阅读说明：本技术 一种生血药物丸剂及其制备方法和应用 (Hematogenesis medicine pill and preparation method and application thereof ) 是由 闾江龙 郑桂娥 于 2019-12-06 设计创作，主要内容包括：本发明公开一种生血药物丸剂及其制备方法和应用,该生血药物丸剂选择阿胶、当归、红枣三味具有生血、补血、和血药效的中药材作为君药,选择黄芪、芍药、川芎、牛膝作为臣药,选择荷叶提取物、海粉提取物、桑葚子作为佐药,选择甘草、蜂蜜作为使药,采用常规的混合挤出工艺制备而成,各位药材相辅相成,协同发挥作用,毒副作用小,生血活血,补血养阴,调经止痛,对女性由于月经不调引起的气血血虚的症状具有良好的治疗效果。(The invention discloses a hematogenesis drug pill and a preparation method and application thereof, the hematogenesis drug pill selects donkey-hide gelatin, Chinese angelica and red date which have the effects of hematogenesis, blood enriching and blood harmonizing as monarch drugs, selects astragalus, peony, ligusticum wallichii and achyranthes root as ministerial drugs, selects lotus leaf extract, sea powder extract and mulberry as adjuvant drugs, selects liquorice and honey as conductant drugs, and is prepared by adopting a conventional mixing extrusion process, the medicinal materials supplement each other, the synergistic effect is achieved, the toxic and side effects are small, the hematogenesis and blood activating, the blood enriching and yin nourishing, the menstruation regulating and the pain relieving are realized, and the hematogenesis drug pill has a good treatment effect on the symptoms of qi-blood deficiency caused by irregular menstruation.)

1. The hematogenesis medicine pill is characterized by comprising the following raw materials in parts by weight: 15-32 parts of donkey-hide gelatin, 10-18 parts of angelica, 8-15 parts of red date, 3-8 parts of astragalus, 2-6 parts of lotus leaf extract, 3-8 parts of sea meal extract, 2-6 parts of mulberry, 0.5-3 parts of peony, 0.2-0.8 part of ligusticum wallichii, 0.5-2.5 parts of achyranthes root, 20-36 parts of liquorice, 40-60 parts of honey and 6-12 parts of flavoring agent;

the preparation method of the lotus leaf extract comprises the following steps:

(1) pretreatment: collecting lotus leaves of young leaves of 6-7 months old, removing petioles, rinsing with clear water to remove impurities on the lotus leaves, shearing off worm-eaten and mildewed parts, shearing into thin strips with the width of 1-3cm, air-drying the dried and ventilated parts until the water content is less than 10%, placing the dried and ventilated parts in a sealed container, introducing low-temperature nitrogen at-8 ℃, standing for 20-30min after the volume of the low-temperature nitrogen reaches 60-70% of the volume of the sealed container, and then placing the sealed container in a drying oven at 80-90 ℃ for drying for 10-20 min;

(2) extraction: pulverizing folium Nelumbinis into fine powder, adding into extraction tank, adding water 8-10 times of folium Nelumbinis, slowly adding dropwise leaf nutrition powder 20-30% of folium Nelumbinis, heating and extracting at 80-100 deg.C under 0.1-0.2MPa for 1-2 hr to obtain folium Nelumbinis extractive solution;

(3) filtering and collecting: filtering 120-150 parts by weight of lotus leaf extract, adding 40-60 parts by weight of mixed solution consisting of petroleum ether and 4-5 parts by weight of ethanol into the filtrate, uniformly stirring at normal temperature, standing for 2 hours, and adding into a volatile oil extractor for cyclic extraction for 3-4 hours; and (4) performing rotary evaporation on the collected extracting solution to remove low-boiling petroleum ether and ethanol to obtain the lotus leaf extract.

2. The hematogenesis drug pill of claim 1, wherein the preparation method of the leaf nutritional powder of step (2) comprises the steps of:

(1) selecting fresh aloe leaves, cleaning, peeling, cutting into segments, placing into a wall breaking machine, adding clear water with the mass of 1.2-1.5 times of that of the aloe leaves, breaking the wall, pulping to obtain pulp, and filtering to obtain aloe juice;

(2) selecting fresh rosemary stems and leaves, cleaning and peeling, distilling at the temperature of 100 ℃ and 120 ℃, collecting distillate, and refrigerating at the temperature of 4-8 ℃ for later use; respectively grinding seaweed, pollen pini and chitosan into powder for later use;

(3) uniformly mixing aloe juice, distillate, seaweed, pine pollen, chitosan and honey according to the mass ratio of 2:1:1:2:0.2:0.5, rapidly stirring into slurry, crushing and drying to obtain the leaf nutrition powder.

