according to the mass percentage and uniformly stirring the raw materials by a batching tank: and (3) chitosan 26: 0.8 of hyaluronic acid; the concentration of the acetic acid solution was 3.6 mmol/L.

8. The method for preparing a degradable and absorbable medical suture line and the dispensing equipment for the suture line according to claim 7, wherein: the drying is gone on in the drying cabinet, the drying cabinet includes outer container (12), outer container (12) embeds there is inner box (13), inner box (13) roof is detachable construction, be provided with gas vent (18) on the roof, the clearance has between outer container (12) and inner box (13), this clearance is annular inner chamber, install heater strip (14) in the cavity, annular inner chamber's top has annular last shrouding (15), upward install fan (16) on shrouding (15), the air intake and the external world of fan (16) are linked together, the air outlet and the annular inner chamber of fan (16) are linked together, thing board (19) are put to the inside of inner box (13), air intake (17) have been seted up to the bottom of inner box (13), the inner chamber and the annular inner chamber of inner box (13) are linked together through air intake (17).

9. A degradable medical suture line which is characterized in that: the method according to any one of claims 1 to 4, wherein the suture thread material is a multi-strand braided thread comprising a core yarn (1), a braided layer (2) and an antimicrobial coating layer (3), the braided layer (2) being provided outside the core yarn (1) and the antimicrobial coating layer (3) being provided outside the braided layer (2).

10. The degradable absorbable medical suture of claim 9, wherein: the suture thread is 35 cm in length, circular in cross-section and 5 mm in diameter.

Technical Field

The invention relates to a preparation method of a degradable and absorbable medical suture and batching equipment of the suture, belonging to the technical field of preparation of medical sutures.

Background

Suture (stitch) refers to a thread for suturing a wound or a portion of a human body damaged by an operation or the like. At the beginning of suture, catgut (catgut) extracted from organs such as sheep, pig, and horse intestines or tendons is widely used, but its use is gradually reduced due to improper use, tissue rejection, and spread of diseases from animals due to low strength. Since alternative materials such as nylon and silk, which are synthetic polymer materials having high physical properties, have been developed and widely used, they are not decomposable in the human body and are not physiologically compatible, and therefore, they should be removed by additional surgery after a predetermined period of time has passed after surgery, and thus, they are not easily used, and thus, they are limited in use.

The chitosan fiber belongs to a natural material, has the advantages of no toxicity, hemostasis, inflammation diminishing and the like, has good compatibility with biological cells, has small immunogenicity, and does not generate rejection reaction with body fluid and cells; the biodegradable chitosan can be biodegraded, and the degradation product in organisms is glucosamine; glucosamine is harmless to human bodies and does not accumulate in the bodies, so chitosan has wide application prospect in the field of biological medicines. The chitosan and the derivatives thereof have the effects of promoting wound healing, preventing tissue adhesion, resisting blood coagulation, reducing blood fat, reducing cholesterol, resisting ulcer, resisting tumor and the like when being used as a tissue scaffold, a drug carrier and the like, are often used as medical sutures, but are influenced by raw materials, and the main reason for restricting the development of chitosan fibers is that the mechanical strength of the chitosan fibers is not high, and the breaking strength of the chitosan fibers obtained by conventional spinning is only 1.07 cNntex, which is far from meeting the requirement of practical application. Therefore, the chitosan fiber is enhanced to improve the mechanical property of the chitosan fiber.

Disclosure of Invention

According to the defects in the prior art, the technical problems to be solved by the invention are as follows: in order to solve one of the problems, a preparation method of a degradable and absorbable medical suture and a dispensing device of the suture are provided.

The invention relates to a preparation method of a degradable and absorbable medical suture and a batching device of the suture, which is characterized in that: the method comprises the following steps:

s1: making a core yarn:

s11, weighing the raw materials, chitosan and hyaluronic acid according to the requirement, dissolving the chitosan in an acetic acid solution, and stirring to obtain a first mixture;

s12, adding hyaluronic acid into the first mixture, stirring at the speed of 150-200rpm for 5-8min, and defoaming to obtain a coating solution;

s13, coating the suture I with the coating solution, and then drying to obtain core yarn;

s2: manufacturing a woven layer:

s21, weighing the raw materials, chitosan and hyaluronic acid according to the requirement, dissolving the chitosan in an acetic acid solution, and stirring to obtain a first mixture;

s22, adding hyaluronic acid into the first mixture, stirring at the speed of 150-200rpm for 5-8min, and defoaming to obtain a coating solution;

s23, coating the suture II with the coating solution, and then drying to obtain a single strand of the braided layer;

s3: weaving the core yarn obtained in the step one and the single-strand ropes of the woven layer obtained in the step two together:

s31, taking single strands and core yarns of a plurality of woven layers, and connecting the head ends and the tail ends of the core yarns to form an annular guide piece; wherein, the single-stranded rope of the braided layer is arranged into a spiral structure;

s32, connecting the two ends of the core yarn to form an annular guide piece, and winding the single-strand rope of the woven layer on the annular guide piece to arrange the annular guide piece at the central position of the spiral structure of the single-strand rope of the woven layer;

s33, arranging single strands of the braided layers to be wound outside the annular guide piece and tightly attached to the annular guide piece to obtain the braided layers;

s4: manufacturing an antibacterial coating layer:

and (4) taking the coating solution prepared in the step two, coating the core yarn and woven layer combined body obtained in the step three with the coating solution, and then drying to obtain the medical operation suture line with the antibacterial coating layer.

