Biochemical detection equipment
阅读说明:本技术 一种生化检测设备 (Biochemical detection equipment ) 是由 张清 于 2019-10-28 设计创作,主要内容包括:本发明公开了一种生化检测设备,属于快速诊断技术领域。所述生化检测设备包括基板和设于所述基板上的:液体通道,所述液体通道包括相互连通的进液通道和反应通道;定标通道,其与所述反应通道相连通,定标试剂能通过所述定标通道流入所述反应通道;气体通道,其与所述进液通道连通,气体能经由所述气体通道驱动所述进液通道内的液体流动至所述反应通道;检测试纸,所述检测试纸上的反应电极伸入所述反应通道内。本发明通过设置相互连通的气体通道和液体通道,使得样本能够在气体的推动作用下方便地由进液通道流至反应通道,采用气动方式驱动样本流动,操作简单方便,同时也简化了生化检测设备的制造工艺,降低了成本。(The invention discloses biochemical detection equipment, and belongs to the technical field of rapid diagnosis. The biochemical detection device comprises a substrate and arranged on the substrate: the liquid channel comprises a liquid inlet channel and a reaction channel which are communicated with each other; a calibration channel in communication with said reaction channel through which a calibration reagent can flow into said reaction channel; a gas channel which is communicated with the liquid inlet channel, wherein gas can drive liquid in the liquid inlet channel to flow to the reaction channel through the gas channel; and the reaction electrode on the detection test paper extends into the reaction channel. The invention has the advantages that the gas channel and the liquid channel which are communicated with each other are arranged, so that a sample can conveniently flow from the liquid inlet channel to the reaction channel under the pushing action of gas, the sample is driven to flow in a pneumatic mode, the operation is simple and convenient, meanwhile, the manufacturing process of biochemical detection equipment is simplified, and the cost is reduced.)
1. A biochemical detection apparatus, comprising a substrate (100) and, provided on the substrate (100):
a liquid channel including a liquid inlet channel (200) and a reaction channel (300) which are communicated with each other;
a calibration channel (400) in communication with said reaction channel (300), calibration reagent being flowable into said reaction channel (300) through said calibration channel (400);
a gas channel (600) communicating with the inlet channel (200), gas being capable of driving the liquid in the inlet channel (200) to flow to the reaction channel (300) via the gas channel (600);
and the reaction electrode on the detection test paper (800) extends into the reaction channel (300).
2. The biochemical detection apparatus according to claim 1, further comprising a waste channel (500) disposed on the substrate (100), wherein the waste channel (500) is in communication with the reaction channel (300), and the liquid in the reaction channel (300) can flow to the waste channel (500) under the driving of gas.
3. The biochemical detection apparatus according to claim 1 or 2, further comprising a pneumatic drive mechanism (1), the pneumatic drive mechanism (1) comprising:
the air bag (12) is arranged inside the substrate (100) and communicated with the gas channel (600), and gas is stored inside the air bag (12);
the driving piece (13) is used for pressing the air bag (12) so that the gas in the air bag (12) is output from the gas channel (600) to drive the liquid in the liquid channel.
4. The biochemical detection apparatus according to claim 3, wherein the substrate (100) has a storage cavity (11), the airbag (12) is located in the storage cavity (11), the storage cavity (11) has a through hole (14) communicating with the outside, and the driving element (13) is a thin sheet disposed between the airbag (12) and the through hole (14), and pressing the thin sheet can output the gas in the airbag (12) through the gas channel (600).
5. The biochemical detection apparatus according to claim 1, further comprising a calibration reagent storage mechanism (4), wherein the calibration reagent storage mechanism (4) comprises a reservoir (41) disposed on the substrate (100) and a calibration reagent pack (42) disposed in the reservoir (41), the reservoir (41) is in communication with the calibration channel (400), the calibration reagent pack (42) stores the calibration reagent, and the calibration reagent in the calibration reagent pack (42) flows out of the calibration channel (400) after being released.
