阅读说明：本技术 一种医用冷藏箱用温度模拟液及其配制方法 (Temperature simulation liquid for medical refrigerator and preparation method thereof ) 是由 冯贵武 苗晨雨 钱小军 于 2018-07-12 设计创作，主要内容包括：本发明公开了一种医用冷藏箱用温度模拟液,该温度模拟液包括丙三醇水溶液、模拟液助剂a、模拟液助剂b；所述的丙三醇水溶液占总模拟液与水之总量的20%-70%,所述模拟液助剂a按5-10g/L加入丙三醇水溶液中；所述模拟液助剂b按0.002-0.004g/L加入丙三醇水溶液中。所述模拟液助剂a为十二烷基二甲基苄基氯化铵。所述模拟液助剂b为缓蚀剂。所述的缓蚀剂为苯骈三氮唑BTA。温度模拟液在温控范围内物理状态不发生明显变化,即保持液态,不固化,不汽化,不凝胶等；温度模拟液在更换周期内不发生霉变,不滋生微生物。温度模拟液对存放的显示温度探头中性,包括塑料和金属材质,不产生腐蚀。(The invention discloses a temperature simulation liquid for a medical refrigerator, which comprises a glycerol aqueous solution, a simulation liquid auxiliary agent a and a simulation liquid auxiliary agent b; the glycerol aqueous solution accounts for 20-70% of the total amount of the simulated liquid and the water, and the simulated liquid auxiliary agent a is added into the glycerol aqueous solution according to 5-10 g/L; the simulated liquid additive b is added into the glycerol aqueous solution according to 0.002-0.004 g/L. The simulation liquid additive a is dodecyl dimethyl benzyl ammonium chloride. The simulated liquid additive b is a corrosion inhibitor. The corrosion inhibitor is benzotriazole BTA. The physical state of the temperature simulation liquid does not change obviously in the temperature control range, namely the temperature simulation liquid is kept in a liquid state, is not solidified, is not vaporized, is not gelled and the like; the temperature simulation liquid does not mildew or breed microorganisms in the replacement period. The temperature simulation liquid is neutral to the stored temperature display probe, comprises plastic and metal materials, and does not corrode.)

1. The utility model provides a temperature simulation liquid for medical fridge which characterized in that: the temperature simulation liquid comprises a glycerol aqueous solution, a simulation liquid auxiliary agent a and a simulation liquid auxiliary agent b; the glycerol aqueous solution accounts for 20-70% of the total amount of the simulated liquid and the water, and the simulated liquid auxiliary agent a is added into the glycerol aqueous solution according to 5-10 g/L; the simulated liquid additive b is added into the glycerol aqueous solution according to 0.002-0.004 g/L.

2. The temperature simulating fluid for a medical refrigerator according to claim 1, wherein: the simulation liquid additive a is dodecyl dimethyl benzyl ammonium chloride.

3. The temperature simulating fluid for a medical refrigerator according to claim 1, wherein: the simulated liquid additive b is a corrosion inhibitor.

4. The temperature simulating fluid for a medical refrigerator according to claim 3, wherein: the corrosion inhibitor is benzotriazole BTA.

5. A method for preparing a temperature simulant liquid for a medical refrigerator as set forth in any one of claims 1 to 4, wherein: the lowest freezing point of the glycerol aqueous solution matrix is determined according to the temperature control requirement, the mixture ratio is selected,

when the freezing point of the medical refrigerating box body is required to be below 5 ℃ below zero, a prepared glycerol aqueous solution accounts for 20% of the total amount of the simulation liquid and the water;

when the freezing point is required to be below-10 degrees, the glycerol aqueous solution is selected to be prepared to account for 30 percent of the total amount of the simulated liquid and the water;

when the freezing point is required to be below 23 ℃, the glycerol aqueous solution is selected to be prepared to account for 50 percent of the total amount of the simulation liquid and the water;

when the freezing point is required to be 46 ℃ below zero, preparing a glycerol aqueous solution accounting for 67 percent of the total amount of the simulation liquid and the water;

the simulated liquid additive a is added into the glycerol aqueous solution according to the proportion of 5-10g/L, and the simulated liquid additive b is added into the glycerol aqueous solution according to the proportion of 0.002-0.004g/L, and the mixture is shaken up to obtain the simulated liquid.

