阅读说明：本技术 一种接骨用钛钉的表面处理工艺及钛钉 (Surface treatment process of titanium nail for bone setting and titanium nail ) 是由 徐仲棉 徐益波 张立法 于 2019-10-18 设计创作，主要内容包括：一种接骨用钛钉的表面处理工艺及钛钉,通过对钛钉表面进行粗化处理,包括喷砂、酸蚀、喷砂和酸蚀相结合、阳极氧化、微弧氧化或阳极氧化和微弧氧化相结合中的一种,使表面获得粗糙或多孔结构,然后采用冻干的方式去除粗糙或多孔结构内部的残留液体,再进行真空抽滤方式进行透明质酸,从而使钛钉表面具有仰制骨质表面粘附性生长的特定能力,使钛钉驱除与骨生物较好的相容性,最终获得轻松的取钉效果,减少手术时间及患者痛苦。(A surface treatment process of a titanium nail for bone setting and the titanium nail are provided, the surface of the titanium nail is roughened, the roughening treatment comprises one of sand blasting, acid etching, combination of sand blasting and acid etching, anodic oxidation, micro-arc oxidation or combination of anodic oxidation and micro-arc oxidation, so that a rough or porous structure is obtained on the surface, then residual liquid inside the rough or porous structure is removed in a freeze-drying mode, and hyaluronic acid is carried out in a vacuum filtration mode, so that the surface of the titanium nail has the specific capacity of inhibiting the adhesion growth of a bone surface, the titanium nail is prevented from having better compatibility with bone organisms, the easy nail taking effect is finally obtained, and the operation time and the pain of a patient are reduced.)

1. A surface treatment process of a titanium nail for bone setting is characterized by comprising the following steps:

1) soaking a titanium nail sample by using one or more of absolute ethyl alcohol, acetone or a metal surface degreasing agent, and then carrying out ultrasonic cleaning to remove stains on the surface of the sample;

2) roughening the surface of the titanium nail sample, wherein the roughening treatment comprises one of a sand blasting process, an acid etching process, a combination of the sand blasting process and the acid etching process, an anodic oxidation process, a micro-arc oxidation process or a combination of the anodic oxidation process and the micro-arc oxidation process, so that the surface of the titanium nail sample is in a porous structure;

3) carrying out freeze-drying treatment on the titanium nail sample subjected to the roughening treatment so as to remove residual liquid in a porous structure on the surface of the titanium nail sample;

4) and carrying out a vacuum suction filtration hyaluronic acid loading process on the surface of the titanium nail sample, so that the hyaluronic acid is attached in the porous structure.

2. The surface treatment process of the bone-knitting titanium nail according to claim 1, characterized in that: the sand blasting process comprises the following steps: selecting sand grains with the size of 40-100 meshes, continuously carrying out sand blasting on the surface of the titanium nail sample in the environment with the air pressure of 0.2-0.8 Mpa for 1-5 minutes, and then putting the titanium nail sample into pure water for cleaning and drying.

3. The surface treatment process of the bone-knitting titanium nail according to claim 1, characterized in that: the acid etching process comprises the following steps: and (3) putting the titanium nail sample into a solution containing sulfuric acid, hydrochloric acid and hydrofluoric acid for 5-30 minutes, and then putting the titanium nail sample into pure water for cleaning and drying.

4. The surface treatment process of the bone-knitting titanium nail according to claim 1, characterized in that: the anodic oxidation process comprises the following steps: and (3) putting the titanium nail sample into the anodic oxidation electrolyte, continuously oxidizing for 3-30 minutes under the voltage of 20-100V, and then putting the titanium nail sample into pure water for cleaning and drying.

5. The surface treatment process of the bone-knitting titanium nail according to claim 1, characterized in that: the micro-arc oxidation process comprises the following steps: placing the titanium nail sample into the electrolyte of micro-arc oxidation, wherein the cut-off voltage of the micro-arc oxidation power supply parameters is 360V-480V, and the current density is 0.05mA/cm²～0.7 mA/cm²The reaction time is 30-200S, and after the reaction is finished, the reaction product is put into pure water for cleaning and drying.

