阅读说明：本技术 一种防控动物病毒类疾病的无抗组合物及其制备方法和应用 (Nonreactive composition for preventing and controlling animal virus diseases and preparation method and application thereof ) 是由 肖勇 于 2021-08-11 设计创作，主要内容包括：本发明属于防疫饲料兽药技术领域,公开了一种防控动物病毒类疾病的无抗组合物及其制备方法和应用。该组合物是以多种中草药提取与微生物、多种微量元素等结合后,获得的一款防控非洲猪瘟疫情,净化蓝耳稳定,全面保护猪的健康、提高母猪繁殖生产性能、促进猪的生长和辅助治疗于一体的产品。该组合物抗菌、消炎、抗病毒、抗感染、调节激活免疫、抗氧化应激,清除自由基、改善肠道健康、保肝排毒、提高繁殖生产性能、促进生长,降低料肉比。促进消化酶分泌和营养物质消化吸收,降解饲料中抗营养因子,提高饲料转换率8-10％,降低料肉比0.15-0.2；促进类胰岛素生长因子分泌和蛋白质合成,增加采食,促进生长,育肥猪可提前15天以上出栏。(The invention belongs to the technical field of epidemic prevention feed and veterinary drugs, and discloses a nonreactive composition for preventing and controlling animal virus diseases, and a preparation method and application thereof. The composition is a product which is obtained by combining various Chinese herbal medicine extracts with microorganisms, various trace elements and the like, prevents and controls the epidemic situation of the African swine fever, purifies and stabilizes blue ears, comprehensively protects the health of pigs, improves the reproductive production performance of sows, promotes the growth of the pigs and integrates auxiliary treatment. The composition has antibacterial, antiinflammatory, antiviral, antiinfectious, immunity regulating, antioxidant, free radical scavenging, intestinal health improving, liver protecting, toxic substance removing, reproduction and production performance improving, growth promoting, and feed conversion ratio reducing effects. Promoting digestive enzyme secretion and nutrient substance digestion and absorption, degrading anti-nutritional factors in the feed, improving the feed conversion rate by 8-10%, and reducing the feed conversion ratio by 0.15-0.2; promote the secretion of insulin-like growth factors and the synthesis of proteins, increase the intake of food, promote the growth, and lead the fattening pigs to be slaughtered more than 15 days in advance.)

1. The nonreactive composition for preventing and controlling animal virus diseases is characterized by being mainly prepared from the following raw materials in parts by weight:

10-80 parts of acanthopanax, 8-60 parts of angelica, 2-9 parts of gelsemium elegans, 10-80 parts of wild buckwheat rhizome, 10-80 parts of astragalus, 32-240 parts of liquorice, 10-80 parts of soybean isoflavone, 8-60 parts of honeysuckle, 7-68 parts of folium isatidis, 4-34 parts of houttuynia cordata, 100 parts of trace elements and 800 parts of glucose.

2. The composition of claim 1, wherein the composition is prepared from the following raw materials in parts by weight:

20-50 parts of acanthopanax, 18-40 parts of angelica, 3-8 parts of gelsemium elegans, 20-50 parts of wild buckwheat rhizome, 20-50 parts of astragalus, 72-160 parts of liquorice, 20-50 parts of soybean isoflavone, 18-40 parts of honeysuckle, 14-32 parts of folium isatidis, 7-16 parts of houttuynia cordata, 500 parts of trace elements 200 and 72-160 parts of glucose.

3. The composition of claim 2, wherein the composition is prepared from the following raw materials in parts by weight:

30 parts of acanthopanax, 25 parts of angelica, 5 parts of gelsemium elegans, 30 parts of wild buckwheat rhizome, 30 parts of astragalus, 100 parts of liquorice, 30 parts of soybean isoflavone, 25 parts of honeysuckle, 20 parts of folium isatidis, 10 parts of houttuynia cordata, 300 parts of trace elements and 100 parts of glucose.

4. The composition of any one of claims 1 to 3, wherein the trace elements comprise one or more of iron-containing solutions, copper-containing solutions, zinc-containing solutions, manganese-containing solutions, iodine-containing solutions, cobalt-containing solutions, and selenium-containing solutions.

5. A method for preparing the composition of claim 1-4, wherein the composition is prepared by pulverizing radix Acanthopanacis Senticosi, radix Angelicae sinensis, herba Gelsemii Elegantis, rhizoma Fagopyri Dibotryis, radix astragali, radix Glycyrrhizae, flos Lonicerae, folium Isatidis, and herba Houttuyniae at a certain ratio, mixing, adding soybean isoflavone, trace elements, glucose, and probiotic, mixing, drying, sterilizing, and pulverizing to obtain the final product.

6. The method for preparing the composition of claim 5, wherein the particles of the mixture of radix Acanthopanacis Senticosi, radix Angelicae sinensis, herba Gelsemii Elegantis, rhizoma Fagopyri Dibotryis, radix astragali, radix Glycyrrhizae, flos Lonicerae, folium Isatidis, and herba Houttuyniae are 50-80 mesh;

after the secondary crushing, the particle size is 200-500 meshes.

7. The method of claim 5, wherein the probiotic comprises one or more of Lactobacillus, Bifidobacterium, Bacillus, enterococcus faecalis, enterococcus faecium, and enterococcus lactis.

8. The method for preparing the composition of claim 5, wherein the ratio of the probiotic to the total mass of acanthopanax root, angelica, gelsemium elegans, wild buckwheat rhizome, astragalus root, licorice, honeysuckle flower, dyers woad leaf, cordate houttuynia, soybean isoflavone, trace elements and glucose is 0.3-0.8: 1.

