Active wound and facial skin repair dressing and preparation method thereof
阅读说明：本技术 一种活性创面皮肤修复敷料及其制备方法 (Active wound and facial skin repair dressing and preparation method thereof ) 是由 廖先传 于 2019-11-20 设计创作，主要内容包括：本发明公开了一种活性创面皮肤修复敷料及其制备方法,涉及医用敷料领域,包括敷料主体和粘贴膜,所述敷料主体包括聚阴离子物质与聚阳离子物质合成的骨架材料,所述敷料主体和粘贴膜之间粘结固定,所述粘贴膜的材质为硅橡胶,所述粘贴膜的内部开设有填充槽,所述填充槽的内壁两侧均开设有降温槽,制备方法包括以下步骤,原料处理；制备敷料主体；制备粘贴膜；组装。该活性创面皮肤修复敷料及其制备方法,同时具备天然生物敷料良好的愈合效果以及合成生物敷料低成本的优点,解决了现有的敷料在使用后无法方便的查看伤口的愈合情况,无法方便的在查看伤口和遮挡伤口之间切换,以及无法长时间的保持敷料中活性物质的活性的问题。(The invention discloses an active wound-surface skin repairing dressing and a preparation method thereof, and relates to the field of medical dressings, the dressing comprises a dressing main body and a pasting film, wherein the dressing main body comprises a skeleton material synthesized by polyanionic substances and polycationic substances, the dressing main body and the pasting film are bonded and fixed, the pasting film is made of silicon rubber, a filling groove is formed in the pasting film, and both sides of the inner wall of the filling groove are provided with cooling grooves; preparing a dressing main body; preparing a sticking film; and (6) assembling. The active wound skin repair dressing and the preparation method thereof have the advantages of good healing effect of natural biological dressings and low cost of synthetic biological dressings, and solve the problems that the existing dressing cannot conveniently check the healing condition of a wound after being used, cannot conveniently switch between checking and shielding the wound, and cannot keep the activity of active substances in the dressing for a long time.)
1. The active wound and skin repair dressing comprises a dressing main body (1) and an adhesive film (2), wherein the dressing main body (1) comprises a skeleton material synthesized by polyanionic substances and polycationic substances, and is characterized in that: the utility model discloses a dressing material, including dressing main part (1) and pasting membrane (2), the material of pasting membrane (2) is the silicon rubber, filling groove (3) have been seted up to the inside of pasting membrane (2), cooling groove (4) have all been seted up to the inner wall both sides of filling groove (3), the inside packing of cooling groove (4) has ice-cube (5), the inside packing of filling groove (3) has low concentration alcohol (6), dressing main part (1) and the outside of pasting membrane (2) all cover thermal-insulated protective layer (7), it has menstruation blood source nature mesenchymal stem cell, silica gel and hyaluronic acid to fill in the space of skeleton material.
2. The active wound-skin repair dressing of claim 1, wherein: the dressing is prepared from the following components, by weight, 80-120 parts of silicone rubber, 20-40 parts of polycation substance, 10-20 parts of polyanion substance, 10-30 parts of menstrual blood-derived mesenchymal stem cells, 10-30 parts of silica gel, 5-20 parts of hyaluronic acid, 5-20 parts of ice cubes, 10-40 parts of low-concentration alcohol and 20-50 parts of heat insulation material.
3. The active wound-skin repair dressing of claim 1, wherein: the dressing is prepared from the following components, by weight, 120 parts of silicone rubber, 20-30 parts of polycation substance, 10-15 parts of polyanion substance, 20-30 parts of menstrual blood-derived mesenchymal stem cells, 10-20 parts of silica gel, 5-10 parts of hyaluronic acid, 10-20 parts of ice cubes, 20-40 parts of low-concentration alcohol and 30-40 parts of heat insulation material.
4. The active wound-skin repair dressing of claim 1, wherein: the dressing is prepared from the following components, by weight, 100 parts of silicone rubber, 28 parts of polycation substance, 12 parts of polyanion substance, 20 parts of menstrual blood-derived mesenchymal stem cells, 15 parts of silicone gel, 10 parts of hyaluronic acid, 10 parts of ice cubes, 30 parts of low-concentration alcohol and 40 parts of heat insulation material.