3. The hematogenic pharmaceutical pill according to claim 1, wherein the production process of the sea powder extract comprises the steps of:

(1) selecting and inserting bamboo poles with row spacing of 40-60cm and transverse spacing of 60-80cm into an offshore tidal zone during oviposition of blue spot dorsal anus sea rabbits for 9-10 months, wherein the bamboo poles and a sea plane form an inclination angle of 40-60 degrees, adjacent bamboo poles are connected through a weaving net, stones with concave-convex surfaces are filled into the weaving net from top to bottom, and the net aperture of the weaving net is smaller than the maximum diameter of the stones;

(2) after the eggs of the blue spot dorsal anus sea hare are attached to the bamboo poles and the stones and form an egg group belt, taking out the weaving net and the bamboo poles at the same time, uniformly scraping the egg group belt attached to the bamboo poles and the stones by using a scraper, and soaking in 8-12 wt% of salt solution for 8-10 hours;

(3) filtering the ovum group band soaked in salt water with 100-200 mesh sieve, drying under sea wind for 2-3 days, placing into extraction tank, adding distilled water 10-12 times of the ovum group band mass, heating at 80-100 deg.C for 2-3 hr, filtering, and concentrating the filtrate under reduced pressure to obtain sea powder extract.

4. The hematogenic pharmaceutical pill according to claim 1, wherein the flavoring agent is a combination of one or more of sorbose, xylitol, mannitol, galactose, maltose, lactose.

5. A preparation method of a hematogenesis medicine pill is characterized by comprising the following steps:

1) cleaning colla Corii Asini, radix Angelicae sinensis, fructus Jujubae, and radix astragali, drying, mixing, and pulverizing to obtain mixture A;

2) cutting rhizoma Ligustici Chuanxiong and Achyranthis radix into strips of 1-3cm, cleaning, drying, and pulverizing to obtain mixture B;

3) smashing the peony, the mulberry and the liquorice into juice by using a mortar, uniformly mixing the juice with the mixture A and the mixture B, adding the lotus leaf extract, the sea powder extract, the honey and the flavoring agent, and uniformly stirring and mixing at 200r/min to obtain a premix;

4) the premix is introduced into a double-screw extruder to be pelletized into pills, the rotating speed of the extruder is 250-160 ℃ at the temperature of 140-160 ℃.

6. The application of the hematogenesis medicinal pill is characterized in that the hematogenesis medicinal pill is applied to treating qi deficiency and blood deficiency caused by irregular menstruation.

Technical Field

The invention relates to the technical field of hematogenesis and blood enriching medicines, in particular to a hematogenesis medicine pill and a preparation method and application thereof.

Background

Qi and blood deficiency refers to both qi deficiency and blood deficiency in traditional Chinese medicine. The sources of qi and blood are two: the first is innate essence, that is, innate essence of parents, and the second is acquired essence, that is, food and natural essence of the spleen and stomach. Qi promotes blood circulation, blood is used as the carrier of qi, qi and blood are bred, qi deficiency means little blood, and blood deficiency means qi deficiency.

The theory of traditional Chinese medicine holds that deficiency of qi and blood is a manifestation of blood disorder, which is a disease condition of insufficient blood generation or blood nourishing function decline. Deficiency of qi and blood can be caused by excessive blood loss, consumption of yin-blood due to chronic diseases, dysfunction of spleen and stomach, or failure of food essence to generate blood. The main clinical symptoms are qi deficiency manifested as aversion to cold, cold limbs, spontaneous sweating, dizziness, tinnitus, listlessness, fatigue, weakness, palpitation, short breath and hypoevolutism. Blood deficiency can lead to lusterless and sallow complexion, dry skin, withered hair, dry nails, dim eyesight, numb hands and feet, insomnia, dreaminess, amnesia, palpitation and absentmindedness.