9. The method of claim 5, wherein the drying temperature is not higher than 40 ℃.

10. Use of the non-antibiotic composition according to any one of claims 1 to 9 for the control of viral diseases in animals, wherein the non-antibiotic composition is used in a feed product for the control of animals.

Technical Field

The invention belongs to the technical field of epidemic prevention feed and veterinary medicine, and particularly relates to a nonreactive composition for preventing and controlling animal virus diseases, and a preparation method and application thereof.

Background

With the development of the pig industry, pig breeding methods are developing towards scale, intensification and specialization. In the production of pig farms, the healthy and efficient breeding management of the boars and sows in the breeding period is of great importance, so that the high-quality and healthy piglets can be provided, the healthy and rapid growth of the piglets is accelerated, the breeding risk of the breeding pigs can be reduced, the breeding cost of the breeding pigs is reduced, and the economic benefit of pig breeding is improved. The factors influencing the healthy and efficient breeding of breeding pigs are many, and the most important is breeding pig feed and a breeding method of breeding pigs.

Pigs vary greatly in their nutritional requirements at different reproductive stages and therefore require the use of appropriate feed and the feeding of appropriate amounts of feed at different stages. The pig breeding method is also very important for breeding pigs in a breeding period, and not only can be beneficial to the healthy development of the bred pigs, the hybridization rate of boars and sows is improved, the immunity of the sows is enhanced, the production performance of the sows is shortened, the birth rate of piglets and the weight of the piglets are improved, but also the components in the feed are reasonably utilized, the waste of the feed is reduced, and the breeding cost is reduced.

However, the existing pig feed often has the problems of standard exceeding of antibiotic content, strong feed specificity and the like, the meat quality and taste are influenced while the meat yield is increased, and the feed is economical and practical.

At present, the products for improving the nonspecific immunity of swinery, resisting oxidation, eliminating free radicals, effectively blocking the epidemic disease transmission and resisting the body injury of animals have no great curative effect; any antiviral product that does not improve reproductive and productivity is also a non-valuable product.

Disclosure of Invention

In order to solve the problems in the prior art, the invention aims to provide an antibiotic-free composition for preventing and controlling animal virus diseases, and a preparation method and application thereof.

The technical scheme adopted by the invention is as follows: the non-antibiotic composition for preventing and controlling animal virus diseases is mainly prepared from the following raw materials in parts by mass:

10-80 parts of acanthopanax, 8-60 parts of angelica, 2-9 parts of gelsemium elegans, 10-80 parts of wild buckwheat rhizome, 10-80 parts of astragalus, 32-240 parts of liquorice, 10-80 parts of soybean isoflavone, 8-60 parts of honeysuckle, 7-68 parts of folium isatidis, 4-34 parts of houttuynia cordata, 100 parts of trace elements and 800 parts of glucose.

Acanthopanax root, name of traditional Chinese medicine. Is rhizome or stem of Harms of Acanthopanax senticosus (Rupr. et maxim) belonging to Araliaceae. Has the effects of replenishing qi to invigorate the spleen, tonifying the kidney and soothing the nerves. It can be used for treating spleen and lung qi deficiency, kidney deficiency, soreness of waist and knees, heart and spleen deficiency, insomnia, and amnesia. Sweet in taste, slightly bitter in nature; it enters spleen, lung, heart and kidney meridians. Chemical components: contains a plurality of glycosides, and is the main effective component. Also contains polysaccharide, isofraxidin, chlorogenic acid, sesamin, stearic acid, beta-sitosterol, betulinic acid, amygdalin, etc. The pharmacological action is as follows: 1. effects on the central nervous system: acanthopanax senticosus has an effect on both excitation and inhibition of central nerves. The radix Acanthopanacis Senticosi ethanol extract has anticonvulsive effect. 2. Impact on the respiratory system: the acanthopanax extract has obvious cough relieving effect; the acanthopanax alcohol extract has obvious phlegm eliminating effect. 3. Effects on the cardiovascular system: the radix Acanthopanacis Senticosi extract has effects of dilating blood vessel and improving blood supply of brain. The root, stem and leaf extract has strong inhibiting effect on platelet aggregation, and has antiarrhythmic effect, and can relieve myocardial ischemia tissue injury, promote regeneration of surface cell and recovery of myocardial infarction region. 4. The function of resisting pathogenic microorganisms: the acanthopanax senticosus has certain inhibition effect on staphylococcus albus, neisseria and escherichia coli. The polysaccharide component can enhance the ability of resisting human tubercle bacillus. Acanthopanax senticosus has effect in inhibiting encephalitis virus infection. 5. Effects on the endocrine System: the acanthopanax not only can prevent adrenal hyperplasia caused by adrenal cortical hormone, but also can relieve adrenal cortex atrophy caused by cortisone; can prevent thyroid hypertrophy caused by thyroxine and thyroid atrophy caused by methylthiouracil. 6. Effects on blood cells: acanthopanax senticosus can restore the normal state of red blood cells and white blood cells caused by chemical factors and biological factors. 7. Effects on nucleic acids and proteins: acanthopanax senticosus can accelerate the uptake of the liver cell nucleus to P, increase the synthesis of brain protein and stimulate the regeneration of liver tissue. 8. Effects on sugar metabolism: acanthopanax senticosus can increase serum inorganic phosphorus and blood sugar, increase muscle and liver glycogen, reduce liver and serum lactate, and increase muscle lactate. Eleutheroside can partially prevent decrease of ATP, glycogen and phosphate in muscle and increase of lactic acid and pyruvic acid. 9. In addition, acanthopanax has certain functions of resisting fatigue, stress, tumor, radiation, aging and inflammation, protecting adriamycin nephropathy, improving plasma concentration of eosinophil and alpha-globulin, the number of red blood cells and blood alkali reserve, and the like.

