阅读说明：本技术 一种毛皮动物专用型抗生素促生长剂替代物组方及其应用 (Formula and application of antibiotic growth promoter substitute special for fur-bearing animals ) 是由 曹婧 付继先 刘文华 刘宗柱 赵元华 于 2019-10-23 设计创作，主要内容包括：本发明公开了一种抗生素促生长剂代替物,包括如下重量份数的组分：15-28份肉桂醛、8-15份月桂酸单甘油酯、6-10份百里香酚、15-28份丁酸甘油一酯和1-4份姜黄油；以“抑菌-免疫调节-肠黏膜营养”三元平衡为理论指导,用于毛皮动物养殖可有效减少养殖过程中抗生素的使用,提高了生产性能；从而可以减少动物养殖过程中治疗性抗菌药物的使用,减少动物养殖过程中抗生素残留的环境污染。(The invention discloses an antibiotic growth promoter substitute which comprises the following components in parts by weight: 15-28 parts of cinnamyl aldehyde, 8-15 parts of lauric acid monoglyceride, 6-10 parts of thymol, 15-28 parts of butyric acid monoglyceride and 1-4 parts of turmeric oil; the theory of 'bacteriostasis-immunoregulation-intestinal mucosa nutrition' is used as guidance, and when the feed is used for fur-bearing animal breeding, the use of antibiotics in the breeding process can be effectively reduced, and the production performance is improved; thereby reducing the use of therapeutic antibacterial drugs in the animal breeding process and reducing the environmental pollution caused by antibiotic residues in the animal breeding process.)

1. The formula of the antibiotic growth promoter substitute special for the fur-bearing animals is characterized by comprising the following components in parts by weight: 15-28 parts of cinnamyl aldehyde, 8-15 parts of lauric acid monoglyceride, 6-10 parts of thymol, 15-28 parts of butyric acid monoglyceride and 1-4 parts of turmeric oil.

2. The formula of the antibiotic growth promoter substitute special for the fur-bearing animal according to claim 1, which is characterized by comprising the following raw materials in parts by weight: 15-22 parts of cinnamaldehyde, 8-12 parts of lauric acid monoglyceride, 6-8 parts of thymol, 15-20 parts of butyric acid monoglyceride and 2-4 parts of turmeric oil.

3. The formula of the antibiotic growth promoter substitute special for the fur-bearing animal according to claim 1, which is characterized by comprising the following raw materials in parts by weight: 18 parts of cinnamaldehyde, 10 parts of lauric acid monoglyceride, 8 parts of thymol, 15 parts of butyric acid monoglyceride and 2 parts of turmeric oil.

4. A preparation method of a special antibiotic growth promoter substitute compound composition for fur animals is characterized by comprising the following steps:

weighing the raw materials according to the weight part of the formula of the antibiotic growth promoter substitute special for the fur-bearing animal of any one of claims 1 to 3;

and (2) uniformly stirring and mixing the raw materials weighed in the step (1) to obtain the plant essential oil.

5. The method for preparing the compound composition of antibiotic growth promoter substitutes special for fur animals according to claim 4, characterized in that the stirring time in the step (2) is 20-30min, and the stirring temperature is 23-30 ℃.

6. Use of the antibiotic growth promoter substitute of any one of claims 1 to 3 in feeding fur-bearing animals.

Technical Field

The invention relates to the technical field of feed additives, in particular to a special antibiotic growth promoter substitute for fur-bearing animals and application thereof.

Background

The application of Antibiotic Growth Promoter (AGP) has been in history for more than 60 years at home and abroad, and provides indispensable guarantee for improving the benefit of livestock breeding. However, the continuous addition of low-dose AGP can cause the development of bacterial drug resistance, and the use of antibiotic growth promoter can cause the problems of drug residue in livestock and poultry products and environmental pollution, so that the antibiotic growth promoter capable of effectively solving the problems needs to be provided.

The main reason is that the research in the field is mostly limited to one aspect of AGP action, and the research in the field is undoubtedly limited to effectively replace the key of AGP, namely, the normal function of animal intestinal mucosa barrier is maintained, namely, the normal function of animal intestinal mucosa barrier can be realized, namely, the nutrient can be effectively absorbed, and harmful microorganisms and products thereof can be prevented from entering the body, so that the effective replacement of AGP which is objectively required needs to be realized by ① for inhibiting the excessive propagation of harmful bacteria to condition the microecological balance, ② for regulating the balance of intestinal mucosa immune response and inflammatory response to relieve immune injury, ③ for promoting the updating of intestinal mucosa to stabilize the intestinal mucosa and other 3-aspect of construction systems of the physiological barrier of AGP, and the three different requirements of animal breeding are met in view of different types of daily constitution, duration and different immune structures of the intestinal mucosa.

Fur-bearing animal breeding mainly represented by mink, fox and racoon dog is an important component of special economic animal breeding in China. Because the feed protein level requirement is higher, the microorganism sanitation indexes of leftovers such as chicken skeletons, internal organs, small trash fishes and the like which are used as the raw materials of common feed protein are difficult to effectively control, and the dosage of AGP added in the feed is higher. Therefore, with the comprehensive development of the prohibition of AGP work in China, the development of special AGP substitution technology for fur-bearing animals is more urgent.

Therefore, providing a highly targeted antibiotic growth promoter substitute to replace the use of antibiotic growth promoters in the fur-bearing animal breeding process to solve the problems of drug resistance development, drug residue generation, environmental pollution and the like caused by the antibiotic growth promoters is a problem to be solved by those skilled in the art.

Disclosure of Invention

In view of the above, the invention provides an antibiotic growth promoter and application thereof, which are a substitute formula for constructing a system in 3 aspects of inhibiting excessive reproduction of harmful bacteria by ① to condition microecological balance, regulating balance of immune response and inflammatory response of intestinal mucosa by ② to relieve immune injury, promoting timely update of the intestinal mucosa to stabilize physiological barriers of the intestinal mucosa and the like by taking ternary balance of 'bacteriostasis-immunoregulation-intestinal mucosa nutrition' as theoretical guidance, and are used for fur-bearing animal breeding, so that the use of antibiotics can be effectively reduced in the breeding process, and the use of therapeutic antibacterial drugs and the reduction of drug residues in the animal breeding process can be reduced.

In order to achieve the purpose, the invention adopts the following technical scheme:

a formula of a special antibiotic growth promoter substitute for fur animals comprises the following components in parts by weight: 15-28 parts of cinnamyl aldehyde, 8-15 parts of lauric acid monoglyceride, 6-10 parts of thymol, 15-28 parts of butyric acid monoglyceride and 1-4 parts of turmeric oil.

Preferably, the antibiotic growth promoter substitute is characterized by comprising the following components in parts by weight: 15-22 parts of cinnamaldehyde, 8-12 parts of lauric acid monoglyceride, 6-8 parts of thymol, 15-20 parts of butyric acid monoglyceride and 2-4 parts of turmeric oil.

Further preferably, the antibiotic growth promoter substitute is characterized by comprising the following components in parts by weight: 18 parts of cinnamaldehyde, 10 parts of lauric acid monoglyceride, 8 parts of thymol, 15 parts of butyric acid monoglyceride and 2 parts of turmeric oil.

The invention also provides a preparation method of the formula of the antibiotic growth promoter substitute special for the fur-bearing animals, which comprises the following steps:

weighing raw materials according to the weight part of a formula of the antibiotic growth promoter substitute special for the fur-bearing animals;

and (2) uniformly stirring and mixing the raw materials weighed in the step (1) to obtain the plant essential oil.

The preparation method is simple, easy to operate and suitable for large-scale industrial production.

Preferably, the stirring time in the step (2) is 20-30min, and the stirring temperature is 23-30 ℃.

The invention also provides a preparation method of the antibiotic growth promoter substitute formula microcapsule special for the fur-bearing animals, which comprises the following steps:

step 1), mixing the prepared plant essential oil and chitosan micro powder according to the weight ratio of 1:0.5, and granulating to obtain a core material;

and 2) putting the core material obtained in the step 1) and sodium alginate into a coating pan for coating, so as to obtain the microcapsule.

The plant essential oil is prepared into the microcapsule, so the carrying and the eating are convenient. The method for preparing the microcapsule is simple and easy to operate.

Preferably, the method also comprises the following step of sieving the microcapsules obtained in the step 2) by a 30-50 mesh sieve.

Preferably, the content of the plant essential oil in the microcapsule in the step 2) is 20 wt% to 25 wt%.

Use of an antibiotic growth promoter replacement as described above in feeding fur-bearing animals.

According to the technical scheme, compared with the prior art, the invention discloses an antibiotic growth promoter substitute and application thereof, and the antibiotic growth promoter substitute has the following beneficial effects:

(1) according to the invention, cinnamic aldehyde and thymol in a specific ratio are adopted to play a synergistic effect, so that the reproduction of clostridium perfringens and the α -toxin secretion level can be effectively inhibited, the intestinal microecology of animals is improved, and the absorption of endotoxins such as Lipopolysaccharide (LPS) and the like into the body is reduced;

(2) according to the invention, the turmeric oil with a specific proportion is adopted to adjust the balance of the intestinal mucosa immune response and inflammatory reaction, so that the intestinal mucosa immune injury is reduced;

(3) the invention adopts the butyric acid monoglyceride with a specific proportion to provide energy which can be directly utilized by intestinal mucosa cells, and effectively ensures the completeness of the inherent immune barrier of the intestinal mucosa.

Detailed Description

The technical solutions in the embodiments of the present invention will be clearly and completely described below, and it is obvious that the described embodiments are only a part of the embodiments of the present invention, and not all embodiments. All other embodiments, which can be derived by a person skilled in the art from the embodiments given herein without making any creative effort, shall fall within the protection scope of the present invention.