阅读说明：本技术 一种中药新特性中药型***的制备方法 (Preparation method of traditional Chinese medicine hypnotic with novel traditional Chinese medicine characteristics ) 是由 粟淘 于 2019-12-02 设计创作，主要内容包括：本发明公开了一种中药新特性中药型安眠药的制备方法,具体涉及医疗领域,具体步骤如下：S1、原料选用：S1.1:选用外形、重量适合的人工种植或野生草乌,并称取单次使用重量留用；S1.2:剩余草乌鲜品晒干脱水制成草乌脱水干品备用；S2、清洗去泥：将草乌原料用水浸泡,随后使用清洗装置对其离心清洗6分钟,再漂洗1-2次,漂洗时长设置为1-2分钟,随后沥水备用；S3、熟制加工。本发明通过多种制药方法将熟草乌制备成进食药剂及对药剂使用量的限定,供习惯不同进食习惯的人群选择,可对失眠人群起到较佳的助睡效果,可解决现由化学法合成法安眠药如依赖性诸多弊端。(The invention discloses a preparation method of a traditional Chinese medicine type hypnotic with new characteristics of traditional Chinese medicines, and particularly relates to the field of medical treatment, and the preparation method comprises the following specific steps: s1, selecting the following raw materials: s1.1, selecting artificial planting or wild radix aconiti kusnezoffii with proper shape and weight, and weighing the weight for single use; s1.2, drying and dehydrating the rest fresh radix aconiti kusnezoffii to prepare a dehydrated radix aconiti kusnezoffii dried product for later use; s2, cleaning and removing mud: soaking the raw material of radix aconiti agrestis in water, then centrifugally cleaning the raw material of radix aconiti agrestis for 6 minutes by using a cleaning device, rinsing for 1-2 times, setting the rinsing time to be 1-2 minutes, and then draining for later use; and S3, cooking and processing. The invention prepares the radix aconiti kusnezoffii into the food taking medicament by various pharmaceutical methods and limits the use amount of the medicament, so that the radix aconiti kusnezoffii can be selected by people who are accustomed to different food taking habits, can play a better sleep-assisting effect for insomnia people, and can solve the defects of dependence of the existing chemical synthesis method for hypnotic drugs.)

1. A preparation method of a traditional Chinese medicine hypnotic with new characteristics of traditional Chinese medicines is characterized by comprising the following steps: the method comprises the following specific steps:

s1, selecting the following raw materials:

s1.1, selecting artificial planting or wild radix aconiti kusnezoffii with proper shape and weight, and weighing the weight for single use;

s1.2, drying and dehydrating the rest fresh radix aconiti kusnezoffii to prepare a dehydrated radix aconiti kusnezoffii dried product for later use;

s2, cleaning and removing mud: soaking the raw material of radix aconiti agrestis in water, then centrifugally cleaning the raw material of radix aconiti agrestis for 6 minutes by using a cleaning device, rinsing for 1-2 times, setting the rinsing time to be 1-2 minutes, and then draining for later use;

s3, cooking:

s3.1: putting the cleaned kusnezoff monkshood root which is not required to be peeled and root hairs in the step S2 into a high-pressure steamer, adding water until the kusnezoff monkshood root is completely submerged under the water surface, and steaming for 1.5-2 hours under high pressure;

s3.2: checking the center of the individual radix aconiti kusnezoffii cooked in the step S3.1 by using a tool to twist, judging whether the individual radix aconiti kusnezoffii is numb and tongue-like, if not, continuously putting the individual radix aconiti kusnezoffii back to the high-pressure steamer to cook for 0.5 hour;

s3.3: repeating the step S3.2 until the individual radix aconiti kusnezoffii is completely cooked, and dehydrating by hot air until the water content is 15-20%;

s4, preparing medicine:

s4.1: dehydrating the radix aconiti agrestis cooked in the step S3, drying, sterilizing according to 5-15g equivalent of fresh radix aconiti agrestis, drying and packaging;