Chinese angelica root, named as Chinese medicine. Is root of Angelica sinensis (Oliv) Diels. of Angelica of Umbelliferae. Has effects of replenishing blood, regulating menstruation, promoting blood circulation, relieving pain, and loosening bowel to relieve constipation. It can be used for treating blood deficiency, sallow complexion, menoxenia, amenorrhea, dysmenorrhea, blood deficiency, blood stagnation, pain due to blood cold, traumatic injury, rheumatalgia, superficial infection, pyocutaneous disease, intestinal dryness, and constipation. Sweet and pungent in flavor and warm in nature; it enters liver, heart and spleen meridians. Chemical components: the angelica contains neutral oil components such as beta-pinene, alpha-pinene, camphene and the like. Contains acidic oil components such as p-methylbenzyl alcohol and 5-methoxy-2, 3-xylenol, organic acid, saccharide, vitamins, amino acids, etc. The pharmacological action is as follows: 1. effects on the reproductive system: angelica sinensis has the function of regulating uterine smooth muscle in two directions. Mainly plays a role in inhibiting the isolated uterus and has a role in stimulating the in vivo uterus. 2. Effects on the cardiovascular system: the radix Angelicae sinensis fluid extract has effect in resisting myocardial ischemia, and radix Angelicae sinensis neutral oil also has protective effect on myocardial ischemia. It also has antiarrhythmic effect. The radix Angelicae sinensis extract has effects of dilating coronary artery and increasing coronary blood flow. 3. Effects on the blood system: the radix Angelicae sinensis powder has effects of reducing blood lipid and protecting arteriosclerosis aorta pathological changes. Ligustilide in radix Angelicae sinensis extract has platelet aggregation inhibiting effect. The angelica and the ferulic acid thereof have obvious antithrombotic effect. Angelica polysaccharide has the function of promoting hematopoiesis. 4. Impact on the immune system: the total acid of radix Angelicae sinensis has effects of improving cellular immunity and promoting humoral immunity. Angelica polysaccharide also has immunity enhancing effect. 5. Effects on the central nervous system: the effective component ligustilide in angelica has the function of inhibiting the central nervous system, and angelica has the analgesic function which is stronger than aminopyrine, the acute toxicity is extremely low 6, and the function of resisting pathogenic microorganisms is as follows: the angelica has antibacterial effects on in vitro dysentery, typhoid, paratyphoid, escherichia coli, diphtheria bacillus, vibrio cholerae, alpha and beta hemolytic streptococcus and the like; 7. impact on the respiratory system: the radix Angelicae sinensis component ligustilide has antiasthmatic effect. 8. In addition, radix Angelicae sinensis has effects of protecting liver, resisting tumor, resisting radiation, resisting inflammation, protecting kidney, resisting oxidation, and correcting protein metabolism disorder. And (3) toxicological effects: the toxicity of angelica is low, and LD of angelica is injected into mice by vein₅₀80-100 g/kg; subcutaneous injection and intragastric administration of volatile oil LD₅₀298mg/kg and 96mg/kg respectively; lD of ligustilide abdominal cavity injection₅₀520 mg/kg; sodium ferulate intravenous injection and intragastric LD₅₀1.7g/kg and 3.6g/kg, respectively. The dog has intravenous injection of 2g/kg of angelica for 14 days continuously, and has no obvious effect on liver, kidney, electrocardiogram and hemogram. The 5% angelica diet is used for feeding mice, the animals grow strongly after 3-5 months, and the glutamic acid oxidation capability of the liver is obviously improved.

Gelsemiq Elegantis, name of Chinese medicine. Is Gelsemiumelegans (Gardn. et Champ.) Benth of caulis et folium Linderae of family Marchandae, genus Humulus [ medicinal elegans Gardn. et Champ ]]The whole plant of (1). Has the effects of dispelling pathogenic wind, removing toxic substances, resolving hard mass, and relieving pain. It can be used for treating scabies, eczema, scrofula, carbuncle, furuncle, traumatic injury, rheumatalgia, and neuralgia. Pungent and bitter with warm nature. Chemical components: gelsmium elegans contains alkaloid: gelsemine, i.e., gelsemine, i.e., evergreen gelsemine, gelsemine; the stem contains koumine and evergreen koumine, and the leaf contains koumine, semen Pharbitidis, herba Violae and gelsemine. A first part of the total alkaloids, a second part of the total alkaloids, a third part of the total alkaloids, a fourth part of the total alkaloids, an bicuculline, a 16-Epoxicam Carpine base, a 19-hydroxy dihydro-1-methoxy gelsemine, a hydrogen gelsemine, and the like. The pharmacological action is as follows: 1. the analgesic effect is as follows: the gelsemium elegans total alkaloids extracted from the whole herb has significant analgesic effect, and mouse hot plate test shows that intraperitoneal injection of 0.5mg/kg, 1.0mg/kg and 2.0mg/kg all have significant analgesic effect, and ED with analgesic effect at 30min₅₀0.28mg/kg, 0.39mg/kg when the mouse writhing reaction caused by acetic acid is used for gastric lavage, 0.28mg/kg is used for intraperitoneal injection, and ED (injection-induced emission) for intraperitoneal injection administration in photothermal stimulation rat tail flick test₅₀It was 0.5 mg/kg. The continuous administration mice have no tolerance to the analgesic effect of the gelsemium elegans. 2. Sedation: the injection of gelsemium total alkali by muscle or subcutaneous injection of 0.5mg/kg, 0.7mg/kg and 1mg/kg can obviously enhance the central inhibition effect of the sodium pentobarbital and chloral hydrate in subthreshold dose on mice, and obviously increase the number of mice with positive turning and reflecting disappearance; the gelsemium total alkaloid can also obviously reduce the spontaneous activity of the rat and has quiet appearance, which shows that the gelsemium total alkaloid has lasting central inhibition effect. 3. Anti-inflammatory action: gelsemium elegans total alkali skinThe injection is injected into the lower cavity or the abdominal cavity with 1mg/kg, has obvious inhibition effect on the foot swelling of rats caused by carrageenin and egg white, and can also obviously inhibit the cotton ball granulation tissue hyperplasia of the rats with subcutaneous injection of 0.5 mg/kg. The gelsemine total alkali has no obvious influence on the weight of thymus and adrenal gland of young rats and does not influence the concentration of cortisol in plasma of the rats, but can obviously reduce the content of PGE in rat paws with swelling caused by carageenan, and the content of PGE in rat paws with swelling caused by carageenan is prompted to be related to inhibition of prostaglandin synthesis at inflammation parts instead of passing through a pituitary-adrenal cortex system. 4. Mydriasis: experiments show that the contained gelsemine has obvious mydriasis effect on rabbits and is quick in recovery. Dropping 1% gelsemium solution into eye of human, 2 drops each time, once every 5min, 3 times in total. 69 volunteers can see rapid dilation of pupil, strong action and rapid recovery, and the pupil diameter, distance vision, near point adjustment and the like can be obviously changed 30min after eye dropping until each index is almost recovered to the level before administration in 6 h. 5. The anti-tumor effect is as follows: the gelsemine injection has certain inhibition effect on the proliferation of human lung adenocarcinoma cells AGZY-83-a and gastric adenocarcinoma cells Sc-823 in vitro, and can slow down the growth rate of cancer cells, reduce mitosis index, reduce fluidity of cell membrane lipid and increase death rate. The gelsemium elegans extract is administered by gavage continuously for 14 days at a dose of 0.45g/kg and 0.11g/kg per day (calculated by crude drug), and is used for treating mouse transplantation sarcoma S₁₈₀The growth of the solid bodies has obvious inhibiting effect, but the growth of the solid bodies of the mouse transplanted liver cancer is not obviously inhibited. 6. Impact on immune function: the percentage of phagocytosis and phagocytic index of chicken erythrocyte by mouse abdominal macrophage can be increased obviously by injecting 0.1g/kg of crude extract of rhizome ethanol in abdominal cavity, and inhibition of phagocytic function caused by cyclophosphamide can be antagonized obviously; has no obvious influence on the generation of a mouse hemolysin antibody and the transformation of lymphocytes in vivo, but can obviously antagonize the inhibition of cyclophosphamide. 7. Effects on the heart: 1% of gelsemium water-soluble total alkali is injected into toad lymph sac or abdominal cavity of rat at 2ml/kg, it can be seen that toad heart rate is obviously slowed down, P wave time limit is prolonged, QRS wave group time is prolonged, ST segment and QT time are prolonged, P wave, R wave and T wave pressure are all reduced, it shows that it has negative time-varying force and variable conduction action, and there may be myocardial ischemia; in the case of rats, the voltage drop and Q are divided by ST segmentThe T time limit is prolonged, and no obvious influence is left. 8. Effect on smooth muscle: the gelsemium water-soluble total alkali can obviously reduce outflow quantity by lung and bronchus perfusion of guinea pig, which shows that the gelsemium water-soluble total alkali can shrink the bronchus smooth muscle, isoproterenol has antagonistic effect on the gelsemium water-soluble total alkali, but diphenhydramine has no antagonistic effect, which shows that the effect of shrinking the bronchus smooth muscle is unrelated to histamine H1 receptor and possibly related to beta receptor. 9. Other functions are as follows: 2.5-10mg/ml of gelsemium elegans total alkaloid has no mutagenesis effect, but can inhibit escherichia coli inclined error repair reaction (SOS) caused by UV and MNNG (N-methyl-N-nitro-N1-nitrosoguanidine), but cannot inhibit mutation caused by benzopyrene (B (alpha) P), and also has no antimutation effect. Toxicity of gelsemium elegans alkaloid toxicity (mouse intraperitoneal injection) LD₅₀(mg/g)。

Wild buckwheat rhizome, named Chinese medicine. Is dried rhizome of Fagopyrum dibotrys (D.Don) Hara of Fagopyrum of Polygonaceae. Has the effects of clearing away heat and toxic materials, expelling pus and removing blood stasis. It can be used for treating pulmonary abscess, cough due to lung heat, lymphoid tuberculosis, skin ulcer, furuncle, and sore throat. Slightly pungent and astringent taste and cool; it enters lung meridian. Chemical components: the rhizome contains coumaric acid, ferulic acid, etc. The pharmacological action is as follows: has expectorant, antipyretic, antiinflammatory, and antitumor effects. Although no obvious antibacterial effect exists in vitro experiments, the antibacterial agent has an antagonistic effect on coagulase, hemolysin and pyocyaneus endotoxin of staphylococcus aureus.

Astragalus root, name of traditional Chinese medicine. Is root of Astragalus membranaceus (Fisch.) Bge. of Astragalus of Leguminosae, Astragalus membranaceus (Astragalus membranaceus) Bge. var. mongholicus (Bge.) Hsiao or Astragalus membranaceus (Fisch.) Bge. Has effects in invigorating spleen, strengthening middle warmer, invigorating yang, lifting sink, invigorating defensive qi, consolidating superficial resistance, promoting urination, removing toxic materials, and promoting granulation. It is mainly indicated for spleen qi deficiency syndrome, lung qi deficiency syndrome, qi deficiency spontaneous sweating syndrome, qi and blood deficiency, ulcer and sore difficult to ulcerate and rot, or difficult to heal for a long time. Sweet in flavor and slightly warm in nature; it enters spleen and lung meridians.

