阅读说明：本技术 一种医用敷料 (Medical dressing ) 是由 冯波 袁启江 苏丹 石九曜 赵奇 于 2019-10-23 设计创作，主要内容包括：一种医用敷料属于医用物品技术领域,尤其涉及一种医用敷料。本发明提供一种使用效果好的医用敷料。本发明包括基底、第一膜、第二膜和保护层,其特征在于第一膜和第二膜设置在基底上,保护层覆盖在第一膜和第二膜上；第一膜添加纳米壳聚糖和/或第二膜添加羧甲基壳聚糖。(A medical dressing belongs to the technical field of medical articles, and particularly relates to a medical dressing. The invention provides a medical dressing with good use effect. The invention comprises a substrate, a first film, a second film and a protective layer, and is characterized in that the first film and the second film are arranged on the substrate, and the protective layer covers the first film and the second film; the first film is added with nano chitosan and/or the second film is added with carboxymethyl chitosan.)

1. A medical dressing comprises a substrate, a first film, a second film and a protective layer, wherein the first film and the second film are arranged on the substrate, and the protective layer covers the first film and the second film;

the first film is added with nano chitosan and/or the second film is added with carboxymethyl chitosan.

2. The medical dressing of claim 1, wherein the first and second films are fibrous films.

3. The medical dressing of claim 2, wherein the fibrous membrane is a nanofiber membrane.

4. The medical dressing of claim 1, wherein the first film is stacked over the second film surface and the apertures.

5. The medical dressing according to claim 3, wherein the first nanofiber membrane is cut from a pullulan nanofiber membrane;

the pullulan nanofiber membrane is prepared from pullulan and functional substances, wherein the functional substances take nano chitosan as a main body, and one or more of collagen, amino acid, active collagen, sodium hyaluronate, liquorice, purslane and aloe extract are added.

6. The medical dressing according to claim 5, wherein the pullulan nanofiber membrane is electrospun at a spinning voltage of 20-45kv and a spinning distance of 10-20 cm.

7. The medical dressing according to claim 5, wherein the degree of deacetylation of the nano chitosan is 95% or more, and the particle size is 100 nm.

8. The medical dressing according to claim 3, characterized in that said second nanofibrous membrane (3) is cut out of a polyvinyl alcohol-carboxymethyl chitosan nanofibrous membrane;

the polyvinyl alcohol-carboxymethyl chitosan nano fiber membrane comprises the following raw materials in parts by weight: 5-15 parts of polyvinyl alcohol and 1-10 parts of carboxymethyl chitosan.

9. The medical dressing according to claim 8, wherein the polyvinyl alcohol-carboxymethyl chitosan nanofiber membrane is electrospun at a spinning voltage of 20-40kv and a spinning distance of 10-20 cm.

10. The medical dressing according to claim 8, wherein the polyvinyl alcohol has a molecular weight of 20 to 80 ten thousand and the degree of substitution of carboxymethyl chitosan is 60 to 90%.

Technical Field

The invention belongs to the technical field of medical articles, and particularly relates to a medical dressing.

Background

Medical dressings are wound-covering articles used to cover sores, wounds, or other damaged medical materials. The using effect of the existing medical dressing needs to be further improved.

Disclosure of Invention

The invention aims at the problems and provides a medical dressing with good use effect.

In order to achieve the above object, the present invention adopts the following technical solution, and the present invention includes a substrate, a first film, a second film and a protective layer, wherein the first film and the second film are disposed on the substrate, and the protective layer covers the first film and the second film;

the first film is added with nano chitosan and/or the second film is added with carboxymethyl chitosan.

The substrate of the present invention supports the first film and the second film, and the protective layer prevents contamination of the first film and the second film.

In a preferred embodiment, the first film and the second film of the present invention are fibrous films.

As another preferable scheme, the fiber membrane of the invention adopts a nanofiber membrane.

In another preferred embodiment, the first membrane of the present invention is stacked on the surface and pores of the second membrane.

As another preferred embodiment, the second film of the present invention is processed by electrospinning directly on top of the already formed first film; good ventilation and flexibility.

As another preferable scheme, the first nanofiber membrane is formed by cutting a pullulan nanofiber membrane.

As another preferred scheme, the protective layer adopts release paper.

As another preferred embodiment, the second film of the present invention is bonded to the upper end of the substrate.

As another preferable scheme, the substrate of the present invention is a medical fiber fabric layer.

As another preferred scheme, the manufacturing process of the pullulan nanofiber membrane disclosed by the invention is electrostatic spinning.

As another preferable scheme, the raw materials for preparing the pullulan nanofiber membrane (functional components can be added into spinning solution in a mixing manner, and the spinning solution is used for producing nanofibers through an electrostatic spinning process) are pullulan and functional substances, wherein the functional substances mainly comprise nano chitosan, and one or more of collagen, amino acid, active collagen, sodium hyaluronate, liquorice, purslane and aloe extract are added.

As another preferred scheme, the spinning voltage of the electrostatic spinning of the pullulan nanofiber membrane is 20-45kv, and the spinning distance is 10-20 cm.

In some embodiments provided by the present invention, electrospinning parameters used for electrospinning the pullulan nanofiber membrane are as follows:

the spinning voltage was 35kv and the spinning distance was 20 cm.

In some embodiments provided by the present invention, electrospinning parameters used for electrospinning the pullulan nanofiber membrane are as follows:

the spinning voltage was 30kv and the spinning distance was 15 cm.

In some embodiments provided by the present invention, electrospinning parameters used for electrospinning the pullulan nanofiber membrane are as follows:

the spinning voltage was 30kv and the spinning distance was 18 cm.

As another preferred scheme, the raw materials for manufacturing the pullulan nanofiber membrane comprise the following components in parts by weight: 10-25 parts of pullulan polysaccharide and 1-5 parts of functional substances.

In some embodiments provided by the present invention, the pullulan nanofiber membrane of the present invention is prepared from the following components in parts by weight:

20 parts of pullulan polysaccharide, 2.5 parts of nano chitosan particles, 0.5 part of collagen, 0.2 part of sodium hyaluronate and 0.15 part of liquorice.

In some embodiments provided by the present invention, the pullulan nanofiber membrane of the present invention is prepared from the following components in parts by weight:

14.5 parts of pullulan polysaccharide, 2.6 parts of nano chitosan particles, 0.5 part of collagen, 0.15 part of amino acid, 0.15 part of sodium hyaluronate and 0.1 part of purslane.

In some embodiments provided by the present invention, the pullulan nanofiber membrane of the present invention is prepared from the following components in parts by weight:

16.5 parts of pullulan polysaccharide, 3.5 parts of nano chitosan particles, 0.6 part of collagen, 0.2 part of amino acid and 0.12 part of aloe extract.

As another preferable scheme, the deacetylation degree of the nano chitosan is more than or equal to 95%, and the particle size is 100 nm.

As another preferable scheme, the degree of deacetylation of the nano chitosan is 96%.

As another preferable scheme, the second nano fiber membrane (3) is formed by cutting a polyvinyl alcohol-carboxymethyl chitosan nano fiber membrane.

As another preferable scheme, the manufacturing process of the polyvinyl alcohol-carboxymethyl chitosan nanofiber membrane is electrostatic spinning.

As another preferred scheme, the raw material components of the polyvinyl alcohol-carboxymethyl chitosan nanofiber membrane comprise the following components in parts by weight: 5-15 parts of polyvinyl alcohol and 1-10 parts of carboxymethyl chitosan.

In some embodiments provided by the present invention, the polyvinyl alcohol-carboxymethyl chitosan nanofiber membrane of the present invention is prepared from the following components in parts by weight:

7 parts of polyvinyl alcohol and 2 parts of carboxymethyl chitosan.

In some embodiments provided by the present invention, the polyvinyl alcohol-carboxymethyl chitosan nanofiber membrane of the present invention is prepared from the following components in parts by weight:

6.8 parts of polyvinyl alcohol and 2 parts of carboxymethyl chitosan.

