阅读说明：本技术 一种新型复方独活吲哚美辛胶囊及其制备方法 (Novel compound pubescent angelica root and indometacin capsule and preparation method thereof ) 是由 张庆华 戴毅文 于 2019-11-15 设计创作，主要内容包括：本发明提供了一种新型复方独活吲哚美辛胶囊及其制备方法,包括以下重量份的组分：羌活30-60份,独活30-60份,牛膝30-60份,木瓜30-60份,吲哚美辛15-45份,和/或吡罗昔康5-20份；提供了两种制备新型复方独活吲哚美辛胶囊的方法：其一为先将组分羌活、独活、牛膝、木瓜称取混合之后,进行有效成分的提取,再将提取的有效成分浓缩干燥成粉,再与吲哚美辛和/或吡罗昔康于粉碎机中进行均匀混合,即得；其二是先将组分羌活、独活、牛膝、木瓜称取混合之后,进行有效成分的提取,再将提取的有效成分浓缩干燥成粉,再与吲哚美辛和/或吡罗昔康于粉碎机中进行均匀混合,即得。两种方法均能够得到高纯度的药用成分,抗炎效果更好、安全性更为可靠。(The invention provides a novel compound pubescent angelica and indometacin capsule and a preparation method thereof, wherein the capsule comprises the following components in parts by weight: 30-60 parts of notopterygium root, 30-60 parts of radix angelicae pubescentis, 30-60 parts of achyranthes root, 30-60 parts of pawpaw, 15-45 parts of indomethacin and/or 5-20 parts of piroxicam; two methods for preparing the novel compound pubescent angelica and indometacin capsule are provided: firstly, weighing and mixing components of notopterygium root, radix angelicae pubescentis, achyranthes root and pawpaw, extracting effective components, concentrating and drying the extracted effective components into powder, and uniformly mixing the powder with indometacin and/or piroxicam in a pulverizer to obtain the composition; and secondly, weighing and mixing the components of notopterygium root, radix angelicae pubescentis, achyranthes root and pawpaw, extracting effective components, concentrating and drying the extracted effective components into powder, and uniformly mixing the powder with indometacin and/or piroxicam in a pulverizer to obtain the composition. The two methods can obtain high-purity medicinal components, and have better anti-inflammatory effect and more reliable safety.)

1. A novel compound radix angelicae pubescentis and indometacin capsule is characterized by comprising the following components in parts by weight: 30-60 parts of notopterygium root, 30-60 parts of radix angelicae pubescentis, 30-60 parts of achyranthes root, 30-60 parts of pawpaw, 15-45 parts of indomethacin and/or 5-20 parts of piroxicam;

the radix angelicae pubescentis is the rhizome of radix angelicae pubescentis, the radix achyranthis bidentatae is the rhizome of radix achyranthis bidentatae, and the pawpaw is one or more of fruits and seeds of pawpaw.

2. The preparation method of the novel compound pubescent angelica indometacin capsule as claimed in claim 1, which comprises the following steps: firstly, respectively extracting effective components of notopterygium root, pubescent angelica root, twotooth achyranthes root and pawpaw, respectively filtering, concentrating and spray-drying the effective components of the components to obtain dry powder, uniformly mixing the dry powder of the components, and uniformly mixing the dry powder of the components with indometacin and/or piroxicam in a grinder to obtain the compound.

3. The preparation method of the compound radix angelicae pubescentis and indometacin capsule as claimed in claim 2, wherein the steps of extracting the effective components of the notopterygium root, the radix angelicae pubescentis, the achyranthes root and the pawpaw respectively are as follows:

s01, pulverizing Notopterygii rhizoma, sieving with a third sieve, precisely weighing Notopterygii rhizoma powder into a flask, adding water from the upper end of a condensation tube to fill the scale part of a volatile oil detector, overflowing into the flask, extracting volatile oil from Notopterygii rhizoma powder with the volatile oil detector while keeping the water in the flask slightly boiling, and refrigerating for use;

s02, weighing radix Angelicae Pubescentis, adding 75% methanol by volume, soaking for 20-40min, ultrasonic extracting at 50-65 deg.C for 30-60min, cooling, filtering, supplementing filtrate, and filtering with 0.45um microporous membrane to obtain effective components of radix Angelicae Pubescentis;

