阅读说明：本技术 一种喷雾连续反应的装置及方法 (Device and method for spray continuous reaction ) 是由 刘新哲 于 2019-11-04 设计创作，主要内容包括：本发明提供一种喷雾连续反应器,反应器上安装流体喷枪,利用惰性气体高速流动的原理,使液体微粒化,通过两股高速流动的流体瞬间激烈撞击,实现能量的快速耗散,从而迅速降低两股流体之间的离析程度,达到快速混合的目的。碰撞反应发生的同时惰性气体可以携带走大部分的热量,利于反应的进行。撞击流体可以设计成对称结构,也可以设计成不对称结构。流体的入口可以设计成高压喷嘴形式,也可以设计成用气体输送的双流体喷嘴两股流体经过喷嘴雾形式。雾化后在反应器内相互撞击、混合。实验研究发现雾滴直径约200μm-300μm液滴的碰撞混合更有利于液体的均匀混合。(The invention provides a spray continuous reactor, wherein a fluid spray gun is arranged on the reactor, liquid is micronized by utilizing the principle of high-speed flow of inert gas, and two streams of high-speed flowing fluid are instantaneously and violently collided to realize rapid energy dissipation, so that the segregation degree between the two streams of fluid is rapidly reduced, and the aim of rapid mixing is fulfilled. When the collision reaction occurs, the inert gas can carry away most of heat, and the reaction is facilitated. The impinging fluid may be designed in a symmetrical configuration or in an asymmetrical configuration. The fluid inlet may be designed as a high pressure nozzle or as a two-fluid nozzle with gas delivery through which the two flows pass in the form of a spray. After atomization, they are mutually impacted and mixed in the reactor. Experimental studies find that the collision mixing of droplets with the diameter of about 200-300 μm is more beneficial to the uniform mixing of the liquid.)

1. An apparatus for spray continuous reaction, characterized in that: the two-fluid spray gun type mixing device comprises a reactor and at least two-fluid spray guns arranged on the reactor and used for atomizing liquid conveyed into the two-fluid spray guns into micro droplets, wherein the two-fluid spray guns are arranged towards each other so that the micro droplets generated by the two-fluid spray guns collide with each other and are rapidly mixed to form a mixture.

2. A device for spray continuous reaction according to claim 1, wherein: the at least two dual-fluid spray guns are arranged in pairs to form one or more pairs.

3. A spray continuous reaction apparatus according to claim 2, wherein: each pair of two-fluid guns delivers a different solution and carrier gas into the reactor from at least one direction.

4. A device for spray continuous reaction according to claim 3, wherein: the double-fluid spray gun comprises a spray gun inner pipe and a spray gun outer pipe, the spray gun outer pipe is sleeved at the spray gun inner pipe, liquid reaches the spray head through a liquid inlet of the spray gun inner pipe, gas reaches the spray head through a gas inlet of a gas path formed by the spray gun inner pipe and the spray gun outer pipe, the liquid and the gas are atomized at the spray head, a gas cap and a liquid cap are arranged at the spray head, the spray head is conical, and spray holes are formed in the conical spray head.

5. A device for spray continuous reaction according to claim 1, wherein: a reducing agent injector is also arranged below the reactor.

6. A device for spray continuous reaction according to claim 1, wherein: and a material conveying pump is arranged at a material outlet below the reactor and used for conveying the produced mixture to the next system.

7. A device for spray continuous reaction according to claim 1, wherein: the reactor top still is provided with the radar level gauge, and the bottom is equipped with the differential pressure type level gauge, and radar level gauge, differential pressure type level gauge all connect the PLC controller.

8. A device for spray continuous reaction according to claim 4, characterized in that: and a recovery device is also arranged above the reactor and is used for recycling the carrier gas.

9. A spray continuous reaction apparatus according to claim 8, wherein: the recovery device includes a compressor that delivers the carrier gas to the air inlet.

