阅读说明：本技术 一种含有苯醚甲环唑和丙环唑的微乳剂及其制备方法 (Microemulsion containing difenoconazole and propiconazole and preparation method thereof ) 是由 王爱臣 吴丽文 夏姗姗 莫俊锐 廖联安 于 2019-10-12 设计创作，主要内容包括：本发明实施例公开了一种含有苯醚甲环唑和丙环唑的微乳剂,属于农药技术领域。一种含有苯醚甲环唑和丙环唑的微乳剂,按质量百分比计由如下组分组成：苯醚甲环唑10～20％、丙环唑10～20％、表面活性剂10～25％、溶剂20～30％、增效剂1～5％、防冻剂2～5％,用水补至100％,其中,所述表面活性剂由重量比为3～6：2～3：2～3的三苯乙基酚聚氧乙烯醚、聚氧乙烯醚非离子和双酰胺双磺酸钠组成。本发明的微乳剂使用环境友好的溶剂,具有性能稳定,防效显著的特点,以解决现有微乳剂使用的溶剂存在的环境不友好、使用不安全的问题。(The embodiment of the invention discloses a microemulsion containing difenoconazole and propiconazole, belonging to the technical field of pesticides. The microemulsion containing the difenoconazole and the propiconazole comprises the following components in percentage by mass: 10-20% of difenoconazole, 10-20% of propiconazole, 10-25% of surfactant, 20-30% of solvent, 1-5% of synergist and 2-5% of antifreezing agent, and the mixture is supplemented to 100% by water, wherein the surfactant is prepared from the following components in parts by weight of 3-6: 2-3: 2-3 of triphenylethyl phenol polyoxyethylene ether, polyoxyethylene ether nonionic and bisamide disulfonic acid sodium salt. The microemulsion of the invention uses environment-friendly solvent, has the characteristics of stable performance and obvious control effect, and solves the problems of environment unfriendliness and unsafe use of the solvent used by the existing microemulsion.)

1. The microemulsion containing the difenoconazole and the propiconazole is characterized by comprising the following components in percentage by mass: 10-20% of difenoconazole, 10-20% of propiconazole, 20-30% of solvent, 10-25% of surfactant, 1-5% of synergist and 2-5% of antifreezing agent, and the mixture is supplemented to 100% by water, wherein the surfactant is prepared from the following components in parts by weight of 3-6: 2-3: 2-3 of triphenylethyl phenol polyoxyethylene ether, polyoxyethylene ether nonionic and bisamide disulfonic acid sodium salt.

2. A microemulsion containing difenoconazole and propiconazole according to claim 1, wherein the solvent is selected from one or more of alcohol ether environment-friendly solvents, isopropanol, ethyl acetate, sec-butyl acetate and dimethylsulfoxide.

3. A microemulsion containing difenoconazole and propiconazole according to claim 1, wherein the synergist is selected from one or more of silicone modified polyether, alkyl succinamide sulphonate and high efficiency fluorine-containing wetting penetrant.

4. A microemulsion containing difenoconazole and propiconazole according to claim 1, wherein the antifreeze agent is selected from one or more of glycerol, propylene glycol and polyethylene glycol.

5. A microemulsion containing difenoconazole and propiconazole according to claim 1, wherein the water is selected from tap water, distilled water or deionized water.

6. A method for preparing a microemulsion of difenoconazole and propiconazole according to claim 1, which comprises the following steps:

dissolving difenoconazole and propiconazole by using a solvent, stirring after the difenoconazole and the propiconazole are fully dissolved, adding a surfactant, a synergist and an antifreezing agent during stirring, slowly adding water into the mixed solution after uniformly mixing, and fully stirring to obtain the microemulsion containing the difenoconazole and the propiconazole.

Technical Field

The embodiment of the invention relates to the technical field of pesticides, and particularly relates to a microemulsion containing difenoconazole and propiconazole and a preparation method thereof.

Background

The difenoconazole triazole fungicide has systemic property, is a sterol demethylation inhibitor, has wide bactericidal spectrum, can improve the yield and guarantee the quality of crops by leaf surface treatment or seed treatment, and has lasting protection and treatment activity on the subphylum loachirima, the subphylum basidiomycotina and the fungi imperfecti, powdery mildew, rust fungi and certain species-borne pathogenic bacteria including alternaria, ascochyta, urospora, colletotrichum, gloeophyta and other fungi.

Propiconazole belongs to triazole bactericides in sterol inhibitors, has the action mechanism of influencing the biosynthesis of sterol, destroying the cell membrane function of pathogenic bacteria and finally causing cell death, thereby playing the roles of sterilization, disease prevention and treatment, is a systemic bactericide with the functions of protection and treatment, can be absorbed by roots, stems and leaves and can be quickly conducted upwards in plants, and can prevent and treat diseases caused by ascomycetes, basidiomycetes and imperfect fungi, particularly has better prevention and treatment effects on rot, powdery mildew and bakanae disease of rice.

