阅读说明：本技术 由氢化环戊烷并菲衍生物与纤维素衍生物构成的组合物 (Composition comprising hydrogenated cyclopentanophenanthrene derivative and cellulose derivative ) 是由 向飞 于 2019-01-23 设计创作，主要内容包括：本发明的提供了一种由氢化环戊烷并菲衍生物与纤维素衍生物构成的组合物,该组合物能显著降低纤维素衍生物增强沙眼衣原体生长的作用。(The invention provides a composition consisting of a hydrogenated cyclopentanoperhydrophenanthrene derivative and a cellulose derivative, which can remarkably reduce the effect of the cellulose derivative on enhancing the growth of chlamydia trachomatis.)

1. A composition composed of hydrogenated cyclopentanoperhydrophenanthrene derivatives and cellulose derivatives, characterized in that the cellulose derivatives are one selected from cellulose acetate, low-substituted hypromellose, low-substituted hyprolose, methylcellulose, croscarmellose sodium, microcrystalline cellulose, cellulose acetate, ethylcellulose, hypromellose, hyprolose, hypromellose, hydroxyethylcellulose, carboxymethylcellulose sodium; the hydrogenated cyclopentanoperhydrophenanthrene derivative is one of the following compounds 1-10:

2. composition according to claim 1, characterized in that the mass ratio of cellulose derivative to hydrogenated cyclopentanophenanthrene derivative in the composition is not higher than 100000: 1.

3. Composition according to claim 1 or 2, characterized in that said combination is one selected from the following compositions:

a composition consisting of hypromellose and compound 3,

a composition consisting of ethylene glycol cellulose and a compound 1,

a composition consisting of hydroxyethylcellulose and a compound 3,

a composition comprising cellulose acetate and a compound 3,

a composition consisting of ethylcellulose and compound 9,

a composition comprising methylcellulose and compound 4,

a composition consisting of ethylcellulose and compound 7,

a composition comprising methylcellulose and compound 2,

a composition consisting of hydroxypropylcellulose and compound 2,

a composition consisting of sodium carboxymethylcellulose and compound 3,

a composition consisting of hydroxyethylcellulose and a compound 9,

a composition consisting of hypromellose and compound 9,

a composition consisting of croscarmellose sodium and compound 4,

a composition consisting of hypromellose and compound 5,

a composition consisting of hydroxyethylcellulose and compound 7,

a composition comprising microcrystalline cellulose and compound 1,

a composition consisting of ethylene glycol cellulose and a compound 9,

a composition consisting of sodium carboxymethylcellulose and compound 4,

a composition consisting of methylcellulose and compound 7,

a composition consisting of hydroxypropylcellulose and compound 9,

a composition consisting of croscarmellose sodium and compound 7,

a composition consisting of croscarmellose sodium and compound 9,

a composition consisting of sodium carboxymethylcellulose and compound 9,

a composition consisting of croscarmellose sodium and compound 3,

a composition comprising cellulose acetate and a compound 4,

a composition consisting of hypromellose and compound 4,

a composition consisting of hydroxypropylcellulose and compound 7,

a composition consisting of low-substituted hydroxypropyl cellulose and a compound 1,

a composition consisting of hydroxyethylcellulose and a compound 2,

a composition consisting of methylcellulose and compound 9,

a composition consisting of hydroxypropylcellulose and compound 3,

a composition consisting of hydroxyethylcellulose and a compound 7,

a composition consisting of ethylene glycol cellulose and a compound 4,

a composition consisting of cellulose acetate and a compound 7,

a composition consisting of ethylene glycol cellulose and a compound 7,

a composition consisting of hydroxyethylcellulose and a compound 1,

a composition consisting of hypromellose and compound 7,

a composition consisting of ethylcellulose and compound 4,

a composition consisting of hydroxyethylcellulose and a compound 3,

a composition consisting of cellulose acetate and a compound 4,

a composition consisting of low-substituted hydroxypropylcellulose and a compound 5,

a composition comprising methylcellulose and compound 3,

a composition consisting of croscarmellose sodium and compound 8,

a composition consisting of low-substituted hydroxypropylcellulose and a compound 9,

a composition consisting of microcrystalline cellulose and compound 4,

a composition consisting of low-substituted hydroxypropylcellulose and a compound 4,

a composition of hydroxypropylcellulose and compound 10,

a composition consisting of low-substituted hydroxypropylcellulose and a compound 2,

a composition consisting of low-substituted hydroxypropylcellulose and a compound 3,