6. The biochemical detection apparatus according to claim 5, wherein the reservoir (41) has a bottom provided with a lancet (43), the reservoir (41) is an open slot, and the calibration reagent pack (42) is pressed such that the lancet (43) punctures the calibration reagent pack (42) to release the calibration reagent.
7. Biochemical detection apparatus according to claim 6, wherein the lance (43) is of a pyramidal structure, and the targeting channel (400) extends along a side wall of the reservoir (41) onto the lance (43).
8. The biochemical detection apparatus according to claim 1, wherein the gas channel (600) and the liquid channel are both grooves opened on the same side of the substrate (100), and the grooves are sealed by a cover member (700); a sample inlet (701) is formed in the covering piece (700), and the sample inlet (701) is communicated with the liquid inlet channel (200).
9. The biochemical detection apparatus according to claim 8, further comprising a sealing mechanism (5), wherein the sealing mechanism (5) comprises a sliding slot (51) disposed on the substrate (100) and a sliding block (52) slidably disposed in the sliding slot (51), the sliding block (52) is connected to a sealing block (53) after extending from the sliding slot (51), the sliding block (52) drives the sealing block (53) to slide to the sample inlet (701), and the sealing block (53) blocks the sample inlet (701).
10. The biochemical detection apparatus according to claim 9, wherein one of two ends of the sealing block (53) along the sliding direction is connected to the slider (52), and the other end is suspended, one channel plate (54) is protruded from each of the substrates (100) at two sides of the sliding slot (51), protrusions (533) are disposed at two sides of the middle portion of the sealing block (53), each protrusion (533) corresponds to one channel plate (54), and the height of the bottom surface of each protrusion (533) is smaller than the height of the top surface of the channel plate (54).
11. The biochemical detection apparatus according to claim 1, wherein a first isolation step (2) is disposed between the reaction channel (300) and the inlet channel (200), and a height of the first isolation step (2) is higher than a height of a bottom surface of the reaction channel (300) and the inlet channel (200).
12. The biochemical detection apparatus according to claim 11, wherein the first isolation step (2) is smoothly transited to the bottom surface of the inlet channel (200), and the first isolation step (2) is smoothly transited to the bottom surface of the reaction channel (300).
13. The biochemical detection apparatus according to claim 2, wherein a second isolation step (3) is disposed between the reaction channel (300) and the waste channel (500), and the height of the second isolation step (3) is higher than the height of the bottom surfaces of the reaction channel (300) and the waste channel (500).
14. The biochemical detection apparatus according to claim 13, wherein the second isolation step (3) is smoothly transited to the bottom surface of the inlet channel (200), and the second isolation step (3) is smoothly transited to the bottom surface of the reaction channel (300).
15. The biochemical detection apparatus according to claim 1, wherein the reaction electrode on the detection test paper (800) is provided in plurality.
Technical Field
The invention relates to the technical field of rapid diagnosis, in particular to biochemical detection equipment.
Background
Point-of-care testing (POCT) refers to a new method for rapidly obtaining a test result by performing clinical tests near a patient and performing analysis immediately at a sampling site, thereby eliminating a complicated processing procedure of a specimen during laboratory tests. POCT products have become one of the most important branches of development and the fastest growing fields in the in vitro diagnostic products (IDV) industry. The POCT product starts late in the market of China, has smaller market scale at present, but with the development of public health service of China, the POCT product plays a great market potential and application space in the aspects of on-site rapid inspection of operating rooms/emergency treatment/guardianship rooms in hospitals, construction of medical institutions in remote areas and the like.
