阅读说明：本技术 经***向回盲瓣的深度植入器械及其植入方法 (Deep implantation instrument for transanal ileocecal valve and implantation method thereof ) 是由 张发明 李潘 季国忠 彭炤源 崔伯塔 缪林 于 2015-04-11 设计创作，主要内容包括：本发明公开了一种经肛门向回盲瓣的深度植入器械及其植入方法,包括给药管和固定连接在给药管的远端管壁上的固定线,给药管为具有弹性且可弯曲的高分子材料管,其两端开口,在给药管的远端端侧或在给药管的侧壁上设有一个或多个与给药管内相通的出药孔；在给药管内穿装有能在给药管内前后自由活动的导丝；该导丝的横截面小于所述给药管的内径；在所述给药管的近端可活动连接有一延长件。本发明的经肛门向回盲瓣的深度植入器械,能送到并固定于肠道深部,满足肛门—回盲部管一次性和长期使用功能,它结构巧妙、操作方便、安全有效,可长期保留,并满足多次给药的需求,极大的方便了全结肠给药等临床用途,将被广泛用于临床治疗。(The invention discloses a deep implantation instrument for a transanal ileocecal valve and an implantation method thereof, and the deep implantation instrument comprises an administration tube and a fixing line fixedly connected to the wall of the far end of the administration tube, wherein the administration tube is an elastic and bendable polymer material tube, two ends of the administration tube are opened, and one or more medicine outlet holes communicated with the administration tube are formed in the far end side of the administration tube or the side wall of the administration tube; a guide wire which can freely move back and forth in the administration tube is arranged in the administration tube in a penetrating way; the cross section of the guide wire is smaller than the inner diameter of the administration tube; an extension piece can be movably connected to the near end of the administration tube. The deep implantation instrument for the ileocecal valve from the anus can be delivered to and fixed in the deep part of the intestinal tract, meets the one-time and long-term use functions of the anus-ileocecal tube, has the advantages of ingenious structure, convenient operation, safety and effectiveness, can be reserved for a long time, meets the requirement of multiple times of administration, greatly facilitates clinical applications such as colon administration and the like, and can be widely used for clinical treatment.)

1. A deep implantation instrument for transanally recanalizing a blind valve, comprising: the drug delivery device comprises a drug delivery tube (1) and a fixing wire (2) fixedly connected to the wall of the far end of the drug delivery tube, wherein the drug delivery tube (1) is an elastic and bendable polymer material tube, two ends of the drug delivery tube are open, and one or more drug outlet holes (3) communicated with the drug delivery tube are formed in the far end side of the drug delivery tube or on the side wall of the drug delivery tube; a guide wire (6) which can freely move back and forth in the administration tube is arranged in the administration tube in a penetrating way; the cross section of the guide wire is smaller than the inner diameter of the administration tube; an extension piece (5) can be movably connected with the near end of the administration tube.

2. The transvanial ileocaecal deep implantation instrument as claimed in claim 1, wherein: the device also comprises a connector (7), and the connector (7) is movably connected with the proximal end of the administration tube (1) or the proximal end of the extension piece (5).

3. The transvanial ileocaecal deep implantation instrument as claimed in claim 1, wherein: the extension piece (5) is a flexible and bendable pipe.

4. The transvanial ileocaecal deep implantation instrument as claimed in claim 1, wherein: the length of the administration tube (1) is 30.0-420.0 cm, the diameter of the cross section is 1.0-8.0mm, and the inner surface and the outer surface of the tube are smooth.

5. The transvanial ileocaecal deep implantation instrument as claimed in claim 1, wherein: the guide wire (6) is an elastic and bendable high polymer material wire or metal wire with good biological tissue compatibility, and the length of the guide wire is 30.0-420.0 cm.

6. The transvanial ileocaecal deep implantation instrument as claimed in claim 1, wherein: the fixing line (2) is provided with one or more annular structures, and the length of the fixing line is 5.0-10.0 cm; the joint of the fixing line and the administration tube is 0-30.0 cm away from the tail end of the administration tube.

7. The transvanial ileocaecal deep implantation instrument as claimed in claim 6, wherein: the fixed line (2) is in a double-ring, multi-ring or 8-shaped structure.