s03, weighing achyranthes powder, sieving the achyranthes powder by a No. four sieve, putting the achyranthes powder into a conical bottle with a plug, adding a 45% n-butyl alcohol solution by volume fraction, and weighing, wherein the liquid-material ratio is 12-18: 1, ultrasonic extracting for 1-2h, complementing the filtrate, centrifuging at 10000-15000r/min at 2-5 ℃ for 20-40min, and filtering the supernatant with a 0.45um microporous filter membrane to obtain the active ingredients of the achyranthes bidentata;

s04, precisely weighing coarse powder of fructus Chaenomelis, reflux-extracting with 8 times of 75% ethanol for 2 times, each time for 1-3 hr, concentrating the extractive solution in a rotary evaporator, quantitatively transferring the concentrated solution into a measuring flask, and diluting with 50% ethanol to constant volume to obtain fructus Chaenomelis ethanol extractive solution.

4. The preparation method of the novel compound pubescent angelica and indometacin capsule according to claim 3, wherein in the step S02, the effective components of the pubescent angelica are detected by a chromatographic column, and the chromatographic conditions are as follows: in a volume ratio of 44: 56 acetonitrile-water is used as a mobile phase, the column temperature is 30 ℃, the detection wavelength is 316nm, the flow rate is 1.0mL/min1, and the sample injection amount is 10 uL.

5. The preparation method of the novel compound pubescent angelica indometacin capsule according to claim 3, wherein in the step S03, the power of ultrasonic extraction is 250W, and the frequency is 40 kHz;

taking the subsequent filtrate passing through the microporous membrane as a test solution of the effective components of radix angelicae pubescentis, and carrying out liquid chromatography detection on the effective components of radix achyranthis bidentatae, wherein the chromatography conditions are as follows: taking acetonitrile-0.1% formic acid water as a mobile phase, carrying out gradient elution at a column temperature of 30 ℃, a flow rate of 1.0ml/min, a detection wavelength of 254nm and a sample amount of 10u 1.

6. The method for preparing the compound pubescent angelica indometacin capsule as claimed in claim 3, wherein in step S04, the dregs of papaya after alcohol extraction are taken, dried at 50-65 ℃ to constant weight, 10g of the dried dregs are precisely weighed, and extracted under reflux with 10-13 times of water as solvent for 1.5-3 hours to obtain the solution of papaya to be tested, and the chromatographic column is used for detection, and the chromatographic conditions are as follows: the volume ratio is 265: 35: 0.1: 0.05 of methanol-water-glacial acetic acid-triethylamine is taken as a mobile phase, the flow rate is 0.6mL/min1, the column temperature is 20 ℃, the detection wavelength is 210nm, and the sample injection amount is 20 uL.

7. The preparation method of the novel compound pubescent angelica indometacin capsule as claimed in claim 1, which comprises the following steps: weighing and mixing the components of notopterygium root, radix angelicae pubescentis, radix achyranthis bidentatae and pawpaw, extracting effective components, concentrating and drying the extracted effective components into powder, and uniformly mixing the powder with indomethacin and/or piroxicam in a pulverizer to obtain the composition.

8. The preparation method of the compound radix angelicae pubescentis and indometacin capsule as claimed in claim 7, wherein the steps of extracting the effective components of the mixture of the notopterygium root, the radix angelicae pubescentis, the achyranthes root and the pawpaw are as follows:

according to the mixture ratio of 1: 1: 1: weighing notopterygium root, radix angelicae pubescentis, achyranthes root and pawpaw, adding water, soaking for 1.5-3h, reflux extracting for 3 times, wherein the first time is extracting with 9-12 times of water for 2-4h, the second time is extracting with 6-10 times of water for 1.5-3h, the third time is extracting with 5-7 times of water for 2-3h, combining the extracting solutions, filtering, concentrating, and spray drying to obtain dry powder.

9. The preparation method of the compound radix angelicae pubescentis and indometacin capsule as claimed in claim 7, wherein the steps of extracting the effective components of the mixture of the notopterygium root, the radix angelicae pubescentis, the achyranthes root and the pawpaw are as follows: according to the mixture ratio of 1: 1: 1: weighing Notopterygii rhizoma, radix Angelicae Pubescentis, Achyranthis radix and fructus Chaenomelis, adding 8-12 times of 60%, 75% and 90% ethanol solution respectively, heating to reflux, extracting for 1-3 hr, filtering the extractive solution, and collecting filtrate;

adding 8-12 times of 60%, 75% and 90% ethanol solution into the residue, heating to reflux, and extracting for 1-3 hr to obtain extractive solution;

mixing the filtrate with the extractive solution of the residue, concentrating, and vacuum drying to obtain dry powder.