a composition consisting of hydroxyethylcellulose and a compound 9,

a composition comprising cellulose acetate and a compound 1,

a composition consisting of hydroxyethylcellulose and compound 4,

a composition consisting of sodium carboxymethylcellulose and compound 5,

a composition of hydroxyethylcellulose and compound 10,

a composition consisting of sodium carboxymethylcellulose and compound 2,

a composition comprising a mixture of a cellulose acetate and a compound 1,

a composition consisting of ethylcellulose and compound 3,

a composition consisting of croscarmellose sodium and compound 1,

a composition comprising ethylcellulose and compound 1,

a composition consisting of ethylcellulose and compound 5,

a composition consisting of sodium carboxymethylcellulose and compound 7,

a composition consisting of low-substituted hypromellose and a compound 3,

a composition consisting of cellulose acetate and a compound 9,

a composition comprising methylcellulose and compound 1,

a composition consisting of hypromellose and compound 1,

a composition consisting of hydroxypropylcellulose and compound 1,

a composition consisting of hydroxypropylcellulose and compound 4,

a composition consisting of low-substituted hypromellose and a compound 4,

a composition consisting of low-substituted hypromellose and a compound 1,

a composition consisting of hypromellose and compound 2.

4. Composition according to claim 3, characterized in that it is one selected from the following compositions:

a composition consisting of hypromellose and compound 3,

a composition consisting of ethylene glycol cellulose and a compound 1,

a composition consisting of hydroxyethylcellulose and a compound 3,

a composition comprising cellulose acetate and a compound 3,

a composition consisting of ethylcellulose and compound 9,

a composition comprising methylcellulose and compound 4,

a composition consisting of ethylcellulose and compound 7,

a composition comprising methylcellulose and compound 2,

a composition consisting of hydroxypropylcellulose and compound 2,

a composition consisting of sodium carboxymethylcellulose and compound 3,

a composition consisting of hydroxyethylcellulose and a compound 9,

a composition consisting of hypromellose and compound 9,

a composition consisting of croscarmellose sodium and compound 4,

a composition consisting of hypromellose and compound 5,

a composition consisting of hydroxyethylcellulose and compound 7,

a composition comprising microcrystalline cellulose and compound 1,

a composition consisting of ethylene glycol cellulose and a compound 9,

a composition consisting of sodium carboxymethylcellulose and compound 4,

a composition consisting of methylcellulose and compound 7,

a composition consisting of hydroxypropylcellulose and compound 9,

a composition consisting of croscarmellose sodium and compound 7,

a composition consisting of croscarmellose sodium and compound 9,

a composition consisting of sodium carboxymethylcellulose and compound 9,

a composition consisting of croscarmellose sodium and compound 3,

a composition comprising cellulose acetate and a compound 4,

a composition consisting of hypromellose and compound 4,

a composition consisting of hydroxypropylcellulose and compound 7,

a composition consisting of low-substituted hydroxypropyl cellulose and a compound 1,

a composition consisting of hydroxyethylcellulose and a compound 2,

a composition consisting of methylcellulose and compound 9,

a composition consisting of hydroxypropylcellulose and compound 3,

a composition consisting of hydroxyethylcellulose and a compound 7,

a composition consisting of ethylene glycol cellulose and a compound 4,

a composition consisting of cellulose acetate and a compound 7,

a composition consisting of ethylcellulose and compound 7.

5. The composition of claim 4, wherein said composition is selected from the group consisting of:

a composition consisting of hypromellose and compound 3,

a composition consisting of ethylene glycol cellulose and a compound 1,

a composition consisting of hydroxyethylcellulose and a compound 3,

a composition comprising cellulose acetate and a compound 3,

a composition consisting of ethylcellulose and compound 9,

a composition comprising methylcellulose and compound 4,

a composition consisting of ethylcellulose and compound 7,

a composition comprising methylcellulose and compound 2,

a composition consisting of hydroxypropylcellulose and compound 2,

a composition consisting of sodium carboxymethylcellulose and compound 3,

a composition consisting of hydroxyethylcellulose and a compound 9,

a composition consisting of hypromellose and compound 9,

a composition consisting of croscarmellose sodium and compound 4,

a composition consisting of hypromellose and compound 5,

a composition consisting of hydroxyethylcellulose and compound 7,

a composition comprising microcrystalline cellulose and compound 1,

a composition consisting of ethylene glycol cellulose and a compound 9,

a composition consisting of sodium carboxymethylcellulose and compound 4.

6. The composition of claim 5, wherein said composition is selected from the group consisting of:

a composition consisting of hypromellose and compound 3,

a composition consisting of ethylene glycol cellulose and a compound 1,

a composition consisting of hydroxyethylcellulose and a compound 3,

a composition comprising cellulose acetate and a compound 3,

a composition consisting of ethylcellulose and compound 9,

a composition comprising methylcellulose and compound 4,

a composition consisting of ethylcellulose and compound 7,

a composition comprising methylcellulose and compound 2,

a composition consisting of hydroxypropylcellulose and compound 2.

7. A composition according to claim 1 or 2, characterized in that said composition is one selected from the following:

a composition consisting of low-substituted hypromellose and a compound 4,

a composition consisting of low-substituted hydroxypropylcellulose and a compound 7,

a composition consisting of hydroxyethylcellulose and a compound 7,

a composition consisting of low-substituted hypromellose and a compound 7,

a composition consisting of methylcellulose and compound 7,

a composition consisting of microcrystalline cellulose and compound 7,

a composition consisting of croscarmellose sodium and compound 5,

a composition consisting of hydroxypropylcellulose and compound 5,

a composition comprising methylcellulose and compound 5,

a composition consisting of croscarmellose sodium and compound 7,

a composition consisting of low-substituted hypromellose and a compound 5,

a composition consisting of croscarmellose sodium and compound 4,

a composition comprising cellulose acetate and a compound 5,

a composition of ethylcellulose and compound 10,

a composition consisting of cellulose acetate and a compound 5,

a composition consisting of hydroxyethylcellulose and compound 7,

a composition comprising methylcellulose and compound 4,

a composition consisting of cellulose acetate and a compound 7,

a composition consisting of ethylene glycol cellulose and a compound 5,

a composition of hydroxypropylcellulose and compound 10,

a composition consisting of low-substituted hydroxypropylcellulose and a compound 5,

a composition consisting of ethylene glycol cellulose and a compound 4,

a composition consisting of low-substituted hydroxypropylcellulose and a compound 4,

a composition consisting of hydroxyethylcellulose and a compound 6,

a composition consisting of ethylcellulose and compound 7,

a composition consisting of low-substituted hydroxypropylcellulose and a compound 3,

a composition consisting of hydroxypropylcellulose and compound 7,

a composition consisting of ethylcellulose and compound 5,

a composition consisting of microcrystalline cellulose and compound 5,

a composition consisting of hydroxyethylcellulose and a compound 3,

a composition of croscarmellose sodium and compound 10,

a composition consisting of ethylene glycol cellulose and a compound 7,

a composition comprising methylcellulose and compound 1,

a composition of hydroxyethylcellulose and compound 10,

a composition consisting of hydroxypropylcellulose and compound 4,

a composition of ethylene glycol cellulose and compound 10,

a composition consisting of hydroxyethylcellulose and a compound 5,

a composition of cellulose acetate and compound 10,

a composition consisting of sodium carboxymethylcellulose and compound 7,

a composition of hydroxyethylcellulose and compound 10,

a composition consisting of low-substituted hydroxypropylcellulose and compound 10,

a composition consisting of hydroxyethylcellulose and a compound 5,

a composition comprising microcrystalline cellulose and compound 3,

a composition comprising cellulose acetate and a compound 8,

a composition comprising a mixture of a cellulose acetate and a compound 10,

a composition consisting of methylcellulose and compound 8,

a composition comprising cellulose acetate and a compound 3,

a composition consisting of hypromellose and compound 7,

a composition consisting of ethylcellulose and compound 4,

a composition consisting of hydroxyethylcellulose and compound 4,

a composition consisting of microcrystalline cellulose and compound 6,

a composition consisting of cellulose acetate and a compound 4,

a composition consisting of sodium carboxymethylcellulose and compound 6,

a composition consisting of hypromellose and compound 6,

a composition comprising cellulose acetate and a compound 4,

a composition consisting of hydroxypropylcellulose and compound 6,

a composition consisting of hypromellose and compound 5,

a composition consisting of sodium carboxymethylcellulose and compound 3,

a composition of methylcellulose and compound 10,

a composition consisting of hydroxyethylcellulose and a compound 4,

a composition consisting of ethylcellulose and compound 6,

a composition consisting of low-substituted hypromellose and compound 10,

a composition consisting of hydroxyethylcellulose and a compound 6,

a composition comprising cellulose acetate and a compound 7,

a composition consisting of hydroxypropylcellulose and compound 3,

a composition comprising methylcellulose and compound 3,

a composition consisting of microcrystalline cellulose and compound 8,

a composition consisting of low-substituted hydroxypropyl cellulose and a compound 1,

a composition consisting of cellulose acetate and a compound 2,

a composition comprising fibroacetoester and compound 6.