10. The method for carrying out the spray continuous reaction by using the device is characterized by comprising the following steps: the method comprises the following steps:

step 1, feeding different material solutions and carrier gas into a double-fluid spray gun together for atomization;

step 2, atomizing into small fog drops, then colliding in a reactor, quickly reacting, and pumping the generated materials out through a material conveying pump to enter a next system;

and 3, conveying the carrier gas into the gas inlet through a recovery device for recycling.

Technical Field

The invention belongs to the technical field of pharmaceutical industry, and particularly relates to a device and a method for spray continuous reaction.

Background

The equipment for realizing liquid-liquid mixing by using a turbulent mixing mechanism in industrial production mainly comprises a stirring kettle mixer, a jet flow jet mixer, an impinging stream mixer, a static mixer, a dynamic mixer and the like, wherein the macro mixing time corresponding to the process of mixing fluid in a mechanical stirring mode is longer, the process is mainly controlled by macro mixing, about 85 percent of liquid-liquid mixing process in industrial production is finished in the stirring kettle, and the existing reaction equipment mostly adopts mechanical stirring and intermittent production modes, so that on one hand, the reaction is incomplete, the conversion rate is reduced, on the other hand, the labor intensity of operators is high, and the operation cost is high.

Disclosure of Invention

In view of the above, the present invention is directed to a device for spray continuous reaction, which solves the above mentioned problems in the background art.

In order to achieve the purpose, the technical scheme of the invention is realized as follows:

an apparatus for spray continuous reaction comprising a reactor, and at least two-fluid spray guns disposed on the reactor for atomizing liquid delivered thereto into minute droplets, the at least two-fluid spray guns being disposed toward each other so that the minute droplets produced by the two-fluid spray guns collide with each other and are rapidly mixed to form a mixture.

Further, the at least two dual-fluid spray guns are arranged in pairs to form one or more pairs.

Further, each pair of two-fluid guns delivers a different solution and carrier gas into the reactor from at least one direction.

Furthermore, the double-fluid spray gun comprises a spray gun inner tube and a spray gun outer tube, the spray gun outer tube is sleeved at the spray gun inner tube, liquid reaches the spray head through a liquid inlet of the spray gun inner tube, gas reaches the spray head through a gas inlet of a gas path formed by the spray gun inner tube and the spray gun outer tube, the liquid and the gas are atomized at the spray head, a gas cap and a liquid cap are arranged at the spray head, the spray head is conical, and spray holes are formed in the conical spray head.

Further, a reducing agent injector is arranged below the reactor.

Further, a material conveying pump is arranged at a material outlet below the reactor and used for conveying the produced mixture to the next system.

Further, the top of the reactor is also provided with a radar liquid level meter, the bottom of the reactor is provided with a differential pressure type liquid level meter, and the radar liquid level meter and the differential pressure type liquid level meter are both connected with a PLC (programmable logic controller).

Furthermore, a jacket is also arranged on the outer wall of the reactor.

Furthermore, a recovery device is arranged above the reactor and used for recycling the carrier gas.

Further, the recovery device comprises a compressor, and the compressor conveys the carrier gas to the air inlet.

Another purpose of the invention is to provide a spray continuous reaction method, which comprises the following steps

Step 1, feeding different material solutions and carrier gas into a double-fluid spray gun together for atomization;

step 2, atomizing into small fog drops, then colliding in a reactor, quickly reacting, and pumping the generated materials out through a material conveying pump to enter a next system;

and 3, conveying the carrier gas into the gas inlet through a recovery device for recycling.

Compared with the prior art, the device for spray continuous reaction has the following advantages:

1. the invention can realize continuous feeding and continuous reaction;

2. the invention has the advantages of rapid collision reaction, short time, high conversion rate, less by-products and finished product quality

3. The carrier gas of the invention takes away most of heat and is suitable for heat-sensitive substances;

4. the invention realizes the recycling of carrier gas and is green and emission-free.