The microemulsion consists of pesticide raw materials, surfactant, water, stabilizer and other auxiliary agents, and belongs to a thermodynamic stable dispersion system. It is characterized in that water is used as a medium, and no or little organic solvent is contained, so the water-based fuel oil is non-combustible and non-explosive, the production operation, storage and transportation are safe, the environmental pollution is little, and a large amount of organic solvent is saved; the pesticide has extremely high dispersity to reach the micronization degree, the pesticide particles are generally only 0.1-0.01 micron, and the appearance is similar to that of a transparent or slightly transparent liquid; good dispersibility in water, strong permeability and good adhesive force to a target body, and low requirement on equipment. Therefore, microemulsions are very promising pesticide formulations.

After the difenoconazole and the propiconazole are compounded into the microemulsion for use, on one hand, the drug resistance of pathogenic bacteria is greatly slowed down, on the other hand, the bactericidal spectrum of each single dose is further widened, the dosage is reduced, and the compound difenoconazole microemulsion has positive significance for protecting ecology and environment.

The advantages and disadvantages of pesticide formulations are closely related to the activity of pesticides and the selection of auxiliary agents, the molecular structures and the physicochemical properties of various pesticide raw materials are far different, and the auxiliary agents including surfactants and the like selected for preparing the pesticide formulations are often different in order to ensure that the pesticide formulations have excellent stability and biological activity. The Chinese patent application CN102057923A discloses a sterilization composition with difenoconazole and propiconazole as active components, wherein the microemulsion of the sterilization composition comprises difenoconazole, propiconazole, an emulsifier, a cosolvent, a stabilizer, a synergist, an antifreezing agent and purified water, the stability of the microemulsion is only improved, but no experimental data in the aspect of stability is proved, and the used solvent is cyclohexanone, which has great toxicity to human bodies and causes pollution to the environment.

With the continuous enhancement of environmental awareness and safety knowledge of people, the research and development of the microemulsion which is safe to use, environment-friendly, good in stability and remarkable in control effect has important significance.

Disclosure of Invention

Therefore, the embodiment of the invention provides the microemulsion containing the difenoconazole and the propiconazole and the preparation method thereof, the microemulsion uses an environment-friendly solvent, has the characteristics of stable performance and obvious control effect, and solves the problems of environment unfriendliness and unsafe use of the solvent used by the existing microemulsion.

In order to achieve the above object, the embodiments of the present invention provide the following technical solutions:

according to a first aspect of embodiments of the present invention, there is provided a microemulsion containing difenoconazole and propiconazole, which comprises the following components in percentage by mass: 10-20% of difenoconazole, 10-20% of propiconazole, 20-30% of solvent, 10-25% of surfactant, 1-5% of synergist and 2-5% of antifreezing agent, and the mixture is supplemented to 100% by water, wherein the surfactant is prepared from the following components in parts by weight of 3-6: 2-3: 2-3 of triphenylethyl phenol polyoxyethylene ether, polyoxyethylene ether nonionic and bisamide disulfonic acid sodium salt.

Further, the solvent is selected from one or more of alcohol ether environment-friendly solvents, isopropanol, ethyl acetate, sec-butyl acetate and dimethyl sulfoxide.

Further, the synergist is selected from one or more of siloxane modified polyether, alkyl succinamide sulfonate and high-efficiency fluorine-containing wetting penetrant.

Further, the antifreezing agent is selected from one or more of glycerol, propylene glycol and polyethylene glycol.

Further, the water is selected from tap water, distilled water or deionized water.

According to a second aspect of embodiments of the present invention, there is provided a method of preparing a microemulsion containing difenoconazole and propiconazole as described above, the method comprising the steps of:

dissolving difenoconazole and propiconazole by using a solvent, stirring after the difenoconazole and the propiconazole are fully dissolved, adding a surfactant, a synergist and an antifreezing agent during stirring, slowly adding water into the mixed solution after uniformly mixing, and fully stirring to obtain the microemulsion containing the difenoconazole and the propiconazole.

The embodiment of the invention has the following advantages:

1. according to the invention, the difenoconazole and the propiconazole are used as active ingredients, so that the stability and the biological activity of the dosage form are not influenced by the added auxiliary agents, the types of the surfactant, the synergist, the antifreezing agent and the solvent are screened and optimized in compounding, the prepared microemulsion emulsion is qualified in stability, heat storage stability and low temperature stability, and the transparent temperature range is wide.

2. The invention screens the surfactant, the surface tension (diluted by 2000 times) of the preparation is less than or equal to 37mN/m, the penetration time (canvas method, diluted by 500 times) is less than 30min, the utilization rate of the preparation in use is improved, and the drug effect is improved.

3. The invention uses the solvent with lower toxicity, reduces the health hazard to users, reduces the pollution to the environment, and has environment friendliness and good safety.

Detailed Description

The present invention is described in terms of particular embodiments, other advantages and features of the invention will become apparent to those skilled in the art from the following disclosure, and it is to be understood that the described embodiments are merely exemplary of the invention and that it is not intended to limit the invention to the particular embodiments disclosed. All other embodiments, which can be derived by a person skilled in the art from the embodiments given herein without making any creative effort, shall fall within the protection scope of the present invention.