8. The composition of claim 7, wherein said composition is selected from the group consisting of:

a composition consisting of low-substituted hypromellose and a compound 4,

a composition consisting of low-substituted hydroxypropylcellulose and a compound 7,

a composition consisting of hydroxyethylcellulose and a compound 7,

a composition consisting of low-substituted hypromellose and a compound 7,

a composition consisting of methylcellulose and compound 7,

a composition consisting of microcrystalline cellulose and compound 7,

a composition consisting of croscarmellose sodium and compound 5,

a composition consisting of hydroxypropylcellulose and compound 5,

a composition comprising methylcellulose and compound 5,

a composition consisting of croscarmellose sodium and compound 7,

a composition consisting of low-substituted hypromellose and a compound 5,

a composition consisting of croscarmellose sodium and compound 4,

a composition comprising cellulose acetate and a compound 5,

a composition of ethylcellulose and compound 10,

a composition consisting of cellulose acetate and a compound 5,

a composition consisting of hydroxyethylcellulose and compound 7,

a composition comprising methylcellulose and compound 4,

a composition consisting of cellulose acetate and a compound 7,

a composition consisting of ethylene glycol cellulose and a compound 5,

a composition of hydroxypropylcellulose and compound 10,

a composition consisting of low-substituted hydroxypropylcellulose and a compound 5,

a composition consisting of ethylene glycol cellulose and a compound 4,

a composition consisting of low-substituted hydroxypropylcellulose and a compound 4,

a composition consisting of hydroxyethylcellulose and a compound 6,

a composition consisting of ethylcellulose and compound 7,

a composition consisting of low-substituted hydroxypropylcellulose and a compound 3,

a composition consisting of hydroxypropylcellulose and compound 7,

a composition consisting of ethylcellulose and compound 5,

a composition consisting of microcrystalline cellulose and compound 5,

a composition consisting of hydroxyethylcellulose and a compound 3,

a composition of croscarmellose sodium and compound 10,

a composition consisting of ethylene glycol cellulose and a compound 7,

a composition comprising methylcellulose and compound 1,

a composition of hydroxyethylcellulose and compound 10,

a composition consisting of hydroxypropylcellulose and compound 4.

9. The composition of claim 8, wherein said composition is selected from the group consisting of:

a composition consisting of low-substituted hypromellose and a compound 4,

a composition consisting of low-substituted hydroxypropylcellulose and a compound 7,

a composition consisting of hydroxyethylcellulose and a compound 7,

a composition consisting of low-substituted hypromellose and a compound 7,

a composition consisting of methylcellulose and compound 7,

a composition consisting of microcrystalline cellulose and compound 7,

a composition consisting of croscarmellose sodium and compound 5,

a composition consisting of hydroxypropylcellulose and compound 5,

a composition comprising methylcellulose and compound 5,

a composition consisting of croscarmellose sodium and compound 7,

a composition consisting of low-substituted hypromellose and a compound 5,

a composition consisting of croscarmellose sodium and compound 4,

a composition comprising cellulose acetate and a compound 5,

a composition of ethylcellulose and compound 10,

a composition consisting of cellulose acetate and a compound 5,

a composition consisting of hydroxyethylcellulose and compound 7,

a composition comprising methylcellulose and compound 4,

a composition comprising fibroacetoester and compound 7.

10. The composition of claim 9, wherein said composition is selected from the group consisting of:

a composition consisting of low-substituted hypromellose and a compound 4,

a composition consisting of low-substituted hydroxypropylcellulose and a compound 7,

a composition consisting of hydroxyethylcellulose and a compound 7,

a composition consisting of low-substituted hypromellose and a compound 7,

a composition consisting of methylcellulose and compound 7,

a composition consisting of microcrystalline cellulose and compound 7,

a composition consisting of croscarmellose sodium and compound 5,

a composition consisting of hydroxypropylcellulose and compound 5.

Technical Field

The invention belongs to the technical field of biological medicines, and particularly relates to a composition consisting of a hydrogenated cyclopentanoperhydrophenanthrene derivative and a cellulose derivative.

Background

Cellulose derivatives represented by hydroxyethylcellulose are commonly used auxiliary materials in oral and external solid preparations, however, a research result of Raffai T et al, published in Antimicob Agents Chemother, journal 2018, Vol.63, No. 1, proves that hydroxyethylcellulose can remarkably enhance the growth and infectivity of Chlamydia trachomatis D and E types. Although this study was conducted in vaginal simulants, it has been reported that Chlamydia trachomatis also causes infection of the digestive tract (e.g., Genitourin Med.1990 Feb; 66(1):26-7.), and that, for some special populations with some non-sexual activity, Chlamydia trachomatis growing in the reproductive tract is entirely likely to enter the digestive tract. Experiments carried out by adopting gastric acid simulation liquid as a medium show that cellulose acetate, low-substituted hydroxypropyl methylcellulose, low-substituted hydroxypropyl cellulose, methyl cellulose, croscarmellose sodium, microcrystalline cellulose, cellulose acetate, ethyl cellulose, hydroxyethyl cellulose, hydroxypropyl methylcellulose, hydroxypropyl cellulose, hydroxyethyl methylcellulose, hydroxyethyl cellulose, sodium carboxymethyl cellulose and other cellulose derivative auxiliary materials have similar effects. Therefore, the oral preparation containing the cellulose derivative as the auxiliary material can also promote the growth of chlamydia trachomatis in the alimentary canal after oral administration, and brings certain potential safety hazard to high-risk patients.