Drawings

The accompanying drawings, which are incorporated in and constitute a part of this specification, illustrate an embodiment of the invention and, together with the description, serve to explain the invention and not to limit the invention. In the drawings:

FIG. 1 is a schematic diagram of a droplet fast collision according to an embodiment of the present invention;

FIG. 2 is a schematic diagram of an apparatus for spray continuous reaction according to an embodiment of the present invention;

FIG. 3 is a schematic structural view of a dual fluid spray gun according to an embodiment of the present invention;

FIG. 4 is a schematic structural diagram of a gas cap according to an embodiment of the present invention;

fig. 5 is a schematic view of a threaded connection structure of a gas cap and a liquid cap according to an embodiment of the present invention.

Description of reference numerals:

1-a first dual fluid spray gun; 2-a second dual fluid spray gun; 3-a reactor; 4-a material transfer pump; 5-inner tube of spray gun; 6-spray gun outer tube; 7-a connecting flange; 8-liquid cap; 9-a gas cap; 10-liquid inlet; 11-air inlet.

Detailed Description

It should be noted that the embodiments and features of the embodiments may be combined with each other without conflict.

In the description of the present invention, it is to be understood that the terms "center", "longitudinal", "lateral", "up", "down", "front", "back", "left", "right", "vertical", "horizontal", "top", "bottom", "inner", "outer", and the like, indicate orientations or positional relationships based on those shown in the drawings, and are used only for convenience in describing the present invention and for simplicity in description, and do not indicate or imply that the referenced devices or elements must have a particular orientation, be constructed and operated in a particular orientation, and thus, are not to be construed as limiting the present invention. Furthermore, the terms "first", "second", etc. are used for descriptive purposes only and are not to be construed as indicating or implying relative importance or implicitly indicating the number of technical features indicated. Thus, a feature defined as "first," "second," etc. may explicitly or implicitly include one or more of that feature. In the description of the present invention, "a plurality" means two or more unless otherwise specified.

In the description of the present invention, it should be noted that, unless otherwise explicitly specified or limited, the terms "mounted," "connected," and "connected" are to be construed broadly, e.g., as meaning either a fixed connection, a removable connection, or an integral connection; can be mechanically or electrically connected; they may be connected directly or indirectly through intervening media, or they may be interconnected between two elements. The specific meaning of the above terms in the present invention can be understood by those of ordinary skill in the art through specific situations.

The present invention will be described in detail below with reference to the embodiments with reference to the attached drawings.

As shown in fig. 1-5, the present invention provides a spray continuous reactor, wherein a fluid spray gun is installed on the reactor, the liquid is atomized by using the principle of high-speed flow of inert gas, and two streams of high-speed flowing fluid are instantaneously and violently collided to realize rapid dissipation of energy, so that the separation degree between the two streams of fluid is rapidly reduced, and the purpose of rapid mixing is achieved. When the collision reaction occurs, the inert gas can carry away most of heat, and the reaction is facilitated. The impinging fluid may be designed in a symmetrical configuration or in an asymmetrical configuration. The fluid inlet may be designed as a high pressure nozzle or as a two-fluid nozzle with gas delivery through which the two flows pass in the form of a spray. After atomization, they are mutually impacted and mixed in the reactor. Experimental studies find that the collision mixing of droplets with the diameter of about 200-300 μm is more beneficial to the uniform mixing of the liquid.

Specifically, the reactor comprises a reactor 3 and at least two-fluid spray guns arranged on the reactor 3 and used for atomizing liquid conveyed into the two-fluid spray guns into tiny droplets, wherein the two-fluid spray guns are arranged towards each other, so that the tiny droplets generated by the two-fluid spray guns collide with each other and are rapidly mixed to form a mixture.

More specifically, the impinging stream reactor realizes rapid dissipation of energy by two streams of high-speed flowing fluid being instantaneously and violently impinged, thereby rapidly reducing the segregation degree between the two streams of fluid and achieving the purpose of rapid mixing. The impinging fluid may be designed in a symmetrical configuration or in an asymmetrical configuration. The fluid inlet may be designed as a high pressure nozzle or as a two-fluid nozzle with gas delivery through which the two flows pass in the form of a spray. After atomization, they are mutually impacted and mixed in the mixing chamber.