The existing methods for treating deficiency of qi and blood are many, calcium folinate injection, linoleic acid vitamin E capsule, menadione sodium bisulfite injection and low molecular dextran amino acid injection can be used in western medicine, although the indications are clear and the drug effect is quick, a plurality of contraindications and side effects exist in clinical treatment, and the low molecular dextran amino acid injection cannot be matched with other drugs for use. The clinical application can also use food therapy and Chinese medicament forms to treat deficiency of qi and blood, common blood-generating and blood-enriching traditional Chinese medicinal materials comprise lucid ganoderma, tuber fleeceflower root, donkey-hide gelatin, pilose antler, medlar and the like, and the traditional Chinese medicinal materials are matched according to the compatibility principle of traditional Chinese medicines.

Menoxenia is a common gynecological disease, manifested by menstrual cycle disorders or abnormal blood output, and may be accompanied by premenstrual, menstrual abdominal pain or general pain. Prolonged menoxenia can lead to ischemic anemia, infertility, and serious psychological problems. At present, few reports of traditional Chinese medicine preparations for treating qi and blood deficiency caused by irregular menstruation exist, and a hematogenesis type medicine preparation is needed for treating qi deficiency and blood deficiency symptoms and related complications caused by irregular menstruation.

Disclosure of Invention

In order to overcome the technical problems, the invention aims to provide a hematogenesis drug pill and a preparation method and application thereof, the hematogenesis drug pill is prepared by adopting a conventional mixing extrusion process, and in the selection of components, donkey-hide gelatin, Chinese angelica and red date which have the effects of hematogenesis, blood enriching and blood nourishing are selected as monarch drugs, astragalus, peony, ligusticum wallichii and achyranthes bidentata are selected as ministerial drugs, lotus leaf extract, sea powder extract and mulberry are selected as adjuvant drugs, liquorice and honey are selected as messenger drugs, all the drugs supplement each other to play a role in synergy, have small toxic and side effects, promote blood circulation, enrich the blood, nourish yin, regulate menstruation and relieve pain, and have good treatment effect on symptoms of blood deficiency caused by irregular menstruation.

The purpose of the invention can be realized by the following technical scheme:

the invention provides a hematogenesis medicinal pill which comprises the following raw materials in parts by weight: 15-32 parts of donkey-hide gelatin, 10-18 parts of angelica, 8-15 parts of red date, 3-8 parts of astragalus, 2-6 parts of lotus leaf extract, 3-8 parts of sea meal extract, 2-6 parts of mulberry, 0.5-3 parts of peony, 0.2-0.8 part of ligusticum wallichii, 0.5-2.5 parts of achyranthes root, 20-36 parts of liquorice, 40-60 parts of honey and 6-12 parts of flavoring agent;

the preparation method of the lotus leaf extract comprises the following steps:

(1) pretreatment: collecting lotus leaves of young leaves of 6-7 months old, removing petioles, rinsing with clear water to remove impurities on the lotus leaves, shearing off worm-eaten and mildewed parts, shearing into thin strips with the width of 1-3cm, air-drying the dried and ventilated parts until the water content is less than 10%, placing the dried and ventilated parts in a sealed container, introducing low-temperature nitrogen at-8 ℃, standing for 20-30min after the volume of the low-temperature nitrogen reaches 60-70% of the volume of the sealed container, and then placing the sealed container in a drying oven at 80-90 ℃ for drying for 10-20 min;

(2) extraction: pulverizing folium Nelumbinis into fine powder, adding into extraction tank, adding water 8-10 times of folium Nelumbinis, slowly adding dropwise leaf nutrition powder 20-30% of folium Nelumbinis, heating and extracting at 80-100 deg.C under 0.1-0.2MPa for 1-2 hr to obtain folium Nelumbinis extractive solution;

(3) filtering and collecting: filtering 120-150 parts by weight of lotus leaf extract, adding 40-60 parts by weight of mixed solution consisting of petroleum ether and 4-5 parts by weight of ethanol into the filtrate, uniformly stirring at normal temperature, standing for 2 hours, and adding into a volatile oil extractor for cyclic extraction for 3-4 hours; and (4) performing rotary evaporation on the collected extracting solution to remove low-boiling petroleum ether and ethanol to obtain the lotus leaf extract.

The invention selects the nature, taste and meridian tropism of the Chinese medicinal materials, and the drug effect is as follows:

e, donkey-hide gelatin: [ PROPERTIES AND FLAVOUR ] sweet and neutral. [ GUIJING ] enters lung, liver and kidney meridians. [ FUNCTIONS ] can tonify blood, nourish yin, moisten dryness and stop bleeding. Can be used for treating blood deficiency, sallow complexion, giddiness, cardiopalmus, muscle weakness, vexation, insomnia, deficient wind stirring, cough due to dryness of lung, overstrain cough, hemoptysis, hematemesis, hematuria, hematochezia, metrorrhagia, and gestational fetal leakage.

