阅读说明：本技术 一种抑菌防龋组合物及其制备方法和应用 (Antibacterial and anticarious composition and preparation method and application thereof ) 是由 尹丽娟 张环 邓全富 唐伟月 陆瑜 邓嵘 邱琳 于 2019-10-10 设计创作，主要内容包括：本发明属于日化领域,涉及一种用于口腔用品的组合物及其制备方法和应用,具体涉及一种抑菌防龋组合物及其制备方法和应用。本发明的抑菌防龋组合物由聚多巴胺颗粒和聚磷酸盐组成。在抑制口腔环境常见细菌的功效上,两种物质具有协同增效的现象,由聚多巴胺颗粒和聚磷酸盐组成的抑菌防龋组合物在预防牙周病和预防龋病上都具有较好的效果。本发明的抑菌防龋组合物可以应用到牙膏、液体牙膏、漱口水、牙粉、牙齿凝胶或者口香糖的研发和生产中。(The invention belongs to the field of daily chemicals, relates to a composition for oral products, a preparation method and application thereof, and particularly relates to a bacteriostatic and anticarious composition, a preparation method and application thereof. The bacteriostatic anticarious composition consists of polydopamine particles and polyphosphate. The two substances have the synergistic effect on the effect of inhibiting common bacteria in the oral environment, and the antibacterial and anticarious composition consisting of the polydopamine particles and the polyphosphate has better effects on preventing periodontal diseases and caries. The antibacterial and anticarious composition can be applied to the development and production of toothpaste, liquid toothpaste, mouthwash, tooth powder, tooth gel or chewing gum.)

1. An antibacterial and anticarious composition is characterized by consisting of polydopamine particles and polyphosphate.

2. The bacteriostatic anticariogenic composition according to claim 1, wherein the weight percentage of the polydopamine particles is 1-30%, and the balance is polyphosphate.

3. A bacteriostatic and anticariogenic composition according to claim 2, wherein said polyphosphate is one or a mixture of more than one of magnesium polyphosphate, sodium polyphosphate, calcium polyphosphate, strontium polyphosphate and zinc polyphosphate.

4. use of a bacteriostatic anticaries composition according to any one of claims 1 to 3 in toothpaste, liquid toothpaste, mouthwash, tooth powder, tooth gel or chewing gum.

5. The use according to claim 4, wherein the raw materials of the toothpaste comprise abrasives, thickeners, humectants, flavoring agents, surfactants, perfumes, water, preservatives and bacteriostatic anticaries compositions; the antibacterial and anticarious composition consists of polydopamine particles and polyphosphate.

6. The use of claim 5, wherein the humectant comprises polyethylene glycol and a residual humectant selected from one or a mixture of more than one of glycerin, sorbitol and propylene glycol; the preservative is one or a mixture of more than one of sodium benzoate, hydroxybenzene esters, potassium sorbate and cymene.

7. The use according to claim 6, wherein the thickener is one or a mixture of more than one of hydroxyethylcellulose, xanthan gum, carrageenan, carbomer and hydroxymethylcellulose.

8. the use according to claim 7, wherein the surfactant is one or more of sodium lauryl sulfate, sodium lauroyl sarcosinate, sodium thiolsulfonate and cocamidopropyl betaine.

9. The use of claim 8, wherein the toothpaste comprises the following raw materials in percentage by weight: 0.025-0.5% of polydopamine particles, 1.2-2% of polyphosphate, 5-70% of humectant, 0-60% of abrasive, 0.3-10% of thickener, 0.1-20% of surfactant, 0.1-2% of flavoring agent, 0.1-5% of essence, 0-0.25% of preservative and the balance of water.

10. Use according to any of claims 5 to 9, wherein the toothpaste is prepared by a process comprising:

(1) Dissolving polydopamine particles by using polyethylene glycol, adding the rest humectant, then adding a thickening agent, stirring and homogenizing, sequentially adding a flavoring agent, polyphosphate, a surfactant and water, and uniformly stirring to obtain a mixture A;

(2) Adding a friction agent into the mixture A, vacuumizing a container containing the mixture A, and uniformly stirring the mixture A and the friction agent to obtain a mixture B;

(3) Adding essence into the mixture B, stirring, homogenizing, and degassing to obtain toothpaste.

Technical Field

The invention belongs to the field of daily chemicals, relates to a composition for oral products, a preparation method and application thereof, and particularly relates to a bacteriostatic and anticarious composition, a preparation method and application thereof.

Background

Dopamine (4- (2-ethylamino) benzene-1, 2-diol) is a typical catechol-based derivative that self-polymerizes under alkaline conditions to form polydopamine particles. The poly-dopamine particle has a large amount of active groups such as phenolic hydroxyl groups, amino groups and the like on the surface and in the structure, so that the poly-dopamine particle has excellent surface activity. The polydopamine particles have rich reducing functional groups such as catechol and imine, have certain antioxidant activity, and can effectively inhibit periodontal diseases (including oxidative stress periodontal diseases) caused by excessive active oxygen. The polydopamine particles also have antibacterial property, and experimental tests show that the polydopamine particles have an inhibiting effect on gram-positive staphylococcus aureus and gram-negative escherichia coli. In addition, the polydopamine particles have good adhesion and biocompatibility, and the preparation process is simple and the preparation cost is low. Currently, polydopamine particles have been used in the production of oral cleaning products.