5. The active wound-skin repair dressing of claim 1, wherein: the low-concentration alcohol is prepared from 95% concentration alcohol and distilled water, and the mass ratio of the 95% concentration alcohol to the distilled water is 1: 2.
6. The active wound-skin repair dressing of claim 1, wherein: the heat insulation protective layer (7) is made of a glass fiber film, and the thickness of the dressing main body (1) is 3 times that of the heat insulation protective layer (7).
7. The active wound-skin repair dressing of claim 1, wherein: the silicone gel is one of methyl vinyl silicone oil, methyl silicone oil and ethyl silicone oil.
8. The active wound-skin repair dressing of claim 1, wherein: the framework material is of a three-dimensional net structure, and the dressing main body (1) is of a transparent film shape.
9. The method for preparing an active wound skin repair dressing according to claim 1, wherein the method comprises the following steps: comprises the following steps of (a) carrying out,
(1) treating raw materials, namely respectively pouring polycation substances, polyanion substances and hyaluronic acid into water and uniformly stirring, then mixing and uniformly stirring to obtain a mixed solution, slowly adding the mixed solution into the silica gel, and stirring to obtain a mixed gel;
(2) preparing a dressing main body, adjusting the pH of the mixed gel to 5.8-6.4, then pouring the mixed gel into a stainless steel disc, casting uniformly, drying to obtain a gel film, soaking the gel film into a menstrual blood-derived mesenchymal stem cell solution for 10-20 minutes, taking out and drying;
(3) preparing a sticking film, arranging a filling groove at the top of silicon rubber, arranging a cooling groove in the filling groove, placing ice blocks in the cooling groove, pouring low-concentration alcohol into the filling groove, and sealing the surface layer of the silicon rubber by gluing a silicon rubber thin layer;
(4) and assembling, namely extruding and sticking the adhesive film and the dressing main body for fixation, and then attaching the heat insulation protective layer to the outer sides of the adhesive film and the dressing main body.
10. The method for preparing an active wound skin repair dressing according to claim 9, wherein: the concentrations of the polyanionic substance and the polycationic substance are both 0.005-0.05g/ml, and a small amount of glycerin is added when the polyanionic substance and the polycationic substance are poured into water for mixing.
Technical Field
The invention relates to the field of medical dressings, in particular to an active wound and skin repair dressing and a preparation method thereof.
Background
The wound covering dressing for clinical use at present mainly comprises three major types of traditional dressings, natural biological dressings and synthetic biological dressings, the traditional dressings such as gauze, cotton pads and the like are the dressings commonly used in clinic, and the dressing has the advantages of wound protection, water absorption, simple manufacture and low price, but has the defects of incapability of keeping the wound moist, delayed wound healing, easy falling of dressing fiber, wound foreign body reaction caused by the fact that the wound is easily dropped, wound healing affected and pain caused by easy damage when wound granulation tissues are easily grown into meshes of the gauze for dressing change, wound infection caused by the dressing that pathogens are easily permeated, large dressing change workload, no promotion effect on wound healing and the like, and the inherent defects difficult to overcome; the natural biological dressing comprises autologous skin, allogeneic skin, irradiated pig skin, amniotic membrane and the like, the most ideal method for covering the wound surface at present is to transplant the autologous skin, but the autologous skin source of a large-area wound patient is seriously insufficient; the permeability and the adhesiveness of the allogeneic skin are similar to those of the skin of a patient, the antigenicity can be effectively reduced, the rejection reaction is reduced, but the clinical problems and the ethical problems of high price, limited sources, high requirements on storage conditions and the like exist; although the xenoskin dressing has relatively wide sources and low price, the xenoskin dressing has the problems of antigenicity, irritation, virus infection and the like, and is not suitable for industrial production; the synthetic biological dressing mainly comprises chitin (or chitosan) dressing, alginic acid dressing, silk fibroin dressing, bacterial cellulose dressing and collagen dressing at present, wherein the chitin (or chitosan) dressing has the advantages of good tissue compatibility, good hemostatic function, strong