Nano biomedical product preparation system and method
阅读说明:本技术 一种纳米生物医用产品制备系统及其方法 (Nano biomedical product preparation system and method ) 是由 *** 于 2019-09-23 设计创作,主要内容包括:本发明涉及一种纳米生物医用产品制备系统及其方法,底座通过纵向支柱与限位支撑座固定连接,在限位支撑座的中心部位开设有限位孔,该限位孔内活动安装有升降仓,升降仓的底部与两个同步电动推杆的顶部固定连接,在升降仓内套装有旋转平台,旋转平台的中心部位固定安装有模具套筒,在模具套筒的顶部下方的侧面固定安装有支架线固定座,在限位支撑座上固定安装有与模具套筒相配合的产品制备装置;实现了纳米材料的添加和依附的便捷性,在生产支架结构框架的同时就能实现纳米医用材料的同步添加,使产品整体纳米材料分布均匀,有助于后期纳米医用材料的发挥效果。(The invention relates to a nanometer biomedical product preparation system and a method thereof.A base is fixedly connected with a limit supporting seat through a longitudinal strut, a limit hole is arranged at the central part of the limit supporting seat, a lifting bin is movably arranged in the limit hole, the bottom of the lifting bin is fixedly connected with the tops of two synchronous electric push rods, a rotating platform is sleeved in the lifting bin, a mold sleeve is fixedly arranged at the central part of the rotating platform, a bracket line fixing seat is fixedly arranged on the side surface below the top of the mold sleeve, and a product preparation device matched with the mold sleeve is fixedly arranged on the limit supporting seat; the convenience of adding and attaching the nano material is realized, the synchronous adding of the nano medical material can be realized when the support structure frame is produced, the whole nano material of the product is uniformly distributed, and the later-stage nano medical material can be exerted.)
1. The utility model provides a nanometer biomedical product preparation system, includes base (1), two synchronous electric putter (6) of fixed mounting on base (1), its characterized in that: base (1) through longitudinal support post (2) and spacing supporting seat (3) fixed connection, spacing hole has been seted up at the central point of spacing supporting seat (3), this spacing downthehole movable mounting has lift storehouse (9), the bottom of lift storehouse (9) and the top fixed connection of two synchronous electric putter (6), rotating platform (10) are equipped with to the endotheca in lift storehouse (9), the central point fixed mounting of rotating platform (10) has mould sleeve (18), side fixed mounting below the top of mould sleeve (18) has support line fixing base (19), fixed mounting has the product preparation facilities with mould sleeve (18) matched with on spacing supporting seat (3).
2. The nano biomedical product preparation system according to claim 1, characterized in that: the product preparation device comprises a top support plate (5) fixedly connected with a limit support seat (3) through a longitudinal upright post (4), a nano-biomaterial sprayer (11) is fixedly installed on the limit support seat (3) on the inner side of the longitudinal upright post (4), the bottom of the nano-biomaterial sprayer (11) is communicated with a feed pipeline (12), the top of the nano-biomaterial sprayer (11) is communicated with a discharge pipe (13), the outer side end of the discharge pipe (13) is fixedly provided with a spray head (14), a spray opening of the spray head (14) faces to the longitudinal central part of a mold sleeve (18), the top support plate (5) is provided with a top leak hole, an exposed wire limit pipe (20) is fixedly installed in the top leak hole, a guide wheel (22) is fixedly installed on the top support plate (5) at the top of the exposed wire limit pipe (20), one side of the guide wheel (22) is provided with a wire roller (23, a support production line rope (24) is wound on the online roller (23), one end of the support production line rope (24) is fixedly mounted on a roller of the online roller (23), the middle of the support production line rope (24) is supported by a guide wheel (22) and then enters the exposed limiting pipe (20), and the other end of the support production line rope (24) penetrates out of the exposed limiting pipe (20) and is connected with a support line fixing seat (19).
3. The nano biomedical product preparation system according to claim 1, characterized in that: longitudinal strut (2) be two, two longitudinal strut (2) impartial distribution are between base (1) and spacing supporting seat (3), the bottom of longitudinal strut (2) and the top fixed connection of base (1), the bottom fixed connection of the top of longitudinal strut (2) and spacing supporting seat (3), the shape and the size homoenergetic of base (1) and spacing supporting seat (3) are equal, base (1) and spacing supporting seat (3) are square sheet structure, two synchronous electric putter (6) symmetric distribution are in the both sides of base (1) central point position, the bottom of two synchronous electric putter (6) all with the top fixed connection of base (1), the bottom fixed connection of push rod link (7) and push rod lifter plate (8) has all been provided at the top of two synchronous electric putter (6), the bottom fixed connection of the top of push rod lifter plate (8) and lift storehouse (9).
