阅读说明：本技术 一种漂浮大粒剂用漂浮载体及其制备方法 (Floating carrier for floating large granules and preparation method thereof ) 是由 汪茂勤 柴多里 赵玉叶 米春金 赵燕燕 于 2019-09-23 设计创作，主要内容包括：本发明公开了一种漂浮大粒剂用漂浮载体及其制备方法。本发明所述的漂浮载体通过以下方法制备：(1)将栓皮经粉碎机粉碎,干燥,过80-100目筛；(2)将过筛后的栓皮粉加入的木质素酶溶液中,反应完毕后,过滤,清洗；(3)将步骤(2)反应完毕的栓皮粉加入质量浓度为10-15％的氨水中,反应6-8h,反应完毕后,过滤,清洗；(4)将步骤(3)得到的经过修饰的栓皮粉,加入含有EDC和NHS的溶液中,与含有高分子化合物的溶液混合,交联12-24h,得漂浮载体。本发明通过栓皮作为载体,通过粉碎机粉碎后,具有一定的粒度,随后通过木质素酶的水解,在栓皮粉内形成水解孔,增加载体的负载量,本发明的漂浮载体可完全的生物降解。(The invention discloses a floating carrier for floating large granules and a preparation method thereof. The floating carrier is prepared by the following method: (1) pulverizing cortex Corbi by pulverizer, drying, and sieving with 80-100 mesh sieve; (2) adding the sieved embolic skin powder into a ligninase solution, filtering and cleaning after the reaction is finished; (3) adding the embolic skin powder reacted in the step (2) into ammonia water with the mass concentration of 10-15%, reacting for 6-8h, filtering and cleaning after the reaction is finished; (4) and (4) adding the modified embolic cortex powder obtained in the step (3) into a solution containing EDC and NHS, mixing with a solution containing a high molecular compound, and crosslinking for 12-24h to obtain the floating carrier. According to the floating carrier, the cork is used as a carrier, the cork is crushed by a crusher to have a certain particle size, and then hydrolysis holes are formed in the cork powder through hydrolysis of ligninase, so that the loading capacity of the carrier is increased, and the floating carrier can be completely biodegraded.)

1. A preparation method of a floating carrier for floating large granules is characterized by comprising the following steps:

(1) pulverizing cortex Corbi by pulverizer, drying, and sieving with 80-100 mesh sieve;

(2) adding the sieved embolic skin powder into a ligninase solution with the mass concentration of 8-10g/L, stirring for 4-5h under the condition of 200-300rmp, filtering and cleaning after the reaction is finished;

(3) adding the embolic skin powder reacted in the step (2) into ammonia water with the mass concentration of 10-15%, reacting for 6-8h at the temperature of 160-200 ℃ and the rotating speed of 200-500rmp under the condition of oxygen pressure of 2-3MPa, and filtering and cleaning after the reaction is finished;

(4) and (4) adding the modified embolic cortex powder obtained in the step (3) into a solution containing EDC and NHS, mixing with a solution containing a high molecular compound, crosslinking for 12-24h, filtering, washing and drying after crosslinking is finished, thus obtaining the floating carrier.

2. The method for producing a floating carrier for floating kibbles as claimed in claim 1, wherein in step (4), the polymer compound is one or more selected from the group consisting of chitosan, hyaluronic acid, cellulose, starch and soy protein, and the concentration of the solution of the polymer compound is 10 to 20 g/L.

3. The method for preparing a floating carrier for floating granules according to claim 1, wherein in step (4), the solution of EDC and NHS has a pH of 7.2-7.4, the mass concentration of EDC is 0.5g/L, and the mass concentration of NHS is 2 g/L.

4. The method for producing a floating carrier for floating macrogranules according to claim 1, wherein in step (4), the solution of the polymer compound is a mixed solution of chitosan and hyaluronic acid.

5. The method for preparing a floating carrier for floating macrogranules according to claim 1, wherein in step (4), the mass ratio of the modified embolic powder to the polymeric compound is 10-15: 1-2.

6. The method for producing a floating carrier for floating macrogranules according to claim 4, wherein in step (4), the mass ratio of chitosan to hyaluronic acid is 1: 1.