In some embodiments provided by the present invention, the polyvinyl alcohol-carboxymethyl chitosan nanofiber membrane of the present invention is prepared from the following components in parts by weight:

7.5 parts of polyvinyl alcohol and 2 parts of carboxymethyl chitosan.

As another preferred scheme, the spinning voltage of the polyvinyl alcohol-carboxymethyl chitosan nanofiber membrane electrostatic spinning is 20-40kv, and the spinning distance is 10-20 cm.

In some embodiments provided by the present invention, the polyvinyl alcohol-carboxymethyl chitosan nanofiber membrane electrostatic spinning adopts the following electrospinning parameters:

the spinning voltage was 30kv and the spinning distance was 18 cm.

In some embodiments provided by the present invention, the polyvinyl alcohol-carboxymethyl chitosan nanofiber membrane electrostatic spinning adopts the following electrospinning parameters:

the spinning voltage was 30kv and the spinning distance was 15 cm.

In some embodiments provided by the present invention, the polyvinyl alcohol-carboxymethyl chitosan nanofiber membrane electrostatic spinning adopts the following electrospinning parameters:

the spinning voltage was 30kv and the spinning distance was 20 cm.

As another preferable scheme, the molecular weight of the polyvinyl alcohol is 20-80 ten thousand, and the substitution degree of the carboxymethyl chitosan is 60-90%.

As another preferred embodiment, the polyvinyl alcohol of the present invention has a molecular weight of 30 ten thousand.

As another preferred embodiment, the degree of substitution of the carboxymethyl chitosan according to the present invention is 70%.

Secondly, the degree of substitution of the carboxymethyl chitosan is 65%.

In addition, the degree of substitution of the carboxymethyl chitosan is 80%.

The invention has the beneficial effects.

According to the invention, nano chitosan is added to the first film and/or carboxymethyl chitosan is added to the second film; good antibacterial and moisture absorption effects, and is beneficial to wound healing.

Drawings

The invention is further described with reference to the following figures and detailed description. The scope of the invention is not limited to the following expressions.

Fig. 1 is a schematic structural diagram of an embodiment of the present invention.

Fig. 2 is a plan view of the intermediate adhesive layer 61 and the peripheral adhesive layer 62 according to the present invention.

Detailed Description

The present invention may also employ the structure of fig. 1 and 2. The structure of the embodiment comprises a substrate 7, a middle bonding layer 61 is arranged in the middle of the upper end of the substrate 7, a peripheral bonding layer 62 is arranged on the periphery of the upper end of the substrate 7, a moisture absorption layer 5 is arranged at the upper end of the middle bonding layer 61, a functional layer 4 (namely the first film and the second film) is arranged in the middle of the upper end of the moisture absorption layer 5, and an antibacterial layer 3 is arranged at the upper ends of the moisture absorption layer 5 and the functional layer 4;

middle part tie coat 61, hygroscopic layer 5, functional layer 4 and 3 parcel in anti-adhesion layer 2 of antibiotic layer, anti-adhesion layer 2 parcel is in leaving type layer 1 (the aforesaid protective layer promptly), links to each other with peripheral tie coat 62 upper end from the peripheral lower extreme in type layer 1.

The moisture absorption layer 5, the functional layer 4 and the antibacterial layer 3 are wrapped by the anti-adhesion layer 2, so that the dressing and the wound surface are effectively prevented from being adhered to each other to cause secondary damage.

The functional layer 4 is wrapped by the moisture absorption layer 5 and the antibacterial layer 3, so that loss of functional factors is effectively prevented, the function of the functional factors can be guaranteed, and wound healing is accelerated.

After the release layer 1 is uncovered, the adhesive layer is only adhered and fixed with the skin through the peripheral adhesive layer 62, so that the contact area of the adhesive layer and the skin is reduced, and the size of uncomfortable skin is reduced.