8. A method of implantation based on the transanally-directed ileocecal deep implantation instrument of any of claims 1 to 7, comprising the steps of:

carry out the inspection of whole colon through the enteroscopy under general anesthesia, after exploring the search clearly to the colon disease kitchen, send into through endoscope forceps channel and administer pipe (1), extension (5), the built-up piece of seal wire (6), the distal end of the pipe (1) of dosing of built-up piece reaches focus upper portion 5 ~ 10cm department, use seal wire (6) to support and not follow the endoscope to withdraw from the intestines chamber together with dosing pipe (1) when withdrawing from the endoscope, send the enteroscopy to the distal end of dosing pipe (1) again, use titanium clamp to fix in the top 5 ~ 10cm department of the focus of intestines intracavity with fixed line (2) of dosing pipe (1) distal end under endoscope forceps channel, withdraw from the endoscope, pull out extension (5), the near-end of dosing pipe (1) is fixed in the external suitable position of patient.

9. The method of implanting the transanally retrocealemic deep implantation instrument of claim 8, wherein: a connector (7) is attached to the proximal end of the administration tube 1.

Technical Field

The invention relates to an implantation instrument and an implantation method in the field of medical instruments, in particular to a deep implantation instrument for a transanal ileocecal valve and an implantation method thereof.

Background

The existing gastrointestinal administration comprises gastrointestinal nutrition treatment, and the route comprises oral administration, gastric tube, gastroscope, nasojejunal tube, anus enema, direct input under endoscope and the like. The in-line delivery is a simple and effective interventional procedure, including transnasal (usually including the duodenum and proximal jejunum) tube, intra-anal enema tube, and the like. The nasal and intestinal tube is mainly used for enteral nutrient solution infusion and medicine infusion, can be kept for a long time for use, but the infusion tube cannot be fixed on the intestinal wall and is easy to slip into the stomach or vomit to the outside of the body; traditional transanal administration has been limited to the requirements of cleansing enemas, retention enemas, and direct B colon topical treatments in the area of the rectodactylus, usually by a single infusion followed by withdrawal. However, no technique is available for implantation of the tube along the approach from the anus, throughout the colon, and for long term use of the tube for repeated administration or fecal transplantation therapy.

Disclosure of Invention

The purpose of the invention is as follows: the invention aims to provide a deep implantation instrument for a transvanial ileocaecal valve, which has the advantages of ingenious structure, convenient operation, safety and effectiveness, can be reserved for a long time, and is mainly used for: ileum, whole colon administration, achieving whole colon administration rather than local rectal sigmoid administration, changes the traditional approach to the treatment of ileocecal diseases and the scope of whole colon administration treatment.

It is a second object of the present invention to provide a method of implanting the transanally retrocealescent deep implantation instrument.

The technical scheme is as follows: in order to achieve the above purposes, the invention discloses a deep implantation instrument for a transanal ileocecal valve, which comprises an administration tube and a fixing line fixedly connected to the wall of the far end of the administration tube, wherein the administration tube is an elastic and bendable polymer material tube, two ends of the administration tube are opened, and one or more medicine outlet holes communicated with the administration tube are formed in the far end side of the administration tube or the side wall of the administration tube; a guide wire which can freely move back and forth in the administration tube is arranged in the administration tube in a penetrating way; the cross section of the guide wire is smaller than the inner diameter of the administration tube; an extension piece can be movably connected to the near end of the administration tube.

Wherein, the device also comprises a connector which is movably connected with the proximal end of the administration tube or the proximal end of the extending piece.

Preferably, the extension member is a flexible and bendable pipe.

Furthermore, the length of the administration tube is 30.0-420.0 cm, the diameter of the cross section is 1.0-8.0mm, and the inner surface and the outer surface of the tube are smooth.

Furthermore, the guide wire is an elastic and bendable high polymer material wire or metal wire with good biocompatibility, and the length of the guide wire is 30.0-420.0 cm.

Preferably, the fixing line has one or more annular structures, and the length of the fixing line is 5.0-10.0 cm; the joint of the fixing line and the administration tube is 0-30.0 cm away from the tail end of the administration tube.

Furthermore, the fixing line has a double-ring, multiple-ring or 8-shaped structure.