6. The surface treatment process of the bone-knitting titanium nail according to claim 1, characterized in that: the freeze-drying treatment comprises the following steps:

1) setting the temperature of a cold trap of a freeze dryer at-20 ℃ and carrying out continuous pre-cooling for 0.5-1 hour;

2) the titanium nail sample is put into a vacuum chamber of a freeze dryer for sealing and then is pumped, and meanwhile, the temperature of a cold trap of the freeze dryer is reduced to minus 40 ℃ to minus 50 ℃;

3) starting timing when the internal vacuum degree is 13-15 Pa after air extraction, and continuing for 1-10 hours;

4) and taking out the titanium nail sample after the end.

7. The surface treatment process of the bone-knitting titanium nail according to claim 6, characterized in that: the titanium nail sample is frozen for 12-24 hours at-18 to-80 ℃ before being placed in a vacuum chamber of a freeze dryer.

8. The surface treatment process of the bone-knitting titanium nail according to any one of claims 1 to 7, characterized in that: the vacuum filtration hyaluronic acid loading process comprises the following steps:

1) preparing a hyaluronic acid solution;

2) soaking a part or the whole surface of the coated sample by using the prepared hyaluronic acid solution by one or more methods of dripping, spin coating and soaking;

3) placing the coated titanium nail sample in a vacuum chamber of a freeze dryer, a vacuum drying box or a suction filtration funnel for air suction;

4) starting timing when the air is pumped until the internal vacuum degree is 10-20 Pa, and continuing for 0.2-10 hours;

5) after the air pumping is finished, emptying the vacuum chamber, the vacuum drying box or the suction filtering funnel of the freeze dryer to instantly increase the internal pressure to the atmospheric pressure;

6) the sample was removed.

9. A titanium nail for setting a bone is characterized in that: the titanium nail is processed by the surface treatment process of the titanium nail for bone fracture according to any one of claims 1 to 8.

Technical Field

The invention relates to the field of medical instruments, in particular to a titanium nail for bone setting and a surface treatment process of the titanium nail.

Background

The titanium nail mentioned in the text is a fixing nail applied to medical instruments, and is matched with a bone fracture plate for use to realize the fixation of fracture and bone blocks, and the effect is obvious.

However, when the existing titanium-based material orthopedic implantation nail (i.e. titanium nail) is taken out after recovery, the titanium-based material has better biocompatibility, so that the nail is difficult to take out or cannot be taken out, great nail taking risk hidden danger is brought to an operator, and secondary pain is brought to the patient.

Disclosure of Invention

In order to overcome the defects in the prior art, the invention provides a surface treatment process of a titanium nail for bone setting, which removes biocompatibility between the titanium nail and a human body through the surface treatment of the titanium nail.

The technical scheme for solving the technical problem is as follows: a surface treatment process of an inert titanium nail for bone setting comprises the following steps:

1) soaking a titanium nail sample by using one or more of absolute ethyl alcohol, acetone or a metal surface degreasing agent, and then carrying out ultrasonic cleaning to remove stains on the surface of the sample;

2) roughening the surface of the titanium nail sample, wherein the roughening treatment comprises one of a sand blasting process, an acid etching process, a combination of the sand blasting process and the acid etching process, an anodic oxidation process, a micro-arc oxidation process or a combination of the anodic oxidation process and the micro-arc oxidation process, so that the surface of the titanium nail sample is in a porous structure;

3) carrying out freeze-drying treatment on the titanium nail sample subjected to the roughening treatment so as to remove residual liquid in a porous structure on the surface of the titanium nail sample;

4) and carrying out a vacuum suction filtration hyaluronic acid loading process on the surface of the titanium nail sample, so that the hyaluronic acid is attached in the porous structure.

Further, the sand blasting process comprises the following steps: selecting sand grains with the size of 40-100 meshes, continuously carrying out sand blasting on the surface of the titanium nail sample in the environment with the air pressure of 0.2-0.8 Mpa for 1-5 minutes, and then putting the titanium nail sample into pure water for cleaning and drying. The titanium nail surface porous structures with different sizes can be formed in the sand blasting process, and the size and the number of the titanium nail surface porous structures are in direct proportion to the size of the sand grain mesh number, the air pressure and the duration.

