阅读说明：本技术 一种保护猪胃肠的纳米聚维酮碘口服液及其制备方法 (Nanometer povidone iodine oral liquid for protecting pig intestines and stomach and preparation method thereof ) 是由 邓鸣飞 于 2019-10-25 设计创作，主要内容包括：本发明公开了一种保护猪胃肠的纳米聚维酮碘口服液及其制备方法,其原料按重量比包括：聚维酮20-25％、碘4.5-5.6％、食用甘油1.3-2.5％、山楂片2.1-3.1％、碘化钾2.7-3.6％、去离子水65-80％,涉及兽药及制药技术领域。该保护猪胃肠的纳米聚维酮碘口服液及其制备方法,通过纳米级颗粒的聚维酮碘释放有效碘来直接使菌体内的蛋白质变性、沉淀,致使病原微生物死亡,从而高效消毒和杀菌,实现对猪的肠胃杀菌保护作用,提高了猪的抵抗力和免疫力,降低死亡率。生产工艺简单科学,浸泡、反应、搅拌、烘干、研磨、提取、加温、络合、稀释、灌装一气呵成,耗电少,用工省。一种保护猪胃肠的纳米聚维酮碘口服液无残留环保,零休药期,市场空间大,直接稀释使用,用户操作简单快捷。(The invention discloses a nanometer povidone iodine oral liquid for protecting pig intestines and stomach and a preparation method thereof, wherein the nanometer povidone iodine oral liquid comprises the following raw materials in percentage by weight: 20-25% of povidone, 4.5-5.6% of iodine, 1.3-2.5% of edible glycerol, 2.1-3.1% of hawthorn slices, 2.7-3.6% of potassium iodide and 65-80% of deionized water, and relates to the technical field of veterinary medicines and pharmacy. According to the nanometer povidone iodine oral liquid for protecting the pig intestines and stomach and the preparation method thereof, effective iodine is released by povidone iodine of nanometer particles to directly denature and precipitate protein in bacteria, so that pathogenic microorganisms die, high-efficiency disinfection and sterilization are realized, the pig intestines and stomach sterilization protection effect is realized, the pig resistance and immunity are improved, and the death rate is reduced. The production process is simple and scientific, the soaking, the reaction, the stirring, the drying, the grinding, the extraction, the heating, the complexing, the dilution and the filling are completed in one step, the power consumption is low, and the labor is saved. The nanometer povidone iodine oral liquid for protecting the pig intestines and stomach has the advantages of no residue, environmental protection, zero drug holiday, large market space, direct dilution and use, and simple and quick user operation.)

1. A nanometer povidone iodine oral liquid for protecting pig intestines and stomach is characterized in that: the raw materials comprise the following components in percentage by weight: 20-25% of povidone, 4.5-5.6% of iodine, 1.3-2.5% of edible glycerol, 2.1-3.1% of hawthorn slices, 2.7-3.6% of potassium iodide and 60-80% of deionized water.

2. The nanometer povidone-iodine oral liquid for protecting pig intestines and stomach according to claim 1 is characterized in that: the raw materials comprise the following components: 20% of povidone, 4.5% of iodine, 1.3% of edible glycerin, 2.1% of hawthorn slices, 2.7% of potassium iodide and 69.4% of deionized water.

3. The nanometer povidone-iodine oral liquid for protecting pig intestines and stomach according to claim 1 is characterized in that: the raw materials comprise the following components: 23% of povidone, 5% of iodine, 2% of edible glycerin, 2.8% of hawthorn slices, 3.2% of potassium iodide and 64% of deionized water.

4. The nanometer povidone-iodine oral liquid for protecting pig intestines and stomach according to claim 1 is characterized in that: the raw materials comprise the following components: 25% of povidone, 5.6% of iodine, 1.3% of edible glycerin, 2.1% of hawthorn slices, 2.7% of potassium iodide and 63.3% of deionized water.

5. The nanometer povidone-iodine oral liquid for protecting pig intestines and stomach according to any one of claims 1 to 4, is characterized in that: the preparation method specifically comprises the following steps:

s1, putting the povidone, iodine and haw slices in a container according to the corresponding proportion, fully soaking, reacting, stirring, drying, grinding, extracting, heating and complexing;

s2, preparing deionized water with a corresponding proportion, adding the complexed solid in the S1 into the deionized water, fully vibrating and stirring the deionized water by using a vibration tank, adding edible glycerol and potassium iodide with a corresponding proportion into a deionized water mixed solution after the powder is completely dissolved, stirring the mixture for the second time by using a stirring rod, completely mixing and heating the mixture to 55-75 ℃ in a double-cone double-helix steam tank, and continuously circulating the mixture for three times at the temperature of 55-75 ℃ to obtain the nanometer povidone-iodine oral liquid;

and S3, cooling the nanometer povidone iodine oral liquid to be prepared in the step S2 to normal temperature by using a full-automatic liquid filling machine for filling, and finally labeling, sealing and packaging.