Preferably, the braided layer is a winding structure formed by six single strands of ropes, namely a first strand rope, a second strand rope, a third strand rope, a fourth strand rope, a fifth strand rope and a sixth strand rope.

Preferably, the first strand of rope is helically wound around the core yarn; the second strand is spirally wound on the core yarn and tightly presses the first strand; the third strand is spirally wound on the core yarn and tightly presses the second strand; the fourth strand is spirally wound on the core yarn and tightly presses the third strand; the fifth strand is spirally wound on the core yarn and tightly presses the fourth strand; the sixth strand is helically wound around the core yarn and compresses the fifth strand.

Preferably, the suture is an absorbent suture.

Preferably, the steps S11 and S12 are performed in a batching apparatus, the batching apparatus is a batching tank, and includes a batching tank body, the upper portion of the batching tank body is provided with a plurality of feeding ports for feeding, different types of materials can be fed into the batching tank body for mixing, a mixing motor is fixed at the top of the batching tank body, an output shaft of the mixing motor is fixedly connected with a mixing shaft, the mixing shaft extends into the batching tank body, a stirring paddle for stirring the materials is fixed at the bottom of the mixing shaft, the bottom of the batching tank body is of a hemispherical structure, a discharging device for discharging is fixed at the lowest point position of the bottom of the batching tank body, the discharging device is a liquid pump, a discharging pipe is connected to a discharging port of the discharging device, and a support column foot is further arranged at the bottom of the batching tank body; the hybrid motor is a variable frequency motor and is connected to 380V industrial electricity.

Preferably, the coating solution is obtained by adding the following raw materials into a stirring kettle according to the mass percentage and uniformly stirring the raw materials by a batching tank: 10-30 parts of chitosan: 0.6-0.9 of hyaluronic acid; the concentration of the acetic acid solution is 0.6-5.0 mmol/L.

Preferably, the coating solution is obtained by adding the following raw materials into a stirring kettle according to the mass percentage and uniformly stirring the raw materials by a batching tank: and (3) chitosan 26: 0.8 of hyaluronic acid; the concentration of the acetic acid solution was 3.6 mmol/L.

Preferably, the drying is carried out in the drying cabinet, the drying cabinet includes the outer container, the outer container embeds there is the inner box, the inner box roof is detachable construction, be provided with the gas vent on the roof, the clearance has between outer container and the inner box, this clearance is annular inner chamber, install the heater strip in the cavity, annular inner chamber's top has annular last shrouding, go up and install the fan on the shrouding, the air intake and the external world of fan are linked together, the air outlet and the annular inner chamber of fan are linked together, the thing board has been placed to the inside of inner box, the air intake has been seted up to the bottom of inner box, inner chamber and the annular inner chamber with the inner.

The degradable and absorbable medical suture is prepared by the method, the suture wire is a multi-strand braided wire and comprises a core yarn, a braided layer and an antibacterial coating layer, the braided layer is arranged on the outer side of the core yarn, and the antibacterial coating layer is arranged on the outer side of the braided layer.

Preferably, the suture thread is 35 cm in length, circular in cross-section and 5 mm in diameter.

Compared with the prior art, the invention has the following beneficial effects:

the preparation method of the degradable and absorbable medical suture and the batching equipment of the suture have the advantages of simple process, convenient operation, low cost and energy consumption, and great application prospect;

the preparation method of the degradable and absorbable medical suture and the batching equipment of the suture can effectively improve the mechanical property and the drug-loading property of the fiber and the finally prepared medical suture;

the preparation method of the degradable and absorbable medical suture and the batching equipment of the suture can maintain the appearance and the mechanical physical properties of the suture and simultaneously improve the biocompatibility and various physiological activity effects in a human body.

Drawings

In order to more clearly illustrate the detailed description of the invention or the technical solutions in the prior art, the drawings that are needed in the detailed description of the invention or the prior art will be briefly described below. Throughout the drawings, like elements or portions are generally identified by like reference numerals. In the drawings, elements or portions are not necessarily drawn to scale.

FIG. 1 is a cross-sectional view of the present invention;

FIG. 2 is a process diagram of the present invention;

FIG. 3 is a block diagram of the dispensing tank;

fig. 4 is a structural view of the drying box.

In the figure: 1. core yarn 2, weaving layer 3, antibiotic coating 4, batching jar body 5, pan feeding mouth 6, hybrid motor 7, mixing shaft 8, stirring rake 9, discharging device 10, discharging pipe 11, support column base 12, outer container 13, inner box 14, heater strip 15, last shrouding 16, fan 17, air intake 18, gas vent 19, put the thing board.

Detailed Description

The invention is further described below with reference to the accompanying drawings:

the present invention is further illustrated by the following specific examples, which are not intended to limit the scope of the invention, and any modifications, equivalents, improvements, etc. made within the spirit and principle of the present invention should be included in the scope of the present invention.