The invention relates to an implantation method of a deep implantation instrument based on a transanal ileocecal valve, which comprises the following steps:

carry out the inspection of whole colon or alimentary canal through the enteroscope under general anesthesia, after visiting the inspection clearly to colon focus or alimentary canal focus, send into through the scope pincers way and administer the pipe, the extension piece, the built-up piece of seal wire, the distal end of the pipe of administering of built-up piece reaches focus upper portion 5 ~ 10cm department, use the seal wire to support and not withdraw from the intestines chamber together with the scope for the pipe of administering when withdrawing from the scope, send the enteroscope to the distal end of administering the pipe again, use the titanium clip to be fixed in the top 5 ~ 10cm department of the focus in the intestines chamber with the fixed line of administering the pipe distal end under the scope pincers way, withdraw from the scope, pull out the extension piece, the near-end of administering the pipe is fixed in the external suitable position.

Further, a joint is attached to the proximal end of the administration tube 1.

A deep implantation instrument for a transanal ileocecal valve comprises an administration tube and a fixing line, wherein the administration tube is an elastic and bendable polymer material tube, two ends of the administration tube are open, one or more pore channels communicated with the administration tube are arranged on the end side of the distal end of the administration tube or on the side wall of the administration tube, and a tracer substance is or is not arranged on the tube wall of the administration tube; the fixed wire is fixedly connected to the tube wall of the administration tube. The device of the present invention may further comprise a guide wire and/or an elongate member. The administration tube in the device can be fixed on the intestinal wall through the titanium clamp for the fixing wire, and the length of the fixing wire and the distance between the joint of the fixing wire and the administration tube and the far end of the tube can enable the fixed administration tube to further move in the intestinal tract. The proximal end of the administration tube is used for inserting a guide wire, connecting an extension piece, connecting a joint, injecting medicine and the like, the guide wire in the administration tube can be used for guiding pipeline implantation, assisting in conveying when an endoscope exits, assisting in tube drawing, observing a target in a perspective mode and the like, and the guide wire can be added with an extension component on the basis of a short guide wire. The administration tube of the invention has the length of 30.0-420.0 cm, the diameter of the cross section of 1.0-8.0mm, is soft, elastic and bendable, has smooth inner and outer surfaces, is made of polyethylene, silica gel and other high polymer materials, and can have or not have tracer substances, such as metal wires which are not transparent to X rays, on the wall of the tube. The administration tube is provided with a pore canal which can be positioned at the end side and the wall side of the two ends, the number of the pore canals is preferably 2 or more, and the shape of the pore canal can be round, strip-shaped, polygonal or other irregular shapes. In a preferred scheme, the length of the administration tube is 90.0-120.0 cm, the front end of the administration tube is provided with an opening, 2 side holes are formed in the administration tube, the diameter of the outer tube is 2.0-4.0 mm, the tube wall is made of polyethylene or silica gel materials, 1X-ray-proof metal wire is arranged on the tube wall, a pore channel with the opening direction facing to the near end is arranged at a position more than 1.0cm away from the far end, and scales can be arranged on the tube wall. The proximal end of the administration tube may further be provided with a connector having one end for connection to the administration tube and the other end for connection to a drug pusher such as a syringe or other device capable of introducing the drug into the alimentary canal, such as an extension, a quick connector, or the like. The fixing line is positioned at the far end of the administration tube, can be positioned at an opening of the far end, and also can be positioned at a tube wall with a certain distance from the opening, for example, the connecting part of the fixing line and the administration tube is 0-30.0 cm away from the tail end of the administration tube (namely the far end opening). The fixing thread can be one or more annular structures, the length of the fixing thread is 5.0-10.0 cm, the fixing thread can be conveniently fixed on the wall of the colon intestine by using an auxiliary fixing device such as a titanium clip and the like under an endoscope, the fixing thread has certain tensile force and stronger tensile force, and the fixing thread can be made of materials with no tissue stimulation reaction such as nylon thread, catgut thread or polypropylene synthetic thread and the like. The preferred length of fixed line is 8.0cm, is dicyclo, polycyclic or "8" word structure, and nylon thread or catgut line material is located the administration pipe distal segment.