Chinese patent CN106176378A (a preparation method of toothpaste and mouthwash for preventing caries and repairing dental caries) discloses a dopamine-containing toothpaste, wherein when the toothpaste is used for cleaning oral cavity, dopamine is oxidized and self-polymerized to form polydopamine particles which are adhered to the surface of dentin, thereby realizing remineralization of the dentin, forming a firm and compact protective layer, and effectively preventing caries and repairing dental caries. However, the prior art solutions have the following drawbacks: (1) polydopamine particles alone have limited ability to combat bacteria commonly found in the oral environment (e.g., streptococcus mutans and porphyromonas gingivalis); (2) the poly-dopamine particles are easy to aggregate, so that the poly-dopamine particles cannot be uniformly attached to the surfaces of teeth, the application of the poly-dopamine particles in the oral environment is hindered, and the antibacterial and anticarious effects of the poly-dopamine particles are limited.

Disclosure of Invention

The invention aims to provide a bacteriostatic and anticarious composition which can effectively inhibit common bacteria in the oral environment and has the effect of preventing caries.

In order to solve the technical problems, the technical scheme of the invention is as follows:

A composition with antibacterial and anticarious effects comprises polydopamine granule and polyphosphate.

By adopting the technical scheme, the technical principle and the beneficial effects are as follows:

The polydopamine particles have antioxidant and antibacterial effects, and can effectively inhibit periodontal diseases; the polyphosphate can influence and inhibit the generation and development of dental caries by changing the physicochemical and biological properties of teeth, saliva and dental plaque. Based on the properties of the two substances, the inventors added both substances to the oral cleaning article to achieve their respective effects. The inventor unexpectedly found that the two substances have a synergistic effect in inhibiting bacteria which are common in the oral environment. The inventor carries out a large number of bacteriostatic tests and verifies that the combined use of the polydopamine particles and the polyphosphate has a synergistic phenomenon. Compared with the single use of polydopamine particles and the single use of polyphosphate, the bacteriostatic effect of the bacteriostatic caries-preventing composition (namely the combined use of polydopamine particles and polyphosphate) is obviously improved. The inventor analyzes that the mechanism of the synergy of the two substances is as follows: the polydopamine particles have cell adhesion, can be attached to biomolecules and coated on the surfaces of bacteria, so that the permeation and absorption of vital substances (such as nutrients and other chemical substances) of the bacteria are hindered, and the discharge of metabolic waste is blocked, so that the growth of the bacteria is inhibited; the polyphosphate can change the biological characteristics of the surface of bacteria, so that poly-dopamine particles can be easily accumulated and covered on the surface of the bacteria, and the exchange of substances between the bacteria and the external environment is more strongly inhibited.

In summary, the antibacterial and anticarious composition consisting of the polydopamine particles and the polyphosphate has the beneficial effects that:

(1) The polydopamine particles and the polyphosphate are combined for the first time, and the composition formed by the polydopamine particles and the polyphosphate has the functions of inhibiting bacteria and preventing caries. In addition, the two substances have a synergistic effect on the effect of inhibiting common bacteria in the oral environment. Because of the synergistic effect of the two on the bacteriostasis, the effects of preventing periodontal disease and caries of the bacteriostasis and caries-prevention composition are enhanced.

(2) the polyphosphate has the effect of inhibiting the occurrence and the development of caries, can replace fluoride in the prior art to be added into oral products, and avoids toxic side effects caused by excessive fluorine intake. The polyphosphate can effectively change the physicochemical and biological properties of teeth, saliva and dental plaque, thereby inhibiting the occurrence and development of dental caries.

(3) The polydopamine particles have double effects of oxidation resistance and antibiosis, and can cover the surfaces of teeth, thereby having a certain effect of protecting the teeth and preventing dental caries. In addition, polydopamine particles coat the surface of a living body, so that the source of substances required by the life of bacteria is blocked, and the purpose of bacteriostasis is achieved. In addition, the polydopamine particle surface has rich reducing functional groups such as catechol and imine, and can effectively inhibit oral diseases (including oxidative stress periodontal diseases) caused by excessive active oxygen.

(4) The polydopamine particles and the polyphosphate have the advantages of good biocompatibility, simple preparation method and low cost.

Further, the weight percentage of the polydopamine particles is 1-30%, and the balance is polyphosphate.

By adopting the technical scheme, the antibacterial and anticarious composition can obtain better antibacterial effect, thereby preventing the occurrence of caries.

Further, the polyphosphate is one or a mixture of more than one of magnesium polyphosphate, sodium polyphosphate, calcium polyphosphate, strontium polyphosphate and zinc polyphosphate.

by adopting the technical scheme, different types of polyphosphates can be selected according to actual needs. For example, strontium polyphosphate is selected to cooperate with polydopamine particles, and in addition to the synergistic bacteriostatic effect of the two, strontium ions also have the effect of preventing tooth sensitivity.