Different from the traditional large-scale in-vitro diagnosis equipment, the POCT product does not need operators to collect a large number of samples for centralized processing, but directly diagnoses individual samples on a sampling site to quickly obtain the biochemical detection result of the samples. However, in the existing POCT products, most samples flow by adopting a siphon effect, the siphon effect has high requirements on the length and the section size of a liquid channel, the manufacturing process is complex, and the operation of a user side is also troublesome; in addition, the traditional POCT product is difficult to acquire a sample once and measure a plurality of biological and chemical indexes simultaneously.
Therefore, it is desirable to provide a biochemical detection apparatus to solve the above problems.
Disclosure of Invention
The invention aims to provide biochemical detection equipment which is simple in manufacturing process and convenient to operate and can realize detection of a plurality of biochemical indexes.
In order to realize the purpose, the following technical scheme is provided:
a biochemical detection apparatus comprising a substrate and, disposed on the substrate:
the liquid channel comprises a liquid inlet channel and a reaction channel which are communicated with each other;
a calibration channel in communication with said reaction channel through which a calibration reagent can flow into said reaction channel;
a gas channel which is communicated with the liquid inlet channel, wherein gas can drive liquid in the liquid inlet channel to flow to the reaction channel through the gas channel;
and the reaction electrode on the detection test paper extends into the reaction channel.
As a preferable technical scheme, the device further comprises a waste liquid channel arranged on the substrate, the waste liquid channel is communicated with the reaction channel, and liquid in the reaction channel can flow to the waste liquid channel under the driving of gas.
As a preferred technical solution, the pneumatic driving device further comprises a pneumatic driving mechanism, and the pneumatic driving mechanism comprises:
the air bag is arranged in the substrate and communicated with the gas channel, and gas is stored in the air bag;
and the driving piece is used for pressing the air bag so as to enable the gas in the air bag to be output from the gas channel and drive the liquid in the liquid channel.
According to the preferable technical scheme, the base plate is provided with an object placing cavity, the air bag is located in the object placing cavity, the object placing cavity is provided with a through hole communicated with the outside, the driving piece is a sheet arranged between the air bag and the through hole, and the sheet is pressed to enable gas in the air bag to be output through the gas channel.
Preferably, the device further comprises a calibration reagent storage mechanism, wherein the calibration reagent storage mechanism comprises a liquid storage tank arranged on the substrate and a calibration reagent pack arranged in the liquid storage tank, the liquid storage tank is communicated with the calibration channel, the calibration reagent pack stores the calibration reagent, and the calibration reagent in the calibration reagent pack flows out from the calibration channel after being released.
As a preferable technical scheme, a pricker is arranged at the bottom of the liquid storage tank, the liquid storage tank is an open slot, and the scaling reagent bag is pressed to enable the pricker to pierce the scaling reagent bag so as to release the scaling reagent.
As a preferred technical scheme, the puncture needle is of a pyramid structure, and the scaling channel extends to the puncture needle along the side wall of the liquid storage tank.
As a preferred technical scheme, the gas channel and the liquid channel are both grooves formed in the same side of the substrate, and the grooves are sealed by covering parts; the covering piece is provided with a sample inlet which is communicated with the liquid inlet channel.
As the preferred technical scheme, the biochemical detection equipment further comprises a sealing mechanism, wherein the sealing mechanism comprises a sliding groove arranged on the substrate and a sliding block arranged in the sliding groove, the sliding block is connected with a sealing block after the sliding groove stretches out, the sliding block drives the sealing block to slide to the rear of the sample inlet, and the sealing block seals the sample inlet.
As a preferred technical scheme, one end of the two ends of the sealing block along the sliding direction is connected with the sliding block, the other end of the sealing block is suspended, the two side substrates of the sliding chute are respectively provided with a channel plate in a protruding manner, the two sides of the middle part of the sealing block are provided with protrusions, each protrusion corresponds to one channel plate, and the height of the bottom surface of each protrusion is smaller than that of the top surface of the channel plate.
As a preferred technical scheme, a first isolation step is arranged between the reaction channel and the liquid inlet channel, and the height of the first isolation step is higher than the height of the bottom surfaces of the reaction channel and the liquid inlet channel.
As a preferable technical solution, the first isolation step is in smooth transition with the bottom surface of the liquid inlet channel, and the first isolation step is also in smooth transition with the bottom surface of the reaction channel.
As a preferable technical scheme, a second isolation step is arranged between the reaction channel and the waste liquid channel, and the height of the second isolation step is higher than the height of the bottom surfaces of the reaction channel and the waste liquid channel.
As a preferable technical solution, the second isolation step is in smooth transition with the bottom surface of the liquid inlet channel, and the second isolation step is also in smooth transition with the bottom surface of the reaction channel.
Preferably, the reaction electrodes on the test strip are provided in plurality.
Compared with the prior art, the invention has the beneficial effects that:
according to the invention, the gas channel and the liquid channel which are communicated with each other are arranged, so that a sample can conveniently flow from the liquid inlet channel to the reaction channel under the pushing action of gas; the sample is driven to flow by adopting a pneumatic driving mode, the operation is simple and convenient, the strict requirement on the manufacturing process when the liquid flow is completed by adopting the siphon effect in the prior art is also overcome, the manufacturing process of biochemical detection equipment is simplified, and the production cost is reduced.
Drawings
FIG. 1 is a schematic structural diagram of a biochemical detection apparatus according to an embodiment of the present invention;
FIG. 2 is a front view of a biochemical detection apparatus according to an embodiment of the present invention;
FIG. 3 is a schematic view of a part of the structure of the biochemical detecting apparatus according to the embodiment of the present invention;
FIG. 4 is a schematic cross-sectional view of a biochemical detection apparatus according to an embodiment of the present invention;
FIG. 5 is a schematic structural view of a seal in an embodiment of the present invention;
fig. 6 is a partially enlarged schematic view of a portion a of fig. 1.
Reference numerals:
100-a substrate; 101-detection end plate; 102-a handheld end plate;
200-a liquid inlet channel; 300-a reaction channel; 400-scaling the channel; 500-a waste channel; 600-a gas channel;
700-a cover; 701-a sample inlet; 800-detection test paper;
1-a pneumatic drive mechanism; 11-a storage cavity; 12-an air bag; 13-a drive member; 14-a through hole;
2-a first isolation step; 3-a second isolation step;
4-a calibration reagent storage mechanism; 41-a liquid storage tank; 42-scaling reagent pack; 43-a needle;
5-a sealing mechanism; 51-a chute; 52-a slide block; 53-sealing block; 531-a drive section; 532-sealing part; 5321-a seal; 533-projection; 54-channel plate.
Detailed Description
In order to make the objects, technical solutions and advantages of the embodiments of the present invention clearer, the technical solutions in the embodiments of the present invention will be clearly and completely described below with reference to the drawings in the embodiments of the present invention, and it is obvious that the described embodiments are some, but not all, embodiments of the present invention. The components of embodiments of the present invention generally described and illustrated in the figures herein may be arranged and designed in a wide variety of different configurations.
Thus, the following detailed description of the embodiments of the present invention, presented in the figures, is not intended to limit the scope of the invention, as claimed, but is merely representative of selected embodiments of the invention. That is, the examples of the present invention are only examples for clearly illustrating the present invention, and are not intended to limit the embodiments of the present invention. Other variations and modifications will be apparent to persons skilled in the art in light of the above description. And are neither required nor exhaustive of all embodiments. Any modification, equivalent replacement, and improvement made within the spirit and principle of the present invention should be included in the protection scope of the claims of the present invention. That is, all other embodiments obtained by a person skilled in the art based on the embodiments of the present invention without any inventive step are within the scope of the present invention.
It should be noted that: like reference numbers and letters refer to like items in the following figures, and thus, once an item is defined in one figure, it need not be further defined and explained in subsequent figures.