Disclosure of Invention

The invention aims to provide a composition consisting of a hydrogenated cyclopentanoperhydrophenanthrene derivative and a cellulose derivative, which can significantly reduce the growth-enhancing effect of the cellulose derivative on chlamydia trachomatis.

In order to achieve the above object, the present invention provides a composition comprising a hydrogenated cyclopentanophene derivative and a cellulose derivative, wherein the cellulose derivative is one selected from the group consisting of cellulose acetate (C1), low-substituted hypromellose (C2), low-substituted hypromellose (C3), methylcellulose (C4), croscarmellose sodium (C5), microcrystalline cellulose (C6), cellulose acetate (C7), ethylcellulose (C8), ethylcellulose (C9), hypromellose (C10), hypromellose (C11), hydroxyethylmethylcellulose (C12), hydroxyethylcellulose (C13), and carboxymethylcellulose sodium (C14); the hydrogenated cyclopentanoperhydrophenanthrene derivative is one of the following compounds 1-10:

the cellulose derivatives of the present invention are all Excipients found in Handbook of Pharmaceutical Excipients (Six Edition) written by Raymond C Rowe et al and meet the quality standards thereof.

Preferably, the mass ratio of the cellulose derivative to the hydrogenated cyclopentanophenanthrene derivative in the composition according to the invention is not higher than 100000: 1.

In one aspect, preferably, the combination according to the invention is one selected from the following compositions, according to the AUC data of form D in table 2:

a composition consisting of hypromellose and compound 3,

a composition consisting of ethylene glycol cellulose and a compound 1,

a composition consisting of hydroxyethylcellulose and a compound 3,

a composition comprising cellulose acetate and a compound 3,

a composition consisting of ethylcellulose and compound 9,

a composition comprising methylcellulose and compound 4,

a composition consisting of ethylcellulose and compound 7,

a composition comprising methylcellulose and compound 2,

a composition consisting of hydroxypropylcellulose and compound 2,

a composition consisting of sodium carboxymethylcellulose and compound 3,

a composition consisting of hydroxyethylcellulose and a compound 9,

a composition consisting of hypromellose and compound 9,

a composition consisting of croscarmellose sodium and compound 4,

a composition consisting of hypromellose and compound 5,

a composition consisting of hydroxyethylcellulose and compound 7,

a composition comprising microcrystalline cellulose and compound 1,

a composition consisting of ethylene glycol cellulose and a compound 9,

a composition consisting of sodium carboxymethylcellulose and compound 4,

a composition consisting of methylcellulose and compound 7,

a composition consisting of hydroxypropylcellulose and compound 9,

a composition consisting of croscarmellose sodium and compound 7,

a composition consisting of croscarmellose sodium and compound 9,

a composition consisting of sodium carboxymethylcellulose and compound 9,

a composition consisting of croscarmellose sodium and compound 3,

a composition comprising cellulose acetate and a compound 4,

a composition consisting of hypromellose and compound 4,

a composition consisting of hydroxypropylcellulose and compound 7,

a composition consisting of low-substituted hydroxypropyl cellulose and a compound 1,

a composition consisting of hydroxyethylcellulose and a compound 2,

a composition consisting of methylcellulose and compound 9,

a composition consisting of hydroxypropylcellulose and compound 3,

a composition consisting of hydroxyethylcellulose and a compound 7,

a composition consisting of ethylene glycol cellulose and a compound 4,

a composition consisting of cellulose acetate and a compound 7,

a composition consisting of ethylene glycol cellulose and a compound 7,

a composition consisting of hydroxyethylcellulose and a compound 1,

a composition consisting of hypromellose and compound 7,

a composition consisting of ethylcellulose and compound 4,

a composition consisting of hydroxyethylcellulose and a compound 3,

a composition consisting of cellulose acetate and a compound 4,

a composition consisting of low-substituted hydroxypropylcellulose and a compound 5,

a composition comprising methylcellulose and compound 3,

a composition consisting of croscarmellose sodium and compound 8,

a composition consisting of low-substituted hydroxypropylcellulose and a compound 9,

a composition consisting of microcrystalline cellulose and compound 4,

a composition consisting of low-substituted hydroxypropylcellulose and a compound 4,