anti-infection capability, but poor adhesion and compliance; the alginic acid dressing has high moisture absorption performance, can maintain a moist environment of the wound surface, has low cost, but is easy to harden to cause the wound surface to be injured again; the silk fibroin dressing has good cell and tissue affinity and good oxygen permeability and air permeability, but the water absorption, toughness, mechanical property and antibacterial property of the silk fibroin dressing need to be improved; the bacterial cellulose dressing has no immunogenicity, good water and air permeability, close adhesion with wound surfaces, strong mechanical strength and plasticity, but lacks an effective fermentation system for large-scale low-cost production; the collagen dressing has good biocompatibility, has the effects of stopping bleeding, promoting coagulation and promoting cell division and differentiation, but has weak stability, poor elasticity, crisp texture and water resistance, is derived from animals, has the risk of infection, and is developed rapidly, various biological dressings emerge continuously, and although various biological dressings have good performance on one aspect, the various biological dressings have more or less defects, and the collagen dressing has no dressing with low price and very good various performances. The existing biological dressing, such as a skin wound biological induction active dressing and a medical dressing composite disclosed by the invention CN202920687U in China, adopts a double-layer composite dressing, utilizes an outer-layer dressing to prevent body fluid loss, control water evaporation and inhibit bacterial infection, and an inner-layer dressing promotes adhesion to a wound and promotes tissue growth, thereby making up for the defects of a single dressing, but the existing dressing cannot conveniently check the healing condition of the wound after being used, and simultaneously cannot conveniently switch between checking and shielding the wound, and cannot keep the activity of active substances in the dressing for a long time.
Disclosure of Invention
Technical problem to be solved
Aiming at the defects of the prior art, the invention provides an active wound and skin repair dressing and a preparation method thereof, and solves the problems that the healing condition of a wound cannot be conveniently checked after the existing dressing is used, the switching between the checking of the wound and the shielding of the wound cannot be conveniently carried out, and the activity of active substances in the dressing cannot be maintained for a long time.
(II) technical scheme
In order to achieve the purpose, the invention is realized by the following technical scheme: the utility model provides an active wound face skin repair dressing, includes dressing main part and adhesive film, the dressing main part includes polyanion material and the synthetic skeleton material of polycation material, the dressing main part with paste between the membrane bonding fixed, adhesive film's material is silicon rubber, the filling groove has been seted up to adhesive film's inside, the cooling groove has all been seted up to the inner wall both sides in filling groove, the inside packing in cooling groove has the ice-cube, the inside packing in filling groove has low concentration alcohol, dressing main part and adhesive film's the outside all covers has thermal-insulated protective layer, it has menstruation blood source nature mesenchymal stem cell, silica gel and hyaluronic acid to fill in skeleton material's the space.
Preferably, the dressing is prepared from the following components, by weight, 80-120 parts of silicone rubber, 20-40 parts of polycation substance, 10-20 parts of polyanion substance, 10-30 parts of menstrual blood-derived mesenchymal stem cells, 10-30 parts of silicone gel, 5-20 parts of hyaluronic acid, 5-20 parts of ice cubes, 10-40 parts of low-concentration alcohol and 20-50 parts of heat insulation material.
Preferably, the dressing is prepared from the following components, by weight, 120 parts of silicone rubber, 20-30 parts of polycation substance, 10-15 parts of polyanion substance, 20-30 parts of menstrual blood-derived mesenchymal stem cells, 10-20 parts of silica gel, 5-10 parts of hyaluronic acid, 10-20 parts of ice cubes, 20-40 parts of low-concentration alcohol and 30-40 parts of heat insulation material.
Preferably, the dressing is prepared from the following components, by weight, 100 parts of silicone rubber, 28 parts of polycation substance, 12 parts of polyanion substance, 20 parts of menstrual blood-derived mesenchymal stem cells, 15 parts of silicone gel, 10 parts of hyaluronic acid, 10 parts of ice cubes, 30 parts of low-concentration alcohol and 40 parts of heat insulation material.
