阅读说明：本技术 一种用于治疗慢性咽炎的药物及其制备方法 (Medicine for treating chronic pharyngitis and preparation method thereof ) 是由 李志俊 于 2019-12-12 设计创作，主要内容包括：本发明提供了一种用于治疗慢性咽炎的药物,是由中药沉香经45-60%vol的食用酒精浸泡后得到的浸取液。并以所述浸取液为原料,按药剂学的常规工艺和辅料制备成的各类内服制剂或含片。其浸取液的制备方法为：将中药沉香与食用酒精按3-10:100的重量比进行配比,将中药沉香投入食用酒精中常温密闭浸泡5-10天,过滤后得到滤液,即得产品浸取液。本发明药物能够达到治愈慢性咽炎的效果且治愈率较高,治愈后不易复发；药物成分取自天然中草药,毒副作用小；原料易得,制备简便。(The invention provides a medicine for treating chronic pharyngitis, which is an extract obtained by soaking Chinese medicine agilawood in 45-60 vol% edible alcohol. The extract is used as a raw material, and is prepared into various oral preparations or buccal tablets according to the conventional process and auxiliary materials of pharmacy. The preparation method of the leaching solution comprises the following steps: mixing Chinese medicine lignum Aquilariae Resinatum with edible alcohol at a weight ratio of 3-10:100, soaking in edible alcohol at room temperature under sealed condition for 5-10 days, and filtering to obtain filtrate to obtain product extract. The medicine can achieve the effect of curing chronic pharyngitis, has high cure rate, and is not easy to relapse after being cured; the medicinal components are taken from natural Chinese herbal medicines, so that the toxic and side effects are small; the raw materials are easy to obtain, and the preparation is simple.)

1. A medicine for treating chronic pharyngitis is characterized in that the medicine is an extract obtained by soaking Chinese medicine agilawood in 45-60 vol% edible alcohol.

2. The medicine for treating chronic pharyngitis according to claim 1, wherein the medicine is various oral preparations or buccal tablets prepared from the extract as a raw material by using conventional pharmaceutical processes and auxiliary materials.

3. The medicine for treating chronic pharyngitis according to claim 2, wherein the oral preparation comprises tablet, pill, capsule or oral liquid.

4. The medicine for treating chronic pharyngitis according to claim 1, wherein the edible alcohol is white spirit.

5. A method for preparing a medicament for treating chronic pharyngitis according to claim 1, which comprises the steps of:

mixing Chinese medicine lignum Aquilariae Resinatum with edible alcohol at a weight ratio of 3-10:100, soaking in edible alcohol at room temperature under sealed condition for 5-10 days, and filtering to obtain filtrate to obtain product extract.

6. A process for preparing a medicine according to claim 5, wherein the lignum Aquilariae Resinatum is pulverized into 0.3-0.6cm pieces before soaking.

Technical Field

The invention belongs to the field of traditional Chinese medicines, and relates to a medicine for treating chronic pharyngitis and a preparation method thereof.

Background

Chronic pharyngitis is a common frequently-occurring disease, is a diffuse chronic inflammation of pharyngeal mucosa, submucosa and lymphoid tissue, is a part of chronic inflammation of upper respiratory tract, and is often seen in adults. The disease has long course of disease, stubborn symptoms and difficult cure. The causes of the disease are mainly: 1. recurrent attacks of acute pharyngitis, the main cause; 2. chronic rhinitis, sinusitis, etc. can also be caused by long-term nasal obstruction, mouth breathing, nasal discharge, throat irritation, chronic tonsillitis, periodontitis, etc.; 3. excessive smoking and drinking for a long time, dust, harmful gas stimulation, overeating stimulating food and the like; 4. occupational factors such as teachers, announcers, etc., excessive speaking and voice consumption; 5. systemic factors such as anemia, chronic bronchitis, bronchial asthma, endocrine disturbance and the like cause the disease secondarily.

Clinically, the disease has no obvious general symptoms, and is mainly manifested by various uncomfortable sensations in the pharynx, such as foreign body sensation, dryness, burning sensation, itching, slight pain, and the like. The sticky and thick secretions often adhere to the back wall of the pharynx, and frequent irritating dry cough with nausea and even bloody secretions can appear in the morning. The secretion is increased and sticky, so it is usually a throat clearing action. At present, no effective treatment means for the disease is available in medicine. The existing treatment methods are summarized mainly as follows: 1. for the reasons, the treatment mainly comprises the steps of keeping on outdoor activities, giving up smoking, giving up drinking and other bad hobbies, keeping indoor air fresh, and actively treating rhinitis, tracheobronchitis and other chronic respiratory inflammations and the like; 2. the traditional Chinese medicine is used for treating the diseases, and the commonly used Chinese patent medicines comprise pills of six ingredients with rehmannia, pills of medlar, chrysanthemum and rehmannia, capsules of ginseng and wheat, certain traditional Chinese medicine buccal tablets and the like; the commonly used single proved recipe mainly comprises boat-fruited sterculia seed, honeysuckle flower, chrysanthemum flower, dwarf lilyturf tuber, liquorice root and the like which are brewed by boiled water and drunk as tea; 3. the topical treatment mainly comprises gargling with compound borax solution, and smearing throat with 5% silver nitrate or 2% iodine glycerol.