Technical Field

The invention relates to the technical field of veterinary drugs and pharmacy, in particular to a nanometer povidone iodine oral liquid for protecting pig intestines and stomach and a preparation method thereof.

Background

The stomach is the source of all diseases of animals, and the health of the pig stomach directly influences the morbidity of pigs. Early swine transmissible gastroenteritis is caused by swine transmissible gastroenteritis virus of bacteria and coronavirus, acute high-contact mucosal and intestinal infectious diseases, and is characterized by high fever, vomiting, severe diarrhea and dehydration.

Povidone iodine is a loose complex formed by combining element iodine and a polymer carrier, povidone iodine has the functions of carrier and dissolution aid, is amorphous powder from yellow brown to brownish red at normal temperature, is slightly smelly, is easily soluble in water or ethanol, is acidic in aqueous solution, is insoluble in diethyl ether, chloroform, acetone, ethane and carbon tetrachloride, has no defect of iodine tincture, is light in color, easy to elute, has no stimulation to mucous membranes, does not need ethanol for deiodination, has no corrosion effect, has low toxicity, is a broad-spectrum powerful sterilization disinfectant, has strong killing effect on viruses, bacteria, fungi and mould spores, has lasting effect, is safe and simple to use, has no stimulation to tissues basically, is used for disinfecting skin and mucous membranes, such as cleaning before operation, disinfecting operation parts and wounds, and is widely used in various fields at present. In the pig breeding process, particularly in the piglet growth process, a reagent for protecting the stomach and the intestine is required to be frequently filled so as to reduce the stomach and intestine diseases and ensure the normal growth of the piglets.

The existing iodine oral liquid for protecting the pig gastrointestinal tract is few, the povidone iodine oral liquid product diluted by the nano povidone iodine does not contain alcohol and any stabilizing agent, can protect the pig gastrointestinal tract through the pig gastrointestinal mucosa, and has the advantages of permeability and slow-release sterilization effect, and the sterilization effect is directly improved. The nanometer povidone iodine raw material is a key raw material for producing the nanometer povidone iodine oral liquid, and the raw material is a product which passes the GMP acceptance of the first domestic ministry of agriculture in 2007.

Disclosure of Invention

Technical problem to be solved

Aiming at the defects of the prior art, the invention provides the nanometer povidone iodine oral liquid for protecting the pig intestines and stomach and the preparation method thereof, and solves the problems of stability, effectiveness, safety, no residue and no withdrawal period of the existing iodine oral liquid for protecting the pig intestines and stomach, improves the sterilization capability to the pig intestines and stomach, can promote the digestion function of the pig intestines and stomach, and has simple preparation process and low cost.

(II) technical scheme

In order to achieve the purpose, the invention is realized by the following technical scheme: a nanometer povidone iodine oral liquid for protecting pig intestines and stomach comprises the following raw materials in percentage by weight: 20-25% of povidone, 4.5-5.6% of iodine, 1.3-2.5% of edible glycerol, 2.1-3.1% of hawthorn slices, 2.7-3.6% of potassium iodide and 60-80% of deionized water.

As a further preferable technical scheme of the invention, the raw materials comprise the following components in percentage by weight: 20% of povidone, 4.5% of iodine, 1.3% of edible glycerin, 2.1% of hawthorn slices, 2.7% of potassium iodide and 69.4% of deionized water.

As a further preferable technical scheme of the invention, the raw materials comprise the following components in percentage by weight: 23% of povidone, 5% of iodine, 2% of edible glycerin, 2.8% of hawthorn slices, 3.2% of potassium iodide and 64% of deionized water.

As a further preferable technical scheme of the invention, the raw materials comprise the following components in percentage by weight: 25% of povidone, 5.6% of iodine, 1.3% of edible glycerin, 2.1% of hawthorn slices, 2.7% of potassium iodide and 63.3% of deionized water.

The hawthorn has important medicinal value and has the effects of promoting digestion, invigorating stomach, promoting blood circulation, removing blood stasis, astringing, stopping dysentery, resisting oxidation, enhancing immunity and removing harmful bacteria in gastrointestinal tract.

The iodine function and thyroid hormone synthesis, thyroxine is an iodine-containing amino acid, thyroxine has the functions of regulating animal organism metabolic function and whole body oxidation process, thyroid gland has the functions of regulating substance metabolism and maintaining normal growth and development, and in the absence of iodine, because thyroxine synthesis and release are reduced, piglet growth and development are stagnated, the sexual maturity of growing pigs is delayed, the production and reproduction performance of adult pigs is reduced, fetus development is incomplete, and malformation occurs.

The potassium iodide can participate in the metabolism and inflammation diminishing of animals, and is a good assistant and stabilizer.