Chinese angelica: [ PROPERTIES AND FLAVOUR ] sweet and warm. [ GUIJING ] can be attributed to heart, liver and spleen meridians. [ FUNCTIONS ] can tonify blood, regulate menstruation, alleviate pain, moisten dryness and smooth intestines. Treating menoxenia, amenorrhea, abdominal pain, abdominal mass, metrorrhagia; headache due to blood deficiency, vertigo, flaccidity arthralgia; intestinal dryness, difficulty in defecation, and severe dysentery; carbuncle, deep-rooted carbuncle, sore, traumatic injury.

Red dates: [ PROPERTIES AND FLAVOUR ] sweet and warm. [ GUIJING ] can enter spleen and stomach meridians. [ FUNCTIONS ] can tonify middle warmer, replenish qi, nourish blood, and induce tranquilization. Can be used for treating spleen deficiency, anorexia, asthenia, loose stool, and hysteria of women.

Astragalus root: [ PROPERTIES AND FLAVOUR ] sweet and warm. [ GUIJING ] enters lung and spleen meridians. [ FUNCTIONS ] can tonify qi, strengthen superficies, induce diuresis, remove toxicity, expel pus, heal wound and promote granulation. Can be used for treating deficiency of vital energy, asthenia, anorexia, loose stool, collapse of middle-warmer energy, chronic diarrhea, rectocele, hematochezia, metrorrhagia, superficial deficiency, spontaneous perspiration, qi deficiency, edema, carbuncle, cellulitis, intractable ulcer, blood deficiency, debility with yellowish complexion, internal heat, and diabetes; proteinuria due to chronic nephritis and diabetes.

Mulberry fruit: [ PROPERTIES AND FLAVOUR ] sweet and cold. [ GUIJING ] enters liver and kidney meridians. [ FUNCTIONS ] can nourish yin and tonify blood; promote the production of body fluid and moisten dryness. Can be used for treating dizziness due to deficiency of liver and kidney and blood and essence; waist soreness and tinnitus; the beard and hair are early white; insomnia and dreaminess; thirst due to body fluid consumption; quenching thirst; constipation due to intestinal dryness.

Peony: [ PROPERTIES AND FLAVOUR ] bitter and neutral. [ GUIJING ] enters liver and spleen meridians. [ FUNCTIONS ] can remove blood stasis, relieve pain, remove heat from the blood, and relieve swelling. It is indicated for amenorrhea due to stasis, hernia and mass, abdominal pain, hypochondriac pain, epistaxis, bloody dysentery, intestinal wind and blood, conjunctival congestion, carbuncle and swelling.

Ligusticum wallichii: [ PROPERTIES AND FLAVOUR ] pungent and warm. [ GUIJING ] enters liver, gallbladder and pericardium. [ FUNCTIONS ] can promote blood circulation, promote the circulation of qi, dispel wind, and relieve pain. Can be used for treating menoxenia, amenorrhea, dysmenorrhea, abdominal mass, abdominal pain, pricking pain in chest and hypochondrium, traumatic injury, swelling and pain, headache, and rheumatalgia.

Achyranthes root: [ PROPERTIES AND FLAVOUR ] bitter, sour and neutral. [ GUIJING ] enters liver and kidney meridians. [ FUNCTIONS ] can tonify liver and kidney, strengthen tendons and bones, remove blood stasis, dredge channels, and draw blood downward. Can be used for treating soreness of waist and knees, weakness of tendons and bones, amenorrhea, abdominal mass, and vertigo due to liver-yang.

Licorice root: [ PROPERTIES AND FLAVOUR ] sweet and neutral. [ GUIJING ] can enter heart, lung, spleen and stomach meridians. [ FUNCTIONS ] has effects in invigorating spleen, invigorating qi, clearing away heat and toxic materials, expelling phlegm, relieving cough, relieving spasm, relieving pain, and harmonizing the drugs. Can be used for treating weakness of spleen and stomach, asthenia, palpitation, short breath, cough, excessive phlegm, abdominal and limb spasm, pain, carbuncle, swelling, sore, and drug toxicity and strong nature.