10. The preparation method of the compound radix angelicae pubescentis and indometacin capsule as claimed in claim 7, wherein the steps of extracting the effective components of the mixture of the notopterygium root, the radix angelicae pubescentis, the achyranthes root and the pawpaw are as follows: according to the mixture ratio of 1: 1: 1: weighing notopterygium root, radix angelicae pubescentis, achyranthes root and pawpaw, adding water, soaking for 1-3h, and carrying out reflux extraction for 3 times, wherein 9-12 times of water is used for 2-4h for the first time, 7-9 times of water is used for 1.5-3h for the second time, and 5-7 times of water is used for the third time for 2-3h, and extracting solutions are combined and concentrated under reduced pressure to obtain an extract;

adding 95% ethanol into the extract, standing overnight for precipitation, collecting supernatant, concentrating, and vacuum drying to obtain dry powder.

Technical Field

The invention relates to the technical field of medicines, in particular to a novel compound pubescent angelica root indometacin capsule and a preparation method thereof.

Background

Rheumatic diseases generally refer to a group of diseases affecting bones, joints and their surrounding soft tissues, such as muscles, bursa, tendons, fascia, nerves, etc. The etiology of the disease can be infectious, immune, metabolic, endocrine, degenerative, geographic environmental, genetic, tumorous and the like, and the pain is the main symptom. With the development of society, the improvement of the sanitary level and the change of life style, the rheumatic fever related to the streptococcus infection is obviously reduced, and the incidence rate of osteoarthritis and gouty arthritis is in an increasing trend. The rheumatic disease is one of common diseases and frequently encountered diseases in China, has high morbidity and certain disability rate, is harmful to human health, and brings heavy economic burden to society and families.

The compound radix angelicae pubescentis indometacin capsules are popular with clinicians and patients due to the bright characteristics and obvious curative effect of the compound radix angelicae pubescentis indometacin capsules, the compound medicine plays a role in attenuation and synergy for the treatment of rheumatic diseases through a strategy of combining Chinese medicines and western medicines, however, the substance basis of the compound radix angelicae pubescentis indometacin capsules is not deeply researched, the action mechanism of attenuation and synergy is not clear, and the compound radix angelicae pubescentis indometacin capsules has large stimulation to the stomach when the dosage of the compound radix angelicae pubescentis indometacin capsules is large, so that toxic reactions such as nausea, vomiting, tension headache, somnolence, psychobehavioral disorders and the like are easily caused. Therefore, the dialectical treatment strategy of the existing compound product, namely the radix angelicae pubescentis and indometacin capsule, of 'combination of traditional Chinese medicines and western medicines' needs to be further upgraded urgently so as to obtain the effects of higher efficiency and lower toxicity and improve the medication safety.

Disclosure of Invention

The invention provides a novel compound radix angelicae pubescentis and indometacin capsule, which is subjected to product upgrade through the idea of 'secondary product development', and relevant research on the compound radix angelicae pubescentis and indometacin capsule on the basis of determining the substance action of each component; the invention also provides two preparation methods of the novel compound radix angelicae pubescentis and indometacin capsule, and the pharmacological activity and safety of the novel compound radix angelicae pubescentis and indometacin capsule for resisting rheumatism are evaluated to obtain the novel compound radix angelicae pubescentis and indometacin capsule which is more efficient and low in toxicity.

In order to solve the problems, the invention discloses a novel compound pubescent angelica root indometacin capsule which comprises the following components in parts by weight: 30-60 parts of notopterygium root, 30-60 parts of radix angelicae pubescentis, 30-60 parts of achyranthes root, 30-60 parts of pawpaw, 15-45 parts of indomethacin and/or 5-20 parts of piroxicam; the radix angelicae pubescentis is the rhizome of radix angelicae pubescentis, the radix achyranthis bidentatae is the rhizome of radix achyranthis bidentatae, and the pawpaw is one or more of fruits and seeds of pawpaw.