7. A floating carrier obtained by the production method according to any one of claims 1 to 6.

Technical Field

The invention relates to a floating carrier and a preparation method thereof, in particular to a floating carrier for floating large granules and a preparation method thereof.

Background

The preparation developed at the earliest is a pesticide water surface floating agent, which mainly comprises: in 1977, japanese patent JP52038095 reports that Kawasaki Masashi, Watanabe Fujinori and the like in japan first developed a powdered phytoether floating agent, which is composed of an organic pesticide, an inorganic carrier, a hydrophobic substance and a film material. The floating powder has the defects of easy drifting and easy pollution; later turned to the development of floating (granular) granules on water. The research and development of the floating granule mainly comprise the following points: firstly, the foaming tablet can float on the water surface or can foam when being immersed in the water, so that the effective ingredients can be diffused in the water; secondly, the foaming particles or powder and the like are packaged by a water-soluble packaging bag; thirdly, packaging the water surface developing agent, the water dispersible granules, the powder and the like by using a water-soluble packaging bag; fourthly, the water surface developing agent or the emulsifying liquid agent and the gel agent are packaged by a water-soluble packaging bag. The floating large granules used at present are particles which are dispersed on the water surface of a rice field by 3-8 mm, and only need to be scattered on ridges of the rice field without entering the rice field through different pesticide application modes, so that the floating large granules are a labor-saving dosage form, and the diffusivity of active ingredients in the preparation can meet the requirement of practical application in the field.

The key technology for developing the floating large particle agent is the preparation of a floating carrier, the earliest floating carrier is beaded sodium borate particles with certain granularity formed by processing sodium borate, and the carrier prepared by sodium borate particles with different granularities is used for loading pesticide active components, but the existing floating carrier has the problems of poor environmental compatibility and poor loading capacity.

Disclosure of Invention

The purpose of the invention is as follows: in order to solve the problems in the prior art, the invention provides a floating carrier for floating large granules and a preparation method of the floating carrier.

The technical scheme is as follows: the invention relates to a preparation method of a floating carrier for floating large granules, which comprises the following steps:

(1) pulverizing cortex Corbi by pulverizer, drying, and sieving with 80-100 mesh sieve;

(2) adding the sieved embolic skin powder into a ligninase solution with the mass concentration of 8-10g/L, stirring for 4-5h under the condition of 200-300rmp, filtering and cleaning after the reaction is finished;

(3) adding the embolic skin powder reacted in the step (2) into ammonia water with the mass concentration of 10-15%, reacting for 6-8h at the temperature of 160-200 ℃ and the rotating speed of 200-500rmp under the condition of oxygen pressure of 2-3MPa, and filtering and cleaning after the reaction is finished;

(4) and (4) adding the modified embolic cortex powder obtained in the step (3) into a solution containing EDC and NHS, mixing with a solution containing a high molecular compound, crosslinking for 12-24h, filtering, washing and drying after crosslinking is finished, thus obtaining the floating carrier.

Preferably, in the step (4), the polymer compound is selected from one or more of chitosan, hyaluronic acid, cellulose, starch and soy protein, and the concentration of the solution of the polymer compound is 10-20 g/L.

Preferably, in the step (4), the solution of EDC and NHS has a pH of 7.2-7.4, the mass concentration of EDC is 0.5g/L, and the mass concentration of NHS is 2 g/L.

Preferably, in the step (4), the solution of the polymer compound is a mixed solution of chitosan and hyaluronic acid.

Preferably, in the step (4), the mass ratio of the modified embolic powder to the high molecular compound is 10-15: 1-2.

Preferably, in the step (4), the mass ratio of the chitosan to the hyaluronic acid is 1: 1.

The floating carrier obtained by the preparation method.

Has the advantages that: (1) according to the invention, the cork is used as a carrier, the cork is crushed by a crusher to have a certain particle size, and then hydrolysis holes are formed in the cork powder through hydrolysis of ligninase, so that the loading capacity of the carrier is increased; (2) the surface of the embolic powder is aminated and modified by a macromolecular compound, so that the bonding firmness of an active substance and a carrier is improved; (3) the floating carrier of the present invention is completely biodegradable.

Detailed Description