4. The nano biomedical product preparation system according to claim 1, characterized in that: lift storehouse (9) have the tubular structure of rotary platform installing port for the top, rotary platform (10) are installed in the inboard of this rotary platform installing port, bottom fixed mounting at rotary platform (10) has rotary platform fixed connection frame (25), the bottom of rotary platform fixed connection frame (25) and the top fixed connection of rotating gear (26), the inboard cover of rotating gear (26) is equipped with bottom sprag bearing (29), bottom sprag bearing mounting hole has been seted up at the central point of rotating gear (26), bottom sprag bearing (29) suit is in this bottom sprag bearing mounting hole, outside meshing at rotating gear (26) is connected with initiative rotating gear (27), the output fixed connection of initiative rotating gear (27) and motor (28), the bottom fixed mounting of motor (28) is on the bottom of lift storehouse (9).
5. The nano biomedical product preparation system according to claim 1 or 4, characterized in that: center part fixed mounting of rotary platform (10) have mould sleeve support (15), the mould sleeve mounting groove has been seted up on mould sleeve support (15), the bottom of mould sleeve (18) is installed on mould sleeve support (15) through this mould sleeve mounting groove, symmetry fixed mounting has two fixed spacing platforms of mould sleeve (16) on mould sleeve support (15) in this mould sleeve mounting groove outside, fastening bolt mounting hole has all been seted up on every fixed spacing platform of mould sleeve (16), there are two fastening bolt (17) at two fastening bolt mounting hole difference movable mounting, mould sleeve (18) are located the middle part of two fastening bolt (17).
6. The nano biomedical product preparation system according to claim 1, characterized in that: the die sleeve (18) is of a hollow cylindrical tubular structure, the support line fixing seat (19) is fixedly installed on the side face of the upper portion of the die sleeve (18), the support line fixing seat (19) is of an letter T-shaped structure, the long and narrow end of the support line fixing seat (19) is fixedly connected with the outer wall of the die sleeve (18), and the height of the die sleeve (18) is equal to the stroke length of the synchronous electric push rod (6).
7. The nano biomedical product preparation system according to claim 2, characterized in that: the device is characterized in that the number of the longitudinal upright columns (4) is two, the two longitudinal upright columns (4) are equally distributed between the limiting support seat (3) and the top support plate (5), the bottom of each longitudinal upright column (4) is fixedly connected with the top of the limiting support seat (3), the top of each longitudinal upright column (4) is fixedly connected with the bottom of the top support plate (5), the shapes and the sizes of the limiting support seat (3) and the top support plate (5) are equal, the limiting support seat (3) and the top support plate (5) are both of a square sheet structure, the nano-biomaterial sprayer (11) is of a cylindrical structure, a suction pump is fixedly installed in the nano-biomaterial sprayer (11), one end of the suction pump is communicated with the feeding pipeline (12), the other end of the suction pump is communicated with the discharge pipe (13), the discharge pipe (13) is communicated with the spray head (14), an exposed wire limiting pipe fixing block (21) is sleeved on the outer side of the exposed, the bottom center position of the exposed limiting pipe fixing block (21) is positioned above the top center position of the die sleeve (18).
8. The nano biomedical product preparation system according to claim 2 or 7, characterized in that: the height of the nanometer biomaterial sprayer (11) is not less than the length of the mold sleeve (18), the center of the spray head (14) and the top surface of the initial position of the mold sleeve (18) are on the same horizontal plane, the distance between the longitudinal axis of the nanometer biomaterial sprayer (11) and the longitudinal axis of the mold sleeve (18) is not less than the length of the discharge pipe (13), the discharge pipe (13) is a cylindrical tubular structure made of metal, and one side of the discharge pipe (13) is fixedly connected with the outer wall of the nanometer biomaterial sprayer (11).