Licorice, name of Chinese medicine. Is aerial part of Glycyrrhrizae radix of Glycyrrhiza of Labiatae. Has effects of dispelling pathogenic wind and heat, clearing head and eyes, relieving sore throat, promoting eruption, dispersing stagnated liver qi, and activating qi-flowing. Can be used for treating wind-heat type common cold, early stage epidemic febrile disease, wind-heat type headache, conjunctival congestion, lacrimation, sore throat, measles without adequate eruption, pruritus, stagnation of qi due to depression of liver, chest distress, and hypochondriac pain. Pungent taste and cool nature; it enters lung and liver meridians.

Soy isoflavones, which are flavonoids, are a class of secondary metabolites formed during the growth of soybeans, and are bioactive substances. Since it is extracted from plants and has a structure similar to that of estrogen, soy isoflavones are also called phytoestrogens. The estrogenic action of soy isoflavones affects hormone secretion, metabolic biological activity, protein synthesis, growth factor activity, and is a natural cancer chemopreventive agent. Isoflavones are a weak plant female planning economic hormone, and soybeans are the only effective source for obtaining isoflavones for human beings. Under the condition of strong physiological activity of estrogen, isoflavone can play a role in resisting estrogen and reducing the risk of cancers activated by estrogen, such as breast cancer, and when the level of estrogen is reduced in the menopause period of women, isoflavone can play a role in replacing, thereby avoiding the occurrence of menopause symptoms such as hot flashes and the like. Isoflavone has outstanding anticancer property, can inhibit the growth and diffusion of cancer cells, has effect on cancer cells only, and has no influence on normal cells. Isoflavones are also effective antioxidants that prevent the formation of oxygen radicals, a potent carcinogen. Thus, isoflavone has various modes and ways for resisting cancer. A large number of researches find that the soybean isoflavone can convert cancer cells into cells with normal functions, inhibit adverse lump structures and prevent lump hyperplasia and cancer cell diffusion.

Flos Lonicerae, wherein the flos Lonicerae is Lonicera Japonica of Lonicera of Caprifoliaceae and its congeneric plant, and its dried bud or flower with initial bloom. Honeysuckle is known as a good medicine for clearing heat and removing toxicity from old times. It is sweet and cold in nature and fragrant, sweet and cold in nature and clearing heat without hurting stomach, and the fragrance is thorough and can eliminate pathogens. The honeysuckle can disperse wind-heat and clear away blood toxin, and has obvious effect on various heat diseases such as fever, eruption, macula, sore and carbuncle due to heat toxin, sore throat and the like. Is cold in nature and sweet in taste, enters lung, heart and stomach meridians, has the effects of clearing away heat and toxic materials, resisting inflammation, tonifying deficiency and treating wind, and is mainly used for treating diseases such as distending pain, fever due to epidemic febrile disease, toxic heat, carbuncle and ulcer, tumor and the like. It has therapeutic effects on dizziness, thirst, hyperhidrosis, vexation, enteritis, bacillary dysentery, measles, pneumonia, encephalitis B, epidemic encephalitis, acute mastitis, septicemia, appendicitis, skin infection, carbuncle, furuncle, erysipelas, parotitis, and suppurative tonsillitis.

Folium Isatidis, the name of Chinese medicine. Is dried leaf of Isatis tinctoria Isatis indigotica fort. of Isatis in Brassicaceae. Has the effects of clearing away heat and toxic materials, cooling blood and removing ecchymoses. Mainly treats heat entering nutrient blood, warm poison and macula, sore throat and aphtha, mumps and erysipelas. Bitter taste and cold nature; it enters heart and stomach meridians. Chemical components: the Isatis tinctoria leaf contains tryptophan, indirubin B, glucose brassin, new glucose brassin, glucose brassin-1-sulfonate and indigo. The pharmacological action is as follows: the isatis tinctoria leaves have certain inhibiting effect on staphylococcus aureus and hemolytic streptococcus; folium Isatidis has inhibitory effect on hepatitis B surface antigen and influenza virus A. Indirubin has significant anti-leukemia effect.

Cordate houttuynia, name of Chinese traditional medicine. Is dried aerial part of houttuynia cordata Thunb of houttuynia of Saururaceae. Has effects of clearing away heat and toxic materials, eliminating carbuncle, expelling pus, promoting urination, and treating stranguria. It can be used for treating lung abscess with purulent vomiting, cough due to lung heat, sore due to heat-toxin, carbuncle, stranguria due to damp-heat, and dysentery due to damp-heat. Pungent taste and slightly cold nature; it enters lung meridian. Chemical components: the product contains houttuynin, volatile oil, houttuynine, quercetin, potassium chloride, etc. The pharmacological action is as follows: the houttuynin has different degrees of inhibition effects on various gram positive and negative bacteria such as staphylococcus aureus, diplococcus pneumoniae, streptococcus A, bacillus influenzae, catacoccus, typhoid bacillus, tubercle bacillus and the like; it is non-volatile extracted with diethyl ether, and has antiviral effect. The product has effects in improving phagocytic ability of leukocyte, enhancing immunity, and relieving inflammation. The contained quercetin and potassium salt can dilate renal artery and increase renal artery blood flow, thus having stronger diuretic effect. In addition, it also has analgesic, hemostatic, tissue regeneration promoting, wound healing promoting, and antitussive effects.