Preferably, the low-concentration alcohol is prepared from 95% concentration alcohol and distilled water, and the mass ratio of the 95% concentration alcohol to the distilled water is 1: 2.
Preferably, the heat insulation protective layer is made of a glass fiber film material, and the thickness of the dressing main body is 3 times of that of the heat insulation protective layer.
Preferably, the silicone gel is one of methyl vinyl silicone oil, methyl silicone oil and ethyl silicone oil.
Preferably, the framework material is a three-dimensional net structure, and the dressing main body is in a transparent film shape.
Preferably, the preparation method of the active wound skin repair dressing comprises the following steps,
(1) treating raw materials, namely respectively pouring polycation substances, polyanion substances and hyaluronic acid into water and uniformly stirring, then mixing and uniformly stirring to obtain a mixed solution, slowly adding the mixed solution into the silica gel, and stirring to obtain a mixed gel;
(2) preparing a dressing main body, adjusting the pH of the mixed gel to 5.8-6.4, then pouring the mixed gel into a stainless steel disc, casting uniformly, drying to obtain a gel film, soaking the gel film into a menstrual blood-derived mesenchymal stem cell solution for 10-20 minutes, taking out and drying;
(3) preparing a sticking film, arranging a filling groove at the top of silicon rubber, arranging a cooling groove in the filling groove, placing ice blocks in the cooling groove, pouring low-concentration alcohol into the filling groove, and sealing the surface layer of the silicon rubber by gluing a silicon rubber thin layer;
(4) and assembling, namely extruding and sticking the adhesive film and the dressing main body for fixation, and then attaching the heat insulation protective layer to the outer sides of the adhesive film and the dressing main body.
Preferably, the concentrations of the polyanionic material and the polycationic material are both 0.005 to 0.05g/ml, and a small amount of glycerin is added when the polyanionic material and the polycationic material are poured into water to be mixed.
(III) advantageous effects
The invention provides an active wound and skin repair dressing. The method has the following beneficial effects:
the active wound skin repair dressing is fixed by bonding between a dressing main body and a pasting film, the pasting film is made of silicon rubber, a filling groove is formed in the pasting film, cooling grooves are formed in two sides of the inner wall of the filling groove, ice blocks are filled in the cooling grooves, low-concentration alcohol is filled in the filling groove, heat insulation protective layers cover the outer sides of the dressing main body and the pasting film, menstrual blood-derived mesenchymal stem cells, silica gel and hyaluronic acid are filled in gaps of a framework material, the menstrual blood-derived mesenchymal stem cells are added in the dressing, and the menstrual blood-derived mesenchymal stem cells have lower immunocompetence, so that antigenicity can be effectively reduced, rejection reaction is reduced, and meanwhile, the menstrual blood-derived mesenchymal stem cells are easy to obtain, the cost is lower, ethical limitation does not exist, and meanwhile, the dressing has the advantages of good healing effect of natural biological dressings and low cost of synthetic biological dressings, the silicon rubber is filled with low-concentration alcohol and ice blocks, the ice blocks are protected by a heat insulation protective layer from melting when the dressing is not used, when the dressing is used, the low-concentration alcohol has a lower temperature due to the existence of the ice blocks, the solubility of oily higher fatty acid esters such as ethyl palmitate, ethyl oleate and ethyl linoleate in the low-concentration alcohol in ethanol is reduced, a large amount of white flocculent turbid precipitates are generated, wounds can be blocked, the oily higher fatty acid esters such as ethyl palmitate, ethyl oleate and ethyl linoleate in the low-concentration alcohol are gradually dissolved by using a hand or a hot towel, the low-concentration alcohol becomes clear, the healing condition of the wounds can be observed through the adhesive film and the dressing, the concentration of the alcohol is further reduced as the ice blocks are gradually melted into the low-concentration alcohol along with the increase of the temperature, and the flocculent precipitates are more easily generated in the interior due to the reduction of the, the low concentration alcohol turns turbid again and blocks the wound, and the ice-cube has also reduced the temperature of dressing simultaneously, is favorable to keeping the activity of active material in the dressing, has solved the unable convenient healing condition of looking over the wound of current dressing after using, and unable convenient simultaneously looks over the wound and shelters from switching between the wound, the unable active problem of active material in the long-time maintenance dressing.