The at least two dual-fluid spray guns are arranged in pairs to form one or more pairs.

Each pair of two-fluid guns delivers a different solution and carrier gas into the reactor 3 from at least one direction. Wherein the carrier is inert gas.

As most of the fast reactions in the pharmaceutical industry belong to strong exothermic reactions, in order to ensure that the fast reactions are carried out within a proper temperature range, considering that the double-fluid spray gun generates proper droplet size to ensure the retention time of the droplets and avoid the upward movement of the droplets, partial reaction heat can be taken away by utilizing the inert gas circulation in the double-fluid spray device.

The double-fluid spray gun comprises a spray gun inner tube 5 and a spray gun outer tube 6, the spray gun outer tube 6 is sleeved at the spray gun inner tube 5, liquid reaches a spray head through a liquid inlet 10 of the spray gun inner tube 5, gas reaches the spray head through a gas inlet 11 of a gas path formed by the spray gun inner tube 5 and the spray gun outer tube 6, the liquid and the gas are atomized at the spray head, a gas cap 9 and a liquid cap 8 are arranged at the spray head, the spray head is conical, and a spray hole is formed in the conical spray head. The two-fluid spray gun can make the particle diameter of liquid drop below 10 μm by high speed flow of compressed air.

The liquid drop contacts the in-process that the collision mixes and reacts, and the liquid solid mixture of production can descend under the effect of gravity, because the viscidity effect of liquid solid mixture, partial solid particle can be attached to the reactor wall, consequently, still sets up the reductant sprayer in the below of reactor, dissolves the material on the reactor inner wall, avoids the solid wall sticking phenomenon in the reactor.

A material delivery pump 4 is provided at a material outlet below the reactor 3 for delivering the produced mixture to the next system. The solution and inert gas are metered by a flowmeter, sprayed into the reactor according to the required quality, and adapted to the operation load of the production line through the interlocking control of the liquid level and the delivery pump after reaction.

The top of the reactor 3 is also provided with a radar liquid level meter, the bottom of the reactor is provided with a differential pressure type liquid level meter, and the radar liquid level meter and the differential pressure type liquid level meter are both connected with a PLC controller. The accuracy of liquid level measurement is ensured by the two liquid level meters because the viscosity of the generated material is not easy to measure and the requirement of the middle part of the reactor on the radar liquid level meter is higher due to the spray area. The whole system is controlled by a PLC, the system realizes automatic operation, the operation is basically unattended, core data has a report function, the labor cost is reduced, and the labor intensity is reduced. It should be noted that the electronic components such as the level meter and the PLC used in the present invention are all existing products, and the connection relationship with the PLC is a connection relationship that is commonly used by those skilled in the art.

The outer wall of the reactor 3 is also provided with a jacket, and partial reaction heat is taken away by utilizing the heat exchange of the jacket on the outer wall of the reactor.

And a recovery device is arranged above the reactor 3 and used for recycling the carrier gas. The recovery device 3 comprises a compressor which delivers the carrier gas to the inlet.

When the device is used, the material A solution and the material B solution respectively enter a first double-fluid spray gun 1 and a second double-fluid spray gun 2 together with inert gas, are atomized into small fog drops and then collide in a reactor 3 to rapidly react, and after the generated material is detected to be qualified, a reducing agent is introduced to dissolve viscous materials, and the materials are pumped out through a material conveying pump 4 to enter the next system; the atomized liquid drops have small particle size, the contact and reaction are carried out in the collision process, and the carrier gas (inert gas) used by the double-fluid spray gun can be recycled in consideration of large consumption and no influence of other impurities.

The above description is only for the purpose of illustrating the preferred embodiments of the present invention and is not to be construed as limiting the invention, and any modifications, equivalents, improvements and the like that fall within the spirit and principle of the present invention are intended to be included therein.