Technical Field

The invention belongs to the technical field of low-temperature refrigeration, and particularly relates to a temperature simulation liquid for a medical refrigerator and a preparation method thereof.

Background

The medical refrigerator is mainly used for storing medicines, reagents or vaccines with strict requirements on storage temperature, and the temperature control range is generally 2-8 ℃. The medical refrigerator is internally provided with temperature sensors with two functions, one is a control sensor for monitoring and controlling the start and stop of the compressor, and the other is a display sensor for displaying the temperature. Two temperature monitoring modes of the display sensor are provided, one mode is to monitor and display the temperature of the circulating air in the box and ensure the storage temperature range of the storage object; the other is to put a display temperature sensor into the simulation liquid to simulate and monitor the internal temperature of the stored object. The former is mainly to monitor the storage environment temperature, and cannot simulate the actual temperature of the storage object, and the latter simulates the actual temperature of the storage object through the simulation liquid. At present, most of medical refrigerating boxes adopt the former mode, a display sensor is directly fixed in a small box, and the small box has the fixing function and mainly avoids the phenomenon that circulating air directly blows to the display sensor to cause severe fluctuation of temperature and cannot truly express the true temperature of a storage object. The latter approach is gradually adopted in pursuit of temperature control and authenticity of display temperature. The good and cheap simulation liquid is water, but the simulation liquid is easy to freeze when the temperature of a refrigerator is abnormally reduced to be below 0 ℃, the melting time is long, and the temperature of a storage object cannot be reflected in vacuum, so that substances for reducing the freezing point need to be added into the water, and substances such as polysaccharide, alcohol and the like are generally adopted in reports. The metal temperature sensor probe can generate corrosion after being soaked in water solution for a long time, and the temperature sensor is damaged, so that products are scrapped. The aqueous solution is not replaced for a long time, is easy to smell and deteriorate, generates mould, influences user experience and even infects stored articles.

Disclosure of Invention

The invention aims to provide a temperature simulation liquid for a medical refrigerator and a preparation method thereof, aiming at the problem that the freezing point temperature of the existing temperature measurement simulation liquid is higher.

In order to achieve the purpose, the technical scheme adopted by the invention is as follows:

a temperature simulation liquid for a medical refrigerator comprises a glycerol aqueous solution, a simulation liquid auxiliary agent a and a simulation liquid auxiliary agent b; the glycerol aqueous solution accounts for 20-70% of the total amount of the simulated liquid and the water, and the simulated liquid auxiliary agent a is added into the glycerol aqueous solution according to 5-10 g/L; the simulated liquid additive b is added into the glycerol aqueous solution according to 0.002-0.004 g/L. The simulation liquid additive a is dodecyl dimethyl benzyl ammonium chloride. The simulated liquid additive b is a corrosion inhibitor. The corrosion inhibitor is benzotriazole BTA.

The preparation method of the temperature simulation liquid for the medical refrigerator comprises the following steps of determining the lowest freezing point of the glycerol aqueous solution according to the temperature control requirement, and selecting the following mixture ratio:

when the freezing point of the medical refrigerating box body is required to be below 5 ℃ below zero, a prepared glycerol aqueous solution accounts for 20% of the total amount of the simulation liquid and the water;

when the freezing point is required to be below-10 degrees, the glycerol aqueous solution is selected to be prepared to account for 30 percent of the total amount of the simulated liquid and the water;

when the freezing point is required to be below 23 ℃, the glycerol aqueous solution is selected to be prepared to account for 50 percent of the total amount of the simulation liquid and the water;

when the freezing point is required to be 46 ℃ below zero, preparing a glycerol aqueous solution accounting for 67 percent of the total amount of the simulation liquid and the water;

the simulated liquid additive a is added into the glycerol aqueous solution according to the proportion of 5-10g/L, and the simulated liquid additive b is added into the glycerol aqueous solution according to the proportion of 0.002-0.004g/L, and the mixture is shaken up to obtain the simulated liquid.

Compared with other methods, the method has the beneficial technical effects that:

(1) the invention adopts different percentage ratios of the glycerol natural mineral water matrix, ensures that no physical state change occurs in a temperature zone of the refrigerator, and truly simulates the actual control temperature of a storage object. The selected matrix is safe and harmless, the natural mineral water meets the national standard requirements, the glycerol is easily soluble in water, can absorb moisture from the air, and the moisture is not easy to volatilize, so that the mineral water is suitable for long-term use in the medical refrigerator.

(2) According to the invention, dodecyl dimethyl benzyl ammonium chloride is used as a sterilization algicide, so that the temperature simulation liquid is prevented from mildewing and breeding microorganisms in a replacement period. Dodecyl dimethyl benzyl ammonium chloride is dissolved in water, belongs to a quaternary ammonium salt non-oxidizing bactericide, has broad-spectrum and high-efficiency sterilization and algae removal effects in different pH value ranges, also has deodorization and anti-discoloration effects, and is matched with a simulation liquid auxiliary agent b to enhance the corrosion inhibition effect.

(3) The present invention adopts benzotriazole BTA as copper-silver corrosion inhibitor, which is dissolved in water. BTA can be adsorbed on metal materials such as copper, silver, stainless steel and the like of the temperature sensor to form a thin film, so that the metal materials are protected from being corroded by harmful media.

Detailed Description

The present invention will be further described with reference to the following examples.

A temperature simulation liquid for a medical refrigerator comprises a glycerol aqueous solution, a simulation liquid auxiliary agent a and a simulation liquid auxiliary agent b; the glycerol aqueous solution accounts for 20-70% of the total amount of the simulated liquid and the water, and the simulated liquid auxiliary agent a is added into the glycerol aqueous solution according to 5-10 g/L; the simulated liquid additive b is added into the glycerol aqueous solution according to 0.002-0.004 g/L. The simulation liquid additive a is dodecyl dimethyl benzyl ammonium chloride. The simulated liquid additive b is a corrosion inhibitor. The corrosion inhibitor is benzotriazole BTA. The preparation method of the temperature simulation liquid for the medical refrigerator comprises the following steps of determining the lowest freezing point of the glycerol aqueous solution according to the temperature control requirement, and selecting the mixture ratio according to the following requirements:

when the freezing point of the medical refrigerating box body is required to be below 5 ℃ below zero, a prepared glycerol aqueous solution accounts for 20% of the total amount of the simulation liquid and the water;

when the freezing point is required to be below-10 degrees, the glycerol aqueous solution is selected to be prepared to account for 30 percent of the total amount of the simulated liquid and the water;

when the freezing point is required to be below 23 ℃, the glycerol aqueous solution is selected to be prepared to account for 50 percent of the total amount of the simulation liquid and the water;

when the freezing point is required to be 46 ℃ below zero, preparing a glycerol aqueous solution accounting for 67 percent of the total amount of the simulation liquid and the water;

the simulated liquid additive a is added into the glycerol aqueous solution according to the proportion of 5-10g/L, and the simulated liquid additive b is added into the glycerol aqueous solution according to the proportion of 0.002-0.004g/L, and the mixture is shaken up to obtain the simulated liquid.

According to the proportion and the freezing point, the temperature simulation liquid of medical refrigeration and freezing boxes with different temperature requirements can be selected. The aqueous glycerol solution was neutral and had a pH (25 ℃ C.) of 7. The natural mineral water (meeting the national standard of GB 8537-2008) is prepared by filtering the water by quartz sand and active carbon, sterilizing by ozone, mixing and the like, and the mineral water on the market can also be directly adopted.

According to the steps, the temperature simulation liquid is obtained and is suitable for different temperature requirements.

The foregoing shows and describes the general principles, essential features, and advantages of the invention. It will be understood by those skilled in the art that the present invention is not limited to the embodiments described above, which are described in the specification and illustrated only to explain the principles of the invention, and that various modifications and alterations can be made by those skilled in the art without departing from the spirit and scope of the invention.