s4.2: dehydrating the radix Aconiti Kusnezoffii cooked in step S3 under aseptic condition, pulverizing into powder, and aseptically packaging according to 5-15g equivalent of fresh radix Aconiti Kusnezoffii;

s4.3: crushing the radix aconiti agrestis cooked in the step S3 under the aseptic environment, pressing into phi 5mm tablets or granules, and aseptically packaging according to 5-15g equivalent of fresh radix aconiti agrestis;

s4.4: pulverizing radix Aconiti Kusnezoffii cooked in step S3 in sterile environment, extracting with organic solvent capable of dissolving hypoaconitine, removing organic solvent, adsorbing with dextrin, granulating, and packaging with 5-15g equivalent weight of fresh radix Aconiti Kusnezoffii;

s4.5: soaking the radix Aconiti Kusnezoffii cooked in step S3 in wine to extract hypo-aconitine, and directly drinking the soaked wine according to 5-15g equivalent of fresh radix Aconiti Kusnezoffii.

2. The preparation method of a traditional Chinese medicine hypnotic with new traditional Chinese medicine characteristics according to claim 1, is characterized in that: in the step S1.1, the Chinese wu single fresh product is selected from individuals with weight not less than 20g and no appearance damage.

3. The preparation method of a traditional Chinese medicine hypnotic with new traditional Chinese medicine characteristics according to claim 1, is characterized in that: and S1.2, drying the fresh Chinese herbal medicine dark-skinned herbs in the sun or in ventilation for 10-45 days, wherein the weight of a single dehydrated dry product is 5-9 g.

4. The preparation method of a traditional Chinese medicine hypnotic with new traditional Chinese medicine characteristics according to claim 1, is characterized in that: and in the step S2, the fresh product is soaked in normal-temperature water for 10-15 minutes.

5. The preparation method of a traditional Chinese medicine hypnotic with new traditional Chinese medicine characteristics according to claim 1, is characterized in that: the soaking time of the dehydrated dry product in the step S2 is set to be 22-24 hours, and the dried product is cleaned by wetting the cut checking raw material center.

6. The preparation method of a traditional Chinese medicine hypnotic with new traditional Chinese medicine characteristics according to claim 1, is characterized in that: the method for judging whether the individual kusnezoff monkshood root is cooked in the step S3.2 comprises the following steps: the cooking is successful if the center of the individual kusnezoff monkshood root is in a planar shape after being rolled and checked by a tool; the center of the individual radix Aconiti Kusnezoffii can not be in planar shape and is hard and unhealthy after being checked by rolling with a tool.

7. The preparation method of a traditional Chinese medicine hypnotic with new traditional Chinese medicine characteristics according to claim 1, is characterized in that: the degree of comminution in step S4.2 is set to 80-200 mesh.

8. The preparation method of a traditional Chinese medicine hypnotic with new traditional Chinese medicine characteristics according to claim 1, is characterized in that: the soaking time in the step S4.5 is set to be more than 15 days.

Technical Field

The invention relates to the technical field of medical treatment, in particular to a preparation method of a traditional Chinese medicine type hypnotic with new characteristics of traditional Chinese medicines.

Background

Kusnezoff monkshood root, which is called as: aconitum kusnezoffii, gelsemium elegans, rhizoma cyperi, toxylon gong, aconitum japonicum koch and radix aconiti pentandrae. The Chinese medicine is dry root tuber of Aconitum kusnezoffii Reichb. Collected in autumn when stem and leaf withered, removed fibrous root and silt, and dried. The wild radix aconiti kusnezoffii is in an irregular long cone shape, slightly bent, 20-80 mm long and 10-25 m in diameter, and the mass of the wild radix aconiti kusnezoffii is usually 20-85 g. There are usually residual stem and few adventitious root residues at the tip, some have a withered bud on one side of the tip and a round or oblate adventitious root residue on one side. The surface is gray brown or dark brown, and has wrinkle, longitudinal wrinkle, punctate fibrous root scar and several nodular lateral roots. Hard, grey or dark grey cross section, with fissures, forming a polygonal or quasi-circular ring-shaped cambium with a large or hollow medullary part. Light smell, pungent and numb taste. Can be used for treating arthralgia due to wind-cold-dampness, arthralgia, psychroalgia of heart and abdomen, cold hernia pain, and anesthesia and pain relieving.

The insomnia is difficult to fall asleep, easy to wake up and early wake up in the middle of sleep, low sleep quality, dreaminess, sleep time is obviously reduced, and serious patients still do not sleep all night. Long-term insomnia is easy to cause upset, fatigue and weakness, even headache, dreaminess, hyperhidrosis and hypomnesis, and can also cause a series of clinical symptoms and induce some psychosomatic diseases. Particularly, in the current fast-paced society of life and work, the number of insomnia people is increasing, and partial patients can select to take hypnotics to help the patients to enter the sleep state so as to ensure the work state of the next day. In addition to the dependence, the central nervous system is also inhibited, for example, respiration is inhibited, skeletal muscle is relaxed, and the like, which may aggravate dyspnea, induce bradycardia, blood pressure decrease, heart failure, and the like.

Disclosure of Invention

In order to overcome the defects in the prior art, the embodiment of the invention provides a preparation method of a traditional Chinese medicine type hypnotic with new traditional Chinese medicine characteristics, and the kusnezoff monkshood root is used for preparing a natural insomnia medicine with small dependence, small toxic and side effects and safety, so that the defects of the existing hypnotic are overcome.

In order to achieve the purpose, the invention provides the following technical scheme: a preparation method of Chinese medicinal hypnotic with new characteristics of Chinese medicines comprises the following steps:

s1, selecting the following raw materials:

s1.1, selecting artificial planting or wild radix aconiti kusnezoffii with proper shape and weight, and weighing the weight for single use;

s1.2, drying and dehydrating the rest fresh radix aconiti kusnezoffii to prepare a dehydrated radix aconiti kusnezoffii dried product for later use;

s2, cleaning and removing mud: soaking the raw material of radix aconiti agrestis in water, then centrifugally cleaning the raw material of radix aconiti agrestis for 6 minutes by using a cleaning device, rinsing for 1-2 times, setting the rinsing time to be 1-2 minutes, and then draining for later use;

s3, cooking:

s3.1: putting the cleaned kusnezoff monkshood root which is not required to be peeled and root hairs in the step S2 into a high-pressure steamer, adding water until the kusnezoff monkshood root is completely submerged under the water surface, and steaming for 1.5-2 hours under high pressure;

s3.2: checking the center of the individual radix aconiti kusnezoffii cooked in the step S3.1 by using a tool to roll, judging whether the individual radix aconiti kusnezoffii is cooked, and if not, continuously putting the individual radix aconiti kusnezoffii into a high-pressure steamer to cook for 0.5 hour;

s3.3: repeating the step S3.2 until the individual radix aconiti kusnezoffii is completely cooked, and dehydrating by hot air until the water content is 15-20%;

s4, preparing medicine:

s4.1: dehydrating the radix Aconiti Kusnezoffii cooked in step S3, drying, sterilizing according to 5-15g equivalent of fresh radix Aconiti Kusnezoffii (to avoid poisoning caused by excessive consumption of cooked radix Aconiti Kusnezoffii), drying, and packaging, and can be directly eaten, or processed with other food by heating or cooking with water;

s4.2: dehydrating and crushing the wild aconite prepared in the step S3 into powder in a sterile environment (meeting pharmaceutical or food processing environment and ensuring that the finished product reaches the allowable colony value condition under the edible condition), and aseptically packaging the fresh wild aconite according to 5-15g equivalent for a consumer to adjust water for taking, wherein the powder is prevented from being inhaled into the trachea by mistake when in use, so as to cause discomfort;

s4.3: crushing the wild aconite root cooked in the step S3 in an aseptic environment (meeting pharmaceutical or food processing environment and ensuring that a finished product reaches the allowable colony value condition under the edible condition), pressing into phi 5mm slices or granules, aseptically packaging according to 5-15g equivalent of fresh wild aconite root (avoiding the occurrence of poisoning events caused by excessive consumption of the cooked wild aconite root), and carrying out chewing and eating by a consumer after wetting with water;