A preparation method of a novel compound pubescent angelica indometacin capsule comprises the following steps: firstly, respectively extracting effective components of notopterygium root, pubescent angelica root, twotooth achyranthes root and pawpaw, respectively filtering, concentrating and spray-drying the effective components of the components to obtain dry powder, uniformly mixing the dry powder of the components, and uniformly mixing the dry powder of the components with indometacin and/or piroxicam in a grinder to obtain the compound.

Preferably, the steps of extracting the effective components of the notopterygium root, the radix angelicae pubescentis, the achyranthes root and the pawpaw respectively are as follows:

s01, pulverizing Notopterygii rhizoma, sieving with a third sieve, precisely weighing Notopterygii rhizoma powder into a flask, adding water from the upper end of a condensation tube to fill the scale part of a volatile oil detector, overflowing into the flask, extracting volatile oil from Notopterygii rhizoma powder with the volatile oil detector while keeping the water in the flask slightly boiling, and refrigerating for use;

s02, weighing radix Angelicae Pubescentis, adding 75% methanol by volume, soaking for 20-40min, ultrasonic extracting at 50-65 deg.C for 30-60min, cooling, filtering, supplementing filtrate, and filtering with 0.45um microporous membrane to obtain effective components of radix Angelicae Pubescentis;

s03, weighing achyranthes powder, sieving the achyranthes powder by a No. four sieve, putting the achyranthes powder into a conical bottle with a plug, adding a 45% n-butyl alcohol solution by volume fraction, and weighing, wherein the liquid-material ratio is 12-18: 1, ultrasonic extracting for 1-2h, complementing the filtrate, centrifuging at 10000-15000r/min at 2-5 ℃ for 20-40min, and filtering the supernatant with a 0.45um microporous filter membrane to obtain the active ingredients of the achyranthes bidentata;

s04, precisely weighing coarse powder of fructus Chaenomelis, reflux-extracting with 8 times of 75% ethanol for 2 times, each time for 1-3 hr, concentrating the extractive solution in a rotary evaporator, quantitatively transferring the concentrated solution into a measuring flask, and diluting with 50% ethanol to constant volume to obtain fructus Chaenomelis ethanol extractive solution.

Wherein, in the step S01, since the relatively representative substance in the notopterygium root volatile oil is α -pinene, when the volatile oil is extracted by using gas chromatography, the content of the volatile oil is reflected by α -pinene content, and the boiling point is 155 ℃.

Further preferably, in step S02, the effective components of pubescent angelica are detected by using a chromatographic column, and the chromatographic conditions are as follows: in a volume ratio of 44: 56 acetonitrile-water is used as a mobile phase, the column temperature is 30 ℃, the detection wavelength is 316nm, the flow rate is 1.0mL/min1, and the sample injection amount is 10 uL.

Further preferably, in the step S03, the power of the ultrasonic extraction is 250W, and the frequency is 40 kHz;

taking the subsequent filtrate passing through the microporous membrane as a test solution of the effective components of radix angelicae pubescentis, and carrying out liquid chromatography detection on the effective components of radix achyranthis bidentatae, wherein the chromatography conditions are as follows: taking acetonitrile-0.1% formic acid water as a mobile phase, carrying out gradient elution at a column temperature of 30 ℃, a flow rate of 1.0ml/min, a detection wavelength of 254nm and a sample amount of 10u 1.

Preferably, in step S04, the herb residue of the pawpaw after alcohol extraction is taken, dried at 50-65 ℃ to constant weight, 10g of the dried herb residue is precisely weighed, and is extracted by refluxing with 10-13 times of water as a solvent for 1.5-3 hours to obtain a sample solution of the pawpaw, and a chromatographic column is used for detection, wherein the chromatographic conditions are as follows: the volume ratio is 265: 35: 0.1: 0.05 of methanol-water-glacial acetic acid-triethylamine is taken as a mobile phase, the flow rate is 0.6mL/min1, the column temperature is 20 ℃, the detection wavelength is 210nm, and the sample injection amount is 20 uL.

A preparation method of a novel compound pubescent angelica indometacin capsule comprises the following steps: weighing and mixing the components of notopterygium root, radix angelicae pubescentis, radix achyranthis bidentatae and pawpaw, extracting effective components, concentrating and drying the extracted effective components into powder, and uniformly mixing the powder with indomethacin and/or piroxicam in a pulverizer to obtain the composition.