In the transanal ileocecal valve deep implantation instrument of the invention, the extension piece is optional, and when the extension piece is not provided, the length of the administration tube can be properly extended. When the extension piece is arranged, the proximal end of the administration tube is movably connected with the extension piece. Typically, the elongate member has a length of 30.0 to 300.0cm and a cross-section of 1.0 to 8.0mm and one end of the elongate member is adapted to engage the proximal end of the administration tube. The extension piece can be another tube which is the same as or different from the administration tube, the two administration tubes can be connected through a guide wire or other connecting devices, the administration tubes are delivered to the proper position of the digestive tract under an endoscope in an auxiliary way, and if the extension piece is the same, an operator can cut off the redundant tube by scissors after implantation; the extension piece can also be a guide wire, and after the proximal end of the administration tube is fixed, the administration tube is delivered to a proper position of the alimentary canal under an endoscope in an auxiliary way; the extension piece can also be a pipe with hardness slightly larger than that of the administration tube, elasticity, flexibility and smooth inner and outer surfaces, the material is polyethylene or other high polymer materials, and the wall of the pipe can be provided with or without a tracer substance, such as a metal wire which is not transparent to X-rays. The extension piece is preferably another administration tube.

The guide wire is arranged in the administration tube in a penetrating way and can freely move back and forth in the administration tube, and the cross section of the guide wire is smaller than the inner diameter of the administration tube. The guide wire can be an elastic bendable high polymer material wire or a metal wire with good biocompatibility, and the length of the guide wire is 30.0-420.0 cm. Furthermore, the guide wire can be inserted into the administration tube and the extension piece (pipeline), is soft, elastic, bendable and smooth in surface, is made of high polymer materials with good biological tissue compatibility, and can be added with an extension part on the basis of a short guide wire. The guide wire is preferably as long as or longer than the administration tube, the cross section of the guide wire is smaller than the inner diameter of the administration tube, the material is metal or plastic, and the guide wire can be inserted into the administration tube and used for guiding the implantation of a pipeline, the auxiliary delivery when an endoscope exits, the auxiliary tube drawing, the perspective observation of a target and the like.

Has the advantages that: compared with the prior art, the invention has the following remarkable advantages: the deep implantation instrument for the ileocecal valve from the anus can be delivered to and fixed in the deep part of the intestinal tract, meets the requirements of one-time implantation and long-term use of the anus-ileocecal part, has the advantages of ingenious structure, convenient operation, safety and effectiveness, can be reserved for a long time, meets the requirement of multiple times of administration, greatly facilitates the clinical application of the total colon administration, and can be widely used for clinical treatment.

Drawings

FIG. 1 is a schematic structural view of the present invention;

FIG. 2 is a graph showing the effect of the lower digestive tract implantation of the present invention.

Detailed Description

The technical scheme of the invention is further explained by combining the attached drawings.

As shown in figure 1, the invention relates to a deep implantation instrument for a retrocecal valve through the anus, namely the initial part of the large intestine is connected with the ileum through the retrocecal valve, and the deep implantation instrument comprises an administration tube 1, a fixed wire 2, an extension piece 5 and a guide wire 6, wherein the administration tube 1 is made of polyethylene or silica gel, has elasticity, can be bent, and has smooth inner and outer surfaces. The administration tube 1 is provided with a ring-shaped or linear X-ray opaque metal wire. The end side and the wall side of the administration tube are provided with a plurality of medicine outlet holes 3, and the medicine outlet holes 3 are in a circular shape, a strip shape, a polygonal shape or other irregular shapes. The administration tube 1 has openings at both ends, and the proximal end of the administration tube 1 may or may not have a joint. The far end of the administration tube 1 is fixed with a fixing wire 2, the fixing wire 2 is in an 8-shaped structure, and the endoscope is conveniently fixed on the intestinal wall by using auxiliary fixing devices such as a titanium clamp and the like. When an extension piece is used, the extension piece 5 and the proximal end of the administration tube 1 are connected at a joint 4. The guide wire 6 is made of high polymer material with good biological tissue compatibility, is soft and elastic, can be bent and has a smooth surface; the guide wire 6 can be inserted into the extension piece 5 and the administration tube 1 for guiding the implantation of a pipeline, the auxiliary delivery when the endoscope exits, the auxiliary tube drawing, the perspective observation of a target and the like, the quick connector 7 can be connected with the proximal connector 4 of the administration tube 1 and also can be connected with the proximal end of the extension piece 5, and a medicine propulsion device such as a syringe and the like can guide the medicine into the alimentary canal through the connector 7. The connector 7 can be closed by a switch device when necessary, and can also be connected with a device such as a syringe.