The middle bonding layer 61 is a rectangular bonding layer, the peripheral bonding layer 62 is a rectangular frame bonding layer, and the outer end of the peripheral bonding layer 62 is flush with the outer end of the substrate 7.

Moisture absorption layer 5 is rectangle moisture absorption layer 5, and moisture absorption layer 5's outer end and middle part tie coat 61 outer end parallel and level, and 5 upper end middle parts in moisture absorption layer are provided with sunkenly, and functional layer 4 sets up in sunkenly, and 4 up end of functional layer and 5 up end parallel and level in moisture absorption layer.

The longitudinal section of the recess is an isosceles trapezoid with a small lower part and a big upper part. The cross-section of functional layer 4 is trapezoidal, imbeds moisture absorption layer 5, and the trapezoidal cube is giving consideration to releasing functional component, guarantees that the dressing has sufficient moisture absorption function simultaneously.

The outer end of the antibacterial layer 3 is flush with the outer end of the moisture absorption layer 5.

The longitudinal section of the anti-adhesion layer 2 is Jiong shapes, the inner side of the upper end of the anti-adhesion layer 2 is flush with the upper end of the antibacterial layer 3, and the inner end of the side wall of the anti-adhesion layer 2 is flush with the outer end of the antibacterial layer 3, the outer end of the moisture absorption layer 5 and the outer end of the middle bonding layer 61.

The release layer 1 is formed by overlapping two side separation type layers, and the overlapping position is located in the middle of the upper end of the anti-adhesion layer 2.

The longitudinal section of the release layer 1 is an isosceles trapezoid frame with a small upper part and a large lower part, the lower end of the trapezoid frame is provided with an opening, the lower ends of two sides of the trapezoid frame extend outwards to form transverse edges, and the lower ends of the transverse edges are connected with the upper end of the substrate 7; the upper end length of trapezoidal frame is greater than 2 upper ends lengths on the anti-sticking layer, from 1 outer end on type layer and 62 outer end parallel and level of peripheral tie coat.

The release layer 1 is silicone oil release paper.

The anti-adhesion layer 2 is a polylactic acid nanofiber layer.

The antibacterial layer 3 is a chitin and derivative fiber layer thereof; has good antibacterial and hemostatic effects.

The moisture absorption layer 5 is a biomedical fiber layer, and the biomedical fiber layer is a sodium carboxymethylcellulose fiber layer, an alginate fiber layer or a polyester fiber layer; the moisture absorption is good.

The middle bonding layer 61 and the peripheral bonding layer 62 are medical adhesive layers; is safe and has no side effect.

The substrate 7 is a medical fiber fabric layer; good air permeability, water resistance and protection.

The peripheral adhesive layer 62 is a medical pressure sensitive adhesive layer.

The antibacterial layer 3 and the moisture absorption layer 5 can be connected by gluing and/or hot pressing.

The thickness of the substrate 7 can be 1-5mm, the thickness of the middle bonding layer 61 and the peripheral bonding layer 62 can be 0.2-1mm, the thickness of the moisture absorption layer 5 can be 1-5mm, the thickness of the functional layer 4 can be 0.3-1.5mm, the thickness of the antibacterial layer 3 can be 1.5-5mm, the thickness of the anti-adhesion layer 2 can be 0.5-1mm, and the thickness of the release layer 1 can be 0.5-2 mm. The thickness of the moisture absorption layer 5 is 0.5-5mm, so that the dressing has excellent moisture absorption and a supporting function, and the influence of external pressure on a wound surface can be relieved.

The invention can be applied to wound surfaces, gall and infected wounds, stanch, prevent infection and promote wound healing.

When the wound dressing is used, the release layer 1 is uncovered from the overlapped part, the anti-adhesion layer 2 is aligned to the wound surface, and then the substrate 7 is lightly stroked to be fixed on the complete skin around the wound through the peripheral adhesion layer 62.

In the present invention, the raw materials used are all commercially available, and in the following examples, the degree of deacetylation of the nano-chitosan is 96%, and the particle size is 100 nm; the molecular weight of the polyvinyl alcohol is 30 ten thousand.