Honey: [ PROPERTIES AND FLAVOUR ] sweet and neutral. [ GUIJING ] enters lung, spleen and large intestine meridians. [ FUNCTIONS ] can tonify middle energizer, moisten dryness, alleviate pain, and remove toxicity. Can be used for treating abdominal pain, dry cough due to lung dryness, and constipation due to intestinal dryness; it is indicated for sores and ulcers, scald due to hot water or fire.

The preparation method of the lotus leaf extract fully considers the characteristics of the raw materials of the lotus leaves and the dissolution characteristics of the effective components of nuciferine, flavonoid compounds and carbohydrate in the lotus leaves, adopts the steps of pretreatment, extraction, filtration and collection, and has scientific and reasonable design.

Specifically, the parts damaged by worms and mildewed parts are cut off in the pretreatment step, so that the introduction of deteriorated components can be avoided, low-temperature nitrogen is introduced, the nutritional components in the lotus leaves can be protected by standing, the nuciferine is converted from a flowing state to a solidification state, water extraction is carried out by utilizing the water solubility of the nuciferine in the extraction process, the extraction rate is improved to the maximum extent, and the added leaf nutritional powder can increase the nutritional components of the lotus leaf extract; adding mixed solution of petroleum ether and ethanol with small polarity into the filtrate to dissolve saccharides and flavonoids in the folium Nelumbinis extractive solution, and concentrating and removing with the mixed solution during rotary evaporation. The obtained folium Nelumbinis extract contains nuciferine up to 92%, and also contains water soluble flavonoids and saccharides with medium polarity and large polarity, and has effects of clearing summer-heat, promoting diuresis, promoting hair growth, clearing yang, cooling blood, stopping bleeding, scavenging free radicals, and regulating endocrine, and has good absorption for human body.

As a further scheme of the invention, the preparation method of the leaf nutrition powder in the step (2) comprises the following steps:

(1) selecting fresh aloe leaves, cleaning, peeling, cutting into segments, placing into a wall breaking machine, adding clear water with the mass of 1.2-1.5 times of that of the aloe leaves, breaking the wall, pulping to obtain pulp, and filtering to obtain aloe juice;

(2) selecting fresh rosemary stems and leaves, cleaning and peeling, distilling at the temperature of 100 ℃ and 120 ℃, collecting distillate, and refrigerating at the temperature of 4-8 ℃ for later use; respectively grinding seaweed, pollen pini and chitosan into powder for later use;

(3) uniformly mixing aloe juice, distillate, seaweed, pine pollen, chitosan and honey according to the mass ratio of 2:1:1:2:0.2:0.5, rapidly stirring into slurry, crushing and drying to obtain the leaf nutrition powder.

The preparation method of the leaf nutrition powder comprises the steps of firstly breaking the wall of an aloe leaf and pulping to obtain aloe juice, preparing a distillate from rosemary stems and leaves, mixing and stirring the distillate with seaweed, pine pollen, chitosan and honey, and drying to obtain the leaf nutrition powder.

As a further aspect of the present invention, the process for producing the sea powder extract comprises the steps of:

(1) selecting and inserting bamboo poles with row spacing of 40-60cm and transverse spacing of 60-80cm into an offshore tidal zone during oviposition of blue spot dorsal anus sea rabbits for 9-10 months, wherein the bamboo poles and a sea plane form an inclination angle of 40-60 degrees, adjacent bamboo poles are connected through a weaving net, stones with concave-convex surfaces are filled into the weaving net from top to bottom, and the net aperture of the weaving net is smaller than the maximum diameter of the stones;

(2) after the eggs of the blue spot dorsal anus sea hare are attached to the bamboo poles and the stones and form an egg group belt, taking out the weaving net and the bamboo poles at the same time, uniformly scraping the egg group belt attached to the bamboo poles and the stones by using a scraper, and soaking in 8-12 wt% of salt solution for 8-10 hours;

(3) filtering the ovum group band soaked in salt water with 100-200 mesh sieve, drying under sea wind for 2-3 days, placing into extraction tank, adding distilled water 10-12 times of the ovum group band mass, heating at 80-100 deg.C for 2-3 hr, filtering, and concentrating the filtrate under reduced pressure to obtain sea powder extract.

The production process of the sea powder extract comprises the steps of selecting a special bamboo pole and a special stone to attach and collect egg groups in the spawning peak period of the Lanzhou, dorsal anus and sea hares, enabling the egg groups to be easily attached to a rough surface and not to be easily washed by tidal water due to the inclined bamboo pole and the stone with concave and convex surfaces, removing water-soluble impurities and bacteria in sea water due to the soaking in salt water, extracting water-soluble nutrient components in an egg group zone by heating water extraction, and concentrating to form the sea powder extract. The production process has low cost and high efficiency, and is suitable for large-scale production.

As a further embodiment of the present invention, the flavoring agent is one or more of sorbose, xylitol, mannitol, galactose, maltose, and lactose.

The invention also provides a preparation method of the hematogenesis medicinal pill, which comprises the following steps:

1) cleaning colla Corii Asini, radix Angelicae sinensis, fructus Jujubae, radix astragali and radix Paeoniae, drying, mixing, and pulverizing to obtain mixture A;

2) cutting rhizoma Ligustici Chuanxiong and Achyranthis radix into strips of 1-3cm, cleaning, drying, and pulverizing to obtain mixture B;

3) smashing the peony, the mulberry and the liquorice into juice by using a mortar, uniformly mixing the juice with the mixture A and the mixture B, adding the lotus leaf extract, the sea powder extract, the honey and the flavoring agent, and uniformly stirring and mixing at 200r/min to obtain a premix;

4) the premix is introduced into a double-screw extruder to be pelletized into pills, the rotating speed of the extruder is 250-160 ℃ at the temperature of 140-160 ℃.

Compared with the traditional method, the preparation method of the hematogenesis drug pill has the advantages that the peony, the mulberry and the liquorice are smashed into juice, the juice participates in the preparation of the pill, large-particle impurities and components which are not easy to be absorbed by human bodies are avoided, and the obtained pill is good in absorption degree and small in toxic and side effects.

The invention also provides application of the hematogenesis medicinal pill, and particularly relates to application of the hematogenesis medicinal pill in treating qi deficiency and blood deficiency caused by irregular menstruation.

The invention has the beneficial effects that:

1. the hematogenesis drug pill is prepared by adopting a conventional mixing extrusion process, three traditional Chinese medicinal materials of donkey-hide gelatin, Chinese angelica and red date with the efficacy of hematogenesis, blood enrichment and blood are selected as monarch drugs, astragalus, Chinese herbaceous peony, ligusticum wallichii and achyranthes root are selected as ministerial drugs, lotus leaf extract, sea powder extract and mulberry are selected as adjuvant drugs, and liquorice and honey are selected as messenger drugs, so that the medicinal materials supplement each other to play a role in a synergistic manner, the hematogenesis and blood circulation promotion, blood enrichment and yin nourishing, liver and kidney nourishing, heat clearing and toxin removing, menstruation regulating and pain relieving are realized, and the hematogenesis drug pill has a good treatment effect on symptoms of blood deficiency caused by irregular menstruation.

2. In the preparation method of the lotus leaf extract, the part damaged by worms and mildewed parts is cut in the pretreatment step, so that the introduction of metamorphic components can be avoided, the nutritional components in the lotus leaves can be protected by low-temperature nitrogen, and the extraction rate is improved to the maximum extent by water extraction in the extraction process; adding a small-polarity mixed solution consisting of petroleum ether and ethanol into the filtrate to dissolve small-polarity saccharides and flavonoids compounds in the lotus leaf extract, and concentrating and removing the small-polarity saccharides and flavonoids compounds along with the mixed solution in the rotary evaporation process; the obtained folium Nelumbinis extract contains nuciferine up to 92%, and also contains water soluble flavonoids and saccharides with medium polarity and large polarity, and has effects of clearing summer-heat, promoting diuresis, promoting hair growth, clearing yang, cooling blood, stopping bleeding, scavenging free radicals, and regulating endocrine, and has good absorption for human body.

3. In the production process of the sea powder extract, the obliquely arranged bamboo poles and the stones with concave-convex surfaces can enable egg groups to be attached to rough surfaces more easily and not to be washed away by tide water easily, water-soluble impurities and bacteria in sea water can be removed by soaking in salt water, water-soluble nutrient components in egg group belts can be extracted by heating water extraction, and the sea powder extract is formed after concentration. The production process has low cost and high efficiency, and is suitable for large-scale production.

Detailed Description

The technical solutions in the embodiments of the present invention will be clearly and completely described below with reference to the embodiments of the present invention, and it is obvious that the described embodiments are only a part of the embodiments of the present invention, and not all of the embodiments. All other embodiments, which can be derived by a person skilled in the art from the embodiments given herein without making any creative effort, shall fall within the protection scope of the present invention.