In the description of the present invention, it should be noted that the terms "center", "upper", "lower", "left", "right", "vertical", "horizontal", "inner", "outer", etc. indicate orientations or positional relationships based on the orientations or positional relationships shown in the drawings or the orientations or positional relationships that the products of the present invention are conventionally placed in use, and are only used for convenience in describing the present invention and simplifying the description, but do not indicate or imply that the devices or elements referred to must have a specific orientation, be constructed and operated in a specific orientation, and thus, should not be construed as limiting the present invention. Furthermore, the terms "first," "second," "third," and the like are used solely to distinguish one from another and are not to be construed as indicating or implying relative importance. Wherein the terms "first position" and "second position" are two different positions. In the description of the present invention, "a plurality" means two or more unless otherwise specified.
In the description of the present invention, it should also be noted that, unless otherwise explicitly specified or limited, the terms "disposed" and "connected" are to be interpreted broadly, e.g., as being either fixedly connected, detachably connected, or integrally connected; either mechanically or electrically. The specific meanings of the above terms in the present invention can be understood in specific cases to those skilled in the art.
In the present invention, unless otherwise expressly stated or limited, "above" or "below" a first feature means that the first and second features are in direct contact, or that the first and second features are not in direct contact but are in contact with each other via another feature therebetween. Also, the first feature being "on," "above" and "over" the second feature includes the first feature being directly on and obliquely above the second feature, or merely indicating that the first feature is at a higher level than the second feature. A first feature being "under," "below," and "beneath" a second feature includes the first feature being directly under and obliquely below the second feature, or simply meaning that the first feature is at a lesser elevation than the second feature.
Reference will now be made in detail to embodiments of the present invention, examples of which are illustrated in the accompanying drawings, wherein like or similar reference numerals refer to the same or similar elements or elements having the same or similar function throughout. The embodiments described below with reference to the accompanying drawings are illustrative only for the purpose of explaining the present invention, and are not to be construed as limiting the present invention.
As shown in fig. 1 to 3, the present embodiment provides a biochemical test device, which includes a
The biochemical detection device further comprises a
Referring to fig. 4, the biochemical detection apparatus further includes a pneumatic driving mechanism 1, which specifically includes an air bag 12 and a driving member 13, the air bag 12 is disposed inside the
Referring to fig. 3 again, in order to ensure that the
In order to avoid the sample in the
Referring to FIG. 1, in the present embodiment, the biochemical detecting apparatus further includes a scale reagent storage mechanism 4 for storing a scale reagent. Referring to fig. 2 and 3, the calibration reagent storage mechanism 4 includes a
In this embodiment, the
Optionally, referring to fig. 5 again, the sealing
Further, referring to fig. 5 and 6, a
In this embodiment, optionally, the
In this embodiment, the
In summary, the biochemical detection device provided in this embodiment can be used in a variety of medical scenes by cooperating with the diagnostic device, so as to implement rapid detection in the operating room, emergency treatment or monitoring room of a hospital, and meet the requirement of high-efficiency fast-paced working modes.
Specifically, the biochemical detection device provided by this embodiment includes the following steps:
1) filling a sample into the
2) pushing the sealing element to finish sealing after the
3) inserting the
4) the corresponding mechanism arranged in the diagnostic device presses down the
5) after calibration is completed, the diagnostic device is also provided with a corresponding mechanism to press the driving part 13 and the air bag 12, so that the sample is pushed to the
It is to be noted that the foregoing is only illustrative of the preferred embodiments of the present invention and the technical principles employed. It will be understood by those skilled in the art that the present invention is not limited to the particular embodiments described herein, but is capable of various obvious changes, rearrangements and substitutions as will now become apparent to those skilled in the art without departing from the scope of the invention. Therefore, although the present invention has been described in greater detail by the above embodiments, the present invention is not limited to the above embodiments, and may include other equivalent embodiments without departing from the spirit of the present invention, and the scope of the present invention is determined by the scope of the appended claims.
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