阅读说明：本技术 具有持续活性的四环素类络合物 (Tetracycline complex with sustained activity ) 是由 安德烈亚斯·基佐 米尔科·布赫霍尔兹 桑德拉·萨雷米尔 卡斯滕·梅德 马丁·基希贝格 西格 于 2019-10-29 设计创作，主要内容包括：本发明一般涉及四环素类抗生素的受控释放。具体地,其涉及包含四环素类化合物(TC)或其药用盐、水合物或溶剂化物和二价金属羧酸盐的络合物；包含所述络合物的药物制剂,用于制备所述络合物和所述药物制剂的方法,以及用于治疗人体或动物体、特别地用于治疗和/或预防细菌感染；和/或其中在延长的时间段内保持抗生素活性；和/或用于治疗和/或预防急性、慢性或复发性牙周病的方法的络合物或药物制剂。(The present invention relates generally to the controlled release of tetracycline antibiotics. Specifically, it relates to a complex comprising a Tetracycline Compound (TC) or a pharmaceutically acceptable salt, hydrate or solvate thereof and a divalent metal carboxylate; pharmaceutical formulations comprising said complexes, processes for the preparation of said complexes and said pharmaceutical formulations, and for use in the treatment of the human or animal body, in particular for the treatment and/or prevention of bacterial infections; and/or wherein antibiotic activity is maintained for an extended period of time; and/or a complex or a pharmaceutical preparation for use in a method of treatment and/or prevention of acute, chronic or recurrent periodontal disease.)