Preferably, the steps of extracting the effective components of the mixture of notopterygium root, pubescent angelica root, twotooth achyranthes root and pawpaw are as follows: according to the mixture ratio of 1: 1: 1: weighing notopterygium root, radix angelicae pubescentis, achyranthes root and pawpaw, adding water, soaking for 1.5-3h, reflux extracting for 3 times, wherein the first time is extracting with 9-12 times of water for 2-4h, the second time is extracting with 6-10 times of water for 1.5-3h, the third time is extracting with 5-7 times of water for 2-3h, combining the extracting solutions, filtering, concentrating, and spray drying to obtain dry powder.

Preferably, the steps of extracting the effective components of the mixture of notopterygium root, pubescent angelica root, twotooth achyranthes root and pawpaw are as follows: according to the mixture ratio of 1: 1: 1: weighing Notopterygii rhizoma, radix Angelicae Pubescentis, Achyranthis radix and fructus Chaenomelis, adding 8-12 times of 60%, 75% and 90% ethanol solution respectively, heating to reflux, extracting for 1-3 hr, filtering the extractive solution, and collecting filtrate; adding 8-12 times of 60%, 75% and 90% ethanol solution into the residue, heating to reflux, and extracting for 1-3 hr to obtain extractive solution; mixing the filtrate with the extractive solution of the residue, concentrating, and vacuum drying to obtain dry powder.

Preferably, the steps of extracting the effective components of the mixture of notopterygium root, pubescent angelica root, twotooth achyranthes root and pawpaw are as follows: according to the mixture ratio of 1: 1: 1: weighing notopterygium root, radix angelicae pubescentis, achyranthes root and pawpaw, adding water, soaking for 1-3h, and carrying out reflux extraction for 3 times, wherein 9-12 times of water is used for 2-4h for the first time, 7-9 times of water is used for 1.5-3h for the second time, and 5-7 times of water is used for the third time for 2-3h, and extracting solutions are combined and concentrated under reduced pressure to obtain an extract; adding 95% ethanol into the extract, standing overnight for precipitation, collecting supernatant, concentrating, and vacuum drying to obtain dry powder.

The notopterygium root, wonderful, notopterygium, excrementia and black drug belong to rhizome medicinal materials, are pungent in taste and warm in nature, and have the effects of treating scouring wind, aphonia, multiple itching, blood, hands and feet, facial distortion, and obstinate obstruction of the whole body, treating wind-cutting and qi, muscle and bone fist spasm, limb weakness, head-rotation eye and eye pain, damp and damp in the breast, five-strain seven injury, deficiency cold, bone joint soreness and pain, and benefiting five internal organs in the Chinese angelica in the property treatise of property.

Radix Angelicae Pubescentis, also called Huwang Shi, Dusha Cao, Du Hua, Chang Sheng Cao, Chuan Du Huo, etc. Belongs to the rhizome class of medicinal materials. 2, pungent taste; bitter; and (5) slightly warming. In the book of entries, it is said that it treats all kinds of wind, and there is no long-term new gout in hundreds of segments. The pubescent angelica root and notopterygium root are the same effective medicine pair in clinic. Modern pharmacological research shows that radix angelicae pubescentis has anti-inflammatory and analgesic effects, and the main active ingredients are coumarin compounds, wherein the osthole and isoimperatorin have the highest content.

Achyranthis radix is also named as Achyranthis radix, herba Pileae Scriptae, herba Amaranthi Tricoloris, radix Aconiti Kusnezoffii, radix Achyranthis bidentatae, and radix Achyranthis bidentatae. Belongs to the rhizome class of medicinal materials. The nature is flat; bitter and sour in taste. Achyranthis radix contains various chemical components such as saccharide, saponins, phytosterol, and flavone. Modern pharmacological research shows that achyranthes bidentata also has the pharmacological effects of resisting inflammation, easing pain, regulating immunity, reducing blood pressure, resisting tumor, delaying senility and the like. Is often used for treating knee arthritis, cardiovascular diseases, asthma and the like in modern clinic.

MAO (common floweringquince fruit), fructus Chaenomelis, fructus Pyri, autumn fructus Chaenomelis, and fructus Chaenomelis. Belongs to fruit/seed medicinal materials. A monosodium glutamate; and (4) temperature. In the book of entry, it is said that it is mainly indicated for damp arthralgia with pathogenic qi, and cholera is vomiting and not rotating tendons. The pawpaw extract has the functions of resisting inflammation, easing pain, inhibiting tumor growth, protecting liver, reducing enzyme, resisting oxidation, inhibiting bacteria and the like, and active ingredients mainly comprise triterpenes, organic acids, polyphenols and polysaccharide compounds.

