阅读说明：本技术 用于选择性消除和替换造血干细胞的组合物和方法 (Compositions and methods for selective depletion and replacement of hematopoietic stem cells ) 是由 E.奥斯特塔 D.舍德洛克 J.D.道恩 于 2018-03-13 设计创作，主要内容包括：公开了消除受试者中的至少一种靶细胞的方法,其包括向受试者施用有效量的包含多种免疫细胞的组合物,其中所述多种中的各免疫细胞表达一种或多种嵌合配体受体(CLR),所述嵌合配体受体各自特异性结合至少一种靶细胞上的靶配体,其中一种或多种CLR与靶标的特异性结合活化免疫细胞,且其中活化的免疫细胞诱导靶细胞的死亡。示例性靶细胞包括,但不限于,造血干细胞(HSC)。(Disclosed are methods of eliminating at least one target cell in a subject comprising administering to the subject an effective amount of a composition comprising a plurality of immune cells, wherein each immune cell in the plurality expresses one or more Chimeric Ligand Receptors (CLRs) that each specifically binds a target ligand on at least one target cell, wherein the specific binding of one or more CLRs to a target activates the immune cell, and wherein the activated immune cell induces death of the target cell. Exemplary target cells include, but are not limited to, Hematopoietic Stem Cells (HSCs).)