The above methods generally only achieve the effect of relieving symptoms, and are difficult to cure, and although there are cases of cure, the overall cure rate is still not high.

Disclosure of Invention

The invention aims to provide a medicine capable of effectively treating chronic pharyngitis, aiming at the problems in the prior art.

Therefore, the invention adopts the following technical scheme:

a medicine for treating chronic pharyngitis is prepared by soaking lignum Aquilariae Resinatum in 45-60% vol edible alcohol to obtain extractive solution.

Furthermore, the extract is used as a raw material to prepare various oral preparations or buccal tablets according to the conventional process and auxiliary materials of pharmacy.

Further, the oral preparation comprises tablets, pills, capsules or oral liquid.

Further, the edible alcohol is white spirit.

The preparation method of the medicine for treating chronic pharyngitis comprises the following steps:

mixing Chinese medicine lignum Aquilariae Resinatum with edible alcohol at a weight ratio of 3-10:100, soaking in edible alcohol at room temperature under sealed condition for 5-10 days, and filtering to obtain filtrate to obtain product extract.

Further, before soaking, the agilawood is crushed into 0.3-0.6cm fragments, so as to be beneficial to leaching out the active ingredients of the agilawood.

The quality standard of the raw material agilawood medicinal material is required to meet the record of agilawood in the 2015 edition of Chinese pharmacopoeia. The source is a resin-containing wood derived from Gilg of Aquilaria sinensis (Lour.) of the Thymelaeaceae family.

Chen Xiang is pungent and bitter in flavor and slightly warm in nature. Move qi and alleviate pain, warm middle energizer and arrest vomiting, receive qi and relieve dyspnea. The bibliography: treat wind-damp-toxicity swelling and remove bad breath. "(materia Medica of sea medicine): "governing heart and abdominal pain, cholera, nausea and vomiting, refreshing mind; it is used in plaster for treating sores and swelling. "

The clinical treatment difficulty of the chronic pharyngitis is more difficult than that of the acute pharyngitis, the course of disease is long, the chronic pharyngitis is not easy to cure, and no better treatment method exists in the traditional Chinese medicine and the western medicine at present. According to the traditional Chinese medicine theory, the disease is equivalent to slow throat impediment, deficiency fire throat impediment and yang deficiency throat impediment. As for the pathogenesis of the disease, the current traditional Chinese medicine theory generally holds that the disease is caused by viscera deficiency, throat malnutrition, phlegm coagulation and blood stasis and the like. According to the ancestral treatment method and clinical medication practice, the inventor thinks that the pathogenesis of the disease is mainly caused by qi disorder and deficiency and cold of lower elements. Because the efficacy of Chenxiang is characterized by pungent and warm property entering kidney meridian, it can warm kidney and receive qi, move qi and alleviate pain, and it is good at treating qi stagnation syndrome and deficiency-cold syndrome of lower origin, so it is used singly. Because the traditional usage of the agilawood is decoction in water and then administration is carried out, the dosage is generally 1-5g, the effective ingredients are not easy to dissolve out under the drug administration method, and the drug effect cannot be fully exerted, the treatment is carried out by using edible alcohol or white spirit leachate. In order to ensure the safety of medication, the treatment dosage of the method is far lower than the traditional Chinese medicine dosage of agilawood.

Modern medical research shows that the agilawood contains benzyl acetone, so that the agilawood has an effective cough relieving effect, and experiments also show that the linalool extract can promote the in-vitro guinea pig trachea antihistamine effect, so that the cough relieving effect is achieved. In addition, the agilawood extract also has anti-inflammatory and antibacterial effects, and has obvious inhibitory effect on bacillus bonder, typhoid bacillus, staphylococcus aureus and the like (huhuoxepin, sunhui, zhanyunfeng and the like, pharmacological action and quality control research progress of traditional Chinese medicine agilawood [ J ] evaluation and analysis of medication in hospitals in China, 2018,18 (2)).

However, the Chinese medicine for treating chronic pharyngitis, or the symptoms of chronic pharyngitis, deficiency fire pharyngitis, yang deficiency pharyngitis and the like which are called by Chinese medicine, has no report in traditional Chinese medicine literature and modern medical research data.

In conclusion, the beneficial effects of the invention are as follows: provides a new medicament for treating chronic pharyngitis, can achieve the effect of healing, has higher healing rate and is not easy to relapse after healing; the medicinal components are taken from natural Chinese herbal medicines, so that the toxic and side effects are small; the raw materials are easy to obtain, and the preparation is simple.

Detailed Description

The present invention will be further described with reference to the following specific examples.