The novel compound radix angelicae pubescentis and indometacin capsule is prepared by adopting notopterygium root, radix angelicae pubescentis, radix achyranthis bidentatae, pawpaw, indometacin and/or piroxicam, wherein the notopterygium root, the radix angelicae pubescentis, the radix achyranthis bidentatae and the pawpaw are extracted for effective components, concentrated, spray-dried into dry powder, then uniformly mixed with the indometacin and/or the piroxicam to obtain medicinal components, and then the medicinal components are prepared into the capsule by adopting the existing capsule preparation technology. Preferably, in the present invention, the uniform mixing process of the dry powder of each extract with indomethacin and piroxicam is performed in a pulverizer. The pawpaw is preferably chaenomeles speciosa.

The invention preferably provides two preparation methods of the novel compound pubescent angelica indometacin capsule: one is as follows according to the mixture ratio of 1: 1: 1: 1, mixing and crushing notopterygium root, radix angelicae pubescentis, achyranthes and pawpaw, then carrying out a solvent multistage extraction method based on an activity guiding method by adopting an anti-rheumatism pharmacological model to obtain an effective component with anti-rheumatism activity, then combining the effective component with indomethacin and/or piroxicam in a ratio to obtain a medicinal component, and then preparing a capsule by adopting the medicinal component to obtain the novel compound radix angelicae pubescentis and indomethacin capsule. And secondly, respectively carrying out multistage extraction on notopterygium root, heracleum hemsleyanum michaux, achyranthes and pawpaw by adopting different solvents based on an activity guiding method, so as to obtain effective components with anti-rheumatic activity from the notopterygium root, the heracleum hemsleyanum michaux, the achyranthes and the pawpaw, then proportionally combining the effective components of the notopterygium root, the heracleum hemsleyanum michaux, the achyranthes and the pawpaw with indomethacin and/or piroxicam according to a certain proportion to obtain medicinal components, and preparing capsules by adopting the medicinal components to obtain the novel compound pubescent angelica and indomethacin capsules. The novel compound radix angelicae pubescentis and indometacin capsules prepared by the two preparation methods are evaluated for pharmacological activity and safety against rheumatism, and the results show that compared with the existing compound radix angelicae pubescentis and indometacin capsules, the novel compound radix angelicae pubescentis and indometacin capsules have better anti-inflammatory effect, smaller toxic and side effects, and are safer and more reliable.

Compared with the prior art, the embodiment of the invention has the following advantages:

the invention extracts the effective components of single component or a plurality of components in notopterygium root, pubescent angelica root, achyranthes root and pawpaw, and then mixes the extracted effective components with indomethacin and/or piroxicam to prepare the new compound pubescent angelica root and indomethacin capsule. The novel compound radix angelicae pubescentis and indometacin capsule prepared by the preparation method of the upgraded compound radix angelicae pubescentis and indometacin capsule has higher content of effective medicinal ingredients and stronger safety.

Detailed Description

The present invention will be described in further detail with reference to specific embodiments in order to make the above objects, features and advantages more apparent and understandable.

A novel compound pubescent angelica indometacin capsule comprises the following components in parts by weight as shown in the following table 1:

TABLE 1

Group of

Notopterygium root

Radix Angelicae Pubescentis

Root of bidentate achyranthes

Pawpaw

Indometacin

Piroxicam

Composition 1

30 portions of

30 portions of

30 portions of

30 portions of

15 portions of

5 portions of

Composition 2

50 portions of

50 portions of

50 portions of

50 portions of

25 portions of

10 portions of

Composition 3

60 portions of

60 portions of

60 portions of

60 portions of

45 portions of

20 portions of

Wherein the medicinal part of the notopterygium root is a rhizome; the medicinal part of the radix angelicae pubescentis is a rhizome; the medicinal part of the achyranthes root is a rhizome; the medicinal part of the pawpaw is fruit/seed, preferably chaenomeles speciosa nakai. The following examples were employed

The following preparation methods of examples 1-12 are adopted to prepare the composition 1, the composition 2 and the composition 3 in the table 1 to obtain the novel compound pubescent angelica root indometacin capsules. The preparation method comprises the following steps: