阅读说明：本技术 一种中药挥发油组合物及其应用 (Traditional Chinese medicine volatile oil composition and application thereof ) 是由 陈志维 于 2019-11-04 设计创作，主要内容包括：本发明涉及一种中药挥发油组合物及其应用,由以下重量配比的原料药制成：零陵香挥发油1～35份、广藿香挥发油1～15份、野菊花挥发油1～15份和冰片1～5份。该组合物以零陵香挥发油为主要原料,配合加入广藿香挥发油、野菊花挥发油以及冰片等芳香化湿药物,各组分产生协同增效作用,经体外抗病毒药效学实验证明,本发明组合物能够预防和抑制流感病毒引起的感冒。(The invention relates to a traditional Chinese medicine volatile oil composition and application thereof, wherein the traditional Chinese medicine volatile oil composition is prepared from the following raw material medicines in parts by weight: 1-35 parts of holy basil volatile oil, 1-15 parts of patchouli volatile oil, 1-15 parts of wild chrysanthemum flower volatile oil and 1-5 parts of borneol. The composition takes the volatile oil of holy basil as a main raw material, and aromatic dampness-resolving medicines such as the volatile oil of patchouli, the volatile oil of wild chrysanthemum and borneol are added, so that the components generate synergistic interaction, and the in vitro antiviral pharmacodynamics experiment proves that the composition can prevent and inhibit cold caused by influenza virus.)

1. The traditional Chinese medicine volatile oil composition is characterized in that active ingredients of the composition are prepared from the following raw material medicines in parts by weight: 1-35 parts of holy basil volatile oil, 1-15 parts of patchouli volatile oil, 1-15 parts of wild chrysanthemum flower volatile oil and 1-5 parts of borneol.

2. The traditional Chinese medicine volatile oil composition of claim 1, wherein the weight ratio of each raw material medicine is as follows: 5-20 parts of holy basil volatile oil, 3-6 parts of patchouli volatile oil, 3-6 parts of wild chrysanthemum flower volatile oil and 1-3 parts of borneol.

3. The traditional Chinese medicine volatile oil composition of claim 1, wherein the weight ratio of each raw material medicine is as follows: 10 parts of holy basil volatile oil, 5 parts of patchouli volatile oil, 5 parts of wild chrysanthemum flower volatile oil and 1 part of borneol.

4. The use of the Chinese medicinal volatile oil composition according to any one of claims 1 to 3 in the preparation of a medicament for preventing or treating influenza.

5. Use according to claim 4, characterized in that: the dosage form of the medicine is air disinfectant, aromatherapy essential oil, smokeless aromatherapy, massage cream or nasal drop.

6. An air disinfectant comprising the Chinese medicinal volatile oil composition of any one of claims 1 to 3.

Technical Field

The invention belongs to the technical field of traditional Chinese medicines, and particularly relates to a traditional Chinese medicine volatile oil composition and application thereof in medicines for preventing and inhibiting influenza caused by influenza viruses.

Background

Influenza is an acute respiratory infectious disease caused by influenza virus, and has the characteristics of rapid spread and wide spread range. Influenza a i (H1N 1) has caused a worldwide pandemic since 1918 in spanish outbreaks, and particularly in 2009 influenza a i has caused a great economic loss as well as a serious threat to human health. In recent years, the spread of highly pathogenic avian influenza in humans has led to an increase in the number of infectious and dead people due to the variation of influenza virus antigens. In the high-incidence stage of influenza, the most effective prevention method is to prevent and treat the spread of influenza virus in the air, and isolation and space environment disinfection are well performed to avoid secondary spread. Common air disinfection methods include chemical reagent methods such as peracetic acid, hydrogen peroxide, formaldehyde, 84 disinfectant, and the like, and physical methods such as ultraviolet irradiation, ozone generators, and the like. Although these methods can kill pathogenic microorganisms or viruses in the air, have rapid action and low effective concentration, they have certain defects, such as toxicity, irritation, metal corrosivity and poor sustained effect; many of the pollutants form pollutants, influence human health to different degrees and are not suitable for the environment of people; all personnel must leave the field during disinfection, and the operating system needs protective measures; the peculiar smell can not be eliminated quickly after the disinfection, and the long-term use of the disinfectant can cause the danger of accumulation and poisoning of human bodies. Therefore, the research on a safe and effective air disinfectant is of great significance.

Infectious diseases caused by pathogenic bacteria or viruses transmitted through the air belong to the category of warm diseases in traditional Chinese medicine, and the treatment medicine mainly comprises two traditional Chinese medicines of clearing heat and removing toxicity and eliminating dampness with aromatics. Lysimachia foenum-graecum, also known as Lysimachia foenum-graecum, lavender, and holy basil, are dried aerial herbs of Lysimachia foenum-graecum Hance, which are commonly used as spices. The herba Lysimachiae foenumgraeci contains a large amount of volatile oil, coumarin, etc., and has effects of dispelling pathogenic wind cold, removing filth, treating seasonal pathogens of common cold headache, upper qi lumbago, chest distress, abdominal distention, spermatorrhea, ascarid expelling, etc. At present, the prior art is mostly a research on an extraction method of the effective components of holy basil, and no literature report on the application of holy basil to air disinfectants is found.

Disclosure of Invention

In view of the above, the primary objective of the present invention is to provide a Chinese medicine volatile oil composition, which has the function of in vitro influenza virus inhibition and the function of mucosal immunity stimulation, thereby preventing and inhibiting the cold caused by influenza virus.

The technical scheme for realizing the aim of the invention is as follows:

a traditional Chinese medicine volatile oil composition is prepared from the following raw material medicines in parts by weight: 1-35 parts of holy basil volatile oil, 1-15 parts of patchouli volatile oil, 1-15 parts of wild chrysanthemum flower volatile oil and 1-5 parts of borneol.

Preferably, the weight ratio of each raw material medicine of the invention is as follows: 5-20 parts of holy basil volatile oil, 3-6 parts of patchouli volatile oil, 3-6 parts of wild chrysanthemum flower volatile oil and 1-3 parts of borneol,

preferably, the weight ratio of each raw material medicine is as follows: 10 parts of holy basil volatile oil, 5 parts of patchouli volatile oil, 5 parts of wild chrysanthemum flower volatile oil and 1 part of borneol.

The volatile oil of holy basil, the volatile oil of patchouli and the volatile oil of wild chrysanthemum can be extracted and prepared from related plants by a steam distillation method, a water diffusion steam distillation method, a solvent extraction method, a carbon dioxide supercritical extraction method and the like.

The composition takes the volatile oil of holy basil as a monarch drug, and has the effects of eliminating dampness and avoiding dirty with aromatics; the patchouli volatile oil is a ministerial drug, has the efficacy of eliminating dampness by fragrance, and has better efficacy when used with a monarch drug; the volatile oil of flos Chrysanthemi Indici is used as adjuvant drug, has effects of clearing heat and detoxicating, and can be used for adjuvant treatment of febrile disease and fever; borneol is a guiding drug and has the functions of inducing resuscitation by fragrance and promoting the ascending of drugs. The raw materials are combined together, and have synergistic effect, and the in vitro antiviral pharmacodynamics experiment and the in vivo mucosa stimulating immunity experiment prove that the composition can prevent and inhibit the cold caused by the influenza virus.

The invention also aims to provide application of the traditional Chinese medicine volatile oil composition in preparing a medicine for preventing or treating cold caused by influenza. The Chinese medicinal volatile oil composition is used as an effective component, pharmaceutically acceptable auxiliary materials such as preservatives, emulsifiers, humectants, thickeners and the like are added, and the Chinese medicinal volatile oil composition is prepared into dosage forms such as air disinfectants, aromatherapy essential oil, smokeless aromatherapy, massage cream or nasal drops and the like according to the conventional technical means in the field.

The invention also provides an air disinfectant, which takes the traditional Chinese medicine volatile oil composition as an active ingredient, and the auxiliary materials can be added with a proper amount of emulsifier such as Tween-80 and then diluted by a proper amount of deionized water, so that the preparation method is simple and easy. The air disinfectant disclosed by the invention takes four natural plant components of holy basil, cablin potchouli herb, wild chrysanthemum flower and borneol as raw materials, does not contain other chemical components, and does not bring any negative influence on the environment and the health of human bodies on the basis of preventing and inhibiting cold caused by influenza virus.

Compared with the prior art, the invention has the following beneficial effects:

the composition disclosed by the invention has the advantages that the holy basil volatile oil is taken as a main raw material, and aromatic dampness-resolving medicines such as the patchouli volatile oil, the wild chrysanthemum volatile oil and the borneol are added in a matching manner, so that the components generate a synergistic interaction effect, pharmacodynamic studies show that the composition has the effects of inhibiting and preventing influenza viruses in vitro on one hand, and can effectively induce mucosal immunoreaction in vivo by nasal drip or atomization administration on the other hand, so that a large amount of s-IgA antibodies with a cross protection effect are generated to cause the mucosal immunoreaction, and the composition has a better antiviral effect, is better than the single holy basil volatile oil and a traditional Chinese medicine control group (combination of the patchouli volatile oil, the wild chrysanthemum volatile oil and the borneol) in the aspects of inhibiting the viruses and improving the mucosal immunity of mice, and can be applied to preventing and.

Detailed Description

The present invention is further illustrated by the following specific embodiments, which are not intended to limit the scope of the invention.

Preparing the volatile oil of holy basil: taking 2.0kg of dried holy basil, adding 10 times of water, soaking for 30 minutes, carrying out ultrasonic treatment (70 kHz) for 30 minutes, heating, collecting water vapor, and condensing the water vapor to obtain an oil-water separation part. Collecting the upper layer volatile oil, and adding anhydrous sodium sulfate for dehydration treatment to obtain herba Lysimachiae Foenumgraeci volatile oil.

Preparing patchouli volatile oil: taking 1.0kg of dried cablin potchouli herb, adding 8 times of water, soaking for 40 minutes, carrying out ultrasonic treatment (60 kHz) for 40 minutes, heating, collecting water vapor, and condensing the water vapor to obtain an oil-water separation part. Collecting the upper layer volatile oil, and adding anhydrous sodium sulfate for dehydration treatment to obtain herba Agastaches volatile oil.

Preparing wild chrysanthemum volatile oil: taking 1.0kg of dried wild chrysanthemum, adding 9 times of water, soaking for 30 minutes, carrying out ultrasonic treatment (80 kHz) for 45 minutes, heating, collecting water vapor, and condensing the water vapor to obtain an oil-water separation part. Collecting the upper layer volatile oil, and adding anhydrous sodium sulfate for dehydration treatment to obtain flos Chrysanthemi Indici volatile oil.