Drawings
FIG. 1 is a schematic cross-sectional view of a dressing of the present invention;
FIG. 2 is a schematic view of a filling trench structure according to the present invention;
fig. 3 is a schematic view of the external structure of the dressing of the present invention.
In the figure: 1-dressing main body, 2-adhesive film, 3-filling groove, 4-cooling groove, 5-ice block, 6-low concentration alcohol and 7-heat insulation protective layer.
Detailed Description
The technical solutions in the embodiments of the present invention will be clearly and completely described below with reference to the drawings in the embodiments of the present invention, and it is obvious that the described embodiments are only a part of the embodiments of the present invention, and not all of the embodiments. All other embodiments, which can be derived by a person skilled in the art from the embodiments given herein without making any creative effort, shall fall within the protection scope of the present invention.
Referring to fig. 1-3, the present invention provides a technical solution: the utility model provides an active wound face skin repair dressing, including dressing
The dressing
The dressing is prepared from the following components, by weight, 100 parts of silicone rubber, 28 parts of polycation substance, 12 parts of polyanion substance, 20 parts of menstrual blood-derived mesenchymal stem cells, 15 parts of silicone gel, 10 parts of hyaluronic acid, 10 parts of ice cubes, 30 parts of low-concentration alcohol and 40 parts of heat insulation material.
The low-concentration alcohol is prepared from 95% concentration alcohol and distilled water, and the mass ratio of the 95% concentration alcohol to the distilled water is 1: 2.
The heat insulation protective layer 7 is made of glass fiber film, and the thickness of the dressing
The silicone gel is one of methyl vinyl silicone oil, methyl silicone oil and ethyl silicone oil.
The framework material is a three-dimensional net structure, and the dressing
A preparation method of an active wound skin repair dressing comprises the following steps,
(1) treating raw materials, namely respectively pouring polycation substances, polyanion substances and hyaluronic acid into water and uniformly stirring, then mixing and uniformly stirring to obtain a mixed solution, slowly adding the mixed solution into the silica gel, and stirring to obtain a mixed gel;
(2) preparing a dressing main body, adjusting the pH of the mixed gel to 6, pouring the mixed gel into a stainless steel disc, uniformly casting, drying to obtain a gel film, soaking the gel film into a menstrual blood-derived mesenchymal stem cell solution for 15 minutes, taking out and drying;
(3) preparing a sticking film, arranging a filling groove at the top of silicon rubber, arranging a cooling groove in the filling groove, placing ice blocks in the cooling groove, pouring low-concentration alcohol into the filling groove, and sealing the surface layer of the silicon rubber by gluing a silicon rubber thin layer;
(4) and assembling, namely extruding and sticking the adhesive film and the dressing main body for fixation, and then attaching the heat insulation protective layer to the outer sides of the adhesive film and the dressing main body.
The concentrations of the polyanionic material and polycationic material were both 0.05g/ml, and a small amount of glycerin was added when the polyanionic material and polycationic material were poured into water and mixed.
It is noted that, herein, relational terms such as first and second, and the like may be used solely to distinguish one entity or action from another entity or action without necessarily requiring or implying any actual such relationship or order between such entities or actions. Also, the terms "comprises," "comprising," or any other variation thereof, are intended to cover a non-exclusive inclusion, such that a process, method, article, or apparatus that comprises a list of elements does not include only those elements but may include other elements not expressly listed or inherent to such process, method, article, or apparatus.
Although embodiments of the present invention have been shown and described, it will be appreciated by those skilled in the art that changes, modifications, substitutions and alterations can be made in these embodiments without departing from the principles and spirit of the invention, the scope of which is defined in the appended claims and their equivalents.
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