聚赖氨酸衍生物及其在固体基组合物中的用途

文档序号:1618118 发布日期:2020-01-10 浏览:29次 >En<

阅读说明:本技术 聚赖氨酸衍生物及其在固体基组合物中的用途 (Polylysine derivatives and their use in solid based compositions ) 是由 M·卡尔特 H·维特勒 T·施罗德-格里萌邦特 M·迈泽 H-P·泽尔曼-埃格贝特 F·克 于 2018-04-17 设计创作,主要内容包括:本发明涉及通过包括以下步骤的方法获得的聚赖氨酸衍生物:(a)将赖氨酸水溶液加热至沸腾,(b)将赖氨酸水溶液的温度升高至约105-约180℃的反应温度,(c)将反应温度保持在约105-约180℃的范围内,直至i.当在160℃下测量时,反应混合物的熔体粘度为约350-约6,500mPa*s,ii.获得约100-约500mg KOH/g的胺值,(d)任选地,释放所施加的真空,(e)相对于反应混合物中所含的聚赖氨酸的理论量,以2.5-10mol%的量添加烷基羧酸或烯基羧酸,(f)提高或保持反应温度在约105-约180℃的范围内,直至游离烷基羧酸或烯基羧酸的量相对于反应混合物总重量为≤9重量%,其中在步骤(a)、(b)和/或(c)中施加真空,并且在整个方法期间连续除去水。(The present invention relates to polylysine derivatives obtained by a process comprising the following steps: (a) heating an aqueous solution of lysine to boiling, (b) raising the temperature of the aqueous solution of lysine to a reaction temperature of about 105 to about 180 ℃, (c) maintaining the reaction temperature in the range of about 105 to about 180 ℃ until i.e. the melt viscosity of the reaction mixture is about 350 to about 6,500mPa s, when measured at 160 ℃, ii.an amine value of about 100 to about 500mg KOH/g is obtained, (d) optionally releasing the applied vacuum, (e) adding an alkyl or alkenyl carboxylic acid in an amount of 2.5 to 10 mol% relative to the theoretical amount of polylysine contained in the reaction mixture, (f) increasing or maintaining the reaction temperature in the range of about 105 to about 180 ℃ until the amount of free alkyl or alkenyl carboxylic acid is 9 wt% relative to the total weight of the reaction mixture, wherein vacuum is applied in steps (a), (b) and/or (c), and water is continuously removed throughout the process.)

36页详细技术资料下载
上一篇:一种医用注射器针头装配设备
下一篇:聚赖氨酸衍生物稳定包含一种或多种盐的固体基组合物

网友询问留言

已有0条留言

还没有人留言评论。精彩留言会获得点赞!

精彩留言,会给你点赞!