9. A method for preparing a nano biomedical product by using the nano biomedical product preparation system of claim 2, which is characterized by comprising the following steps: in an initial state, a support production line rope (24) is wound and fixed on a support line fixing seat (19), then a rotating platform (10) and two synchronous electric push rods (6) are opened, the two synchronous electric push rods (6) drive the rotating platform (10) to ascend while slowly lifting, the support production line rope (24) is wound on a mold sleeve (18) from top to bottom by taking the support line fixing seat (19) as a starting point while rotating and ascending until the two synchronous electric push rods (6) are lifted to a highest state, the support production line rope (24) winds the outside of the mold sleeve (18) on a one-way support production line rope ring, after the two synchronous electric push rods (6) are lifted to the highest state, shrinkage operation is carried out without interruption, and at the moment, under the action of non-stop rotation of the rotating platform (10), the support production line rope (24) continuously winds the mold sleeve (18) on which the one-way support production line rope ring is wound from bottom to top And form the two-way support production line loop, after two synchronous electric push rods (6) are lifted to the highest state, the bottom position of the mold sleeve (18) corresponds to the spray head (14), the nanometer biomaterial sprayer (11) is started, and the spraying operation is implemented when the contraction operation of the two synchronous electric push rods (6) is started, the nanometer mixed liquid (25) formed by mixing the nanometer biomaterial slurry and the solidification raw material is sprayed onto the mold sleeve (18) from the spray head (14) at the same time, along with the spraying operation, the rotation of the rotary platform (10) and the contraction operation of the two synchronous electric push rods (6), when the contraction operation of the two synchronous electric push rods (6) is operated to the complete contraction state, the mold sleeve (18) realizes the mixing of the nanometer mixed liquid (25) and the two-way support production line loop while forming the two-way support production line loop, and after the solidification raw material liquid is solidified, a double-layer bidirectional scaffold product with the nano biological material is formed.
Technical Field
The invention relates to the field of medical treatment, in particular to a system and a method for preparing a nano biomedical product.
Background
The biomedical nano material is a biomedical material with a nano effect. Common nano-biomaterials are: the nanometer material for cell separation, namely the American scientific household nanometer particle, successfully separates out trace fetal cells in a blood sample of a pregnant woman, thereby simply, conveniently and accurately judging whether the fetal cells have genetic defects; the nano material for dyeing the inside of the cell selects the types of antibodies by utilizing the obvious difference of the sensitivity and the affinity of different antibodies to various organs and bone tissues in the cell, and the nano gold particles are mixed with pre-refined antibodies or monoclonal antibodies to prepare various nano gold/antibody compounds; the nanometer material for antibiotic and wound dressing is divided into three types according to antibiotic mechanism: one is an Ag-based antibacterial material which uses Ag to inactivate proteins on cell membranes, thereby killing bacteria. The comprehensive performance of the titanium-based nano material can be effectively improved by adding the titanium-based nano material and introducing Zn, Cu and the like into the material; the second type is a photocatalyst type nano antibacterial material such as ZnO, TiO2 and the like, and the photocatalyst type nano antibacterial material reacts with H2O or OH to generate hydroxyl with strong oxidizing property to kill germs; the third kind is inorganic material such as nano montmorillonite, etc. which has strong cation exchange capacity due to its special structure and unsaturated negative charge, and has strong adsorption and fixation effect on pathogenic bacteria and bacteria, thus playing the role of antibiosis; a nano-class scaffold of biologic material for tissue engineering is disclosed, which plays an important role in tissue engineering because the anchorage dependent cells can only grow and differentiate after they are attached to the material. The prepared biodegradable material containing the nano-fibers is started to be applied to in vitro and animal experiments of tissue engineering by simulating the structure of natural extracellular matrix type-2 collagen, and has good application prospect.
With the development of scientific technology, the combination of materials science and biomedicine is more and more compact, and the nano material has achieved great achievement in biological application and shows good development momentum and huge development potential. Production systems matched with nano biomedical materials are continuously improved and researched, and as for nano biomedical material supports, the traditional support production is simple to form the supports at present, and the intersection parts of the support net lines are welded or bonded by using welding and other processes to form products. The addition and attachment of the nano-materials are both the addition treatment after the scaffold production is completed at the later stage, and due to the characteristics of the nano-medical materials, the raw materials are difficult to directly form the grid-type staggered and interwoven structure of the scaffold, while the traditional mode of directly attaching the nano-medical materials is adopted, so that the manufacturing steps are increased, the volatilization effect of the nano-medical materials is not facilitated, and the development of the nano-biomaterial scaffold is restricted by the difficult problem.
Therefore, the system and the method for preparing the nano biomedical product have the advantages of simple structure, convenient operation, high working and running efficiency, simple and easy operation, obvious composite effect and simple production steps, and have wide market prospect.