Further, an application of the antibacterial and anticarious composition in toothpaste, liquid toothpaste, mouthwash, tooth powder, tooth gel or chewing gum.

by adopting the technical scheme, the antibacterial and anticarious composition consisting of the polydopamine particles and the polyphosphate is applied to toothpaste, liquid toothpaste, mouthwash, tooth powder, tooth gel or chewing gum, and the two substances (the polydopamine particles and the polyphosphate) are synergistic in the using process, so that the inhibition of oral bacteria and the prevention and treatment of caries can be realized. The antibacterial and anticarious composition has multiple protection effects on the oral cavity, can improve some pathological symptoms of the oral cavity, slow down periodontal disease and gingivitis, inhibit the breeding of streptococcus mutans, and help users to prevent and treat caries.

The toothpaste body of the liquid toothpaste is transparent colloidal liquid, is amorphous liquid particles, is developed on the basis of the toothpaste, and can quickly go deep into the slit between the teeth to cover the whole teeth.

Further, the raw materials of the toothpaste comprise an abrasive, a thickening agent, a humectant, a flavoring agent, a surfactant, essence, water and a bacteriostatic and anticarious composition; the antibacterial and anticarious composition consists of polydopamine particles and polyphosphate.

by adopting the technical scheme, the toothpaste is the most common oral cavity cleaning product with the highest use frequency, and the antibacterial and anticarious composition is added into the toothpaste, so that the use frequency of the antibacterial and anticarious composition can be increased, and better effects of inhibiting oral bacteria and preventing caries can be obtained.

Further, the humectant comprises polyethylene glycol and the rest humectant, wherein the rest humectant is one or a mixture of more than one of glycerol, sorbitol and propylene glycol.

By adopting the technical scheme, the polyethylene glycol can prevent polydopamine particles from aggregating, so that the biological efficacy (bacteriostasis and caries prevention effect) of the polydopamine particles is increased. The inventor finds that the polydopamine particles are easy to aggregate in the preparation process of the toothpaste, and particularly when the antibacterial and anticarious composition is directly added into a toothpaste system, the polydopamine particles and other water materials in the toothpaste system have compatibility, so that the toothpaste can agglomerate and dry, and the stability of the toothpaste is poor. In an attempt to solve the above problems, the inventors have found that the addition of polyethylene glycol to toothpaste can functionalize the surface of polydopamine particles, greatly enhance the stability and functionality of polydopamine particles, and reduce the aggregation of polydopamine particles. And one or more of glycerin, sorbitol and propylene glycol are compounded, so that the toothpaste body system containing the toothpaste is stable, and the problems of poor stability and difficult storage of the toothpaste are solved.

Further, the thickening agent is one or a mixture of more than one of hydroxyethyl cellulose, xanthan gum, carrageenan, carbomer and hydroxymethyl cellulose.

By adopting the technical scheme, the thickening agent is a commonly used substance in the prior art, and has the advantages of good safety and stability, low price and easy acquisition.

Further, the surfactant is one or a mixture of more than one of sodium lauryl sulfate, sodium lauroyl sarcosinate, sodium sulfur sulfonate and cocamidopropyl betaine.

By adopting the technical scheme, the surfactant is a commonly used substance in the prior art, and has the advantages of good safety and stability, low price and easy acquisition.

Further, the toothpaste comprises the following raw materials in percentage by weight: 0.025-0.5% of polydopamine particles, 1.2-2% of polyphosphate, 5-70% of humectant, 0-60% of abrasive, 0.3-10% of thickener, 0.1-20% of surfactant, 0.1-2% of flavoring agent, 0.1-5% of essence, 0-0.25% of preservative and the balance of water.

By adopting the technical scheme, the toothpaste prepared according to the components and the content has better effects of resisting bacteria, preventing decayed teeth and relieving periodontal disease and gingivitis.

further, the toothpaste is prepared by the following method:

(1) Dissolving polydopamine particles by using polyethylene glycol, adding the rest humectant, then adding a thickening agent, stirring and homogenizing, sequentially adding a flavoring agent, polyphosphate, a surfactant and water, and uniformly stirring to obtain a mixture A;

(2) Adding a friction agent into the mixture A, vacuumizing a container containing the mixture A, and uniformly stirring the mixture A and the friction agent to obtain a mixture B;

(3) Adding essence into the mixture B, stirring, homogenizing, and degassing to obtain toothpaste.

By adopting the technical scheme, the toothpaste product has the effects of resisting bacteria, preventing decayed teeth and relieving periodontal disease and gingivitis. Firstly, polyethylene glycol is used for dissolving polydopamine particles, so that the polyethylene glycol and the polydopamine particles act to functionalize the surfaces of the polydopamine particles, the dispersion degree of the polydopamine particles is increased, and then other components are compounded, so that the stability of the finally prepared toothpaste body is ensured.

Detailed Description

The following is further detailed by way of specific embodiments: