阅读说明：本技术 一种疤痕止痒软化乳膏及其制备方法 (Scar itching-relieving softening cream and preparation method thereof ) 是由 不公告发明人 于 2018-07-06 设计创作，主要内容包括：本发明涉及一种疤痕止痒软化乳膏及其制备方法,所述药膏中含有以下物质：复方五倍子浸膏、薄荷脑、樟脑、冰片、水杨酸甲酯、硬脂酸、羊毛脂、凡士林、液体石蜡、司盘60、硬脂酸镁、甘油、吐温80、羟苯乙酯、羟苯丙酯和蒸馏水。跟现有技术相比,本发明改变了药膏的基质配方、比例并优化了制备工艺,显著提高了产品的稳定性。(The invention relates to a scar itching-relieving softening cream and a preparation method thereof, wherein the cream contains the following substances: compound gallnut extract, menthol, camphor, borneol, methyl salicylate, stearic acid, lanolin, vaseline, liquid paraffin, span 60, magnesium stearate, glycerol, tween 80, ethylparaben, propylparaben and distilled water. Compared with the prior art, the invention changes the matrix formula and proportion of the ointment, optimizes the preparation process and obviously improves the stability of the product.)

1. The scar itching-relieving softening cream is characterized by being a W/O type traditional Chinese medicine cream and consisting of the following components:

10-15% of compound gallnut extract, 2-4% of menthol, 2-4% of camphor, 3-5% of borneol and 2-5% of methyl salicylate;

40-50% of oil phase component, 3-7% of humectant, 10-25% of emulsifier, 0.1-0.3% of preservative and 3-15% of water;

the oil phase component is one or more selected from stearic acid, lanolin, vaseline, liquid paraffin, beeswax, and higher fatty alcohol;

the humectant is selected from one or more of glycerol, propylene glycol or sorbitol;

the emulsifier is one or more selected from span 60, magnesium stearate, tween 80 and triethanolamine;

the preservative is selected from one or two of ethyl hydroxybenzoate and propyl hydroxybenzoate.

2. The itching-relieving softening cream for scars as claimed in claim 1, wherein the compound Chinese gall extract is prepared by the following method:

pulverizing Galla chinensis 85.7g, radix Clematidis 85.7g, cortex moutan 42.9g, and herba Lycopi 42.9g into fine powder, reflux-extracting with 90% ethanol for three times, adding 6 times of solvent each time, refluxing for 1 hr each time, filtering, mixing filtrates, recovering ethanol, and concentrating to 120g to obtain compound Galla chinensis extract.

3. The itching-relieving softening cream for scars according to claim 1, wherein said oil phase component is stearic acid, lanolin, vaseline and liquid paraffin.

4. The scar itch-softening cream of claim 1, wherein the humectant is glycerin.

5. The scar antipruritic softening cream of claim 1, wherein the emulsifier is span 60, magnesium stearate and tween 80.

6. The scar itch-softening cream of claim 1, wherein the preservatives are ethylparaben and propylparaben.

7. The cream for softening and relieving itching of scars as claimed in any one of claims 1 to 6, wherein the cream for softening and relieving itching of scars is a W/O type traditional Chinese medicine cream prepared from 12% of compound nutgall extract, 3.4% of menthol, 3.4% of camphor, 4.3% of borneol, 2.6% of methyl salicylate, 11% of stearic acid, 2% of lanolin, 27.3% of vaseline, 2% of liquid paraffin, 608% of span, 5% of magnesium stearate, 5% of glycerol, 8010% of tween, 0.1% of ethylparaben, 0.1% of propylparaben and 3.8% of distilled water.

8. The scar itch-softening cream of claim 7, wherein 1000g of the scar itch-softening cream is prepared by:

(1) weighing 110g of stearic acid, 20g of lanolin, 273g of vaseline, 20g of liquid paraffin, 6080 g of span, 50g of magnesium stearate, 43g of borneol, 34g of camphor and 34g of menthol, stirring and melting at 85 ℃ to obtain an oil phase, and keeping the temperature for later use;

(2) weighing 50g of glycerol, 80100 g of tween, 1g of ethylparaben, 1g of propyl hydroxybenzoate, 120g of extract and 38g of purified water, stirring and dissolving at 85 ℃ to obtain a water phase, and keeping the temperature for later use;

(3) slowly adding the water phase into the oil phase under stirring, homogenizing and emulsifying at 85 deg.C for 1min, and then continuously stirring and cooling to 55 deg.C;

(4) weighing 26g of methyl salicylate, stirring and mixing at 55 ℃, dissolving uniformly, adding into the emulsion, continuously stirring for 1min, cooling to 35 ℃, vacuumizing, and filling to obtain the scar itching-relieving and softening cream.

Technical Field

The invention relates to a traditional Chinese medicine emulsifiable paste.

