阅读说明：本技术 皮肤老化或皮肤皱纹改善用化妆品组合物 (Cosmetic composition for improving skin aging or skin wrinkles ) 是由 庆瑞娟 李敬银 吕炫周 姜承贤 朴明三 于 2019-04-17 设计创作，主要内容包括：本发明涉及包含菊花、芦荟、洋常春藤混合提取物作为有效成分的皮肤老化或皮肤皱纹改善用化妆品组合物,更具体地,涉及包含通过抑制紫外线引起的皮肤老化来有效改善皮肤皱纹的提取物的皮肤外用剂组合物。根据本发明,包含菊花、芦荟及洋常春藤混合提取物作为有效成分的化妆品组合物使作为胶原蛋白生物合成基因的COL1A1的表达增加,并抑制作为胶原蛋白分解酶的MMP-1的表达,由此可呈现皮肤老化防止或皱纹改善效果。(The present invention relates to a cosmetic composition for skin aging or skin wrinkle improvement comprising a mixed extract of chrysanthemum, aloe, and ivy as an effective ingredient, and more particularly, to a composition for skin external use comprising an extract effective for improving skin wrinkles by inhibiting skin aging caused by ultraviolet rays. According to the present invention, a cosmetic composition comprising a mixed extract of chrysanthemum, aloe and ivy as an active ingredient can exhibit skin aging prevention or wrinkle improvement effects by increasing the expression of COL1a1, which is a collagen biosynthesis gene, and inhibiting the expression of MMP-1, which is a collagen catabolic enzyme.)

1. A cosmetic composition for improving skin aging or skin wrinkles, characterized by comprising a mixed extract of chrysanthemum, aloe and ivy as an active ingredient.

2. The cosmetic composition for skin aging or skin wrinkle improvement according to claim 1, characterized in that the extract is extracted with water, an organic solvent or a mixed solvent thereof.

3. The cosmetic composition for improving skin aging or skin wrinkles as claimed in claim 1, wherein the extracts of chrysanthemum, aloe and ivy are mixed in the mixing at a weight ratio of 1-5: 1-5.

4. The cosmetic composition for skin aging or skin wrinkle improvement according to claim 1, characterized by comprising 0.001 to 30 weight percent of mixed extract of chrysanthemum, aloe and hedera helix, based on the total weight of the cosmetic composition.

5. The cosmetic composition for skin aging or skin wrinkle improvement according to claim 1, wherein the mixed extract of chrysanthemum, aloe and ivy increases the expression of type i collagen (COL1a1) or inhibits the expression of matrix metalloproteinase-1 (MMP-1).

6. The cosmetic composition for improving skin aging or skin wrinkles according to claim 1, wherein the composition is in the form of one or more agents selected from the group consisting of a skin lotion, a skin softener, a skin toner, an astringent, a skin lotion, an emulsion, a moisturizing lotion, a nourishing lotion, a massage cream, a nourishing cream, a moisturizing cream, a hand cream, a foundation, an essence, a nourishing essence, a mask, a soap, a face cleanser, a skin cleanser, a face cleanser, a body lotion, and a body lotion.

Technical Field

The present invention relates to a cosmetic composition for skin aging or skin wrinkle improvement comprising a mixed extract of chrysanthemum, aloe, and ivy as an effective ingredient, and more particularly, to a composition for skin external preparation comprising an extract effective for wrinkle improvement by inhibiting skin aging caused by ultraviolet rays.

Background

The skin, which is the outermost organ in the body, protects our body from external environments and irritation. The skin is exposed to external irritants at all times as compared with many organs in the body, and thus may be easily attacked, and in particular, the facial skin is exposed directly to ultraviolet rays and pollutants, and thus has a characteristic of being easily aged as compared with other body skins.

Skin aging is classified into intrinsic aging occurring due to genetic factors and extrinsic aging occurring due to environmental exposure. Intrinsic aging occurs naturally as a result of biological metabolic processes, whereas extrinsic aging occurs as a result of continuous exposure, stress, smoking, and the like. In addition, from the clinical viewpoint, although the skin is dry and pale with loss of elasticity and shows fine lines due to intrinsic aging, deep wrinkles due to extrinsic aging are observed, and spots are generated and colored due to irregular pigmentation, rough skin and the like are observed, and in severe cases, diseases such as moles, black spots, skin cancer and the like are caused, and thus the skin is affected more. Therefore, in order to prevent skin aging, it is more effective to block such extrinsic aging in advance and to suppress the progression of extrinsic aging.