The edible glycerin is sweet and colorless, makes the food smooth and delicious, and has the special effects of high activity, oxidation resistance, alcoholization promotion and the like.

The strong sterilization mechanism is that the free iodine is slowly released in water, and the active group of the protoplasm protein of the pathogen is oxidized and can be combined with the amino acid of the protein to denature and shrink the protein so as to cause the cell death of the pathogen, thereby achieving the aim of sterilization and disinfection, and gradually decomposing the free iodine to play the role of inhibiting and sterilizing the intestines and stomach of the pig.

The invention also discloses a preparation method of the nanometer povidone iodine oral liquid for protecting the pig stomach and intestine, which comprises the following steps:

s1, putting the povidone, iodine and haw slices in a container according to the corresponding proportion, fully soaking, reacting, stirring, drying, grinding, extracting, heating and complexing;

s2, preparing deionized water with a corresponding proportion, adding the complexed solid in the S1 into the deionized water, fully vibrating and stirring the deionized water by using a vibration tank, adding edible glycerol and potassium iodide with a corresponding proportion into a deionized water mixed solution after the powder is completely dissolved, stirring the mixture for the second time by using a stirring rod, completely mixing and heating the mixture to 55-75 ℃ in a double-cone double-helix steam tank, and continuously circulating the mixture for three times at the temperature of 55-75 ℃ to obtain the nanometer povidone-iodine oral liquid;

and S3, cooling the nanometer povidone iodine oral liquid to be prepared in the step S2 to normal temperature by using a full-automatic liquid filling machine for filling, and finally labeling, sealing and packaging.

(III) advantageous effects

The invention provides a nanometer povidone iodine oral liquid for protecting pig intestines and stomach and a preparation method thereof. Compared with the prior art, the method has the following beneficial effects:

1. the povidone iodine oral liquid is prepared from povidone and iodine raw materials, has the function of repairing intestinal tracts, and has remarkable bactericidal and antiviral effects: 1. safety test, Lide PVP-I iodine oral liquid is nontoxic (LD50 is more than 10000mg/kg BW); 2. in a sterilization test, 0.1% of Lide PVP-I (0.1%) iodine oral liquid kills escherichia coli and staphylococcus aureus, and Lide PVP-I accounts for 1: 600 dilution, namely 1.6 PPM acts on the Escherichia coli for 1 minute, the sterilization effect reaches 99.92 percent, the same concentration acts on the staphylococcus aureus for 1 minute, and the same can reach 99.94 percent. 800 times diluted to 99 in 3 min. 97 percent. The action time is 5 minutes, and the killing log value of the bacillus coli and the staphylococcus aureus is more than 5.00. Antifungal candida albicans test, clerical 0.1% 1: the standard is reached after 100 dilutions of 9.6 PPM1 minutes, 99.99%. 1: 150 times of 5 minutes also reaches 99.98%; 3. and (3) a stability test, namely placing the Lide PVP-I (0.1%) iodine oral liquid in a 37-DEG incubator for 3 months (a two-year test on the validity period), wherein the reduction rate of the content of available iodine is 0.11%.

2. The iodine oral liquid does not use alcohol, hydrochloric acid, sulfuric acid and phosphoric acid as solvents, and the problems of large irritation, unsafety and the like commonly existing in the iodine oral liquid are thoroughly solved.

3. The composition can effectively block viruses to kill various germs, repair intestinal tracts, adjust the flora structure of the intestinal tracts, has no residue, can not cause livestock and poultry poisoning after long-term use, can be used for preventing and treating intestinal diseases by drinking water, has strong killing effect on viral, bacterial and fungal diseases and the like, can kill the pathogens once contacting, has the killing efficiency of 99.99 percent on microorganisms within 30 to 60 seconds, can kill the microorganisms after being diluted by 100 times, and has the effect of 50 to 100 times of that of similar products.

4. The raw materials have stable performance, and the change of conditions such as illumination, ion concentration, pH value and the like has little influence on the raw materials, can be packaged by a completely transparent container, and has the effective period of more than 2 years.

5. The hawthorn can invigorate spleen, stimulate appetite, digest and remove food stagnation, the iodine is used for supplementing iodine components and preventing iodine deficiency, the oral liquid is simple to prepare, convenient to popularize and low in preparation cost, and can be added into pig food to be mixed for eating.

Detailed Description

The technical solutions in the embodiments of the present invention will be clearly and completely described below, and it is obvious that the described embodiments are only a part of the embodiments of the present invention, and not all embodiments. All other embodiments, which can be derived by a person skilled in the art from the embodiments given herein without making any creative effort, shall fall within the protection scope of the present invention.

The embodiment of the invention provides three technical schemes: a preparation method of a nanometer povidone iodine oral liquid for protecting pig intestines and stomach specifically comprises the following embodiments: