阅读说明：本技术 样品处理装置 (Sample processing device ) 是由 长冈嘉浩 山崎基博 于 2018-05-11 设计创作，主要内容包括：本发明提供一种样品处理装置,其包括在下表面侧具有流路的分析芯片、在上表面侧具有多个凹部的驱动部、位于分析芯片与驱动部之间的弹性膜、切换弹性膜向分析芯片侧紧贴还是向驱动部侧紧贴的气压控制部,其中,分析芯片包括用于液体的定量的定量流路和从该定量流路分支的至少4条分支流路,驱动部在4条分支流路中的非定量流路侧的端部各自的下方具有凹部,各个凹部与气压控制部连通。(The invention provides a sample processing device, which comprises an analysis chip having a flow path on the lower surface side, a drive part having a plurality of concave parts on the upper surface side, an elastic membrane positioned between the analysis chip and the drive part, and an air pressure control part for switching between the close contact of the elastic membrane to the analysis chip side and the close contact to the drive part side, wherein the analysis chip comprises a quantitative flow path for quantitative determination of liquid and at least 4 branch flow paths branched from the quantitative flow path, the drive part has a concave part below each end part of the non-quantitative flow path side of the 4 branch flow paths, and each concave part is communicated with the air pressure control part.)

1. A sample processing device comprising an analysis chip having a flow path on a lower surface side, a drive section having a plurality of concave sections on an upper surface side, an elastic membrane positioned between the analysis chip and the drive section, and an air pressure control section for switching between contact of the elastic membrane with the analysis chip side and contact with the drive section side, the sample processing device characterized in that:

the analysis chip includes a quantitative flow path for quantification of a liquid and at least 4 branch flow paths branched from the quantitative flow path,

the driving part has a concave part below each end part of the 4 branch flow paths on the non-quantitative flow path side,

each concave portion communicates with the air pressure control portion.

2. The sample processing device of claim 1, wherein:

2 of the 4 branch flow paths are liquid feeding flow paths for feeding liquid, the remaining 2 branch flow paths are gas feeding flow paths for feeding gas,

the liquid supply channel further has a set of channels and recesses on the upstream side or the downstream side, and the gas supply channel further has a set of channels and recesses on the upstream side or the downstream side, and these recesses are also communicated with the gas pressure control section.

3. The sample processing device of claim 1, wherein:

2 of the 4 branch flow paths are liquid feeding flow paths for feeding liquid, the remaining 2 branch flow paths are gas feeding flow paths for feeding gas,

the liquid supply channel further includes two sets of channels and recesses on the upstream side or the downstream side, and the air supply channel further includes two sets of channels and recesses on the upstream side or the downstream side, and these recesses are also communicated with the air pressure control unit.

4. A sample processing device as claimed in claim 2 or 3, wherein:

the operation of the elastic membrane is controlled by the air pressure control part, and the liquid is conveyed to the concave part at the downstream side.

5. A sample processing device as claimed in any one of claims 2 to 4, wherein:

the liquid in the quantitative flow path is filled with the liquid using the liquid feeding flow path, and then the liquid in the quantitative flow path is made to flow to the downstream side using the air feeding flow path.

6. A sample processing device as claimed in any one of claims 2 to 4, wherein:

a pair of branch flow paths and a concave portion are further provided in the branch flow path as the liquid feeding flow path.

Technical Field

The present invention relates to a sample processing device.

Background

Patent document 1 describes a microfluidic system and a method. This patent document describes: the "microfluidic system includes a rigid layer, an elastomer layer, a fluid chamber or flow path between the rigid layer and the elastomer layer, and a control unit for operating the fluid of the fluid chamber or flow path to deform the elastomer layer".

Disclosure of Invention

Problems to be solved by the invention

Patent document 1 describes a microfluidic system including a control unit for operating a fluid in a fluid chamber or a flow path to deform an elastic body layer. However, although the microflow system described in patent document 1 achieves a predetermined volume flow rate, that is, a predetermined volume of fluid flowing per unit time by repeating deformation of the elastomer layer, there is no description about an operation for quantifying a certain amount of fluid. Therefore, in an operation of taking out a certain amount of fluid and processing it, for example, an operation of mixing 2 kinds of fluids at a certain volume ratio, there is a problem that a volume ratio with sufficient accuracy cannot be achieved.

The present invention aims to provide a sample processing device capable of quantifying a fluid by deformation of an elastic membrane.

Means for solving the problems

In order to solve the above problem, a typical sample processing apparatus according to the present invention includes: an analysis chip having a flow path on a lower surface side; a drive section having a plurality of recesses on an upper surface side; an elastic membrane located between the analysis chip and the driving part; and an air pressure control unit for switching between the state where the elastic membrane is in close contact with the analysis chip and the state where the elastic membrane is in close contact with the drive unit,

the analysis chip includes a quantitative flow path for quantification of a liquid and at least 4 branch flow paths branched from the quantitative flow path,

the driving part has a concave part below each end part of the 4 branch flow paths on the non-quantitative flow path side,

each concave portion communicates with the air pressure control portion.

Effects of the invention

According to the present invention, a sample processing device capable of quantifying a fluid by deformation of an elastic membrane can be provided.

Problems, structures, and effects other than those described above will be apparent from the following description of the embodiments.

Drawings

FIG. 1 is a top view and a side sectional view of an analysis chip of example 1.

Fig. 2 is a top view and a side view of the sample processing device of example 1.

Fig. 3 is an air piping system diagram for controlling the pressure of the driving unit in the sample processing device according to embodiment 1.

FIG. 4 is a view showing the flow of operation of the sample processing device according to example 1.

FIG. 5 is a diagram showing an analysis operation flow of the sample processing apparatus according to example 1.

FIG. 6 is a diagram showing a flow of a sample introduction operation of the sample processing device according to example 1.

FIG. 7a is a diagram illustrating a sample introducing operation of the sample processing device according to example 1.

FIG. 7b is a diagram for explaining a sample introducing operation of the sample processing device according to example 1.

FIG. 8 is an explanatory view showing a state of holding a sample in the sample processing device according to example 1.

Fig. 9 is a diagram showing a flow of a sample disposal operation of the sample processing apparatus according to example 1.

Fig. 10a is an explanatory diagram of a sample disposal operation of the sample processing apparatus according to embodiment 1.

Fig. 10b is an explanatory diagram of a sample disposal operation of the sample processing apparatus of example 1.

FIG. 11 is a diagram showing a flow of a sample cutting operation of the sample processing apparatus according to example 1.

Fig. 12a is an explanatory diagram of a sample cutting operation of the sample processing device of example 1.

Fig. 12b is an explanatory diagram of a sample cutting operation of the sample processing device of example 1.

FIG. 13 is a diagram showing a flow of a reagent introducing operation in the sample processing apparatus according to example 1.

FIG. 14 is a diagram showing a flow of an agitating operation in the sample processing apparatus according to example 1.

FIG. 15a is a diagram illustrating an agitating operation of the sample processing apparatus according to example 1.

FIG. 15b is a diagram illustrating the stirring operation of the sample processing apparatus according to example 1.

Fig. 16 is a diagram showing a flow of a metering operation of the sample processing apparatus according to example 1.

FIG. 17 is a top view and a side sectional view of an analysis chip of example 2.

FIG. 18 is a top view and a side sectional view of an analysis chip of example 3.

Detailed Description

Hereinafter, embodiments will be described with reference to the drawings.