From a histological point of view, skin aging is caused by changes in the composition of the Extracellular tissue (Extracellular matrix proteins) of the skin. In the dermal extracellular tissue, various collagens account for 90% of the dermal layer of the skin, and impart strength and tension to external stimuli or forces to protect the skin. Therefore, the reduction of collagen is closely related to skin aging and wrinkle formation. One of the main cross-linked constituents of healthy dermis is type i collagen, the precursor of which is significantly reduced in skin damaged by photoaging. When aging progresses, collagen is also decomposed, but biosynthesis of various collagen decomposition enzymes (matrix metalloproteinases (MMPs)) is increased by stimulation such as ultraviolet rays to reduce collagen synthesis, thereby forming wrinkles. Various kinds of collagen degrading enzymes (MMPs) are enzymes that decompose and recombine components of the extracellular structure of dermis as intracellular proteases, and among them, matrix metalloproteinase-1 (MMP-1) acts on collagen in dermis to fractionate collagen. Therefore, the amount of expression and the degree of activity of this enzyme in vivo play an important role in the generation or amelioration of wrinkles.

Meanwhile, as a raw material for wrinkle improvement, vitamin C, α -tocopherol, retinol and derivatives thereof, etc. have been mainly used in the form of being blended into cosmetics and pharmaceuticals, but these have disadvantages of generating a bad odor or having poor chemical stability when blended into a dosage form.

In order to overcome such drawbacks, recently, development of wrinkle-improving cosmetic compositions using these natural product-derived substances has been attracting attention, and there is a need to develop such wrinkle-improving cosmetic compositions.

Chrysanthemum (Chrysanthemum homum morifolium), which is a flower that is generally widely used for ornamental purposes, is known to be used in china as a good drug for eyes and contains various vitamin precursors and minerals, and β -carotene, which is a pigment having good antioxidant ability, as an active ingredient, Aloe (Aloe Vera), which is a succulent plant that grows in tropical regions, is a plant that has been used for years as a medicine or for nutritional purposes.

In view of the above, the present inventors have conducted intensive studies in order to overcome the various problems of the prior art as described above, and finally have confirmed that a mixed extract of chrysanthemum, aloe, and ivy has superior efficacy in skin aging and wrinkle improvement than a case where a single extract is contained as an active ingredient, and have completed the present invention.

Disclosure of Invention

The main object of the present invention is to provide a wrinkle-improving cosmetic composition comprising a mixed extract of chrysanthemum, aloe and ivy, which is effective in improving skin aging and wrinkle formation.

According to one embodiment of the present invention, there is provided a cosmetic composition for skin aging or skin wrinkle improvement comprising a mixed extract of chrysanthemum, aloe, and caulis hederae chamomillae as an active ingredient.

The present invention is characterized in that the skin aging is caused by external factors, more specifically, the skin aging is skin photoaging caused by ultraviolet rays.

The present invention is characterized in that the extract can be extracted with any solvent conventionally used, preferably with water, an organic solvent or a mixed solvent thereof, and more preferably with at least one solvent selected from the group consisting of water, anhydrous or hydrous methanol, ethanol, propanol, butanol, glycerol, propylene glycol, butylene glycol or a mixed solvent thereof.

The present invention is characterized in that the mixed extract can be mixed in a ratio of 1-5: 1-5: 1-5, extracting chrysanthemum in a mixed weight ratio: aloe vera: the hedera helix extract, preferably, can be present in a ratio of 1-3: 1-3: 1-3, more preferably, can be extracted in a weight ratio of 1: 1: 1, mixing chrysanthemum in the mixing weight ratio: aloe vera: caulis Hederae sinensis extract. The mixed extract of the present invention may be extracted together after mixing each natural product, or may be mixed after separate extraction. The present invention is characterized in that the above mixed extract can be extracted from a certain part of chrysanthemum, aloe and hedera helix, but preferably, their flowers, leaves or stems are extracted.

The invention is characterized in that the extract is contained in an amount of 0.001 to 30 weight percent based on the total weight of the composition. When the content is less than the above range, the effectiveness may be lowered, and when the content is more than the above range, the formulation may be difficult, which is not preferable.

The present invention is characterized in that the above composition has the effects of promoting the gene expression of type I collagen (COL1A1), inhibiting the gene expression of MMP-1 increased by ultraviolet rays to inhibit aging, and improving wrinkles.

According to the experimental examples of the present invention, it was confirmed that when human fibroblasts were treated with the mixed extract of chrysanthemum, aloe, and ivy, the synergistic effect of increasing the gene expression of COL1a1 was exhibited, as compared to the case of treating the extract of chrysanthemum, aloe, or ivy alone. Furthermore, it was confirmed that, in fibroblasts irradiated with ultraviolet light, when a mixed extract of chrysanthemum, aloe and caulis hederae, a synergistic effect was exhibited when the expression of MMP-1 was suppressed, as compared with the case where the extract of chrysanthemum, aloe and caulis hederae is treated alone. From these results, it was found that the mixed extract of chrysanthemum, aloe and ivy of the present invention promotes the expression of type i procollagen gene, and shows skin aging-inhibiting and wrinkle-improving effects by inhibiting the increase of MMP-1 gene expression caused by ultraviolet rays.

The present invention is characterized in that the composition can be prepared using any formulation generally prepared in this field, and preferably, the composition is one or more formulations selected from the group consisting of a skin lotion, a skin softener, a toner, an astringent, a lotion, an emulsion, a moisturizing lotion, a nourishing lotion, a massage cream, a nourishing cream, a moisturizing cream, a hand cream, a foundation, an essence, a nourishing essence, a mask, a soap, a face cleanser, a cleansing lotion, a cleansing cream, a body lotion, and a body lotion.