Glucose (chemical formula C6H12O6) is also called corn Glucose and corn cob, abbreviated as Glucose. Chemical name: 2, 3, 4, 5, 6-pentahydroxyhexanal, another name: dextrose, Cornsugar, Grapesugar, Bloodsugar. Is a monosaccharide which is the most widely distributed and important monosaccharide in the nature and is a polyhydroxy aldehyde. Pure glucose is colorless crystals, has sweetness less than sucrose (no sweetness is usually tasted by people), is easily soluble in water, is slightly soluble in ethanol, and is insoluble in diethyl ether. Aqueous natural glucose solution rotates to the right and is thus "dextrose". Glucose plays an important role in the field of biology, and is an energy source and a metabolic intermediate product of living cells, namely a main energy supply substance of organisms. Plants can produce glucose through photosynthesis. Has wide application in the candy manufacturing industry and the medicine field.

Preferably, the composition is mainly prepared from the following raw materials in parts by mass:

20-50 parts of acanthopanax, 18-40 parts of angelica, 3-8 parts of gelsemium elegans, 20-50 parts of wild buckwheat rhizome, 20-50 parts of astragalus, 72-160 parts of liquorice, 20-50 parts of soybean isoflavone, 18-40 parts of honeysuckle, 14-32 parts of folium isatidis, 7-16 parts of houttuynia cordata, 500 parts of trace elements 200 and 72-160 parts of glucose.

Preferably, the composition is mainly prepared from the following raw materials in parts by mass:

30 parts of acanthopanax, 25 parts of angelica, 5 parts of gelsemium elegans, 30 parts of wild buckwheat rhizome, 30 parts of astragalus, 100 parts of liquorice, 30 parts of soybean isoflavone, 25 parts of honeysuckle, 20 parts of folium isatidis, 10 parts of houttuynia cordata, 300 parts of trace elements and 100 parts of glucose.

Preferably, the trace elements include one or more of an iron element-containing solution, a copper element-containing solution, a zinc element-containing solution, a manganese element-containing solution, an iodine element-containing solution, a cobalt element-containing solution, and a selenium element-containing solution.

The various trace elements may be derived from: the iron-containing solution comprises ferrous sulfate solution, ferrous fumarate solution, ferrous citrate solution, and ferrous lactate solution. The copper element-containing solution comprises a copper sulfate solution and a basic copper chloride solution. The zinc-containing solution comprises zinc sulfate solution and zinc oxide solution. The manganese-containing solution comprises manganese sulfate solution, manganese oxide solution and manganese chloride solution. The iodine-containing solution comprises potassium iodide solution, potassium iodate solution, and calcium iodate solution. The cobalt-containing solution comprises cobalt sulfate solution, cobalt chloride solution, cobalt acetate solution and cobalt carbonate solution. The selenium-containing solution comprises sodium selenite solution and yeast selenium solution.

A method for preparing a nonreactive composition for preventing and controlling animal virus diseases comprises selecting radix Acanthopanacis Senticosi, radix Angelicae sinensis, herba Gelsemii Elegantis, rhizoma Fagopyri Dibotryis, radix astragali, Glycyrrhrizae radix, flos Lonicerae, folium Isatidis, and herba Houttuyniae according to corresponding proportion, pulverizing, mixing, adding soybean isoflavone, microelements, glucose and probiotic, mixing, drying, sterilizing, and pulverizing again to obtain the final product.

Preferably, the acanthopanax, the angelica, the gelsemium elegans, the wild buckwheat rhizome, the astragalus, the liquorice, the honeysuckle, the dyers woad leaf and the houttuynia cordata are crushed, and the particle sizes are all 50-80 meshes;

after the secondary crushing, the particle size is 200-500 meshes.

Preferably, the probiotic comprises one or more of lactobacilli, bifidobacteria, bacilli, enterococcus faecalis, enterococcus faecium and enterococcus lactis.

Preferably, the mass ratio of the probiotics to the total mass of acanthopanax, angelica, gelsemium elegans, wild buckwheat rhizome, astragalus, liquorice, honeysuckle, folium isatidis, houttuynia cordata, soybean isoflavone, trace elements and glucose is 0.3-0.8: 1.

Preferably, the drying temperature is not higher than 40 degrees celsius.

The application of a non-antibiotic composition for preventing and controlling animal virus diseases and the application of the finished product of the non-antibiotic composition in animal prevention and control feed products.

The invention has the beneficial effects that:

the invention provides a non-antibiotic composition for preventing and controlling animal virus diseases, which is a product integrating comprehensive health protection, improvement of reproductive and productive performance of sows, promotion of pig growth and adjuvant therapy.