s4.4: crushing the radix aconiti agrestis cooked in the step S3 in a sterile environment (meeting pharmaceutical or food processing environment and ensuring that a finished product reaches an allowable colony value condition under an edible condition), extracting the aconitine with an organic solvent capable of dissolving the aconitine, removing the organic solvent, adsorbing and granulating with dextrin, packaging according to 5-15g equivalent weight of fresh radix aconiti agrestis (avoiding toxic events caused by eating excessive cooked aconitum agrestis), and taking the tablets as enteric tablets with warm boiled water;

s4.5: soaking the radix Aconiti Kusnezoffii cooked in step S3 in wine to extract hypo-aconitine, and directly drinking the soaked wine according to 5-15g equivalent of fresh radix Aconiti Kusnezoffii (to avoid poisoning caused by excessive consumption of cooked radix Aconiti Kusnezoffii).

In a preferred embodiment, in step S1.1, the fresh single Chinese medicinal herb in the raw material is selected from individuals with a weight of not less than 20g and no appearance damage, so as to avoid the reduction of the medicinal effect caused by the appearance damage or immature kusnezoff monkshood root.

In a preferred embodiment, the sun-drying condition of the fresh radix aconiti kusnezoffii product in step S1.2 is sunlight or ventilation drying, the drying time is set to be 10-45 days, the weight of a single dehydrated dry product is 5-9g, the dehydrated dry product is easier to store, and rotting and deterioration of the fresh radix aconiti kusnezoffii product during storage are avoided.

In a preferred embodiment, in the step S2, the fresh product is soaked in the normal temperature water for 10-15 minutes, and the soaking purpose mainly plays a role in separating soil from the radix aconiti agrestis to facilitate machine cleaning and soaking silt on the outer wall of the fresh product to facilitate subsequent cleaning.

In a preferred embodiment, the soaking time of the dehydrated dry product in the step S2 is set to be 22-24 hours, and the dried product is cleaned by cutting to check the wetting of the raw material center, so as to soak the silt on the outer wall of the dry product, thereby facilitating the subsequent cleaning work.

In a preferred embodiment, the method for determining whether the individual radix aconiti kusnezoffii is cooked in step S3.2 comprises the following steps: the cooking is successful if the center of the individual kusnezoff monkshood root is in a planar shape after being rolled and checked by a tool; the center of the individual kusnezoff monkshood root cannot be in a planar shape through the rolling inspection of a tool, and the hardness is not good, so that the poisoning event that the life is endangered due to the blockage of trachea, esophagus and blood vessel and asphyxia caused by the swelling of organism tissues caused by the arrival of raw kusnezoff monkshood root alkali is avoided.

In a preferred embodiment, the degree of comminution in step S4.2 is set to 80-200 mesh.

In a preferred embodiment, the soaking period in step S4.5 is set to 15 days or more.

The invention has the technical effects and advantages that:

according to the invention, through researching the efficacy of the kusnezoff monkshood root, the cooked kusnezoff monkshood root and the sub-kusnezoff monkshood root alkali are found to have the sleep-improving efficacy and are natural sleep-improving medicines, the chemical component of the raw kusnezoff monkshood root is the kusnezoff monkshood root alkali (except starch), the chemical component of the cooked kusnezoff monkshood root is the sub-kusnezoff monkshood root alkali, the cooked kusnezoff monkshood root is prepared into eating medicaments and the use amount of the medicaments is limited by various pharmaceutical methods for people who are accustomed to different eating habits, generally has no: the natural plants have the same source of food and medicine, better safety and little toxic and side effect, and can solve the defects of the existing chemical synthesis method of hypnotic drugs such as dependence.

Detailed Description

The technical solutions in the embodiments of the present invention will be clearly and completely described below with reference to the embodiments of the present invention, and it is obvious that the described embodiments are only a part of the embodiments of the present invention, and not all of the embodiments. All other embodiments, which can be derived by a person skilled in the art from the embodiments given herein without making any creative effort, shall fall within the protection scope of the present invention.