Disclosure of Invention
Aiming at the defects of the prior art, the invention provides the preparation system and the preparation method of the nano biomedical product, which have the advantages of simple structure, convenient operation, high working and running efficiency, simple and easy operation, obvious composite effect and simple production steps, and are used for overcoming the defects in the prior art.
The technical scheme of the invention is realized as follows: the utility model provides a nanometer biomedical product preparation system, includes the base, two synchronous electric putter of fixed mounting on the base, the base pass through longitudinal support and spacing supporting seat fixed connection, spacing hole has been seted up at the central point of spacing supporting seat, this spacing downthehole movable mounting has the lift storehouse, the bottom in lift storehouse and two synchronous electric putter's top fixed connection, rotating platform is equipped with to the storehouse endotheca that goes up and down, rotating platform's central point fixed mounting has the mould sleeve, side fixed mounting below the top of mould sleeve has support line fixing base, fixed mounting has the product preparation facilities with mould sleeve matched with on spacing supporting seat.
The product preparation device comprises a top support plate fixedly connected with a limit support seat through a longitudinal upright post, a nano-biomaterial sprayer is fixedly arranged on the limit support seat on the inner side of the longitudinal upright post, the bottom of the nano-biomaterial sprayer is communicated with a feeding pipeline, the top of the nano-biomaterial sprayer is communicated with a discharging pipe, the outer side end of the discharging pipe is fixedly provided with a spray head, a spray opening of the spray head faces to the longitudinal central part of a mold sleeve, a top leak hole is formed in the top support plate, a line exposure limit pipe is fixedly arranged in the top leak hole, a guide wheel is fixedly arranged on the top support plate at the top of the line exposure limit pipe, one side of the guide wheel is provided with a wire roller, a support production wire rope is wound on the wire roller, one end of the support production wire rope is fixedly arranged on the roller of the wire roller, the middle part of the support, the other end of the bracket production line rope penetrates out of the exposed line limiting pipe and is connected with the bracket line fixing seat.
The utility model discloses a novel electric lifting device, including base, vertical pillar, base and spacing supporting seat, the bottom of vertical pillar and the top fixed connection of base, the top of vertical pillar and the bottom fixed connection of spacing supporting seat, the shape and the size of base and spacing supporting seat all equal, base and spacing supporting seat are square sheet structure, two synchronous electric putter symmetric distributions are in the both sides that the base central point put, two synchronous electric putter's bottom all with the top fixed connection of base, the bottom fixed connection of push rod link and push rod lifter plate has all been provided at two synchronous electric putter's top, the top of push rod lifter plate and the bottom fixed connection in lift storehouse.
The lift storehouse have the tubular structure of rotary platform installing port for the top, rotary platform installs the inboard at this rotary platform installing port, bottom fixed mounting at rotary platform has rotary platform fixed connection frame, rotary platform fixed connection frame's bottom and rotary gear's top fixed connection, rotary gear's inboard cover is equipped with the bottom sprag bearing, bottom sprag bearing mounting hole has been seted up at rotary gear's central point, bottom sprag bearing suit is in this bottom sprag bearing mounting hole, outside meshing at rotary gear is connected with initiative rotary gear, the output fixed connection of initiative rotary gear and motor, the bottom fixed mounting of motor is on the bottom in lift storehouse.
The center part fixed mounting of rotary platform have a mould sleeve support, the mould sleeve mounting groove has been seted up on the mould sleeve support, install on the mould sleeve support through this mould sleeve mounting groove mould sleeve's bottom, symmetrical fixed mounting has two fixed spacing platforms of mould sleeve on the mould sleeve support in this mould sleeve mounting groove outside, fastening bolt mounting hole has all been seted up on the fixed spacing platform of every mould sleeve, there are two fastening bolts at two movable mounting respectively in the fastening bolt mounting hole, the mould sleeve is located two fastening bolt's middle part.
The die sleeve is of a hollow cylindrical tubular structure, the support line fixing seat is fixedly installed on the side face above the die sleeve and is of an letter T-shaped structure, the long and narrow end of the support line fixing seat is fixedly connected with the outer wall of the die sleeve, and the height of the die sleeve is equal to the stroke length of the synchronous electric push rod.