The composition has the following advantages: 1. antibacterial, antiinflammatory, antiviral, and antiinfectious effects. Inhibiting the reproduction and replication of viruses with cyst membrane structure, such as African swine fever, blue ear, classical swine fever, influenza, epidemic diarrhea, etc.; the porcine reproductive and respiratory syndrome virus inhibitor can purify porcine reproductive and respiratory syndrome, eliminate porcine reproductive and respiratory syndrome virus blood disease, prevent the transverse and vertical transmission of virus and effectively prevent the secondary infection of viral diseases. 2. Modulating and activating immunity. Improve the nonspecific and specific immune function of the organism, relieve the immunosuppression and eliminate the sub-health of the swinery. 3. Resisting oxidative stress and scavenging free radicals. Reducing the oxidative damage of free radicals to cells, repairing damaged cells and tissues and organs, and maintaining the normal metabolic function of an organism. 4. Improving intestinal health. Improving intestinal microecological flora environment, protecting mucosa cells, promoting intestinal mucosa villus development, repairing mucosa villus injury, enhancing mucosa immune barrier, and preventing pathogen invasion. 6. Protecting liver and expelling toxin. Nourishing and protecting liver, maintaining the functions of detoxifying and expelling toxin of liver, removing toxin in vivo and improving the disease resistance of organism; preventing mildew, inhibiting mildew, degrading mycotoxin, and relieving mycotoxin poisoning. 7. Improve the reproductive productivity of sows. The hybridization rate and the farrowing rate of the sows are improved; protecting placenta development, preventing abortion, premature labor, weak child production, dead fetus production, and mummy production, and improving newborn weight, uniformity and activity of piglets; promoting the development of mammary gland, promoting the synthesis of protein and milk fat, improving the feed intake of sows in the lactation period, increasing milk, and improving the weight of weaned piglets by about 1 kg; improving the antioxidant and immune antibody level of the primary milk and the normal milk of the sow, preventing the diarrhea and the disease infection of the delivery room piglets and improving the survival rate; delaying the physiological function aging of sows and prolonging the service life of sows by more than 2 years. 8. Promoting growth and reducing feed conversion ratio. Promoting digestive enzyme secretion and nutrient substance digestion and absorption, degrading anti-nutritional factors in the feed, improving the feed conversion rate by 8-10%, and reducing the feed conversion ratio by 0.15-0.2; promote the secretion of insulin-like growth factors and the synthesis of proteins, increase the intake of food, promote the growth, and lead the fattening pigs to be slaughtered more than 15 days in advance.

The composition has simple preparation method, high safety, no toxic and side effects, and high practicability.

Detailed Description

The present invention is further illustrated below with reference to specific examples. It will be appreciated by those skilled in the art that the following examples, which are set forth to illustrate the present invention, are intended to be part of the present invention, but not to be construed as limiting the scope of the present invention. The reagents used are all conventional products which are commercially available.

Example 1:

a preparation method of a nonreactive composition for preventing and controlling animal virus diseases comprises the steps of selecting 10 g of acanthopanax root, 8 g of angelica, 2g of gelsemium elegans, 10 g of wild buckwheat rhizome, 10 g of astragalus root, 32 g of liquorice, 10 g of honeysuckle, 7g of dyers woad leaf and 4 g of houttuynia cordata according to corresponding proportions, crushing, screening by a 50-mesh screen, mixing uniformly, adding 10 g of soybean isoflavone, 100g of iron-containing element solution, 32 g of glucose and 186.4 g of lactobacillus agent, mixing, drying and sterilizing at the temperature of not higher than 40 ℃, crushing again, screening by a 200-mesh screen, and obtaining a finished feed.

Example 2:

a preparation method of a nonreactive composition for preventing and controlling animal virus diseases comprises the steps of selecting 80 g of acanthopanax root, 60 g of angelica, 9 g of gelsemium elegans, 80 g of wild buckwheat rhizome, 80 g of astragalus root, 240 g of liquorice, 80 g of honeysuckle, 68 g of dyers woad leaf and 34 g of houttuynia cordata according to corresponding proportions, crushing, screening by a 80-mesh screen, mixing uniformly, adding 80 g of soybean isoflavone, 800 g of copper-containing solution, 240 g of glucose and 549.3 g of bifidobacterium agent, mixing, drying and sterilizing at the temperature of not higher than 40 ℃, crushing again, screening by a 500-mesh screen, and obtaining a finished feed.

Example 3:

a preparation method of a nonreactive composition for preventing and controlling animal virus diseases comprises the steps of selecting 20 g of acanthopanax root, 18 g of angelica, 3 g of gelsemium elegans, 20 g of wild buckwheat rhizome, 20 g of astragalus root, 72 g of liquorice, 18 g of honeysuckle, 14 g of dyers woad leaf and 7g of houttuynia cordata according to corresponding proportions, crushing, screening by a 50-mesh screen, mixing uniformly, adding 20 g of soybean isoflavone, 200 g of zinc-containing element solution, 72 g of glucose and 387.2 g of bacillus agent, mixing, drying and sterilizing at the temperature of not higher than 40 ℃, crushing again, screening by a 200-mesh screen, and obtaining a finished feed.

Example 4:

a preparation method of a nonreactive composition for preventing and controlling animal virus diseases comprises the steps of selecting 50 g of acanthopanax root, 40 g of angelica, 8 g of gelsemium elegans, 50 g of wild buckwheat rhizome, 50 g of astragalus root, 160 g of liquorice, 40 g of honeysuckle, 32 g of dyers woad leaf and 16 g of houttuynia cordata according to corresponding proportions, crushing, screening by a 80-mesh screen, mixing uniformly, adding 50 g of soybean isoflavone, 500 g of manganese-containing solution, 160 g of glucose and 346.8 g of enterococcus faecalis agent, mixing, drying and sterilizing at the temperature of not higher than 40 ℃, crushing again, and screening by a 500-mesh screen to obtain a finished feed.

Example 5:

a method for preparing a nonreactive composition for preventing and controlling animal virus diseases comprises the steps of selecting 30 g of acanthopanax root, 25 g of angelica, 5g of gelsemium elegans, 30 g of wild buckwheat rhizome, 30 g of astragalus, 100g of liquorice, 30 g of honeysuckle, 20 g of dyers woad leaf and 10 g of houttuynia cordata according to corresponding proportions, crushing, screening by a 80-mesh screen, mixing uniformly, adding 30 g of soybean isoflavone, 300 g of iodine-containing element solution, 100g of glucose and 211.5 g of enterococcus faecium agent, mixing, drying and sterilizing at the temperature of not higher than 40 ℃, crushing again, and screening by a 500-mesh screen to obtain a finished feed.

Example 6:

a preparation method of a nonreactive composition for preventing and controlling animal virus diseases comprises the steps of selecting 30 g of acanthopanax root, 25 g of angelica, 5g of gelsemium elegans, 30 g of wild buckwheat rhizome, 30 g of astragalus, 100g of liquorice, 30 g of honeysuckle, 20 g of dyers woad leaf and 10 g of cordate houttuynia according to corresponding proportions, crushing, screening by a 80-mesh screen, mixing uniformly, adding 30 g of soybean isoflavone, 300 g of a cobalt-containing solution, 100g of glucose and 211.5 g of an enterococcus lactate agent, mixing, drying and sterilizing at a temperature of not higher than 40 ℃, crushing again, and screening by a 500-mesh screen to obtain a finished feed.

Example 7:

a preparation method of a nonreactive composition for preventing and controlling animal virus diseases comprises the steps of selecting 30 g of acanthopanax root, 25 g of angelica, 5g of gelsemium elegans, 30 g of wild buckwheat rhizome, 30 g of astragalus, 100g of liquorice, 30 g of honeysuckle, 20 g of dyers woad leaf and 10 g of houttuynia cordata according to corresponding proportions, crushing, screening by a 80-mesh screen, mixing uniformly, adding 30 g of soybean isoflavone, 300 g of selenium-containing solution, 100g of glucose and 211.5 g of lactobacillus agent, mixing, drying and sterilizing at the temperature of not higher than 40 ℃, crushing again, screening by a 500-mesh screen, and obtaining finished feed.

The invention is based on four scientific ideas, 1, reconstructing the non-specific immune function idea; 2. the concept of intestinal health; 3. the idea of anti-oxidation and free radical removal; 4. nutrition, immunity and disease resistance.

Four key combination techniques

(1) Adopts advanced traditional Chinese medicine extraction and microorganism technology.

The medicine effect can be generated by the quick absorption of the gastrointestinal tract, the balance of bacteria can be maintained by the gastrointestinal tract, and the spread of epidemic diseases can be cut off. Generally, the traditional Chinese medicines are ground into 60-100 meshes of traditional Chinese medicine powder, and the medicine of the mammal belonging to the pig can be discharged out of the body in the form of excrement after staying in the gastrointestinal tract for three to four hours. The crushed Chinese medicinal powder belongs to macromolecular substances which cannot be absorbed in the gastrointestinal tract of the pig for a short time. Therefore, the technology can ensure that the gastrointestinal tract can be completely absorbed and used: purging heat, clearing hollow viscera, promoting aging to cause novelty, removing toxic substance, clearing lung-heat, relieving cough, promoting blood circulation, removing blood stasis, cooling blood, removing ecchymoses, blocking transmission of epidemic diseases to multiple organ injury of organism, and rapidly relieving clinical symptoms such as high fever, decreased appetite, rugged vomiting, constipation or diarrhea, cough and asthma, ecchymoses, etc.

(2) Adopts the technology of oxidation resistance and free radical removal.

Quickly start the antioxidant defense mechanism of the organism and reduce the damage of the inflammation storm to the organism. The special bioactive antioxidant defense substance is combined into body tissue protein, and through turnover degradation of the protein, the antioxidant and immune defense effects are exerted, free radicals are powerfully eliminated, cells are protected from being oxidized and damaged by the free radicals, and the immune disease resistance is improved. Especially, the secondary damage of a large amount of free radicals generated in the protective reaction process of inflammation in a pathological state to the organism can be reduced, and the disease condition can be prevented from getting worse.

(3) Adopts unique plant polysaccharide and plant flavonoid bioactive substances to quickly start an immune defense mechanism of an organism and reconstruct the nonspecific immune function of the organism. According to the important discovery of Nobel prize acquirers Stelman and the like in the field of immunology, the plant polysaccharide and the plant flavone which have the functions of obviously proliferating phagocytes and enhancing the functions of the phagocytes, particularly dendritic cells, are screened out, and the nonspecific immunity function is improved, so that the important discovery that a zookeeper animal husbandry veterinary technical team collects various plant raw materials nationwide and extracts the plant raw materials to pass numerous clinical experiments is also provided. By proliferating the phagocytes and the dendritic cells, the phagocytic and eliminating effects of the phagocytes on pathogens and the antigen presenting function of the dendritic cells are improved, the generation of endogenous antiviral interferon is promoted, and the nonspecific immune function is obviously enhanced.

(4) Adopts a nutrition regulation and control technology.

Supplement body's extra nutrition requirement under disease state, and repair body injury. The special nutrition such as immunity, mucosa, reproduction, etc. is supplemented, the damage of damaged cells, tissues and organs is repaired, the normal metabolic function is maintained, and the recovery of the organism is accelerated.

The using method comprises the following steps: in the finished products prepared in all the embodiments, 800 jin can be mixed for every 3000g, and the mixture can be used for 14-21 days, so that the product can be used for long-term prevention and health care.

The feed is prepared by mixing the feed for feeding piglets 20-30 g, middle pigs 40-60 g and big pigs 70-90 g per day. Continuously using for 7-14 days according to the condition; the application time is reduced to half for 14 days.

The present invention is not limited to the above alternative embodiments, and any other products in various forms can be obtained by the present invention, and the present invention is within the protection scope of the present invention. The above embodiments should not be construed as limiting the scope of the present invention, and it will be understood by those skilled in the art that modifications may be made to the technical solutions described in the above embodiments, or equivalent substitutions may be made to some or all of the technical features thereof, without departing from the scope of the present invention, and at the same time, such modifications or substitutions may not make the essence of the corresponding technical solutions depart from the scope of the embodiments of the present invention.