The cosmetic composition of the present invention may contain, as an active ingredient, in addition to the mixed extract, a water-containing aqueous phase ingredient, an oil phase ingredient containing oil or fat, an organic or inorganic powder, a surfactant, a humectant, a thickener, etc., which are generally used in cosmetic compositions, in different formulations, and may further contain, as other auxiliary ingredients, a preservative, an antioxidant, a pH adjuster, a pigment, a perfume, etc.

According to the present invention, the cosmetic composition comprising the mixed extract of chrysanthemum, aloe and ivy as an active ingredient can increase the expression of COL1a1, which is a collagen biosynthesis gene, and can exhibit skin aging prevention or wrinkle improvement effects by inhibiting the expression of MMP-1, which is a collagen catabolic enzyme.

Drawings

FIG. 1 is a result of Experimental example 1 in which the effect of mixed extracts of Chrysanthemum morifolium, Aloe Vera and hedera helix on mRNA expression of COL1A1 in human fibroblasts was confirmed.

Mixture of chrysanthemum, aloe and common ivy 1: 3.3% of chrysanthemum, 3.3% of aloe, 3.3% of common ivy, 3.3% (ul/ml); mixture of chrysanthemum, aloe and common ivy 2: chrysanthemum 5+ aloe 2.5+ common ivy 2.5 (ul/ml); chrysanthemum, aloe and common ivy stem mixture 3: 2.5% of chrysanthemum, 5% of aloe and 2.5% of caulis hederae chamaecyparis (ul/ml).^*p<0.05,^**p<0.01 (compare with blank group)

FIG. 2 is a result of experimental example 2 in which the effect of mixed extracts of Chrysanthemum morifolium, Aloe vera and caulis Erythrinae on mRNA expression of MMP-1 in human fibroblasts was confirmed.

Mixture of chrysanthemum, aloe and common ivy 1: 0.33% of chrysanthemum, 0.33% of aloe, 0.33% of common ivy, and 0.33 (ul/ml); mixture of chrysanthemum, aloe and common ivy 2: 0.5% of chrysanthemum, 0.25% of aloe and 0.25% of common ivy (ul/ml); chrysanthemum, aloe and common ivy stem mixture 3: chrysanthemum flowerFlower 0.25+ aloe 0.5+ hedera helix 0.25(ul/ml).^**p<0.01 (compared to the blank group),⁺⁺p<0.01 (comparison with UV control)

Detailed Description

Hereinafter, the present invention will be described in detail by way of examples and experimental examples. However, the examples and experimental examples of the present invention may be modified in various other ways, and the scope of the present invention should not be construed as being limited to the examples and experimental examples described in detail below. Examples and experimental examples of the present invention are provided to enable those skilled in the art to more fully understand the present invention.

An embodiment of the present invention provides a cosmetic composition for preventing skin aging or improving wrinkles, comprising a mixture of extracts of chrysanthemum, aloe, and hedera helix as effective ingredients. The extracts of chrysanthemum, aloe, and ivy used in the present invention were supplied from skin laboratory (Derma Lab) to be used in the experiment. The method for obtaining the above chrysanthemum, aloe and common ivy extracts is not particularly limited, and extracts prepared or sold by extraction with an organic solvent or water may be used.

The cosmetic composition is effective in improving skin aging caused by external or internal factors. The external factors are various external factors such as ultraviolet rays, while the internal factors are also called chronological factors, and mainly refer to factors generated with the passage of time.

Specifically, the cosmetic composition of the present invention comprising mixed extracts of chrysanthemum, aloe and caulis hederae chamomillae has the effect of inducing the expression of collagen biosynthesis genes to restore damaged dermis, and the effect thereof shows a synergistic effect compared to the case of treating chrysanthemum, aloe or caulis hederae chamomillae alone.

Also, the cosmetic composition of the present invention can exhibit wrinkle-improving effects and aging-preventing effects by reducing the collagen degrading enzyme gene, and the effects exhibit synergistic effects as compared with the case of treating chrysanthemum, aloe, or ivy alone.

The present invention will be described in more detail below with reference to examples. However, these examples are provided to illustrate the present invention, and the scope of the present invention is not limited to these examples.

Comparative example 1: separate extracts of chrysanthemum, aloe and common ivy

After the chrysanthemum (flower), aloe (leaf) and caulis ampelopsis grossedentata (leaf) were pulverized, each 100g was extracted, and each was put into a separate container as an extraction solvent, and immersed in 70 wt% of 1L of an aqueous ethanol solution, and left to stand at room temperature for 24 hours, thereby obtaining an extract. The obtained extract was filtered with filter paper, and the filtrate was concentrated under reduced pressure with a rotary evaporation dryer to obtain extracts of 50g of chrysanthemum extract, 50g of aloe extract, and 50g of hedera helix extract.