Background

Pathological scars are fibro-metabolic diseases characteristic of the human dermal region, caused by trauma and the like, characterized by the overproduction and deposition of a large amount of connective tissue matrix such as collagen, mainly including hypertrophic scars and keloids. The pathological scar is characterized by massive fibrocyte hyperplasia, excessive deposition of collagen, proteoglycan, glycoprotein and the like in extracellular matrix, and disorganized arrangement of collagen fibers (Jingyasha, Liu-gang, Chinese and Western medicine combined with skin pathology journal, 2009, 8(4), 262-. Hypertrophic scars are mainly caused by the fact that the anabolism of collagen is carried out for a long time and the anabolism speed is exceeded, and collagen fibers are formed in a large quantity. Collagen cellulose is the main substance of scar formation. When a large number of myofibroblasts contract and myocyte surface fibrils form a rigid structure to cause atrophy and hardening of scars, local deformity or dysfunction is caused, and clinical manifestations of abnormal sensation and tumor-like hyperplasia are accompanied by different degrees of dysfunction. Hypertrophic scars differ from normal skin in four ways, namely: itching, hyperplasia, dryness and limited function (forest, Zhangpeng, etc., Chinese pharmacist, 2009, 12(8), 1133-.

The itching-relieving and softening cream for scars is a Chinese medicinal preparation, the main component of which is gallnut, and has a good inhibition effect on the hyperplasia of scars. Modern pharmacological research shows that tannin contained in gallnut can inhibit fibroblast proliferation by precipitating protein, promote small blood vessel contraction and reduce scar blood supply, thereby achieving the purpose of reducing scars. The other components are adjuvant drugs, which are beneficial to the adhesion and penetration of the main drug (Lin Shi, Zhang Peng, etc., Chinese pharmacist, 2009, 12(8), 1133 and 1134). However, the scar itching-relieving softening cream sold in the market has high requirements on storage conditions, and the product is easy to break milk at a high temperature and generate oil-water separation, so that the product is deteriorated and the final treatment effect is influenced, and therefore, a new technical scheme is required to be provided for solving the problems.

Disclosure of Invention

In order to solve the problems, the invention aims to provide the itching-relieving softening cream for scars, which has more stable properties and can ensure the curative effect.

The invention provides a scar itching-relieving softening cream which is a W/O type traditional Chinese medicine cream and consists of the following components:

10-15% of compound gallnut extract, 2-4% of menthol, 2-4% of camphor, 3-5% of borneol and 2-5% of methyl salicylate;

40-50% of oil phase component, 3-7% of humectant, 10-25% of emulsifier, 0.1-0.3% of preservative and 3-15% of water;

the oil phase component is one or more selected from stearic acid, lanolin, vaseline, liquid paraffin, beeswax, and higher fatty alcohol;

the humectant is selected from one or more of glycerol, propylene glycol or sorbitol;

the emulsifier is one or more selected from span 60, magnesium stearate, tween 80 and triethanolamine;

the preservative is selected from one or two of ethyl hydroxybenzoate and propyl hydroxybenzoate.

Furthermore, the compound gallnut extract is prepared by the following method:

pulverizing Galla chinensis 85.7g, radix Clematidis 85.7g, cortex moutan 42.9g, and herba Lycopi 42.9g into fine powder, reflux-extracting with 90% ethanol for three times, adding 6 times of solvent each time, refluxing for 1 hr each time, filtering, mixing filtrates, recovering ethanol, and concentrating to 120g to obtain compound Galla chinensis extract;

the oil phase component comprises stearic acid, lanolin, vaseline and liquid paraffin;

the humectant is glycerin;

the emulsifier is span 60, magnesium stearate and tween 80;

the preservative is ethylparaben and propylparaben.

Still further, the itching-relieving softening cream for scars provided by the invention is a W/O type traditional Chinese medicine cream prepared from 12% of compound gallnut extract, 3.4% of menthol, 3.4% of camphor, 4.3% of borneol, 2.6% of methyl salicylate, 11% of stearic acid, 2% of lanolin, 27.3% of vaseline, 2% of liquid paraffin, 608% of span, 5% of magnesium stearate, 5% of glycerol, 8010% of tween, 0.1% of ethylparaben, 0.1% of propylhydroxybenzoate and 3.8% of distilled water.

Specifically, the itching-relieving softening cream for scars provided by the invention is prepared by the following method (taking 1000g as an example):

(1) weighing 110g of stearic acid, 20g of lanolin, 273g of vaseline, 20g of liquid paraffin, 6080 g of span, 50g of magnesium stearate, 43g of borneol, 34g of camphor and 34g of menthol, stirring and melting at 85 ℃ to obtain an oil phase, and keeping the temperature for later use;

(2) weighing 50g of glycerol, 80100 g of tween, 1g of ethylparaben, 1g of propyl hydroxybenzoate, 120g of extract and 38g of purified water, stirring and dissolving at 85 ℃ to obtain a water phase, and keeping the temperature for later use;

(3) slowly adding the water phase into the oil phase under stirring, homogenizing and emulsifying at 85 deg.C for 1min, and then continuously stirring and cooling to 55 deg.C;

(4) weighing 26g of methyl salicylate, stirring and mixing at 55 ℃, dissolving uniformly, adding into the emulsion, continuously stirring for 1min, cooling to 35 ℃, vacuumizing, and filling to obtain the scar itching-relieving and softening cream.

The percentages are all weight percentages.

In research, the scar itching-relieving softening cream provided by the invention is found to remarkably improve the stability of the product by improving the formula and proportion of the matrix and optimizing the preparation process compared with the prior art.

Detailed Description

The invention is further illustrated by the following description of specific embodiments. It should be understood that these examples are for illustrative purposes only and are not intended to limit the scope of the present invention.