a composition of hydroxypropylcellulose and compound 10,

a composition consisting of low-substituted hydroxypropylcellulose and a compound 2,

a composition consisting of low-substituted hydroxypropylcellulose and a compound 3,

a composition consisting of hydroxyethylcellulose and a compound 9,

a composition comprising cellulose acetate and a compound 1,

a composition consisting of hydroxyethylcellulose and compound 4,

a composition consisting of sodium carboxymethylcellulose and compound 5,

a composition of hydroxyethylcellulose and compound 10,

a composition consisting of sodium carboxymethylcellulose and compound 2,

a composition comprising a mixture of a cellulose acetate and a compound 1,

a composition consisting of ethylcellulose and compound 3,

a composition consisting of croscarmellose sodium and compound 1,

a composition comprising ethylcellulose and compound 1,

a composition consisting of ethylcellulose and compound 5,

a composition consisting of sodium carboxymethylcellulose and compound 7,

a composition consisting of low-substituted hypromellose and a compound 3,

a composition consisting of cellulose acetate and a compound 9,

a composition comprising methylcellulose and compound 1,

a composition consisting of hypromellose and compound 1,

a composition consisting of hydroxypropylcellulose and compound 1,

a composition consisting of hydroxypropylcellulose and compound 4,

a composition consisting of low-substituted hypromellose and a compound 4,

a composition consisting of low-substituted hypromellose and a compound 1,

a composition consisting of hypromellose and compound 2.

More preferably, the composition of the present invention is one selected from the following compositions:

a composition consisting of hypromellose and compound 3,

a composition consisting of ethylene glycol cellulose and a compound 1,

a composition consisting of hydroxyethylcellulose and a compound 3,

a composition comprising cellulose acetate and a compound 3,

a composition consisting of ethylcellulose and compound 9,

a composition comprising methylcellulose and compound 4,

a composition consisting of ethylcellulose and compound 7,

a composition comprising methylcellulose and compound 2,

a composition consisting of hydroxypropylcellulose and compound 2,

a composition consisting of sodium carboxymethylcellulose and compound 3,

a composition consisting of hydroxyethylcellulose and a compound 9,

a composition consisting of hypromellose and compound 9,

a composition consisting of croscarmellose sodium and compound 4,

a composition consisting of hypromellose and compound 5,

a composition consisting of hydroxyethylcellulose and compound 7,

a composition comprising microcrystalline cellulose and compound 1,

a composition consisting of ethylene glycol cellulose and a compound 9,

a composition consisting of sodium carboxymethylcellulose and compound 4,

a composition consisting of methylcellulose and compound 7,

a composition consisting of hydroxypropylcellulose and compound 9,

a composition consisting of croscarmellose sodium and compound 7,

a composition consisting of croscarmellose sodium and compound 9,

a composition consisting of sodium carboxymethylcellulose and compound 9,

a composition consisting of croscarmellose sodium and compound 3,

a composition comprising cellulose acetate and a compound 4,

a composition consisting of hypromellose and compound 4,

a composition consisting of hydroxypropylcellulose and compound 7,

a composition consisting of low-substituted hydroxypropyl cellulose and a compound 1,

a composition consisting of hydroxyethylcellulose and a compound 2,

a composition consisting of methylcellulose and compound 9,

a composition consisting of hydroxypropylcellulose and compound 3,

a composition consisting of hydroxyethylcellulose and a compound 7,

a composition consisting of ethylene glycol cellulose and a compound 4,

a composition consisting of cellulose acetate and a compound 7,

a composition consisting of ethylcellulose and compound 7.

Further preferably, the composition of the present invention is one selected from the following compositions:

a composition consisting of hypromellose and compound 3,

a composition consisting of ethylene glycol cellulose and a compound 1,

a composition consisting of hydroxyethylcellulose and a compound 3,

a composition comprising cellulose acetate and a compound 3,

a composition consisting of ethylcellulose and compound 9,

a composition comprising methylcellulose and compound 4,

a composition consisting of ethylcellulose and compound 7,

a composition comprising methylcellulose and compound 2,

a composition consisting of hydroxypropylcellulose and compound 2,

a composition consisting of sodium carboxymethylcellulose and compound 3,

a composition consisting of hydroxyethylcellulose and a compound 9,

a composition consisting of hypromellose and compound 9,

a composition consisting of croscarmellose sodium and compound 4,

a composition consisting of hypromellose and compound 5,

a composition consisting of hydroxyethylcellulose and compound 7,

a composition comprising microcrystalline cellulose and compound 1,

a composition consisting of ethylene glycol cellulose and a compound 9,

a composition consisting of sodium carboxymethylcellulose and compound 4.

Most preferably, the composition of the present invention is one selected from the following compositions:

a composition consisting of hypromellose and compound 3,

a composition consisting of ethylene glycol cellulose and a compound 1,

a composition consisting of hydroxyethylcellulose and a compound 3,

a composition comprising cellulose acetate and a compound 3,

a composition consisting of ethylcellulose and compound 9,

a composition comprising methylcellulose and compound 4,

a composition consisting of ethylcellulose and compound 7,

a composition comprising methylcellulose and compound 2,

a composition consisting of hydroxypropylcellulose and compound 2.

In another aspect, preferably, the composition according to the invention is one selected from the following compositions according to the AUC data of form E in table 2:

a composition consisting of low-substituted hypromellose and a compound 4,

a composition consisting of low-substituted hydroxypropylcellulose and a compound 7,

a composition consisting of hydroxyethylcellulose and a compound 7,

a composition consisting of low-substituted hypromellose and a compound 7,

a composition consisting of methylcellulose and compound 7,

a composition consisting of microcrystalline cellulose and compound 7,

a composition consisting of croscarmellose sodium and compound 5,

a composition consisting of hydroxypropylcellulose and compound 5,

a composition comprising methylcellulose and compound 5,

a composition consisting of croscarmellose sodium and compound 7,

a composition consisting of low-substituted hypromellose and a compound 5,

a composition consisting of croscarmellose sodium and compound 4,

a composition comprising cellulose acetate and a compound 5,

a composition of ethylcellulose and compound 10,

a composition consisting of cellulose acetate and a compound 5,

a composition consisting of hydroxyethylcellulose and compound 7,

a composition comprising methylcellulose and compound 4,

a composition consisting of cellulose acetate and a compound 7,

a composition consisting of ethylene glycol cellulose and a compound 5,

a composition of hydroxypropylcellulose and compound 10,

a composition consisting of low-substituted hydroxypropylcellulose and a compound 5,

a composition consisting of ethylene glycol cellulose and a compound 4,

a composition consisting of low-substituted hydroxypropylcellulose and a compound 4,

a composition consisting of hydroxyethylcellulose and a compound 6,

a composition consisting of ethylcellulose and compound 7,

a composition consisting of low-substituted hydroxypropylcellulose and a compound 3,

a composition consisting of hydroxypropylcellulose and compound 7,

a composition consisting of ethylcellulose and compound 5,

a composition consisting of microcrystalline cellulose and compound 5,

a composition consisting of hydroxyethylcellulose and a compound 3,

a composition of croscarmellose sodium and compound 10,

a composition consisting of ethylene glycol cellulose and a compound 7,

a composition comprising methylcellulose and compound 1,

a composition of hydroxyethylcellulose and compound 10,

a composition consisting of hydroxypropylcellulose and compound 4,

a composition of ethylene glycol cellulose and compound 10,

a composition consisting of hydroxyethylcellulose and a compound 5,

a composition of cellulose acetate and compound 10,

a composition consisting of sodium carboxymethylcellulose and compound 7,

a composition of hydroxyethylcellulose and compound 10,

a composition consisting of low-substituted hydroxypropylcellulose and compound 10,

a composition consisting of hydroxyethylcellulose and a compound 5,

a composition comprising microcrystalline cellulose and compound 3,

a composition comprising cellulose acetate and a compound 8,

a composition comprising a mixture of a cellulose acetate and a compound 10,

a composition consisting of methylcellulose and compound 8,

a composition comprising cellulose acetate and a compound 3,

a composition consisting of hypromellose and compound 7,

a composition consisting of ethylcellulose and compound 4,

a composition consisting of hydroxyethylcellulose and compound 4,

a composition consisting of microcrystalline cellulose and compound 6,

a composition consisting of cellulose acetate and a compound 4,

a composition consisting of sodium carboxymethylcellulose and compound 6,

a composition consisting of hypromellose and compound 6,

a composition comprising cellulose acetate and a compound 4,

a composition consisting of hydroxypropylcellulose and compound 6,

a composition consisting of hypromellose and compound 5,

a composition consisting of sodium carboxymethylcellulose and compound 3,

a composition of methylcellulose and compound 10,

a composition consisting of hydroxyethylcellulose and a compound 4,

a composition consisting of ethylcellulose and compound 6,

a composition consisting of low-substituted hypromellose and compound 10,

a composition consisting of hydroxyethylcellulose and a compound 6,

a composition comprising cellulose acetate and a compound 7,

a composition consisting of hydroxypropylcellulose and compound 3,

a composition comprising methylcellulose and compound 3,

a composition consisting of microcrystalline cellulose and compound 8,

a composition consisting of low-substituted hydroxypropyl cellulose and a compound 1,

a composition consisting of cellulose acetate and a compound 2,

a composition comprising fibroacetoester and compound 6.

More preferably, the composition of the present invention is one selected from the following compositions:

a composition consisting of low-substituted hypromellose and a compound 4,

a composition consisting of low-substituted hydroxypropylcellulose and a compound 7,

a composition consisting of hydroxyethylcellulose and a compound 7,

a composition consisting of low-substituted hypromellose and a compound 7,

a composition consisting of methylcellulose and compound 7,

a composition consisting of microcrystalline cellulose and compound 7,

a composition consisting of croscarmellose sodium and compound 5,

a composition consisting of hydroxypropylcellulose and compound 5,

a composition comprising methylcellulose and compound 5,

a composition consisting of croscarmellose sodium and compound 7,

a composition consisting of low-substituted hypromellose and a compound 5,

a composition consisting of croscarmellose sodium and compound 4,

a composition comprising cellulose acetate and a compound 5,

a composition of ethylcellulose and compound 10,

a composition consisting of cellulose acetate and a compound 5,

a composition consisting of hydroxyethylcellulose and compound 7,

a composition comprising methylcellulose and compound 4,

a composition consisting of cellulose acetate and a compound 7,

a composition consisting of ethylene glycol cellulose and a compound 5,

a composition of hydroxypropylcellulose and compound 10,

a composition consisting of low-substituted hydroxypropylcellulose and a compound 5,

a composition consisting of ethylene glycol cellulose and a compound 4,

a composition consisting of low-substituted hydroxypropylcellulose and a compound 4,

a composition consisting of hydroxyethylcellulose and a compound 6,

a composition consisting of ethylcellulose and compound 7,

a composition consisting of low-substituted hydroxypropylcellulose and a compound 3,

a composition consisting of hydroxypropylcellulose and compound 7,

a composition consisting of ethylcellulose and compound 5,

a composition consisting of microcrystalline cellulose and compound 5,

a composition consisting of hydroxyethylcellulose and a compound 3,

a composition of croscarmellose sodium and compound 10,

a composition consisting of ethylene glycol cellulose and a compound 7,

a composition comprising methylcellulose and compound 1,

a composition of hydroxyethylcellulose and compound 10,

a composition consisting of hydroxypropylcellulose and compound 4.

Further preferably, the composition of the present invention is one selected from the following compositions:

a composition consisting of low-substituted hypromellose and a compound 4,

a composition consisting of low-substituted hydroxypropylcellulose and a compound 7,

a composition consisting of hydroxyethylcellulose and a compound 7,

a composition consisting of low-substituted hypromellose and a compound 7,

a composition consisting of methylcellulose and compound 7,

a composition consisting of microcrystalline cellulose and compound 7,

a composition consisting of croscarmellose sodium and compound 5,

a composition consisting of hydroxypropylcellulose and compound 5,

a composition comprising methylcellulose and compound 5,

a composition consisting of croscarmellose sodium and compound 7,

a composition consisting of low-substituted hypromellose and a compound 5,

a composition consisting of croscarmellose sodium and compound 4,

a composition comprising cellulose acetate and a compound 5,

a composition of ethylcellulose and compound 10,

a composition consisting of cellulose acetate and a compound 5,

a composition consisting of hydroxyethylcellulose and compound 7,

a composition comprising methylcellulose and compound 4,

a composition comprising fibroacetoester and compound 7.

Most preferably, the composition of the present invention is one selected from the following compositions:

a composition consisting of low-substituted hypromellose and a compound 4,

a composition consisting of low-substituted hydroxypropylcellulose and a compound 7,

a composition consisting of hydroxyethylcellulose and a compound 7,

a composition consisting of low-substituted hypromellose and a compound 7,

a composition consisting of methylcellulose and compound 7,

a composition consisting of microcrystalline cellulose and compound 7,

a composition consisting of croscarmellose sodium and compound 5,

a composition consisting of hydroxypropylcellulose and compound 5.

In another aspect, the invention provides the use of a composition as hereinbefore described for the preparation of a solid formulation.

Preferably, the solid preparation of the present invention is one selected from the group consisting of tablets and capsules.

In vitro test results show that the composition can obviously reduce the growth effect of the cellulose derivative auxiliary materials on enhancing the chlamydia trachomatis.

Detailed Description

The technical solution of the present invention is described in detail and completely with reference to the following embodiments of the present invention, and it is obvious that the described embodiments are only a part of the embodiments of the present invention, and not all of the embodiments. All other embodiments, which can be derived by a person skilled in the art from the embodiments given herein without making any creative effort, shall fall within the protection scope of the present invention.