The device comprises a die sleeve, a limiting support seat, a top support plate, a nanometer biomaterial sprayer, a feeding pipe, a discharging pipe and a spray head, wherein the two longitudinal stand columns are equally distributed between the limiting support seat and the top support plate, the bottom of each longitudinal stand column is fixedly connected with the top of the limiting support seat, the top of each longitudinal stand column is fixedly connected with the bottom of the top support plate, the shapes and sizes of the limiting support seat and the top support plate are equal, the limiting support seat and the top support plate are both of square sheet structures, the nanometer biomaterial sprayer is of a cylindrical structure, a suction pump is fixedly arranged in the nanometer biomaterial sprayer, one end of the suction pump is communicated with the feeding pipe, the other end of the suction pump is communicated with the discharging pipe, the discharging pipe is communicated with the spray head, an exposed wire limiting pipe fixing block.
The height of the nanometer biomaterial sprayer is not less than the length of the mold sleeve, the center of the spray head and the top surface of the initial position of the mold sleeve are on the same horizontal plane, the distance between the longitudinal axis of the nanometer biomaterial sprayer and the longitudinal axis of the mold sleeve is not less than the length of the discharge pipe, the discharge pipe is of a cylindrical tubular structure made of metal, and one side of the discharge pipe is fixedly connected with the outer wall of the nanometer biomaterial sprayer.
A method for preparing a nano biomedical product by using the nano biomedical product preparation system comprises the following steps: in the initial state, winding and fixing the support production cord on a support line fixing seat, then opening a rotary platform and two synchronous electric push rods, wherein the two synchronous electric push rods drive the rotary platform to ascend while slowly lifting, the support production cord is wound on a mold sleeve from top to bottom by taking the support line fixing seat as a starting point while rotating and ascending until the two synchronous electric push rods are lifted to the highest state, the support production cord winds the outside of the mold sleeve on a one-way support production line cord ring, after the two synchronous electric push rods are lifted to the highest state, shrinkage operation is continuously carried out, at the moment, under the action of the rotation of the rotary platform without stopping, the support production cord continuously winds the mold sleeve on which the one-way support production line cord ring is wound from bottom to top to form a two-way support production line cord ring, and after the two synchronous electric push rods are lifted to the highest state, the bottom position of the mold sleeve corresponds to the spray head, the nanometer biological material sprayer is opened, and spraying operation is implemented when the contraction operation of the two synchronous electric push rods starts, nanometer mixed liquid formed by mixing nanometer biological material slurry and solidified raw materials is sprayed out of the mold sleeve from the spray head at the same time, along with the spraying operation, the rotation of the rotating platform and the contraction operation of the two synchronous electric push rods, when the contraction operation of the two synchronous electric push rods is operated to a complete contraction state, the mold sleeve realizes the mixing of the nanometer mixed liquid and the rope loop of the bidirectional support production line while forming the rope loop of the bidirectional support production line, and after the solidified raw material liquid is solidified, a double-layer bidirectional support product with nanometer biological materials is formed.
The invention has the following positive effects: the product has convenient operation and high working and operating efficiency, and overcomes a plurality of defects of the traditional medical bracket product formed by welding or bonding. The whole production process is simple, the continuity is strong, the production steps are reduced, the nano mixed liquid is simultaneously utilized to realize the addition of the nano medical material during the forming, the convenience of the addition and the attachment of the nano material is realized, the synchronous addition of the nano medical material can be realized while the support structure frame is produced, the whole nano material of the product is uniformly distributed, and the later-stage nano medical material can be favorably exerted.
Drawings
FIG. 1 is a schematic view of the present invention.
FIG. 2 is a second schematic structural diagram of the present invention.
Fig. 3 is a third schematic structural diagram of the present invention.
Fig. 4 is a schematic top view of the position-limiting support base.
Fig. 5 is a schematic view of the internal structure of the lifting bin of the present invention.
Detailed Description
As shown in fig. 1, 2, 3, 4, 5, a nanometer biomedical product preparation system comprises a base 1, two synchronous electric push rods 6 fixedly mounted on the base 1, the base 1 is fixedly connected with a
Longitudinal support 2 be two, 2 equipartition of two longitudinal support are between base 1 and spacing supporting
The center part fixed mounting of
The number of the longitudinal
When the nanometer biomedical bracket is specifically produced, in an initial state, a
In addition to the production of the nano medical stent, when some medical materials and medical accessories need to be sprayed with the nano mixed
The foregoing is directed to preferred embodiments of the present invention, other and further embodiments of the invention may be devised without departing from the basic scope thereof, and the scope thereof is determined by the claims that follow. However, any simple modification, equivalent change and modification of the above embodiments according to the technical essence of the present invention are within the protection scope of the technical solution of the present invention.