阅读说明：本技术 包含药代动力学增强子的修饰的松弛素多肽及其用途 (Modified relaxin polypeptides comprising pharmacokinetic enhancers and uses thereof ) 是由 G·M·杜波奇克 O·S·古德蒙森 X·韩 R·M·劳伦斯 D·利波夫斯克 C·S·马德森 于 2018-02-08 设计创作，主要内容包括：本公开总体上涉及包含与药代动力学增强子连接的非天然编码氨基酸的修饰的松弛素多肽,如修饰的人松弛素2多肽,以及这样的多肽的治疗用途,例如用于治疗心血管病症(例如心力衰竭)和/或与纤维化相关的病症。(The present disclosure relates generally to modified relaxin polypeptides, such as modified human relaxin 2 polypeptides, comprising a non-naturally encoded amino acid linked to a pharmacokinetic enhancer, and therapeutic uses of such polypeptides, for example for treating cardiovascular disorders (e.g., heart failure) and/or disorders associated with fibrosis.)