Further, the acid etching process comprises the following steps: and (3) putting the titanium nail sample into a solution containing sulfuric acid, hydrochloric acid and hydrofluoric acid for 5-30 minutes, and then putting the titanium nail sample into pure water for cleaning and drying. In the acid etching process, the size and the number of the porous structures on the surface of the titanium nail are in direct proportion to the time of putting the titanium nail into the solution.

Further, the anodic oxidation process comprises: and (3) putting the titanium nail sample into the anodic oxidation electrolyte, continuously oxidizing for 3-30 minutes under the voltage of 20-100V, and then putting the titanium nail sample into pure water for cleaning and drying. In the anodic oxidation process, the size and the number of the porous structures on the surface of the titanium nail are in direct proportion to the voltage and the continuous oxidation time of anodic oxidation.

Further, the micro-arc oxidation process comprises the following steps: placing the titanium nail sample into the electrolyte of micro-arc oxidation, wherein the cut-off voltage of the micro-arc oxidation power supply parameters is 360V-480V, and the current density is 0.05mA/cm²～0.7 mA/cm²The reaction time is 30-200S, and after the reaction is finished, the reaction product is put into pure water for cleaning and drying. In the micro-arc oxidation process, the size and the number of the porous structures on the surface of the titanium nail are in direct proportion to the cut-off voltage and the reaction time in the micro-arc oxidation and in inverse proportion to the current density.

Further, the lyophilization process comprises:

1) setting the temperature of a cold trap of a freeze dryer at-20 ℃ and carrying out continuous pre-cooling for 0.5-1 hour;

2) the titanium nail sample is put into a vacuum chamber of a freeze dryer for sealing and then is pumped, and meanwhile, the temperature of a cold trap of the freeze dryer is reduced to minus 40 ℃ to minus 50 ℃;

3) starting timing when the internal vacuum degree is 13-15 Pa after air extraction, and continuing for 1-10 hours;

4) and taking out the titanium nail sample after the end. Residual liquid in the porous structure can be effectively removed through a freeze-drying process, and the dryness and tidiness in the porous structure of the sample are guaranteed.

Preferably, the titanium nail sample is frozen for 12-24 hours at-18 to-80 ℃ before being placed in a vacuum chamber of a freeze dryer, so that the titanium nail sample has better drying property.

Further, the vacuum filtration hyaluronic acid loading process comprises the following steps:

1) preparing a hyaluronic acid solution;

2) soaking a part or the whole surface of the coated sample by using the prepared hyaluronic acid solution by one or more methods of dripping, spin coating and soaking;

3) placing the coated titanium nail sample in a vacuum chamber of a freeze dryer, a vacuum drying box or a suction filtration funnel for air suction;

4) when the air is pumped to the internal vacuum degree of 10-20 Pa, the timing is started and lasts for 0.2-10 hours. When the pressure and the duration time of the vacuum degree in the air exhaust are increased, the effect of attaching the hyaluronic acid on the porous structure is better.

5) After the air pumping is finished, emptying the vacuum chamber, the vacuum drying box or the suction filtering funnel of the freeze dryer to instantly increase the internal pressure to the atmospheric pressure;

6) the sample was removed.

The titanium nail for setting bones is prepared by the surface treatment process of each titanium nail for setting bones.

The invention has the beneficial effects that: the surface of the titanium nail is roughened, wherein the roughening treatment comprises one of sand blasting, acid etching, combination of sand blasting and acid etching, anodic oxidation, micro-arc oxidation or combination of anodic oxidation and micro-arc oxidation, so that a rough or porous structure is obtained on the surface, then residual liquid inside the rough or porous structure is removed in a freeze-drying mode, and hyaluronic acid is carried out in a vacuum filtration mode, so that the surface of the titanium nail has the specific capacity of inhibiting the adhesion growth of a bone surface, the titanium nail is removed and has better compatibility with bone organisms, the easy nail taking effect is finally obtained, and the operation time and the pain of a patient are reduced.

Drawings

None.

Detailed Description

The present invention will be described in further detail with reference to specific embodiments.

A surface treatment process of a titanium nail for bone setting comprises the following steps: